|
US3547119A
(en)
|
1967-12-08 |
1970-12-15 |
Baxter Laboratories Inc |
Catheter assembly
|
|
US4211771A
(en)
|
1971-06-01 |
1980-07-08 |
Robins Ronald K |
Treatment of human viral diseases with 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide
|
|
US3798209A
(en)
*
|
1971-06-01 |
1974-03-19 |
Icn Pharmaceuticals |
1,2,4-triazole nucleosides
|
|
US4311137A
(en)
|
1980-04-30 |
1982-01-19 |
Sherwood Medical Industries Inc. |
Infusion device
|
|
US4531937A
(en)
|
1983-01-24 |
1985-07-30 |
Pacesetter Systems, Inc. |
Introducer catheter apparatus and method of use
|
|
CS263951B1
(en)
*
|
1985-04-25 |
1989-05-12 |
Antonin Holy |
9-(phosponylmethoxyalkyl)adenines and method of their preparation
|
|
NZ216172A
(en)
|
1985-05-15 |
1989-08-29 |
Wellcome Found |
Nucleosides and pharmaceutical compositions
|
|
US4806347A
(en)
|
1985-12-11 |
1989-02-21 |
Schering Corporation |
Interferon combinations
|
|
US4755173A
(en)
|
1986-02-25 |
1988-07-05 |
Pacesetter Infusion, Ltd. |
Soft cannula subcutaneous injection set
|
|
CS264222B1
(en)
*
|
1986-07-18 |
1989-06-13 |
Holy Antonin |
N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
|
|
US5082659A
(en)
|
1986-10-06 |
1992-01-21 |
Board Of Regents, The University Of Texas System |
Methods and compositions employing interferon-gamma
|
|
US5190751A
(en)
|
1987-01-20 |
1993-03-02 |
Schering Corporation |
Treatment of certain leukemias with a combination of gamma interferon and alpha interferon
|
|
ES2039276T3
(es)
|
1987-01-20 |
1993-09-16 |
Schering Corporation |
Uso de una combinacion de interferon gamma e interferon alfa para la preparacion de un medicamento para el tratamiento de ciertas leucemias.
|
|
EP0294160A1
(en)
|
1987-06-02 |
1988-12-07 |
Schering Corporation |
Treatment of chronic type b hepatitis with a combination of recombinant human alpha and gamma interferons
|
|
GB8815265D0
(en)
|
1988-06-27 |
1988-08-03 |
Wellcome Found |
Therapeutic nucleosides
|
|
US5539122A
(en)
*
|
1989-05-23 |
1996-07-23 |
Abbott Laboratories |
Retroviral protease inhibiting compounds
|
|
US5232928A
(en)
|
1989-07-25 |
1993-08-03 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Tetrahydroisoquinoline amides
|
|
US5310562A
(en)
|
1989-11-22 |
1994-05-10 |
Margolin Solomon B |
Composition and method for reparation and prevention of fibrotic lesions
|
|
US5716632A
(en)
|
1989-11-22 |
1998-02-10 |
Margolin; Solomon B. |
Compositions and methods for reparation and prevention of fibrotic lesions
|
|
US5518729A
(en)
|
1989-11-22 |
1996-05-21 |
Margolin; Solomon B. |
Compositions and methods for reparation and prevention of fibrotic lesions
|
|
US5372808A
(en)
|
1990-10-17 |
1994-12-13 |
Amgen Inc. |
Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect
|
|
US5610054A
(en)
|
1992-05-14 |
1997-03-11 |
Ribozyme Pharmaceuticals, Inc. |
Enzymatic RNA molecule targeted against Hepatitis C virus
|
|
US5382657A
(en)
|
1992-08-26 |
1995-01-17 |
Hoffmann-La Roche Inc. |
Peg-interferon conjugates
|
|
US5545143A
(en)
|
1993-01-21 |
1996-08-13 |
T. S. I. Medical |
Device for subcutaneous medication delivery
|
|
DE69430251T2
(de)
|
1993-11-10 |
2002-11-07 |
Enzon, Inc. |
Verbesserte interferon-polymerkonjugate
|
|
US5624949A
(en)
|
1993-12-07 |
1997-04-29 |
Eli Lilly And Company |
Protein kinase C inhibitors
|
|
US6693072B2
(en)
|
1994-06-02 |
2004-02-17 |
Aventis Pharmaceuticals Inc. |
Elastase inhibitors
|
|
US5756466A
(en)
|
1994-06-17 |
1998-05-26 |
