NO20073275L - Benzoyl-tetrahydropyridin som GLYT-1 inhibitorer - Google Patents

Benzoyl-tetrahydropyridin som GLYT-1 inhibitorer

Info

Publication number
NO20073275L
NO20073275L NO20073275A NO20073275A NO20073275L NO 20073275 L NO20073275 L NO 20073275L NO 20073275 A NO20073275 A NO 20073275A NO 20073275 A NO20073275 A NO 20073275A NO 20073275 L NO20073275 L NO 20073275L
Authority
NO
Norway
Prior art keywords
lower alkyl
halogen
glyt
tetrahydropyridine
benzoyl
Prior art date
Application number
NO20073275A
Other languages
English (en)
Inventor
Emmanuel Pinard
Synese Jolidon
Roger David Norcross
Robert Narquizian
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20073275L publication Critical patent/NO20073275L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Foreliggende oppfinnelse angår forbindelser med den generelle formel I I hvor R1 er en ikke-aromati sk heterosyklisk gruppe eller OR'; R' er lavere alkyl, lavere alkyl substituert med halogen eller er -(CH2)n-sykloalkyl; R2 er NO2, CN eller SO2R''; R'' er lavere alkyl; Ar er fenyl, eventuelt substituert med halogen, cyano, lavere alkyl substituert med halogen eller SO2R''; n er 0, 1 eller 2; og farmasøytisk aktive syreaddisjonssalter og anvendelse av dem ved behandling av nevrologiske og nevropsykiatriske lidelser.
NO20073275A 2005-01-04 2007-06-27 Benzoyl-tetrahydropyridin som GLYT-1 inhibitorer NO20073275L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05100027 2005-01-04
PCT/EP2005/014052 WO2006072432A1 (en) 2005-01-04 2005-12-27 Benzoyl-tetrahydropyridine as glyt-1 inhibitors

Publications (1)

Publication Number Publication Date
NO20073275L true NO20073275L (no) 2007-07-31

Family

ID=36118130

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20073275A NO20073275L (no) 2005-01-04 2007-06-27 Benzoyl-tetrahydropyridin som GLYT-1 inhibitorer

Country Status (19)

Country Link
US (1) US7485637B2 (no)
EP (1) EP1836168B1 (no)
JP (1) JP4738421B2 (no)
KR (1) KR100957280B1 (no)
CN (1) CN101111477B (no)
AR (1) AR052553A1 (no)
AT (1) ATE423770T1 (no)
AU (1) AU2005324109B2 (no)
BR (1) BRPI0519746A2 (no)
CA (1) CA2594260A1 (no)
DE (1) DE602005012997D1 (no)
ES (1) ES2319220T3 (no)
IL (1) IL184206A (no)
MX (1) MX2007008043A (no)
NO (1) NO20073275L (no)
RU (1) RU2007124546A (no)
TW (1) TW200635898A (no)
WO (1) WO2006072432A1 (no)
ZA (1) ZA200705383B (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2406085T3 (es) * 2006-06-22 2013-06-05 F. Hoffmann-La Roche Ag Derivados de fenil-metanona sustituida y su empleo como inhibidores de receptores de GlyT1 y GlyT2
JP6034215B2 (ja) * 2013-02-19 2016-11-30 株式会社東芝 紙葉類処理装置

