DK2026073T3 - Diagnostik og behandling af makuladegeneration-relaterede forstyrrelser - Google Patents
Diagnostik og behandling af makuladegeneration-relaterede forstyrrelser Download PDFInfo
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- DK2026073T3 DK2026073T3 DK08162987.5T DK08162987T DK2026073T3 DK 2026073 T3 DK2026073 T3 DK 2026073T3 DK 08162987 T DK08162987 T DK 08162987T DK 2026073 T3 DK2026073 T3 DK 2026073T3
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| EP01934962A EP1287364B1 (en) | 2000-04-29 | 2001-04-30 | Diagnostics and therapeutics for macular degeneration-related disorders |
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| US7108982B1 (en) * | 1999-02-19 | 2006-09-19 | University Of Iowa Research Foundation | Diagnostics and the therapeutics for macular degeneration |
| US20020102581A1 (en) * | 1999-02-19 | 2002-08-01 | Hageman Gregory S. | Diagnostics and therapeutics for ocular disorders |
| US7011952B2 (en) * | 2000-02-22 | 2006-03-14 | University Of Iowa Research Foundation | Diagnostics and therapeutics for macular degeneration-related disorders |
| JP4764590B2 (ja) * | 2000-04-29 | 2011-09-07 | ユニバーシティー オブ アイオワ リサーチ ファウンデーション | 黄班変性関連疾患の診断および治療 |
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| US6875165B2 (en) | 2001-02-22 | 2005-04-05 | Retinalabs, Inc. | Method of radiation delivery to the eye |
| US6820011B2 (en) | 2001-04-11 | 2004-11-16 | The Regents Of The University Of Colorado | Three-dimensional structure of complement receptor type 2 and uses thereof |
| AUPS160602A0 (en) * | 2002-04-08 | 2002-05-16 | University Of Queensland, The | Therapeutic method |
| US7354574B2 (en) | 2002-11-07 | 2008-04-08 | Advanced Ocular Systems Limited | Treatment of ocular disease |
| AU2003298650B2 (en) * | 2002-11-15 | 2010-03-11 | Musc Foundation For Research Development | Complement receptor 2 targeted complement modulators |
| JP4269064B2 (ja) * | 2003-02-26 | 2009-05-27 | 国立大学法人 千葉大学 | 重症筋無力症の検査方法及びそのための検査薬 |
| JPWO2004096277A1 (ja) * | 2003-05-01 | 2006-07-13 | 国立大学法人京都大学 | 眼内血管新生疾患の予防又は治療剤 |
| HUE024996T2 (en) | 2003-05-12 | 2016-01-28 | Helion Biotech Aps | Anti-MASP-2 antibodies |
| US7083802B2 (en) | 2003-07-31 | 2006-08-01 | Advanced Ocular Systems Limited | Treatment of ocular disease |
| US7083803B2 (en) | 2003-09-19 | 2006-08-01 | Advanced Ocular Systems Limited | Ocular solutions |
| US7087237B2 (en) * | 2003-09-19 | 2006-08-08 | Advanced Ocular Systems Limited | Ocular solutions |
| BRPI0506629A (pt) * | 2004-02-10 | 2007-05-02 | Univ Colorado | inibição do fator b, a via alternativa do sistema complemento e métodos relacionados |
| EP2298412A1 (en) * | 2004-02-12 | 2011-03-23 | Neovista, Inc. | Apparatus for intraocular brachytherapy |
| US7563222B2 (en) * | 2004-02-12 | 2009-07-21 | Neovista, Inc. | Methods and apparatus for intraocular brachytherapy |
| US20050250745A1 (en) * | 2004-02-25 | 2005-11-10 | Seddon Johanna M | Biomarkers for age-related macular degeneration (AMD) |
| GB0412966D0 (en) | 2004-06-10 | 2004-07-14 | Univ Leicester | Genetically modified non-human mammals and cells |
