DK241887A - Rekombinant-fibroblastvaekstfaktor - Google Patents

Rekombinant-fibroblastvaekstfaktor

Info

Publication number
DK241887A
DK241887A DK241887A DK241887A DK241887A DK 241887 A DK241887 A DK 241887A DK 241887 A DK241887 A DK 241887A DK 241887 A DK241887 A DK 241887A DK 241887 A DK241887 A DK 241887A
Authority
DK
Denmark
Prior art keywords
fgf
dna sequence
recombinant
operably linked
encoding
Prior art date
Application number
DK241887A
Other languages
English (en)
Other versions
DK241887D0 (da
DK175795B1 (da
Inventor
John C Fiddes
Judith A Abraham
Original Assignee
Biotech Res Partners Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27419719&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK241887(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/809,163 external-priority patent/US5439818A/en
Application filed by Biotech Res Partners Ltd filed Critical Biotech Res Partners Ltd
Publication of DK241887D0 publication Critical patent/DK241887D0/da
Publication of DK241887A publication Critical patent/DK241887A/da
Priority to DK200401589A priority Critical patent/DK176067B1/da
Application granted granted Critical
Publication of DK175795B1 publication Critical patent/DK175795B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
DK198702418A 1985-09-12 1987-05-12 Rekombinant eller syntetisk DNA-sekvens, der koder for et FGF-protein, vektor, der indeholder DNA-sekvensen og en rekombinant værtscelle, der indeholder DNA-sekvensen eller vektoren DK175795B1 (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK200401589A DK176067B1 (da) 1985-09-12 2004-10-18 Oprenset basisk human-FGF, fremgangsmåde til fremstilling af denne, samt farmaceutisk sammensætning indeholdende denne

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US77552185A 1985-09-12 1985-09-12
US77552185 1985-09-12
US06/809,163 US5439818A (en) 1985-09-12 1985-12-16 DNA encoding human recombinant basic fibroblast growth factor
US80916385 1985-12-16
US86938286A 1986-05-30 1986-05-30
US86938286 1986-05-30
PCT/US1986/001879 WO1987001728A1 (en) 1985-09-12 1986-09-11 Recombinant fibroblast growth factors
US8601879 1986-09-11

Publications (3)

Publication Number Publication Date
DK241887D0 DK241887D0 (da) 1987-05-12
DK241887A true DK241887A (da) 1987-05-12
DK175795B1 DK175795B1 (da) 2005-02-21

Family

ID=27419719

Family Applications (2)

Application Number Title Priority Date Filing Date
DK198702418A DK175795B1 (da) 1985-09-12 1987-05-12 Rekombinant eller syntetisk DNA-sekvens, der koder for et FGF-protein, vektor, der indeholder DNA-sekvensen og en rekombinant værtscelle, der indeholder DNA-sekvensen eller vektoren
DK200401589A DK176067B1 (da) 1985-09-12 2004-10-18 Oprenset basisk human-FGF, fremgangsmåde til fremstilling af denne, samt farmaceutisk sammensætning indeholdende denne

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK200401589A DK176067B1 (da) 1985-09-12 2004-10-18 Oprenset basisk human-FGF, fremgangsmåde til fremstilling af denne, samt farmaceutisk sammensætning indeholdende denne

Country Status (11)

