DK200401589A - Oprenset basisk human-FGF, fremgangsmåde til fremstilling af denne, samt farmaceutisk sammensætning indeholdende denne - Google Patents

Oprenset basisk human-FGF, fremgangsmåde til fremstilling af denne, samt farmaceutisk sammensætning indeholdende denne Download PDF

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Publication number
DK200401589A
DK200401589A DK200401589A DKPA200401589A DK200401589A DK 200401589 A DK200401589 A DK 200401589A DK 200401589 A DK200401589 A DK 200401589A DK PA200401589 A DKPA200401589 A DK PA200401589A DK 200401589 A DK200401589 A DK 200401589A
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Denmark
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fgf
dna sequence
prodn
factors
fibroblast growth
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DK200401589A
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English (en)
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John C Fiddes
Judith A Abraham
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California Biotechnology Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27419719&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK200401589(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/809,163 external-priority patent/US5439818A/en
Application filed by California Biotechnology Inc filed Critical California Biotechnology Inc
Publication of DK200401589A publication Critical patent/DK200401589A/da
Application granted granted Critical
Publication of DK176067B1 publication Critical patent/DK176067B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)

Description

Patentkrav 1. Oprenset basisk human-FGF som er opnåelig ved udtrykkelse af en DNA-sekvens omfattende codonsekvensen, der er nummereret 16-146 i Figur 4, i en rekombinant bakteriel værtscelle. 2. Protein ifølge krav 1, i hvilket DNA-sekvensen omfatter codonsekvensen, der er nummereret 1-146 i Figur 4. 3. Protein ifølge krav 2, i hvilket DNA-sekvensen omfatter codonsekvensen, der er nummereret (-9) eller (-8) til 146 i Figur 4. 4. Protein ifølge ethvert af kravene 1 til 3, i hvilket den bakterielle værtscelle er E.coli. 5. Fremgangsmåde til fremstilling af basisk human-FGF, hvilken fremgangsmåde omfatter udtrykkelse af en DNA-sekvens omfattende de codons, der er nummereret 16-146 i Figur 4, i en rekombinant bakteriel vært og genvinding af det basiske human-FGF. 6. Farmaceutisk sammensætning omfattende en effektiv mængde af det basiske human-FGF ifølge ethvert af kravene 1 til 4 i en tilblanding med mindst én farmaceutisk acceptabel excipiens.
DK200401589A 1985-09-12 2004-10-18 Oprenset basisk human-FGF, fremgangsmåde til fremstilling af denne, samt farmaceutisk sammensætning indeholdende denne DK176067B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US77552185A 1985-09-12 1985-09-12
US06/809,163 US5439818A (en) 1985-09-12 1985-12-16 DNA encoding human recombinant basic fibroblast growth factor
US86938286A 1986-05-30 1986-05-30
DK198702418A DK175795B1 (da) 1985-09-12 1987-05-12 Rekombinant eller syntetisk DNA-sekvens, der koder for et FGF-protein, vektor, der indeholder DNA-sekvensen og en rekombinant værtscelle, der indeholder DNA-sekvensen eller vektoren

Publications (2)

Publication Number Publication Date
DK200401589A true DK200401589A (da) 2004-10-18
DK176067B1 DK176067B1 (da) 2006-03-06

Family

ID=27419719

Family Applications (2)

Application Number Title Priority Date Filing Date
DK198702418A DK175795B1 (da) 1985-09-12 1987-05-12 Rekombinant eller syntetisk DNA-sekvens, der koder for et FGF-protein, vektor, der indeholder DNA-sekvensen og en rekombinant værtscelle, der indeholder DNA-sekvensen eller vektoren
DK200401589A DK176067B1 (da) 1985-09-12 2004-10-18 Oprenset basisk human-FGF, fremgangsmåde til fremstilling af denne, samt farmaceutisk sammensætning indeholdende denne

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK198702418A DK175795B1 (da) 1985-09-12 1987-05-12 Rekombinant eller syntetisk DNA-sekvens, der koder for et FGF-protein, vektor, der indeholder DNA-sekvensen og en rekombinant værtscelle, der indeholder DNA-sekvensen eller vektoren

Country Status (11)