| US7919094B2 (en) | 2004-06-10 | 2011-04-05 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| ES2631127T3 (es) * | 2004-06-10 | 2017-08-28 | Omeros Corporation | Métodos para tratar afecciones asociadas con la activación del complemento dependiente de MASP-2 |
| US8840893B2 (en) | 2004-06-10 | 2014-09-23 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| US20060018896A1 (en) * | 2004-06-10 | 2006-01-26 | University Of Leicester | Methods for treating conditions associated with lectin-dependent complement activation |
| CA2513317A1 (en) | 2004-07-06 | 2006-01-06 | Kuhnil Pharmaceutical Co., Ltd. | Composition for the diagnosis of retinal vascular disease comprising aldolase and method for diagnosis using it |
| WO2006042252A2 (en) | 2004-10-08 | 2006-04-20 | Potentia Pharmeceuticals, Inc. | Viral complement control proteins for eye disorders |
| US8043609B2 (en) | 2004-10-08 | 2011-10-25 | Potentia Pharmaceuticals, Inc. | Viral complement control proteins for eye disorders |
| JP2008520242A (ja) * | 2004-11-18 | 2008-06-19 | イェール ユニバーシティ | 視覚障害を処置するための方法および組成物 |
| US7745389B2 (en) * | 2005-02-14 | 2010-06-29 | University Of Iowa Research Foundation | Methods for treatment of age-related macular degeneration |
| US20070037183A1 (en) * | 2005-03-07 | 2007-02-15 | Trustees Of Boston University | Diagnostic and therapeutic target for macular degeneration |
| EP1861114B1 (en) * | 2005-03-11 | 2011-02-02 | Potentia Pharmaceuticals, Inc. | Compositions comprising modulators of g-protein-coupled receptor for treatment of macular degeneration |
| WO2006128006A1 (en) * | 2005-05-26 | 2006-11-30 | The Regents Of The University Of Colorado | Inhibition of the alternative complement pathway for treatment of traumatic brain injury, spinal cord injury and related conditions |
| US20090220953A1 (en) * | 2005-08-24 | 2009-09-03 | C.Y.O'connor Erade Village Foundation | Identification of ancestral haplotypes and uses thereof |
| EP1937706A4 (en) * | 2005-09-09 | 2008-10-22 | Univ Iowa Res Found | ORGANIC MARKERS RELATED TO AGE DEPENDENT MAKULAR GENERATION |
| US8168584B2 (en) | 2005-10-08 | 2012-05-01 | Potentia Pharmaceuticals, Inc. | Methods of treating age-related macular degeneration by compstatin and analogs thereof |
| EP2662089A3 (en) * | 2005-10-08 | 2014-02-19 | Potentia Pharmaceuticals, Inc. | Compstatin and analogs thereof for eye disorders |
| SG10201804008UA (en) * | 2005-11-04 | 2018-06-28 | Genentech Inc | Use of complement pathway inhibitors to treat ocular diseases |
| BRPI0618677A2 (pt) * | 2005-11-15 | 2011-09-06 | Neovista Inc | métodos e aparelho para braquiterapia intra-ocular |
| KR20080087814A (ko) * | 2005-12-22 | 2008-10-01 | 알콘 리서치, 리미티드 | 보체 인자 h의 위험 변이체가 있는 환자에서 연령 관련황반변성의 예방 및 치료를 위한 c3-전환효소 저해제 |
| US20080146501A1 (en) * | 2006-02-13 | 2008-06-19 | University Of Iowa Research Foundation | Protective complement proteins and age-related macular degeneration |
| WO2007120975A2 (en) * | 2006-02-13 | 2007-10-25 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Variants in complement regulatory genes predict age-related macular degeneration |
| US8012683B2 (en) | 2006-02-13 | 2011-09-06 | University Of Iowa Research Foundation | Variants in complement regulatory genes predict age-related macular degeneration |