Country Link
EP (2) EP0593065B1 (da)
JP (3) JPH0789936B2 (da)
AT (2) ATE105868T1 (da)
AU (1) AU590006B2 (da)
CA (1) CA1341640C (da)
DE (2) DE3689845T3 (da)
DK (2) DK175795B1 (da)
ES (1) ES2001967A6 (da)
IE (1) IE66689B1 (da)
IL (1) IL80022A (da)
WO (1) WO1987001728A1 (da)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5235042A (en) * 1984-02-29 1993-08-10 The Children's Medical Center Corporation Endothelial cell growth factor
US4956455A (en) * 1984-03-05 1990-09-11 The Salk Institute For Biological Studies Bovine fibroblast growth factor
US4889919A (en) * 1986-08-13 1989-12-26 Zymogenetics, Inc. Biologically active PDGF derived A-chain homodimers
US5165938A (en) * 1984-11-29 1992-11-24 Regents Of The University Of Minnesota Wound healing agents derived from platelets
US5401832A (en) * 1984-12-24 1995-03-28 Merck & Co., Inc. Brain derived and recombinant acidic fibroblast growth factor
US4994559A (en) * 1985-12-17 1991-02-19 Synergen, Inc. Human basic fibroblast growth factor
DE3689921T2 (de) * 1985-12-17 1994-09-22 Synergen Inc Menschlicher plazentarer angiogenischer Faktor, geeignet für die Reizung der Kapillarsynthese, der Endothelzellprotease, der DNS-Synthese und der Absiedlung.
US5026839A (en) * 1985-12-17 1991-06-25 Synergen, Inc DNA encoding a basic fibroblast growth factor
US5827826A (en) 1986-03-03 1998-10-27 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compositions of human endothelial cell growth factor
US4868113A (en) * 1986-03-03 1989-09-19 Rorer Biotechnology, Inc. Recombinant DNA vector encoding human endothelial cell growth factor
US5552528A (en) 1986-03-03 1996-09-03 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bovine b-endothelial cell growth factor
ATE108459T1 (de) * 1986-04-22 1994-07-15 Salk Inst For Biological Studi Antagonisten des fibroblasten-wachstumsfaktors.
NZ220917A (en) * 1986-07-11 1991-05-28 Merck & Co Inc Human and bovine acidic fibroblast growth factor vectors, hosts and compositions
US5474982A (en) * 1986-08-13 1995-12-12 Zymogenetics, Inc. PDGF analogs and methods of use
CA1323317C (en) * 1987-01-16 1993-10-19 Allen R. Banks Production of fibroblast growth factor
US5852177A (en) * 1987-02-24 1998-12-22 Takeda Chemical Industries, Ltd. Basic fibroblast growth factor (bFGF) muteins
JP2526965B2 (ja) * 1987-02-24 1996-08-21 武田薬品工業株式会社 ムテイン，ｄｎａおよびその用途
EP0288687B1 (en) * 1987-03-03 1994-12-28 Takeda Chemical Industries, Ltd. Monoclonal antibody, hybridoma, their production and use thereof
AU611614B2 (en) * 1987-06-18 1991-06-13 Monash University Growth factors
WO1988010269A1 (en) * 1987-06-18 1988-12-29 Monash University Growth factors
DE3721081A1 (de) * 1987-06-26 1989-01-19 Progen Biotechnik Gmbh Dna-sequenz, die codiert fuer ein zellteilungsfoerderndes polypeptid, sowie ein plasmid, ein wirtsorganismus und ein verfahren zur gewinnung dieses polypeptids
US5312911A (en) * 1987-10-22 1994-05-17 Merck & Co., Inc. Cysteine-modified acidic fibroblast growth factor
NZ226543A (en) * 1987-10-22 1992-02-25 Merck & Co Inc Recombinant mutant acidic fibroblast growth factor
WO1989004832A1 (en) * 1987-11-24 1989-06-01 Amgen Inc. Analogs of fibroblast growth factor
EP0326907A1 (en) * 1988-01-26 1989-08-09 Takeda Chemical Industries, Ltd. Polypeptide, DNA and its use
JPH03503167A (ja) * 1988-02-24 1991-07-18 アメリカン ナショナル レッド クロス 部位指定血管形成素子とその使用法
GB2223497B (en) * 1988-08-08 1992-04-01 British Bio Technology Synthetic gene encoding human beta endothelial cell growth factor
GB2223495B (en) * 1988-08-08 1992-05-20 British Bio Technology Synthetic gene encoding basic fibroblast growth factor
GB2223496B (en) * 1988-08-08 1992-05-27 British Bio Technology Synthetic gene encoding mature human acid fibroblast growth factor
US5175147A (en) * 1988-08-19 1992-12-29 Takeda Chemical Industries, Ltd Acid-resistant fgf composition and method of treating ulcerating diseases of the gastrointestinal tract
US5656458A (en) * 1988-11-04 1997-08-12 Chiron Corporation Expression and processing of amino terminus acetylated FGF's in yeast
JP2840441B2 (ja) * 1988-11-04 1998-12-24 カイロン・コーポレーション 真正ｆｇｆの酵母における発現およびプロセシング
US5464943A (en) * 1989-04-26 1995-11-07 Takeda Chemical Industries, Ltd. DNA encoding glycosylated FGF and production thereof
EP0406738A3 (en) * 1989-07-03 1991-08-14 Takeda Chemical Industries, Ltd. Production of acidic fgf protein