Vertex Pharmaceuticals, Inc. |
Inhibitors of interleukin-1β converting enzyme
|
|
US5847135A
(en)
|
1994-06-17 |
1998-12-08 |
Vertex Pharmaceuticals, Incorporated |
Inhibitors of interleukin-1β converting enzyme
|
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
IL116730A0
(en)
|
1995-01-13 |
1996-05-14 |
Amgen Inc |
Chemically modified interferon
|
|
US6090822A
(en)
|
1995-03-03 |
2000-07-18 |
Margolin; Solomon B. |
Treatment of cytokine growth factor caused disorders
|
|
GB9517022D0
(en)
|
1995-08-19 |
1995-10-25 |
Glaxo Group Ltd |
Medicaments
|
|
US5908621A
(en)
|
1995-11-02 |
1999-06-01 |
Schering Corporation |
Polyethylene glycol modified interferon therapy
|
|
US5980884A
(en)
|
1996-02-05 |
1999-11-09 |
Amgen, Inc. |
Methods for retreatment of patients afflicted with Hepatitis C using consensus interferon
|
|
US5908121A
(en)
|
1996-03-11 |
1999-06-01 |
Dardashti; Shahriar |
Adjustable display assembly
|
|
US5633388A
(en)
|
1996-03-29 |
1997-05-27 |
Viropharma Incorporated |
Compounds, compositions and methods for treatment of hepatitis C
|
|
EP0907659A1
(en)
|
1996-05-10 |
1999-04-14 |
Schering Corporation |
Synthetic inhibitors of hepatitis c virus ns3 protease
|
|
CZ298749B6
(cs)
|
1996-10-18 |
2008-01-16 |
Vertex Pharmaceuticals Incorporated |
Inhibitory serinových proteáz a farmaceutické prostředky s jejich obsahem
|
|
GB9623908D0
(en)
|
1996-11-18 |
1997-01-08 |
Hoffmann La Roche |
Amino acid derivatives
|
|
US5968895A
(en)
|
1996-12-11 |
1999-10-19 |
Praecis Pharmaceuticals, Inc. |
Pharmaceutical formulations for sustained drug delivery
|
|
AU7127298A
(en)
|
1997-04-14 |
1998-11-11 |
Emory University |
Serine protease inhibitors
|
|
GB9707659D0
(en)
|
1997-04-16 |
1997-06-04 |
Peptide Therapeutics Ltd |
Hepatitis C NS3 Protease inhibitors
|
|
DE69829381T2
(de)
|
1997-08-11 |
2006-04-13 |
Boehringer Ingelheim (Canada) Ltd., Laval |
Hepatitis c inhibitor peptide
|
|
EP1012180B1
(en)
|
1997-08-11 |
2004-12-01 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis c inhibitor peptide analogues
|
|
US6767991B1
(en)
|
1997-08-11 |
2004-07-27 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis C inhibitor peptides
|
|
US6172046B1
(en)
|
1997-09-21 |
2001-01-09 |
Schering Corporation |
Combination therapy for eradicating detectable HCV-RNA in patients having chronic Hepatitis C infection
|
|
US5985263A
(en)
|
1997-12-19 |
1999-11-16 |
Enzon, Inc. |
Substantially pure histidine-linked protein polymer conjugates
|
|
IT1299134B1
(it)
|
1998-02-02 |
2000-02-29 |
Angeletti P Ist Richerche Bio |
Procedimento per la produzione di peptidi con proprieta' inibitrici della proteasi ns3 del virus hcv, peptidi cosi' ottenibili e peptidi
|
|
DK1066247T3
(da)
|
1998-03-31 |
2007-04-02 |
Vertex Pharma |
Inhibitorer af serinproteaser, især hepatitis C virus NS3 protease
|
|
GB9812523D0
(en)
|
1998-06-10 |
1998-08-05 |
Angeletti P Ist Richerche Bio |
Peptide inhibitors of hepatitis c virus ns3 protease
|
|
US6323180B1
(en)
*
|
1998-08-10 |
2001-11-27 |
Boehringer Ingelheim (Canada) Ltd |
Hepatitis C inhibitor tri-peptides
|
|
AR022061A1
(es)
|
1998-08-10 |
2002-09-04 |
Boehringer Ingelheim Ca Ltd |
Peptidos inhibidores de la hepatitis c, una composicion farmaceutica que los contiene, el uso de los mismos para preparar una composicion farmaceutica, el uso de un producto intermedio para la preparacion de estos peptidos y un procedimiento para la preparacion de un peptido analogo de los mismos.