| NZ571791A (en) * | 2006-03-08 | 2012-03-30 | Archemix Llc | Complement binding aptamers and anti-C5 agents useful in the treatment of ocular disorders |
| EP2008101A4 (en) * | 2006-04-03 | 2009-04-29 | Univ Iowa Res Found | BINDING OF COMPLEMENT FACTOR H TO C-REACTIVE PROTEIN |
| US7759304B2 (en) | 2006-06-21 | 2010-07-20 | Regents Of The University Of Colorado | Targeting complement factor H for treatment of diseases |
| EP2479284B1 (en) | 2006-07-13 | 2017-09-20 | University of Iowa Research Foundation | Methods and reagents for treatment and diagnosis of vascular disorders and age-related macular degeneration |
| EP2054728A2 (en) * | 2006-08-23 | 2009-05-06 | University of Iowa Research Foundation | Biomarkers associated with age-related macular degeneration |
| TW201716437A (zh) * | 2006-11-02 | 2017-05-16 | 建南德克公司 | 人類化之抗-因子d抗體及其用途 |
| WO2008091617A2 (en) * | 2007-01-23 | 2008-07-31 | Case Western Reserve University | Method for detecting age related macular degeneration in a subject |
| HUE026001T2 (en) * | 2007-02-05 | 2016-04-28 | Apellis Pharmaceuticals Inc | Compstatin analogues for use in the treatment of the inflammatory condition of the respiratory system |
| WO2008103299A2 (en) | 2007-02-16 | 2008-08-28 | Massachusetts Eye & Ear Infirmary | Methods and compositions for prognosing, detecting, and treating age-related macular degeneration |
| JP5332064B2 (ja) * | 2007-03-01 | 2013-11-06 | ウェルスタット イムノセラピューティクス, エルエルシー | 炎症により特徴付けられる疾患の治療 |
| CN101668773B (zh) | 2007-03-14 | 2016-08-31 | 亚力史制药公司 | 人工程化抗b因子抗体 |
| US20100015139A1 (en) * | 2008-07-10 | 2010-01-21 | Rekha Bansal | METHOD OF INHIBITING COMPLEMENT ACTIVATION WITH FACTOR Ba SPECIFIC ANTIBODIES AND USE THEREOF |
| CA2680833A1 (en) * | 2007-04-30 | 2008-11-13 | Alcon Research, Ltd. | Treatment of age-related macular degeneration using inhibitors of complement factor d |
| WO2009029784A1 (en) * | 2007-08-29 | 2009-03-05 | Novelmed Therapeutics, Inc. | Inhibition of complement and cellular activation |
| AU2015202046B2 (en) * | 2008-02-15 | 2017-06-29 | Tufts University | A humanized model of membrane attack complex (mac) formation on murine retina and compositions, kits and methods for treatment of macular degeneration |
| ES2478820T3 (es) * | 2008-02-15 | 2014-07-23 | Tufts University | Tratamiento de degeneración macular |
| US8114592B2 (en) | 2008-03-18 | 2012-02-14 | Cambridge Enterprise Limited | Genetic markers associated with age-related macular degeneration, methods of detection and uses thereof |
| CR20170001A (es) | 2008-04-28 | 2017-08-10 | Genentech Inc | Anticuerpos anti factor d humanizados |
| WO2009149175A1 (en) | 2008-06-04 | 2009-12-10 | Neovista, Inc. | Handheld radiation delivery system for advancing a radiation source wire |
| PY09026846A (es) | 2008-08-05 | 2015-09-01 | Novartis Ag | Composiciones y métodos para anticuerpos que se dirigen a la proteína de complemento c5 |
| GB0816702D0 (en) * | 2008-09-12 | 2008-10-22 | Trinity College Dublin | Complement proteins |
| WO2010129351A1 (en) * | 2009-04-28 | 2010-11-11 | Schepens Eye Research Institute | Method to identify and treat age-related macular degeneration |
| US20100291106A1 (en) * | 2009-05-06 | 2010-11-18 | Novartis Ag | Compositions and methods for antibodies targeting complement protein c3b |