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2423847A1 (de) * 1973-05-28 1975-01-02 Ciba Geigy Ag Neue sulfamoylbenzoesaeureamide
DE2533604A1 (de) 1975-07-26 1977-02-10 Bayer Ag 2-substituierte 5-trifluormethyl1,3,4-thiadiazole, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide und insektizide
DE2611705A1 (de) * 1976-03-18 1977-09-22 Josef Dipl Chem Dr Rer N Klosa N-5-(nitrofurfuryliden-)-1-amino- hydantoin enthaltende kristalloesungsmittel
US4122083A (en) * 1978-01-16 1978-10-24 E. R. Squibb & Sons, Inc. 1,2,3,4-Tetrahydropyrido[4',3':4.5]thiazolo-[3,2-a]benzimidazoles
US4436002A (en) 1981-12-11 1984-03-13 Hughes Tool Company Reversal mechanism for power tong
IT1176613B (it) 1984-08-14 1987-08-18 Ravizza Spa Derivati piperazinici farmacologicamente attivi e processo per la loro preparazione
RU2124511C1 (ru) 1993-05-14 1999-01-10 Фармасьютикал Ко., Лтд Производные пиперазина
TW498067B (en) * 1996-07-19 2002-08-11 Hoffmann La Roche 4-hydroxy-piperidine derivatives
CN1291984A (zh) 1998-03-06 2001-04-18 詹森药业有限公司 甘氨酸传输抑制剂
TR200002567T2 (tr) 1998-03-06 2000-11-21 Janssen Pharmaceutica N.V. Glisin naklini önleyiciler.
US20030216385A1 (en) * 2000-05-19 2003-11-20 Takahiko Tobe Triazole derivatives
GB0021419D0 (en) 2000-08-31 2000-10-18 Oxford Glycosciences Uk Ltd Compounds
GB0106661D0 (en) 2001-03-16 2001-05-09 Pfizer Ltd Pharmaceutically active compounds
ATE449090T1 (de) 2001-07-02 2009-12-15 High Point Pharmaceuticals Llc Substituierte piperazin- und diazepanderivate zur verwendung als histamin h3 rezeptormodulatoren
WO2003035602A1 (en) 2001-10-25 2003-05-01 Sankyo Company, Limited Lipid modulators
CN100457738C (zh) * 2001-12-20 2009-02-04 H·隆德贝克有限公司 芳氧基苯基和芳硫基苯基衍生物
EP1554260A1 (en) 2002-10-22 2005-07-20 Glaxo Group Limited Aryloxyalkylamine derivatives as h3 receptor ligands
CN100372838C (zh) * 2003-02-17 2008-03-05 弗·哈夫曼-拉罗切有限公司 哌啶-苯磺酰胺衍生物
UA85194C2 (ru) * 2003-08-11 2009-01-12 Ф.Хоффманн-Ля Рош Аг Пиперазины с or-замещенной фенильной группой и их применение как ингибиторов glyt 1
ATE374610T1 (de) * 2003-09-09 2007-10-15 Hoffmann La Roche 1-(2-amino-benzoyl)-piperazin-derivate als glycin-aufnahmehemmer zur behandlung von psychosen
AU2004269892B2 (en) * 2003-09-09 2010-03-11 F. Hoffmann-La Roche Ag 1-benzoyl-piperazine derivatives as glycine uptake inhibitors for the treatment of psychoses
RU2395502C2 (ru) * 2004-12-09 2010-07-27 Ф.Хоффманн-Ля Рош Аг Производные фенил-пиперазин метанона
DE602005019465D1 (de) * 2004-12-15 2010-04-01 Hoffmann La Roche Bi- und trizyklische substituierte phenyl-methanone als inhibitoren von glycin-i (glyt-1)-transportern zur behandlung der alzheimer-krankheit
EP2091916A2 (en) * 2005-11-23 2009-08-26 AstraZeneca AB L-phenylalanine derivatives and their use as integrin antagonists

Also Published As

Publication number Publication date
AU2005324109B2 (en) 2011-01-20
JP4738421B2 (ja) 2011-08-03
RU2007124546A (ru) 2009-02-20
KR100957280B1 (ko) 2010-05-12
BRPI0519746A2 (pt) 2009-03-10
JP2008526794A (ja) 2008-07-24
ZA200705383B (en) 2008-09-25
IL184206A (en) 2011-09-27
US20060148797A1 (en) 2006-07-06
WO2006072432A1 (en) 2006-07-13
AU2005324109A1 (en) 2006-07-13
TW200635898A (en) 2006-10-16
ES2319220T3 (es) 2009-05-05
MX2007008043A (es) 2007-07-16
IL184206A0 (en) 2007-10-31
US7485637B2 (en) 2009-02-03
AR052553A1 (es) 2007-03-21
CA2594260A1 (en) 2006-07-13
ATE423770T1 (de) 2009-03-15
DE602005012997D1 (de) 2009-04-09
CN101111477B (zh) 2010-05-26
KR20070094953A (ko) 2007-09-27
EP1836168B1 (en) 2009-02-25
CN101111477A (zh) 2008-01-23
EP1836168A1 (en) 2007-09-26

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