|
|
US6277830B1
(en)
|
1998-10-16 |
2001-08-21 |
Schering Corporation |
5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon
|
|
US7157430B2
(en)
*
|
1998-10-22 |
2007-01-02 |
Idun Pharmaceuticals, Inc. |
(Substituted)acyl dipeptidyl inhibitors of the ICE/CED-3 family of cysteine proteases
|
|
US6245740B1
(en)
|
1998-12-23 |
2001-06-12 |
Amgen Inc. |
Polyol:oil suspensions for the sustained release of proteins
|
|
UA74546C2
(en)
|
1999-04-06 |
2006-01-16 |
Boehringer Ingelheim Ca Ltd |
Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
|
|
US6608027B1
(en)
|
1999-04-06 |
2003-08-19 |
Boehringer Ingelheim (Canada) Ltd |
Macrocyclic peptides active against the hepatitis C virus
|
|
AU772386B2
(en)
|
1999-05-04 |
2004-04-29 |
Boehringer Ingelheim (Canada) Ltd. |
Surrogate cell-based system and method for assaying the activity of hepatitis C virus NS3 protease
|
|
US7256005B2
(en)
|
1999-08-10 |
2007-08-14 |
The Chancellor, Masters And Scholars Of The University Of Oxford |
Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity
|
|
JP4806154B2
(ja)
|
2000-04-03 |
2011-11-02 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
セリンプロテアーゼ、特にc型肝炎ウイルスns3プロテアーゼのインヒビター
|
|
JP4748911B2
(ja)
|
2000-04-05 |
2011-08-17 |
シェーリング コーポレイション |
N−環状p2部分を含むc型肝炎ウイルスの大環状ns3‐セリンプロテアーゼ阻害剤
|
|
NZ521456A
(en)
|
2000-04-19 |
2004-07-30 |
Schering Corp |
Macrocyclic NS3-Serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties
|
|
US7244721B2
(en)
|
2000-07-21 |
2007-07-17 |
Schering Corporation |
Peptides as NS3-serine protease inhibitors of hepatitis C virus
|
|
MXPA03000627A
(es)
*
|
2000-07-21 |
2004-07-30 |
Schering Corp |
Nuevos peptidos como inhibidores de proteasa serina-ns3 del virus de la hepatitis c.
|
|
CA2429359A1
(en)
|
2000-11-20 |
2002-08-08 |
Bristol-Myers Squibb Company |
Hepatitis c tripeptide inhibitors
|
|
DE60229059D1
(de)
|
2001-05-08 |
2008-11-06 |
Univ Yale |
Proteomimetische verbindungen und verfahren
|
|
CA2449504A1
(en)
|
2001-07-11 |
2003-01-23 |
Vertex Pharmaceuticals Incorporated |
Bridged bicyclic serine protease inhibitors
|
|
US6867185B2
(en)
|
2001-12-20 |
2005-03-15 |
Bristol-Myers Squibb Company |
Inhibitors of hepatitis C virus
|
|
US7119072B2
(en)
|
2002-01-30 |
2006-10-10 |
Boehringer Ingelheim (Canada) Ltd. |
Macrocyclic peptides active against the hepatitis C virus
|
|
CA2369711A1
(en)
|
2002-01-30 |
2003-07-30 |
Boehringer Ingelheim (Canada) Ltd. |
Macrocyclic peptides active against the hepatitis c virus
|
|
CA2370400A1
(en)
|
2002-02-01 |
2003-08-01 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis c inhibitor tri-peptides
|
|
CA2369970A1
(en)
|
2002-02-01 |
2003-08-01 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis c inhibitor tri-peptides
|
|
US6642204B2
(en)
|
2002-02-01 |
2003-11-04 |
Boehringer Ingelheim International Gmbh |
Hepatitis C inhibitor tri-peptides
|
|
CA2370396A1
(en)
|
2002-02-01 |
2003-08-01 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis c inhibitor tri-peptides
|
|
US7091184B2
(en)
|
2002-02-01 |
2006-08-15 |
Boehringer Ingelheim International Gmbh |
Hepatitis C inhibitor tri-peptides
|
|
US6828301B2
(en)
|
2002-02-07 |
2004-12-07 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical compositions for hepatitis C viral protease inhibitors