Country Link
EP (2) EP0593065B1 (da)
JP (3) JPH0789936B2 (da)
AT (2) ATE222602T1 (da)
AU (1) AU590006B2 (da)
CA (1) CA1341640C (da)
DE (2) DE3650774T2 (da)
DK (2) DK175795B1 (da)
ES (1) ES2001967A6 (da)
IE (1) IE66689B1 (da)
IL (1) IL80022A (da)
WO (1) WO1987001728A1 (da)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5235042A (en) * 1984-02-29 1993-08-10 The Children's Medical Center Corporation Endothelial cell growth factor
US4956455A (en) * 1984-03-05 1990-09-11 The Salk Institute For Biological Studies Bovine fibroblast growth factor
US4889919A (en) * 1986-08-13 1989-12-26 Zymogenetics, Inc. Biologically active PDGF derived A-chain homodimers
US5165938A (en) * 1984-11-29 1992-11-24 Regents Of The University Of Minnesota Wound healing agents derived from platelets
US5401832A (en) * 1984-12-24 1995-03-28 Merck & Co., Inc. Brain derived and recombinant acidic fibroblast growth factor
US4994559A (en) * 1985-12-17 1991-02-19 Synergen, Inc. Human basic fibroblast growth factor
ATE107315T1 (de) * 1985-12-17 1994-07-15 Synergen Inc Menschlicher plazentarer angiogenischer faktor, geeignet für die reizung der kapillarsynthese, der endothelzellprotease, der dns-synthese und der absiedlung.
US5026839A (en) * 1985-12-17 1991-06-25 Synergen, Inc DNA encoding a basic fibroblast growth factor
US5552528A (en) * 1986-03-03 1996-09-03 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bovine b-endothelial cell growth factor
US4868113A (en) * 1986-03-03 1989-09-19 Rorer Biotechnology, Inc. Recombinant DNA vector encoding human endothelial cell growth factor
US5827826A (en) * 1986-03-03 1998-10-27 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compositions of human endothelial cell growth factor
ATE108459T1 (de) * 1986-04-22 1994-07-15 Salk Inst For Biological Studi Antagonisten des fibroblasten-wachstumsfaktors.
NZ220917A (en) * 1986-07-11 1991-05-28 Merck & Co Inc Human and bovine acidic fibroblast growth factor vectors, hosts and compositions
US5474982A (en) * 1986-08-13 1995-12-12 Zymogenetics, Inc. PDGF analogs and methods of use
FI884252A0 (fi) * 1987-01-16 1988-09-15 Amgen Inc Foerfarande foer framstaellning av en fibroblasttillvaext-faktor.
US5852177A (en) * 1987-02-24 1998-12-22 Takeda Chemical Industries, Ltd. Basic fibroblast growth factor (bFGF) muteins
JP2526965B2 (ja) * 1987-02-24 1996-08-21 武田薬品工業株式会社 ムテイン，ｄｎａおよびその用途
EP0288687B1 (en) * 1987-03-03 1994-12-28 Takeda Chemical Industries, Ltd. Monoclonal antibody, hybridoma, their production and use thereof
EP0364481A4 (en) * 1987-06-18 1992-01-22 Monash University Growth factors
AU611614B2 (en) * 1987-06-18 1991-06-13 Monash University Growth factors
DE3721081A1 (de) * 1987-06-26 1989-01-19 Progen Biotechnik Gmbh Dna-sequenz, die codiert fuer ein zellteilungsfoerderndes polypeptid, sowie ein plasmid, ein wirtsorganismus und ein verfahren zur gewinnung dieses polypeptids
US5312911A (en) * 1987-10-22 1994-05-17 Merck & Co., Inc. Cysteine-modified acidic fibroblast growth factor
NZ226543A (en) * 1987-10-22 1992-02-25 Merck & Co Inc Recombinant mutant acidic fibroblast growth factor
WO1989004832A1 (en) * 1987-11-24 1989-06-01 Amgen Inc. Analogs of fibroblast growth factor
EP0326907A1 (en) * 1988-01-26 1989-08-09 Takeda Chemical Industries, Ltd. Polypeptide, DNA and its use
JPH03503167A (ja) * 1988-02-24 1991-07-18 アメリカン ナショナル レッド クロス 部位指定血管形成素子とその使用法
GB2223496B (en) * 1988-08-08 1992-05-27 British Bio Technology Synthetic gene encoding mature human acid fibroblast growth factor
GB2223497B (en) * 1988-08-08 1992-04-01 British Bio Technology Synthetic gene encoding human beta endothelial cell growth factor
GB2223495B (en) * 1988-08-08 1992-05-20 British Bio Technology Synthetic gene encoding basic fibroblast growth factor
US5175147A (en) * 1988-08-19 1992-12-29 Takeda Chemical Industries, Ltd Acid-resistant fgf composition and method of treating ulcerating diseases of the gastrointestinal tract
US5656458A (en) * 1988-11-04 1997-08-12 Chiron Corporation Expression and processing of amino terminus acetylated FGF's in yeast
CA2002210C (en) * 1988-11-04 2001-04-24 Philip J. Barr Expression and processing of authentic fgf's in yeast
US5464943A (en) * 1989-04-26 1995-11-07 Takeda Chemical Industries, Ltd. DNA encoding glycosylated FGF and production thereof
EP0406738A3 (en) * 1989-07-03 1991-08-14 Takeda Chemical Industries, Ltd. Production of acidic fgf protein
