DK2010531T3 - Spirocykliske cyklohexanderivater med smertestillende virkning - Google Patents

Spirocykliske cyklohexanderivater med smertestillende virkning

Info

Publication number
DK2010531T3
DK2010531T3 DK07724560.3T DK07724560T DK2010531T3 DK 2010531 T3 DK2010531 T3 DK 2010531T3 DK 07724560 T DK07724560 T DK 07724560T DK 2010531 T3 DK2010531 T3 DK 2010531T3
Authority
DK
Denmark
Prior art keywords
alkyl
heteroaryl
aryl
cycloalkyl
saturated
Prior art date
Application number
DK07724560.3T
Other languages
English (en)
Inventor
Beatrix Merla
Stefan Oberboersch
Werner Englberger
Hagen-Heinrich Hennies
Babette-Yvonne Koegel
Stephan Schunk
Heinz Graubaum
Bernd Sundermann
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Application granted granted Critical
Publication of DK2010531T3 publication Critical patent/DK2010531T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK07724560.3T 2006-04-27 2007-04-25 Spirocykliske cyklohexanderivater med smertestillende virkning DK2010531T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006019597A DE102006019597A1 (de) 2006-04-27 2006-04-27 Spirocyclische Cyclohexan-Derivate
PCT/EP2007/003630 WO2007124903A1 (de) 2006-04-27 2007-04-25 Spirocycliche cyclohexanderivate mit analgesischer wirkung

Publications (1)

Publication Number Publication Date
DK2010531T3 true DK2010531T3 (da) 2011-09-19

Family

ID=38293936

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07724560.3T DK2010531T3 (da) 2006-04-27 2007-04-25 Spirocykliske cyklohexanderivater med smertestillende virkning

Country Status (13)

Country Link
US (1) US8124788B2 (da)
EP (1) EP2010531B1 (da)
JP (1) JP2009534437A (da)
AT (1) ATE520693T1 (da)
CA (1) CA2649349A1 (da)
CY (1) CY1111903T1 (da)
DE (1) DE102006019597A1 (da)
DK (1) DK2010531T3 (da)
ES (1) ES2368266T3 (da)
PL (1) PL2010531T3 (da)
PT (1) PT2010531E (da)
SI (1) SI2010531T1 (da)
WO (1) WO2007124903A1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005016460A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
DE102006033114A1 (de) * 2006-07-18 2008-01-24 Grünenthal GmbH Spirocyclische Azaindol-Derivate
US8716308B2 (en) 2008-01-11 2014-05-06 Albany Molecular Research, Inc. (1-azinone)-substituted pyridoindoles
PE20091657A1 (es) 2008-03-27 2009-11-07 Gruenenthal Chemie Derivados de (hetero)aril-ciclohexano
AU2009228643B2 (en) * 2008-03-27 2013-07-11 Grunenthal Gmbh Spiro(5.5)undecane derivatives
CL2009000734A1 (es) 2008-03-27 2009-05-15 Gruenenthal Chemie Compuestos derivados de 4-aminociclohexano sustituido; composicion farmaceutica que comprende a dichos compuestos; y su uso como moduladores del receptor de opioides u y el receptor orl-1 en el tratamiento de la ansiedad, estres, depresion, epilepsia y alzheimer.
TWI466866B (zh) 2008-03-27 2015-01-01 被取代之環己基二胺
PT2260042E (pt) 2008-03-27 2011-12-06 Gruenenthal Gmbh Derivados de ciclo-hexano espirocíclicos substituídos
CN102046591B (zh) 2008-03-27 2014-12-03 格吕伦塔尔有限公司 羟甲基环己胺
US9073925B2 (en) 2009-07-01 2015-07-07 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
WO2011003012A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
US8629158B2 (en) 2009-07-01 2014-01-14 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
WO2011003005A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof
TWI582092B (zh) 2010-07-28 2017-05-11 歌林達股份有限公司 順式－四氫－螺旋（環己烷－１,１’－吡啶［３,４－b］吲哚）－４－胺－衍生物
US8993765B2 (en) 2010-12-21 2015-03-31 Albany Molecular Research, Inc. Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
WO2012088038A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
CN102659662A (zh) * 2012-03-28 2012-09-12 华东师范大学 3-r-3-羟基-2-氧化吲哚类化合物的合成方法
PL3110797T3 (pl) 2014-02-27 2019-11-29 Gruenenthal Gmbh Proces otrzymywania 5-fluorotryptofolu
PL3169666T3 (pl) 2014-07-15 2019-03-29 Grünenthal GmbH Podstawione pochodne azaspiro(4,5)dekanu
TW201607923A (zh) 2014-07-15 2016-03-01 歌林達有限公司 被取代之氮螺環（４．５）癸烷衍生物
CN114149413A (zh) 2016-01-13 2022-03-08 格吕伦塔尔有限公司 3-((杂)芳基)-8-氨基-2-氧代-1,3-氮杂-螺-[4.5]-癸烷衍生物
US20170197949A1 (en) 2016-01-13 2017-07-13 Gruenenthal Gmbh 8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives
MX378995B (es) 2016-01-13 2025-03-11 Gruenenthal Gmbh Derivados de 3-(carboximetil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2663935A1 (fr) * 1990-06-27 1992-01-03 Adir Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE10360793A1 (de) 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE10360792A1 (de) 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
US20050261327A1 (en) * 2004-05-20 2005-11-24 Bock Mark G 2-(Bicyclo)alkylamino-derivatives as mediatores of chronic pain and inflammation
DE102004039382A1 (de) 2004-08-13 2006-02-23 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102005016460A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit

Also Published As

Publication number Publication date
EP2010531B1 (de) 2011-08-17
JP2009534437A (ja) 2009-09-24
ES2368266T3 (es) 2011-11-15
EP2010531A1 (de) 2009-01-07
CY1111903T1 (el) 2015-11-04
US8124788B2 (en) 2012-02-28
DE102006019597A1 (de) 2007-10-31
WO2007124903A1 (de) 2007-11-08
CA2649349A1 (en) 2007-11-08
PL2010531T3 (pl) 2011-12-30
SI2010531T1 (sl) 2011-10-28
ATE520693T1 (de) 2011-09-15
PT2010531E (pt) 2011-09-16
US20090111842A1 (en) 2009-04-30

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