|
|
JP2005535574A
(ja)
*
|
2002-04-11 |
2005-11-24 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
セリンプロテアーゼ、特にhcvns3−ns4aプロテアーゼのインヒビター
|
|
AU2003231765B9
(en)
*
|
2002-04-26 |
2010-01-28 |
Gilead Sciences, Inc. |
Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds and the compounds as such
|
|
EP1506000B9
(en)
|
2002-05-20 |
2011-08-31 |
Bristol-Myers Squibb Company |
Heterocyclicsulfonamide hepatitis c virus inhibitors
|
|
US6878722B2
(en)
|
2002-05-20 |
2005-04-12 |
Bristol-Myers Squibb Company |
Substituted cycloalkyl P1′ hepatitis C virus inhibitors
|
|
US20060199773A1
(en)
*
|
2002-05-20 |
2006-09-07 |
Sausker Justin B |
Crystalline forms of (1R,2S)-N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-L-valyl-(4R)-4-[(6-methoxy-1-isoquinolinyl)oxy]-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenyl-cyclopropanecarboxamide, monopotassium salt
|
|
WO2004032827A2
(en)
|
2002-05-20 |
2004-04-22 |
Bristol-Myers Squibb Company |
Hepatitis c virus inhibitors
|
|
MY140680A
(en)
|
2002-05-20 |
2010-01-15 |
Bristol Myers Squibb Co |
Hepatitis c virus inhibitors
|
|
US20040033959A1
(en)
|
2002-07-19 |
2004-02-19 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Pharmaceutical compositions for hepatitis C viral protease inhibitors
|
|
US20040138109A1
(en)
|
2002-09-30 |
2004-07-15 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Potent inhibitor of HCV serine protease
|
|
PL199412B1
(pl)
|
2002-10-15 |
2008-09-30 |
Boehringer Ingelheim Int |
Nowe kompleksy rutenu jako (pre)katalizatory reakcji metatezy, pochodne 2-alkoksy-5-nitrostyrenu jako związki pośrednie i sposób ich wytwarzania
|
|
US20050075279A1
(en)
|
2002-10-25 |
2005-04-07 |
Boehringer Ingelheim International Gmbh |
Macrocyclic peptides active against the hepatitis C virus
|
|
US7601709B2
(en)
*
|
2003-02-07 |
2009-10-13 |
Enanta Pharmaceuticals, Inc. |
Macrocyclic hepatitis C serine protease inhibitors
|
|
AU2004211637C1
(en)
|
2003-02-07 |
2010-08-19 |
Enanta Pharmaceuticals, Inc. |
Macrocyclic hepatitis C serine protease inhibitors
|
|
US20040180815A1
(en)
|
2003-03-07 |
2004-09-16 |
Suanne Nakajima |
Pyridazinonyl macrocyclic hepatitis C serine protease inhibitors
|
|
EP1601685A1
(en)
|
2003-03-05 |
2005-12-07 |
Boehringer Ingelheim International GmbH |
Hepatitis c inhibiting compounds
|
|
UY28240A1
(es)
|
2003-03-27 |
2004-11-08 |
Boehringer Ingelheim Pharma |
Fases cristalinas de un potente inhibidor de la hcv
|
|
UA81028C2
(en)
|
2003-04-02 |
2007-11-26 |
Boehringer Ingelheim Int |
Pharmaceutical compositions for hepatitis c viral protease inhibitors
|
|
JP4231524B2
(ja)
|
2003-04-10 |
2009-03-04 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
大環状化合物の製造方法
|
|
EP1615949A1
(en)
|
2003-04-10 |
2006-01-18 |
Boehringer Ingelheim International GmbH |
Process for the preparation of macrocyclic compounds by ruthenium complex catalysed metathesis reaction
|
|
TW200510391A
(en)
*
|
2003-04-11 |
2005-03-16 |
Vertex Pharma |
Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
|
|
EP1629000B1
(en)
|
2003-04-16 |
2009-02-18 |
Bristol-Myers Squibb Company |
Macrocyclic isoquinoline peptide inhibitors of hepatitis c virus
|
|
US7176208B2
(en)
|
2003-04-18 |
2007-02-13 |
Enanta Pharmaceuticals, Inc. |
Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors
|
|
PL1628685T3
(pl)
*
|
2003-04-25 |
2011-05-31 |
Gilead Sciences Inc |
Przeciwwirusowe analogi fosfonianowe
|
|
US7300924B2
(en)
*
|
2003-04-25 |
2007-11-27 |
Gilead Sciences, Inc. |
Anti-infective phosphonate analogs
|
|
US20040229848A1
(en)
|
2003-05-05 |
2004-11-18 |
Hans-Ulrich Demuth |
Glutaminyl based DP IV-inhibitors
|
|
US7273851B2
(en)
|
2003-06-05 |
2007-09-25 |
Enanta Pharmaceuticals, Inc. |
Tri-peptide hepatitis C serine protease inhibitors
|
|
US7125845B2
(en)
|
2003-07-03 |
2006-10-24 |
Enanta Pharmaceuticals, Inc. |
Aza-peptide macrocyclic hepatitis C serine protease inhibitors
|
|
PE20050374A1
(es)
|
2003-09-05 |
2005-05-30 |
Vertex Pharma |
Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc
|
|
CA2538791A1
(en)
|
2003-09-18 |
2005-03-31 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
|
|
RS20060197A
(sr)
|
2003-09-22 |
2008-09-29 |
Boehringer Ingelheim International Gmbh., |
Makrociklični peptidi koji su aktivni protiv hepatitisa c virusa
|
|
KR20060085248A
(ko)
*
|
2003-09-26 |
2006-07-26 |
쉐링 코포레이션 |
C형 간염 바이러스 ns3 세린 프로테아제의마크로사이클릭 억제제
|
|
CA2541634A1
(en)
|
2003-10-10 |
2005-04-28 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
|
|
TW201245229A
(en)
|
2003-10-14 |
2012-11-16 |
Hoffmann La Roche |
Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of HCV replication
|
|
US7491794B2
(en)
*
|
2003-10-14 |
2009-02-17 |
Intermune, Inc. |
Macrocyclic compounds as inhibitors of viral replication
|
|
JP4890254B2
(ja)
|
2003-10-27 |
2012-03-07 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Hcvns3−ns4aプロテアーゼ耐性突然変異体
|
|
US7132504B2
(en)
|
2003-11-12 |
2006-11-07 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
US7309708B2
(en)
|
2003-11-20 |
2007-12-18 |
Birstol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
WO2005053735A1
(en)
|
2003-11-20 |
2005-06-16 |
Boehringer Ingelheim International Gmbh |
Method of removing transition metals, especially from metathesis reaction products
|
|
US7135462B2
(en)
|
2003-11-20 |
2006-11-14 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
CA2547770A1
(en)
|
2003-12-08 |
2005-06-23 |
Fabrice Gallou |
Removal of ruthenium by-product by supercritical fluid processing
|
|
CA2549167A1
(en)
*
|
2003-12-11 |
2005-06-30 |
Schering Corporation |
Inhibitors of hepatitis c virus ns3/ns4a serine protease
|
|
ATE495185T1
(de)
|
2004-01-21 |
2011-01-15 |
Boehringer Ingelheim Int |
Makrocyclische peptide mit wirkung gegen das hepatitis-c-virus
|
|
EP1711514B1
(en)
|
2004-01-28 |
2008-12-03 |
Boehringer Ingelheim International GmbH |
Method of removing transition metals from reaction solutions comprising transition metal byproducts
|
|
KR20120090077A
(ko)
|
2004-01-30 |
2012-08-16 |
얀센 알 앤드 디 아일랜드 |
Hcv ns?3 세린 프로테아제 저해제
|
|
EP2311851A3
(en)
|
2004-02-04 |
2011-05-25 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
|
|
AU2005219824B2
(en)
|
2004-02-27 |
2007-11-29 |
Merck Sharp & Dohme Corp. |
Novel ketoamides with cyclic p4's as inhibitors of ns3 serine protease of hepatitis c virus
|
|
ES2328589T3
(es)
*
|
2004-02-27 |
2009-11-16 |
Schering Corporation |
Compuestos de la prolina 3,4(ciclopentil) fusionados como inhibidores de la proteasa serina ns3 del virus de la hepatitis c.