US5126323A (en) * 1989-11-16 1992-06-30 Genetics Institute, Inc. Homogeneous purified k-fgf and compositions containing the same
IT1237795B (it) * 1989-12-22 1993-06-17 Erba Carlo Spa Fattori di crescita fibroblastici per l'uso nella prevenzione e nel trattamento di infezioni virali.
US5143829A (en) * 1990-03-29 1992-09-01 California Biotechnology Inc. High level expression of basic fibroblast growth factor having a homogeneous n-terminus
JPH047617A (ja) * 1990-04-26 1992-01-13 Canon Inc 電子機器
JP3135138B2 (ja) * 1990-12-19 2001-02-13 科研製薬株式会社 骨疾患治療剤
US6833354B1 (en) 1990-12-19 2004-12-21 Kaken Pharmaceutical Co., Ltd. Agent for the treatment of bone diseases
GR1002610B (el) * 1991-01-02 1997-02-20 Johnson & Johnson Consumer Products Inc. Θεραπευτικες συνθεσεις πληγων που περιεχουν παραγοντα αναπτυξης ινοβλαστων και ασκορβικον οξυ.
WO1992013958A1 (en) * 1991-02-06 1992-08-20 Georgetown University Receptor blocking peptides of fibroblast growth factor receptor
EP0499242B1 (en) * 1991-02-15 1996-06-26 Takeda Chemical Industries, Ltd. Stimulation of endosteal bone formation with a cell growth factor
US5492894A (en) * 1991-03-21 1996-02-20 The Procter & Gamble Company Compositions for treating wrinkles comprising a peptide
DE4132005A1 (de) * 1991-09-26 1993-04-01 Merck Patent Gmbh Kombination enthaltend wachstumsfaktoren und polyelektrolyte
EP0615452A4 (en) * 1991-11-25 1995-07-12 Inst Molecular Biology Inc MEDICINE SERVING THE PROMOTION OF THE GROWTH OF A NERVE IN MAMMALS.
AU659723B2 (en) * 1992-02-14 1995-05-25 Kaken Pharmaceutical Co., Ltd. Remedy for airway diseases
GB9203533D0 (en) * 1992-02-19 1992-04-08 Erba Carlo Spa Use of the conjugate between a fibroblast growth factor and a saporin in treating ocular pathologies
US5348941A (en) * 1992-04-01 1994-09-20 Merck & Co., Inc. Stabilizers for fibroblast growth factors
WO1996040726A1 (en) 1995-06-07 1996-12-19 Genta Incorporated Novel carbamate-based cationic lipids
AU2763099A (en) 1998-06-22 2000-01-10 Charles E. Worden Enriched platelet wound healant
EP2123292B1 (en) * 1998-09-03 2016-05-04 Novartis Vaccines and Diagnostics, Inc. Angiogenically effective unit dose of FGF-2 and method of use
US20030166550A1 (en) 1999-08-27 2003-09-04 Chiron Corporation Angiogenically effective unit dose of FGF-2 and method of use
US6649072B2 (en) 2001-11-16 2003-11-18 Robert Brandt Method for producing autologous platelet-rich plasma
HUE025872T2 (en) 2002-06-18 2016-05-30 Eisai R&D Man Co Ltd Primary, cultured adipocytes for gene therapy
WO2005087257A1 (ja) * 2004-03-16 2005-09-22 Kaken Pharmaceutical Co., Ltd. 架橋ゼラチンゲルを担体とする軟骨組織修復治療剤
ES2318915B1 (es) * 2004-12-29 2010-02-16 Universidad De Salamanca Uso de fgf-2 en celulas precursoras de oligodendrocitos.
WO2007072857A1 (ja) 2005-12-22 2007-06-28 Hoya Corporation 眼鏡レンズのレンズ面切削加工装置、レンズ面切削加工方法および眼鏡レンズ
CA2729093C (en) 2008-06-26 2018-04-10 Shin-Ichi Kanemaru Agent for regenerating tympanic membrane or external auditory canal
ES2610356T3 (es) 2009-02-03 2017-04-27 Amunix Operating Inc. Polipéptidos recombinantes extendidos y composiciones que comprenden los mismos
CN104946656B (zh) * 2015-06-08 2018-08-17 吉林省农业科学院 一种人源碱性成纤维细胞生长因子、烟草叶绿体表达载体及生产方法
CN110151977B (zh) * 2019-05-29 2022-11-29 新乡医学院 一种保护aFGF蛋白药物稳定性和活性的方法
JP7725466B2 (ja) 2019-11-13 2025-08-19 アムニクス ファーマシューティカルズ， インコーポレイテッド バーコード化されたｘｔｅｎポリペプチドおよびその組成物、ならびにその作製および使用方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4296100A (en) * 1980-06-30 1981-10-20 Franco Wayne P Method of treating the heart for myocardial infarction
DK161152C (da) * 1983-03-03 1991-11-11 Genentech Inc Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat
US4444760A (en) * 1983-06-17 1984-04-24 Merck & Co., Inc. Purification and characterization of a protein fibroblast growth factor
US4956455A (en) * 1984-03-05 1990-09-11 The Salk Institute For Biological Studies Bovine fibroblast growth factor
JP2770926B2 (ja) * 1985-12-17 1998-07-02 サイナーゲン インコーポレーテッド 毛管内皮細胞プロテアーゼ合成、ｄｎａ合成および遊走を促進することの出来るヒト胎盤血管形成誘導因子
US4868113A (en) * 1986-03-03 1989-09-19 Rorer Biotechnology, Inc. Recombinant DNA vector encoding human endothelial cell growth factor
DK122687A (da) * 1986-03-14 1987-09-15 Takeda Chemical Industries Ltd Polypeptid, dna og anvendelse deraf
NZ220917A (en) * 1986-07-11 1991-05-28 Merck & Co Inc Human and bovine acidic fibroblast growth factor vectors, hosts and compositions