| WO2010135717A2 (en) | 2009-05-21 | 2010-11-25 | Potentia Pharmaceuticals, Inc. | Complement assays and uses thereof |
| WO2011003098A1 (en) | 2009-07-02 | 2011-01-06 | Musc Foundation For Research Development | Methods of stimulating liver regeneration |
| CA2781595C (en) | 2009-07-10 | 2016-07-05 | The Regents Of The University Of Michigan | Compositions and methods for diagnosing and treating macular degeneration |
| US20120190578A1 (en) * | 2009-08-06 | 2012-07-26 | Washington University | Plasma Complement Components as Expression Markers for Age-Related Macular Degeneration and Related Phenotypes |
| DK2488203T3 (da) * | 2009-10-16 | 2017-03-13 | Omeros Corp | Fremgangsmåder til behandling af dissemineret intravaskulær koagulation ved inhibition af masp-2-afhængig komplementaktivering |
| WO2011053774A1 (en) | 2009-10-30 | 2011-05-05 | Alcon Research, Ltd. | Single nucleotide polymorphisms and genes associated with age-related macular degeneration |
| CA2795311A1 (en) | 2009-11-05 | 2011-05-12 | Taligen Therapeutics, Inc. | Treatment of paroxysmal nocturnal hemoglobinuria, hemolytic anemias and disease states involving intravascular and extravascular hemolysis |
| TR201902542T4 (tr) * | 2010-04-13 | 2019-03-21 | M Lab Gmbh | Glokom i̇çi̇n tani yöntemleri̇ |
| BR112012029067A2 (pt) | 2010-05-14 | 2019-09-24 | Univ Colorado Regents | grupos-alvo de receptor do complemento 2 (cr2) melhorados. |
| SG186397A1 (en) | 2010-06-22 | 2013-01-30 | Univ Colorado Regents | Antibodies to the c3d fragment of complement component 3 |
| WO2011163394A2 (en) | 2010-06-22 | 2011-12-29 | Apellis Pharmaceuticals, Inc. | Compstatin analogs for treatment of neuropathic pain |
| CA2843684A1 (en) | 2010-08-13 | 2012-02-16 | Tufts University | Compositions, kits and methods for treatment of macular degeneration using soluble membrane-independent cd59 protein |
| US20140004510A1 (en) | 2010-09-24 | 2014-01-02 | Massachusetts Eye And Ear Infirmary | Methods and compositions for prognosing and/or detecting age-related macular degeneration |
| US8940490B2 (en) | 2010-11-29 | 2015-01-27 | Novelmed Therapeutics, Inc. | Neoantibodies for diagnosing tissue injury |
| KR101256908B1 (ko) | 2011-04-28 | 2013-04-23 | (주)에이치비메디컬스 | 주름제거용 충전체 |
| ES2728278T3 (es) | 2011-12-21 | 2019-10-23 | Novartis Ag | Composiciones que comprenden anticuerpos dirigidos al factor P y C5 |
| US8999292B2 (en) | 2012-05-01 | 2015-04-07 | Translatum Medicus Inc. | Methods for treating and diagnosing blinding eye diseases |
| AU2013255050B2 (en) * | 2012-05-01 | 2016-07-28 | Translatum Medicus Inc. | Methods for treating and diagnosing blinding eye diseases |
| US9803005B2 (en) | 2012-05-24 | 2017-10-31 | Alexion Pharmaceuticals, Inc. | Humaneered anti-factor B antibody |
| US10413620B2 (en) | 2012-08-17 | 2019-09-17 | The Regents Of The University Of Colorado, A Body Corporate | Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging |
| WO2014028861A1 (en) * | 2012-08-17 | 2014-02-20 | Apellis Pharmaceuticals, Inc. | Detection of high risk drusen |
| JP2015535212A (ja) | 2012-08-17 | 2015-12-10 | ザ・リージエンツ・オブ・ザ・ユニバーシテイ・オブ・コロラド、ア・ボデイー・コーポレイト | 補体活性化を検出するための組成物および方法 |