|
|
DE602005023224D1
(de)
|
2004-02-27 |
2010-10-07 |
Schering Corp |
Neuartige Verbindungen als Hemmer von Hepatitis C-Virus NS3-Serinprotease
|
|
US7205330B2
(en)
|
2004-02-27 |
2007-04-17 |
Schering Corporation |
Inhibitors of hepatitis C virus NS3 protease
|
|
US7816326B2
(en)
*
|
2004-02-27 |
2010-10-19 |
Schering Corporation |
Sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease
|
|
JP4654239B2
(ja)
|
2004-03-15 |
2011-03-16 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
C型肝炎ウィルス感染症の治療に適した大環状ジペプチドの調製方法
|
|
US8598127B2
(en)
|
2004-04-06 |
2013-12-03 |
Korea Research Institute Of Bioscience & Biotechnology |
Peptides for inhibiting MDM2 function
|
|
CN1984922A
(zh)
|
2004-05-20 |
2007-06-20 |
先灵公司 |
用作丙型肝炎病毒ns3丝氨酸蛋白酶抑制剂的取代脯氨酸
|
|
WO2005116054A1
(en)
|
2004-05-25 |
2005-12-08 |
Boehringer Ingelheim International, Gmbh |
Process for preparing acyclic hcv protease inhibitors
|
|
US7939538B2
(en)
*
|
2004-06-28 |
2011-05-10 |
Amgen Inc. |
Compounds, compositions and methods for prevention and treatment of inflammatory and immunoregulatory disorders and diseases
|
|
DE102004033312A1
(de)
*
|
2004-07-08 |
2006-01-26 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Kontinuierliches Metatheseverfahren mit Ruthenium-Katalysatoren
|
|
DK1778702T3
(da)
|
2004-07-16 |
2011-10-17 |
Gilead Sciences Inc |
Antivirale forbindelser
|
|
JP4914355B2
(ja)
|
2004-07-20 |
2012-04-11 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
C型肝炎インヒビターペプチド類似体
|
|
UY29016A1
(es)
|
2004-07-20 |
2006-02-24 |
Boehringer Ingelheim Int |
Analogos de dipeptidos inhibidores de la hepatitis c
|
|
CA2577812A1
(en)
|
2004-08-27 |
2006-03-09 |
Schering Corporation |
Acylsulfonamide compounds as inhibitors of hepatitis c virus ns3 serine protease
|
|
EP1794178A1
(en)
|
2004-09-17 |
2007-06-13 |
Boehringer Ingelheim International Gmbh |
Process for preparing macrocyclic hcv protease inhibitors
|
|
US7189844B2
(en)
|
2004-09-17 |
2007-03-13 |
Boehringer Ingelheim International Gmbh |
Ring-closing metathesis process in supercritical fluid
|
|
CA2584485C
(en)
|
2004-10-20 |
2013-12-31 |
Resverlogix Corp. |
Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
|
|
DE102005002336A1
(de)
|
2005-01-17 |
2006-07-20 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Verfahren zur Durchführung von kontinuierlichen Olefin-Ringschluss-Metathesen in komprimiertem Kohlendioxid
|
|
US7323447B2
(en)
|
2005-02-08 |
2008-01-29 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
US7524831B2
(en)
*
|
2005-03-02 |
2009-04-28 |
Schering Corporation |
Treatments for Flaviviridae virus infection
|
|
EP1863941B1
(en)
|
2005-03-04 |
2013-05-08 |
The Rockefeller University |
Infectious, chimeric hepatitis c virus, methods of producing the same and methods of use thereof
|
|
NZ562167A
(en)
|
2005-03-08 |
2011-01-28 |
Boehringer Ingelheim Int |
Process for preparing macrocyclic compounds
|
|
WO2006113942A2
(en)
|
2005-04-20 |
2006-10-26 |
Schering Corporation |
Method of inhibiting cathepsin activity
|
|
WO2006119061A2
(en)
|
2005-05-02 |
2006-11-09 |
Merck & Co., Inc. |
Hcv ns3 protease inhibitors
|
|
MX2007014889A
(es)
*
|
2005-05-26 |
2008-02-19 |
Schering Corp |
Fusion de interferon-inmunoglobulina g.