Also Published As

Publication number Publication date
EP0248819B2 (en) 2000-08-30
CA1341640C (en) 2014-09-16
DE3689845T2 (de) 1994-09-01
DK176067B1 (da) 2006-03-06
JPH0767659A (ja) 1995-03-14
DE3650774T2 (de) 2003-05-28
IL80022A (en) 1993-06-10
ES2001967A6 (es) 1988-07-01
JP2761513B2 (ja) 1998-06-04
JPS63500843A (ja) 1988-03-31
DK241887D0 (da) 1987-05-12
DE3689845D1 (de) 1994-06-23
IE862432L (en) 1987-03-12
DK241887A (da) 1987-05-12
AU6375586A (en) 1987-04-07
EP0593065A1 (en) 1994-04-20
JP2619208B2 (ja) 1997-06-11
WO1987001728A1 (en) 1987-03-26
EP0593065B1 (en) 2002-08-21
JPH0789936B2 (ja) 1995-10-04
IL80022A0 (en) 1986-12-31
IE950301L (en) 1987-03-12
IE66689B1 (en) 1996-01-24
EP0248819A4 (en) 1989-02-23
EP0248819B1 (en) 1994-05-18
ATE105868T1 (de) 1994-06-15
DE3650774D1 (de) 2002-09-26
DE3689845T3 (de) 2001-11-15
EP0248819A1 (en) 1987-12-16
DK175795B1 (da) 2005-02-21
JPH09118695A (ja) 1997-05-06
AU590006B2 (en) 1989-10-26
ATE222602T1 (de) 2002-09-15

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