DK202388A - Azabicycliske forbindelser og fremgangsmaade til fremstilling deraf - Google Patents

Azabicycliske forbindelser og fremgangsmaade til fremstilling deraf

Info

Publication number: DK202388A
Authority: DK; Denmark
Prior art keywords: group; chem; alkyl; nitrogen; methyl
Prior art date: 1987-04-15

Application number

DK202388A

Other languages

Danish (da)

English (en)

Other versions

DK202388D0 (da

Inventor

Michael Stewart Hadley

Paul Adran Wyman

Barry Sidney Orlek

Original Assignee

Beecham Group Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-04-15

Filing date

1988-04-13

Publication date

1988-10-16

1987-04-15 Priority claimed from GB878709025A external-priority patent/GB8709025D0/en

1987-12-22 Priority claimed from GB878729809A external-priority patent/GB8729809D0/en

1988-02-24 Priority claimed from GB888804224A external-priority patent/GB8804224D0/en

1988-04-13 Application filed by Beecham Group Plc filed Critical Beecham Group Plc

1988-04-13 Publication of DK202388D0 publication Critical patent/DK202388D0/da

1988-10-16 Publication of DK202388A publication Critical patent/DK202388A/da

Links

238000000034 method Methods 0.000 title 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 3
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
239000005864 Sulphur Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
239000001301 oxygen Substances 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 1
OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 1
125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)
Pyrrole Compounds (AREA)
Recording Measured Values (AREA)
Luminescent Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Steroid Compounds (AREA)

DK202388A 1987-04-15 1988-04-13 Azabicycliske forbindelser og fremgangsmaade til fremstilling deraf DK202388A (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB878709025A GB8709025D0 (en)	1987-04-15	1987-04-15	Compounds
GB878729809A GB8729809D0 (en)	1987-12-22	1987-12-22	Novel compounds
GB888804224A GB8804224D0 (en)	1988-02-24	1988-02-24	Novel compounds

Publications (2)

Publication Number	Publication Date
DK202388D0 DK202388D0 (da)	1988-04-13
DK202388A true DK202388A (da)	1988-10-16

Family

ID=27263387

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK202388A DK202388A (da)	1987-04-15	1988-04-13	Azabicycliske forbindelser og fremgangsmaade til fremstilling deraf

Country Status (8)