|
|
WO2006130686A2
(en)
|
2005-06-02 |
2006-12-07 |
Schering Corporation |
Hcv protease inhibitors in combination with food
|
|
WO2006130554A2
(en)
|
2005-06-02 |
2006-12-07 |
Schering Corporation |
Methods of treating hepatitis c virus
|
|
WO2006130687A2
(en)
|
2005-06-02 |
2006-12-07 |
Schering Corporation |
Liver/plasma concentration ratio for dosing hepatitis c virus protease inhibitor
|
|
CN101212970B
(zh)
|
2005-06-02 |
2010-07-21 |
先灵公司 |
Hcv蛋白酶抑制剂与表面活性剂的组合物
|
|
US20060275366A1
(en)
|
2005-06-02 |
2006-12-07 |
Schering Corporation |
Controlled-release formulation
|
|
US20070004635A1
(en)
|
2005-06-02 |
2007-01-04 |
Schering Corporation |
Method of treating interferon non-responders using HCV protease inhibitor
|
|
US20060281689A1
(en)
|
2005-06-02 |
2006-12-14 |
Schering Corporation |
Method for modulating activity of HCV protease through use of a novel HCV protease inhibitor to reduce duration of treatment period
|
|
WO2006130627A2
(en)
|
2005-06-02 |
2006-12-07 |
Schering Corporation |
Methods for treating hepatitis c
|
|
US20060287248A1
(en)
|
2005-06-02 |
2006-12-21 |
Schering Corporation |
Asymmetric dosing methods
|
|
US20060276404A1
(en)
|
2005-06-02 |
2006-12-07 |
Anima Ghosal |
Medicaments and methods combining a HCV protease inhibitor and an AKR competitor
|
|
US7608592B2
(en)
*
|
2005-06-30 |
2009-10-27 |
Virobay, Inc. |
HCV inhibitors
|
|
US7601686B2
(en)
|
2005-07-11 |
2009-10-13 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
TWI389908B
(zh)
|
2005-07-14 |
2013-03-21 |
Gilead Sciences Inc |
抗病毒化合物類
|
|
TWI387603B
(zh)
*
|
2005-07-20 |
2013-03-01 |
Merck Sharp & Dohme |
Hcv ns3蛋白酶抑制劑
|
|
JP5249028B2
(ja)
|
2005-07-25 |
2013-07-31 |
インターミューン・インコーポレーテッド |
C型肝炎ウイルス複製の新規大環状阻害剤
|
|
PE20070343A1
(es)
|
2005-07-29 |
2007-05-12 |
Medivir Ab |
Inhibidores macrociclicos del virus de la hepatitis c
|
|
PL1919898T3
(pl)
|
2005-07-29 |
2011-06-30 |
Tibotec Pharm Ltd |
Makrocykliczne inhibitory wirusa zapalenia wątroby typu C
|
|
US7700552B2
(en)
|
2005-07-29 |
2010-04-20 |
Medivir Ab |
Macrocyclic inhibitors of hepatitis C virus
|
|
EP1915382A2
(en)
|
2005-08-01 |
2008-04-30 |
Phenomix Corporation |
Hepatitis c serine protease inhibitors and uses therefor
|
|
GEP20104956B
(en)
|
2005-10-11 |
2010-04-12 |
Array Biopharma Inc |
Compounds for inhibiting hepatitis c viral replication and use thereof
|
|
US7772183B2
(en)
|
2005-10-12 |
2010-08-10 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
US7741281B2
(en)
|
2005-11-03 |
2010-06-22 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
US7705138B2
(en)
*
|
2005-11-11 |
2010-04-27 |
Vertex Pharmaceuticals Incorporated |
Hepatitis C virus variants
|
|
EP1951717A1
(en)
*
|
2005-11-16 |
2008-08-06 |
F.Hoffmann-La Roche Ag |
Novel pyrrolidine derivatives as inhibitors of coagulation factor xa
|
|
US20070274951A1
(en)
|
2006-02-09 |
2007-11-29 |
Xiao Tong |
Combinations comprising HCV protease inhibitor(s) and HCV polymerase inhibitor(s), and methods of treatment related thereto
|
|
WO2007109080A2
(en)
*
|
2006-03-16 |
2007-09-27 |
Vertex Pharmaceuticals Incorporated |
Deuterated hepatitis c protease inhibitors
|
|
JP2009530382A
(ja)
|
2006-03-23 |
2009-08-27 |
シェーリング コーポレイション |
Hcvプロテアーゼインヒビターとcyp3a4インヒビターとの組み合わせ、および関連する処置方法
|
|
CA2643680A1
(en)
|
2006-04-11 |
2007-11-22 |
Novartis Ag |
Hcv/hiv inhibitors and their uses
|
|
US9526769B2
(en)
|
2006-06-06 |