| MX366404B (es) | 2012-11-15 | 2019-07-08 | Apellis Pharmaceuticals Inc | Analogos de compstatina de celula reactiva, de acción prolongada u objetivos y composiciones y metodos relacionados. |
| WO2014151923A1 (en) | 2013-03-14 | 2014-09-25 | Baxter International Inc. | Factor h for treatment of rheumatoid arthritis |
| AU2014236778B2 (en) | 2013-03-14 | 2019-01-03 | Baxalta GmbH | Factor H for transplantation |
| AU2013202965B2 (en) | 2013-03-15 | 2016-07-21 | Takeda Pharmaceutical Company Limited | Improved method for producing factor h from a plasma precipitation fraction |
| WO2014152391A1 (en) | 2013-03-15 | 2014-09-25 | Apellis Pharmaceuticals, Inc. | Cell-penetrating compstatin analogs and uses thereof |
| SG11201601044XA (en) | 2013-08-12 | 2016-03-30 | Genentech Inc | Compositions and method for treating complement-associated conditions |
| CN110724691A (zh) | 2014-02-27 | 2020-01-24 | 阿勒根公司 | 补体因子Bb抗体 |
| AU2015253042A1 (en) | 2014-05-01 | 2016-10-20 | Genentech, Inc. | Anti-factor D antibody variants and uses thereof |
| CN107249433B (zh) | 2015-03-01 | 2019-12-20 | 诺瓦赛特有限公司 | 用于测量眼能动性的系统和方法 |
| EP3115784A1 (en) * | 2015-07-10 | 2017-01-11 | Koss, Michael Janusz | Polypeptide marker for analysis, diagnosis and therapy of eye-related diseases |
| US11903994B2 (en) | 2015-10-07 | 2024-02-20 | Apellis Pharmaceuticals, Inc. | Dosing regimens |
| US10407510B2 (en) | 2015-10-30 | 2019-09-10 | Genentech, Inc. | Anti-factor D antibodies and conjugates |
| EP3368090A1 (en) | 2015-10-30 | 2018-09-05 | H. Hoffnabb-La Roche Ag | Anti-factor d antibody variant conjugates and uses thereof |
| US20190049465A1 (en) * | 2016-02-06 | 2019-02-14 | Georgetown University | Compositions and methods for the diagnosis and treatment of age-related macular degeneration |
| CN109219386B (zh) * | 2016-05-29 | 2021-06-22 | 诺瓦赛特有限公司 | 显示系统和方法 |
| JP6745523B2 (ja) * | 2016-08-16 | 2020-08-26 | 国立大学法人旭川医科大学 | 補体系を検査する方法及びそのためのキット |
| EP3515284B1 (en) | 2016-09-23 | 2023-09-20 | Novasight Ltd. | Screening apparatus |
| EP3529619B1 (en) * | 2016-10-19 | 2021-06-30 | Alexion Pharmaceuticals, Inc. | A method of quantitating unbound c5a in a sample |
| WO2018075758A1 (en) * | 2016-10-19 | 2018-04-26 | Alexion Pharmaceuticals, Inc. | A method of quantitating unbound c5 in a sample |
| IL269844B2 (en) | 2017-04-07 | 2025-01-01 | Apellis Pharmaceuticals Inc | Dosage regimens and related compositions and methods |
| WO2019006153A1 (en) * | 2017-06-30 | 2019-01-03 | Anthrobio | IMPROVEMENT OF THE PROTEOLYTIC CASCADE FOR THE TREATMENT OF A DISEASE |
| EP3655545B1 (en) | 2017-07-18 | 2023-10-18 | The Research Foundation for The State University of New York | Biomarkers for intracranial aneurysm |
| WO2019118938A1 (en) | 2017-12-15 | 2019-06-20 | Apellis Pharmaceuticals, Inc. | Dosing regimens and related compositions and methods |
| WO2020261158A1 (en) | 2019-06-25 | 2020-12-30 | Translatum Medicus Inc. | Processes of making 2-((1-benzyl-1h-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives |
| JP2022541851A (ja) * | 2019-07-26 | 2022-09-27 | アレグロ ファーマシューティカルズ エルエルシー | 眼の非滲出型黄斑変性および他の障害を治療するためのペプチド |