US5126323A (en) * 1989-11-16 1992-06-30 Genetics Institute, Inc. Homogeneous purified k-fgf and compositions containing the same
IT1237795B (it) * 1989-12-22 1993-06-17 Erba Carlo Spa Fattori di crescita fibroblastici per l'uso nella prevenzione e nel trattamento di infezioni virali.
US5143829A (en) * 1990-03-29 1992-09-01 California Biotechnology Inc. High level expression of basic fibroblast growth factor having a homogeneous n-terminus
JPH047617A (ja) * 1990-04-26 1992-01-13 Canon Inc 電子機器
US6833354B1 (en) 1990-12-19 2004-12-21 Kaken Pharmaceutical Co., Ltd. Agent for the treatment of bone diseases
JP3135138B2 (ja) * 1990-12-19 2001-02-13 科研製薬株式会社 骨疾患治療剤
GR1002610B (el) * 1991-01-02 1997-02-20 Johnson & Johnson Consumer Products Inc. Θεραπευτικες συνθεσεις πληγων που περιεχουν παραγοντα αναπτυξης ινοβλαστων και ασκορβικον οξυ.
WO1992013958A1 (en) * 1991-02-06 1992-08-20 Georgetown University Receptor blocking peptides of fibroblast growth factor receptor
ATE139700T1 (de) * 1991-02-15 1996-07-15 Takeda Chemical Industries Ltd Mit einem zellwachstumsfaktor bewirkte anregung von wachstum im knocheninneren
US5492894A (en) * 1991-03-21 1996-02-20 The Procter & Gamble Company Compositions for treating wrinkles comprising a peptide
DE4132005A1 (de) * 1991-09-26 1993-04-01 Merck Patent Gmbh Kombination enthaltend wachstumsfaktoren und polyelektrolyte
AU673659B2 (en) * 1991-11-25 1996-11-21 Institute Of Molecular Biology, Inc. Medicament for promoting growth of mammalian nerve
CA2108277A1 (en) * 1992-02-14 1993-08-15 Mitsuru Watanuki Preparation for the therapy of respiratory tract diseases
GB9203533D0 (en) * 1992-02-19 1992-04-08 Erba Carlo Spa Use of the conjugate between a fibroblast growth factor and a saporin in treating ocular pathologies
US5348941A (en) * 1992-04-01 1994-09-20 Merck & Co., Inc. Stabilizers for fibroblast growth factors
EP0830368A1 (en) 1995-06-07 1998-03-25 Genta Incorporated Novel carbamate-based cationic lipids
WO1999066797A1 (en) 1998-06-22 1999-12-29 Worden Charles E Enriched platelet wound healant
ES2233101T3 (es) * 1998-09-03 2005-06-01 Chiron Corp Dosis unitaria de fgf-2 angiogenicamente efectiva y su utilizacion.
US20030166550A1 (en) 1999-08-27 2003-09-04 Chiron Corporation Angiogenically effective unit dose of FGF-2 and method of use
US6649072B2 (en) 2001-11-16 2003-11-18 Robert Brandt Method for producing autologous platelet-rich plasma
KR101004086B1 (ko) 2002-06-18 2010-12-27 에자이 알앤드디 매니지먼트 가부시키가이샤 유전자 치료용 초대 배양 지방세포
WO2005087257A1 (ja) * 2004-03-16 2005-09-22 Kaken Pharmaceutical Co., Ltd. 架橋ゼラチンゲルを担体とする軟骨組織修復治療剤
ES2318915B1 (es) * 2004-12-29 2010-02-16 Universidad De Salamanca Uso de fgf-2 en celulas precursoras de oligodendrocitos.
US7861626B2 (en) 2005-12-22 2011-01-04 Hoya Corporation Lens surface cutting apparatus and lens surface cutting method for spectacle lens, and spectacle lens
US9161904B2 (en) 2008-06-26 2015-10-20 Nobelpharma Co., Ltd. Agent for regenerating tympanic membrane or external auditory canal
CA2748314C (en) 2009-02-03 2018-10-02 Amunix Operating Inc. Extended recombinant polypeptides and compositions comprising same
CN104946656B (zh) * 2015-06-08 2018-08-17 吉林省农业科学院 一种人源碱性成纤维细胞生长因子、烟草叶绿体表达载体及生产方法
CN110151977B (zh) * 2019-05-29 2022-11-29 新乡医学院 一种保护aFGF蛋白药物稳定性和活性的方法
CN115175920B (zh) 2019-11-13 2025-10-31 阿穆尼克斯制药公司 加条形码的xten多肽及其组合物以及其制备和使用方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4296100A (en) * 1980-06-30 1981-10-20 Franco Wayne P Method of treating the heart for myocardial infarction
DK161152C (da) * 1983-03-03 1991-11-11 Genentech Inc Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat
US4444760A (en) * 1983-06-17 1984-04-24 Merck & Co., Inc. Purification and characterization of a protein fibroblast growth factor
US4956455A (en) * 1984-03-05 1990-09-11 The Salk Institute For Biological Studies Bovine fibroblast growth factor
JP2770926B2 (ja) * 1985-12-17 1998-07-02 サイナーゲン インコーポレーテッド 毛管内皮細胞プロテアーゼ合成、ｄｎａ合成および遊走を促進することの出来るヒト胎盤血管形成誘導因子
US4868113A (en) * 1986-03-03 1989-09-19 Rorer Biotechnology, Inc. Recombinant DNA vector encoding human endothelial cell growth factor
IL81839A0 (en) * 1986-03-14 1987-10-20 Takeda Chemical Industries Ltd Polypeptide,dna and its use
NZ220917A (en) * 1986-07-11 1991-05-28 Merck & Co Inc Human and bovine acidic fibroblast growth factor vectors, hosts and compositions