2016-12-27 |
Enanta Pharmaceuticals, Inc. |
Macrocylic oximyl hepatitis C protease inhibitors
|
|
US7728148B2
(en)
|
2006-06-06 |
2010-06-01 |
Enanta Pharmaceuticals, Inc. |
Acyclic oximyl hepatitis C protease inhibitors
|
|
US20080187516A1
(en)
|
2006-06-06 |
2008-08-07 |
Ying Sun |
Acyclic oximyl hepatitis c protease inhibitors
|
|
EP2029741A4
(en)
*
|
2006-06-08 |
2011-03-16 |
Merck Sharp & Dohme |
QUICK PROCEDURE FOR DETERMINING THE HEMMERSENSITIVITY OF NS3 / 4A PROTEASE SEQUENCES CLONED FROM CLINICAL SAMPLES
|
|
UY30437A1
(es)
|
2006-06-26 |
2008-01-31 |
Enanta Pharm Inc |
Quinoxalinil macroceclicos inhibidores de serina proteasa del virus de la hepatitis c
|
|
KR20090024834A
(ko)
|
2006-07-05 |
2009-03-09 |
인터뮨, 인크. |
C형 간염 바이러스 복제의 신규 억제제
|
|
EP2049474B1
(en)
*
|
2006-07-11 |
2015-11-04 |
Bristol-Myers Squibb Company |
Hepatitis c virus inhibitors
|
|
CA2657618C
(en)
|
2006-07-13 |
2016-10-11 |
Achillion Pharmaceuticals, Inc. |
4-amino-4-oxobutanoyl peptides as inhibitors of viral replication
|
|
CN101674844A
(zh)
*
|
2006-08-04 |
2010-03-17 |
英安塔制药有限公司 |
四唑基大环类c型肝炎丝氨酸蛋白酶抑制剂
|
|
US7635683B2
(en)
*
|
2006-08-04 |
2009-12-22 |
Enanta Pharmaceuticals, Inc. |
Quinoxalinyl tripeptide hepatitis C virus inhibitors
|
|
WO2008019303A2
(en)
|
2006-08-04 |
2008-02-14 |
Enanta Pharmaceuticals, Inc. |
Pyridazinonyl macrocyclic hepatitis c serine protease inhibitors
|
|
US20090035267A1
(en)
|
2007-07-31 |
2009-02-05 |
Moore Joel D |
Acyclic, pyridazinone-derived hepatitis c serine protease inhibitors
|
|
WO2008022006A2
(en)
|
2006-08-11 |
2008-02-21 |
Enanta Pharmaceuticals, Inc. |
Arylalkoxyl hepatitis c virus protease inhibitors
|
|
WO2008021960A2
(en)
|
2006-08-11 |
2008-02-21 |
Enanta Pharmaceuticals, Inc. |
Triazolyl macrocyclic hepatitis c serine protease inhibitors
|
|
US7687459B2
(en)
*
|
2006-08-11 |
2010-03-30 |
Enanta Pharmaceuticals, Inc. |
Arylalkoxyl hepatitis C virus protease inhibitors
|
|
US20080038225A1
(en)
|
2006-08-11 |
2008-02-14 |
Ying Sun |
Triazolyl acyclic hepatitis c serine protease inhibitors
|
|
US20090098085A1
(en)
*
|
2006-08-11 |
2009-04-16 |
Ying Sun |
Tetrazolyl acyclic hepatitis c serine protease inhibitors
|
|
US7605126B2
(en)
*
|
2006-08-11 |
2009-10-20 |
Enanta Pharmaceuticals, Inc. |
Acylaminoheteroaryl hepatitis C virus protease inhibitors
|
|
KR20100024920A
(ko)
*
|
2007-05-03 |
2010-03-08 |
인터뮨, 인크. |
C형 간염 바이러스 복제의 신규 마크로사이클릭 저해제
|
|
MX2009012093A
(es)
*
|
2007-05-10 |
2010-01-25 |
Intermune Inc |
Nuevos peptidos inhibidores de la replicacion del virus de la hepatitis c.
|
|
KR20110005869A
(ko)
*
|
2008-04-15 |
2011-01-19 |
인터뮨, 인크. |
C형 간염 바이러스 복제의 신규한 마크로사이클릭 억제제
|
|
CN102216321A
(zh)
*
|
2008-10-15 |
2011-10-12 |
因特蒙公司 |
治疗性抗病毒肽
|
|
SG173747A1
(en)
|
2009-02-18 |
2011-09-29 |
Univ Wayne State |
Method for identifying a subpopulation of mammalian cells with distinctive ribosome translation profiles
|
|
AR075584A1
(es)
*
|
2009-02-27 |
2011-04-20 |
Intermune Inc |
COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO.
|
|
US20110129444A1
(en)
*
|
2009-09-28 |
2011-06-02 |
Intermune, Inc |
Novel macrocyclic inhibitors of hepatitis c virus replication
|
|
WO2011038293A1
(en)
*
|
2009-09-28 |
2011-03-31 |
Intermune, Inc. |
Cyclic peptide inhibitors of hepatitis c virus replication
|
|
WO2011041551A1
(en)
*
|
2009-10-01 |
2011-04-07 |
Intermune, Inc. |
Therapeutic antiviral peptides
|