| US20230243852A1 (en) * | 2022-01-26 | 2023-08-03 | Idexx Laboratories, Inc. | Methods and compositions for differentiating progressive chronic kidney disease from stable chronic kidney disease |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US102581A (en) * | 1870-05-03 | Improvement in boiler-furnaces | ||
| US3654090A (en) | 1968-09-24 | 1972-04-04 | Organon | Method for the determination of antigens and antibodies |
| US3650090A (en) * | 1970-06-19 | 1972-03-21 | Phillips Petroleum Co | Analysis of gaseous mixtures |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4517288A (en) | 1981-01-23 | 1985-05-14 | American Hospital Supply Corp. | Solid phase system for ligand assay |
| GB8311018D0 (en) | 1983-04-22 | 1983-05-25 | Amersham Int Plc | Detecting mutations in dna |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| CA1291031C (en) | 1985-12-23 | 1991-10-22 | Nikolaas C.J. De Jaeger | Method for the detection of specific binding agents and their correspondingbindable substances |
| US4998617A (en) | 1986-09-15 | 1991-03-12 | Laura Lupton Inc | Facial cosmetic liquid make up kit |
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5256642A (en) | 1988-04-01 | 1993-10-26 | The Johns Hopkins University | Compositions of soluble complement receptor 1 (CR1) and a thrombolytic agent, and the methods of use thereof |
| US5506247A (en) | 1988-04-15 | 1996-04-09 | T Cell Sciences, Inc. | Compounds that inhibit complement and/or suppress immune activity |
| US5221616A (en) | 1988-07-15 | 1993-06-22 | Quidel Corporation | Prevention of spontaneous complement activation in mammalian biological fluids |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5328470A (en) | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| GB8912497D0 (en) | 1989-05-31 | 1989-07-19 | Cobbold Stephen P | Monoclonal antibodies |
| FR2650840B1 (fr) | 1989-08-11 | 1991-11-29 | Bertin & Cie | Procede rapide de detection et/ou d'identification d'une seule base sur une sequence d'acide nucleique, et ses applications |
| DE69120146T2 (de) | 1990-01-12 | 1996-12-12 | Cell Genesys Inc | Erzeugung xenogener antikörper |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| DK0600866T3 (da) | 1990-06-01 | 1998-03-09 | Chiron Corp | Præparater og fremgangsmåder til identifikation af biologisk aktive molekyler |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| WO1993012227A1 (en) | 1991-12-17 | 1993-06-24 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5770358A (en) | 1991-09-18 | 1998-06-23 | Affymax Technologies N.V. | Tagged synthetic oligomer libraries |
| KR100310939B1 (ko) | 1992-10-01 | 2002-06-20 | 추후제출 | 태그로암호화한복합조합화학라이브러리 |
| DE69433811T2 (de) | 1993-01-07 | 2005-06-23 | Sequenom, Inc., San Diego | Dns - sequenzierung durch massenspektronomie |
| EP0682526B1 (en) | 1993-02-12 | 2002-09-04 | Avant Immunotherapeutics, Inc. | PULMONARY ADMINISTRATION OF THE SOLUBLE COMPLEM RECEPTOR TYPE 1 sCR1 |
| WO1995003009A1 (en) | 1993-07-22 | 1995-02-02 | Oculex Pharmaceuticals, Inc. | Method of treatment of macular degeneration |
| US5583973A (en) | 1993-09-17 | 1996-12-10 | Trustees Of Boston University | Molecular modeling method and system |
| US6153203A (en) | 1993-10-08 | 2000-11-28 | Duotol Ab | Immunological tolerance-inducing agent |