Also Published As

Publication number Publication date
ES2001967A6 (es) 1988-07-01
EP0248819B2 (en) 2000-08-30
ATE105868T1 (de) 1994-06-15
JP2761513B2 (ja) 1998-06-04
AU590006B2 (en) 1989-10-26
EP0593065B1 (en) 2002-08-21
DE3650774T2 (de) 2003-05-28
JP2619208B2 (ja) 1997-06-11
DK241887D0 (da) 1987-05-12
JPH0767659A (ja) 1995-03-14
DK200401589A (da) 2004-10-18
DE3689845T3 (de) 2001-11-15
IL80022A (en) 1993-06-10
DK176067B1 (da) 2006-03-06
EP0593065A1 (en) 1994-04-20
IE862432L (en) 1987-03-12
DE3689845D1 (de) 1994-06-23
DK175795B1 (da) 2005-02-21
IE950301L (en) 1987-03-12
CA1341640C (en) 2014-09-16
JPH09118695A (ja) 1997-05-06
JPS63500843A (ja) 1988-03-31
IL80022A0 (en) 1986-12-31
IE66689B1 (en) 1996-01-24
DE3650774D1 (de) 2002-09-26
ATE222602T1 (de) 2002-09-15
AU6375586A (en) 1987-04-07
EP0248819B1 (en) 1994-05-18
JPH0789936B2 (ja) 1995-10-04
WO1987001728A1 (en) 1987-03-26
EP0248819A1 (en) 1987-12-16
EP0248819A4 (en) 1989-02-23
DE3689845T2 (de) 1994-09-01

Similar Documents

Publication Publication Date Title
DE3689845D1 (de) Rekombinanter fibroblast-wachstumsfaktor.
SE8105657L (sv) Mikrobiell framstellning av humanfibroblastinterferon
DE69534822D1 (de) Verfahren zur bakteriellen herstellung von heterologen polypeptiden mit disulfidbrücke
ATE90727T1 (de) Dns-konstruktionen, enthaltend eine kluyveromyces-alpha-factor-leadersequenz zur leitung der sekretion von heterologen polypeptiden.
AU8007087A (en) New forms of colony stimulating factor-1
IE811463L (en) Interferons
ATE127841T1 (de) Hirudinderivate.
FI922204A0 (fi) Proteinkomplex med faktor viii:c- aktivitet och framstaellning av desamma.
ATE79403T1 (de) Herstellung von thrombin-inhibitoren.
EP0147178A3 (en) Expression plasmids for improved production of heterologous protein in bacteria
GB2171703B (en) Expression-secretion vector for gene expression and protein secretion, recombinant dna including the vector, and method of producing proteins by use of the re
GR3024625T3 (es) Calcium-regulated promoter
Blat et al. Growth inhibitory factor diffusing from chick embryo fibroblasts
GB2335193A (en) Rainbow trout ILβ; encoding nucleic acid; materials and methods

Legal Events

Date Code Title Description
PUP Patent expired