Country	Link
US (2)	US4971975A (fr)
EP (1)	EP0287356B1 (fr)
JP (1)	JP2651695B2 (fr)
AT (1)	ATE133415T1 (fr)
AU (1)	AU614513B2 (fr)
DE (1)	DE3854932T2 (fr)
DK (1)	DK202388A (fr)
NZ (1)	NZ224237A (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ219646A (en) *	1986-03-27	1990-10-26	Merck Sharp & Dohme	Oxadiazole derivatives of azacyclics for treating cns disorders
EP0307141B1 (fr) *	1987-09-10	1993-01-13	MERCK SHARP & DOHME LTD.	Oxazoles et thiazoles pour le traitement de la démence sénile
EP0322182A3 (fr) *	1987-12-22	1992-01-02	Beecham Group Plc	Composés azabicycliques, procédé pour leur préparation et compositions pharmaceutiques les contenant
NZ227684A (en) *	1988-01-30	1991-07-26	Merck Sharp & Dohme	Pyrazine, pyridazine, and pyrimidine derivatives and pharmaceutical compositions
DK177889A (da) *	1988-04-15	1989-10-16	Beecham Group Plc	Hidtil ukendte forbindelser
GB8808926D0 (en) *	1988-04-15	1988-05-18	Beecham Group Plc	Novel compounds
EP0363085A3 (fr)	1988-10-03	1991-03-27	Beecham Group Plc	Composés chimiques
CA2000041A1 (fr) *	1988-10-13	1990-04-13	Barry S. Orlek	Composes
SG48315A1 (en) *	1989-04-13	1998-04-17	Beecham Group Plc	Novel compounds
EP0402056A3 (fr) *	1989-06-06	1991-09-04	Beecham Group p.l.c.	Composés azabicycliques, procédé pour leur préparation et compositions pharmaceutiques les contenant
GB8917957D0 (en) *	1989-08-05	1989-09-20	Beecham Group Plc	Novel compounds
EP0413545B1 (fr) *	1989-08-16	1997-05-14	Beecham Group Plc	Composés azabicycliques
US5157160A (en) *	1989-08-16	1992-10-20	Beecham Group P.L.C.	Certain 5-substituted-1-azabicyclo[3.1.1]heptanes and their pharmaceutical use
DE69026197T2 (de) *	1989-10-07	1997-01-09	Beecham Group Plc	Azabizyklische Verbindungen, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
YU84791A (sh) *	1990-05-19	1994-06-10	Boehringer Ingelheim Kg.	Biciklicni 1-aza-cikloalkalni
MX9100779A (es) *	1990-08-24	1992-04-01	Beecham Group Plc	Compuestos azabiciclicos y procedimiento para su preparacion
GB9019095D0 (en) *	1990-09-01	1990-10-17	Beecham Group Plc	Novel compounds
EP0552213A1 (fr) *	1990-10-12	1993-07-28	Beecham Group Plc	Derives oximes de la 1,2,5,6-tetrahydropyridine
WO1993008191A1 (fr) *	1991-10-15	1993-04-29	Warner-Lambert Company	Agents cholinergiques d'amines et d'oximes azabicycliques
SE9201478D0 (sv) *	1992-05-11	1992-05-11	Kabi Pharmacia Ab	Heteroaromatic quinuclidinenes, their use and preparation
US5679693A (en) *	1992-09-30	1997-10-21	Sanofi	1-azoniabicyclo 2.2.1!heptanes, method of preparing them and pharmaceutical compositions in which they are present
AU6010594A (en) *	1993-02-12	1994-08-29	Sankyo Company Limited	Isoxazoleoxy derivative
GB9507203D0 (en) *	1995-04-07	1995-05-31	Smithkline Beecham Plc	Novel compounds
US5733912A (en) *	1997-02-19	1998-03-31	Abbott Laboratories	7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
US6875774B2 (en) *	2002-08-06	2005-04-05	The University Of North Carolina	Aza-bridged bicyclic amine derivatives for use as novel cholinergic receptor ligands
GB0220581D0 (en)	2002-09-04	2002-10-09	Novartis Ag	Organic Compound
AR049401A1 (es)	2004-06-18	2006-07-26	Novartis Ag	Aza-biciclononanos
GB0415746D0 (en)	2004-07-14	2004-08-18	Novartis Ag	Organic compounds
EP2275095A3 (fr)	2005-08-26	2011-08-17	Braincells, Inc.	Neurogenese par modulation des recepteurs muscariniques
EP2258358A3 (fr)	2005-08-26	2011-09-07	Braincells, Inc.	Neurogenèse avec un inhibiteur de l'acetylcholinestérase
GB0521508D0 (en)	2005-10-21	2005-11-30	Novartis Ag	Organic compounds
GB0525672D0 (en)	2005-12-16	2006-01-25	Novartis Ag	Organic compounds
GB0525673D0 (en)	2005-12-16	2006-01-25	Novartis Ag	Organic compounds
AU2007292848A1 (en)	2006-09-08	2008-03-13	Braincells, Inc.	Combinations containing a 4-acylaminopyridine derivative
EP2119716A4 (fr)	2007-02-09	2011-06-01	Astellas Pharma Inc	Composé à cycle à pont aza

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS56156283A (en) *	1980-05-07	1981-12-02	Suntory Ltd	8-substituted pyrrolitidine and its quaternary ammonium salt
JPH0633286B2 (ja) *	1985-01-14	1994-05-02	エーザイ株式会社	セフエム誘導体
US4771051A (en) *	1985-05-17	1988-09-13	A/S Ferrosan	3-substituted-4,5-dihydro-5-oxo imidazoquinazolines, their preparation, and their use in treating benzodiazepin receptor-related ailments
EP0235878A3 (fr) *	1986-01-16	1989-06-14	Beecham Group Plc	Nouveaux composés
GB8607713D0 (en)	1986-03-27	1986-04-30	Merck Sharpe & Dohme Ltd	Oxadiazoles
NZ219646A (en) *	1986-03-27	1990-10-26	Merck Sharp & Dohme	Oxadiazole derivatives of azacyclics for treating cns disorders
GB8630896D0 (en)	1986-12-24	1987-02-04	Merck Sharp & Dohme	Oxadiazoles
ES2061502T3 (es) *	1986-06-27	1994-12-16	Beecham Group Plc	Nuevos n-heterociclos biciclicos puenteados.
GB8615784D0 (en)	1986-06-27	1986-08-06	Beecham Group Plc	Compounds
GB8615785D0 (en) *	1986-06-27	1986-08-06	Beecham Group Plc	Compounds
GB8622380D0 (en)	1986-09-17	1986-10-22	Beecham Group Plc	Compounds
GB8812145D0 (en)	1988-05-23	1988-06-29	Merck Sharp & Dohme	Therapeutic agents
GB8721342D0 (en)	1987-09-10	1987-10-14	Merk Sharp & Dohme Ltd	Therapeutic agents
GB8801758D0 (en)	1988-01-27	1988-02-24	Merck Sharp & Dohme	Therapeutic agents
GB8817311D0 (en)	1988-07-20	1988-08-24	Merck Sharp & Dohme	Therapeutic agents
GB8801759D0 (en)	1988-01-27	1988-02-24	Merck Sharp & Dohme	Therapeutic agents
NZ225999A (en) *	1987-09-10	1992-04-28	Merck Sharp & Dohme	Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions
EP0307141B1 (fr) *	1987-09-10	1993-01-13	MERCK SHARP & DOHME LTD.	Oxazoles et thiazoles pour le traitement de la démence sénile
GB8721343D0 (en)	1987-09-10	1987-10-14	Merk Sharp & Dohme Ltd	Therapeutic agents

1988
- 1988-04-13 AU AU14557/88A patent/AU614513B2/en not_active Ceased
- 1988-04-13 NZ NZ224237A patent/NZ224237A/en unknown
- 1988-04-13 DK DK202388A patent/DK202388A/da not_active Application Discontinuation
- 1988-04-13 AT AT88303334T patent/ATE133415T1/de not_active IP Right Cessation
- 1988-04-13 DE DE3854932T patent/DE3854932T2/de not_active Expired - Fee Related
- 1988-04-13 EP EP88303334A patent/EP0287356B1/fr not_active Expired - Lifetime
- 1988-04-14 JP JP63090466A patent/JP2651695B2/ja not_active Expired - Lifetime
- 1988-04-15 US US07/182,139 patent/US4971975A/en not_active Expired - Fee Related
1990
- 1990-09-21 US US07/573,641 patent/US5132316A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ATE133415T1 (de)	1996-02-15
US5132316A (en)	1992-07-21
DE3854932D1 (de)	1996-03-07
EP0287356B1 (fr)	1996-01-24
DK202388D0 (da)	1988-04-13
EP0287356A3 (en)	1989-09-20
US4971975A (en)	1990-11-20
AU1455788A (en)	1988-10-27
DE3854932T2 (de)	1996-06-13
AU614513B2 (en)	1991-09-05
EP0287356A2 (fr)	1988-10-19
JP2651695B2 (ja)	1997-09-10
JPS63290878A (ja)	1988-11-28
NZ224237A (en)	1991-04-26

Legal Events

Date	Code	Title	Description
1993-11-22	AHS	Application shelved for other reasons than non-payment

Publication	Publication Date	Title
DK202388A (da)	1988-10-16	Azabicycliske forbindelser og fremgangsmaade til fremstilling deraf
ES2079453T3 (es)	1996-01-16	Mejoras en compuestos quimicos.
NZ506574A (en)	2003-06-30	Cyclic amino derivative having a sulphinyl, sulphonyl or disulphanyl group useful in the treatment of thrombosis or embolism
DK289888D0 (da)	1988-05-27	2-substitueret-e-kondenserede oe1,2,4,aatriazolooe1,5-caapyrimidiner, farmaceutiske praeparater og anvendelser deraf
NO892058L (no)	1989-11-27	Fremgangsmaate for fremstilling av terapeutisk aktive benzamider.
ATE98634T1 (de)	1994-01-15	Acryloylsubstituierte pyrrol-derivate.
PT91956A (pt)	1990-04-30	Processo para a preparacao de compostos azabiciclicos
IT1219689B (it)	1990-05-24	Perossiacidi azotati monopersolfati
DE69024397D1 (de)	1996-02-08	Diaminoethylen-Verbindungen
HUT66266A (en)	1994-10-28	Modified oligodeoxyribonucleotides, process for producing them, and pharmaceutical compositions containing them
AU2508888A (en)	1989-05-18	New Peroxycarboxilyc amine derivatives
EP0414394A3 (en)	1991-05-08	Novel compounds
EP0427390A3 (en)	1992-02-12	Azabicyclic compounds, process and intermediates for their preparation and pharmaceutical compositions containing them
SE8303913L (sv)	1984-01-09	Heterocykliska foreningar
DK0904270T3 (da)	2003-12-01	Dihydrobenzofuran og beslægtede forbindelser anvendelige som antiinflammatoriske midler
DE69030695D1 (de)	1997-06-19	Azabicyclische Verbindungen
FI903511A0 (fi)	1990-07-11	Pyrrolo (2,1-b) tiazolderivat.