| US5681571A (en) * | 1993-10-08 | 1997-10-28 | Duotol Ab | Immunological tolerance-inducing agent |
| BR9407947A (pt) | 1993-11-02 | 1996-11-26 | Affymax Tech Nv | Processo para sintetizar moléculas diversas em uma pluralidade de substratos e uma coleçao molecular etiquetade para realizaçao reaçoes de copulaçao em contas em paralelo para triar uma coleçao molecular etiquetada para detectar a presença de um ou mais diferentes etiquetas e para determinar a sequência de síntese aparelho para reaçoes de copulaçao paralelas em suportes sólidos bloco de alinhamento ótico para uso com um detector ótico sistemas de distribuiçao para distribuir reagentes dispositiv |
| AU1441395A (en) * | 1993-12-21 | 1995-07-10 | St. Louis University | Ocular diagnostics and therapies |
| US6140466A (en) | 1994-01-18 | 2000-10-31 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| US6074642A (en) | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
| CA2189634A1 (en) | 1994-05-06 | 1995-11-16 | John J. Baldwin | Combinatorial dihydrobenzopyran library |
| GB2290293A (en) | 1994-06-08 | 1995-12-20 | Rupert Donald Holms | Preparation which inhibits the autoimmune response in HIV, or SLE, patients |
| US5663046A (en) | 1994-06-22 | 1997-09-02 | Pharmacopeia, Inc. | Synthesis of combinatorial libraries |
| US5612894A (en) | 1995-02-08 | 1997-03-18 | Wertz; David H. | System and method for molecular modeling utilizing a sensitivity factor |
| US6103235A (en) | 1995-10-30 | 2000-08-15 | The United States Of America As Represented By The Department Of Health And Human Services | Methods of inducing immune tolerance using immunotoxins |
| JPH09194393A (ja) | 1996-01-22 | 1997-07-29 | Meiji Milk Prod Co Ltd | 免疫寛容を誘導する方法、免疫寛容誘導食品キットおよび免疫寛容誘導剤キット |
| EP0888459A1 (en) | 1996-02-02 | 1999-01-07 | Stichting Onderzoeksbeleid Cardiopulmonale Chirurgie | Measurement of complement activation by biomaterials by means of complement convertase cleavage of peptide substrates |
| UA66757C2 (en) | 1996-02-26 | 2004-06-15 | Advanced Res & Tech Inst | Ophthalmologic composition of carbonic anhydrase inhibitors, method for treating or preventing macular edema or age-related macular degeneration |
| US5843449A (en) | 1996-03-25 | 1998-12-01 | Akzo Nobel N.V. | Proteins and novel peptides derived from autoantigen for use in immunotherapy of autoimmune diseases |
| US5705380A (en) * | 1996-09-04 | 1998-01-06 | Sequana Theraputics, Inc. | Identification of a gene encoding TULP2, a retina specific protein |
| US5686598A (en) * | 1996-08-22 | 1997-11-11 | The Jackson Laboratory | Genes associated with retinal dystrophies |
| CA2251603A1 (en) | 1996-04-10 | 1997-10-16 | Axys Pharmaceuticals, Inc. | Gene family associated with neurosensory defects |
| US6102236A (en) * | 1997-01-31 | 2000-08-15 | Tetra Laval Holdings & Finance S.A. | Lid of a container for beverages |
| US5773673A (en) * | 1997-07-01 | 1998-06-30 | Occidental Chemical Corporation | Method of making chlorinated hydrocarbons |
| DE69829402T2 (de) | 1997-10-31 | 2006-04-13 | Affymetrix, Inc. (a Delaware Corp.), Santa Clara | Expressionsprofile in adulten und fötalen organen |
| US6956107B2 (en) * | 1998-02-20 | 2005-10-18 | Tanox, Inc. | Inhibitors of complement activation |
| US6015803A (en) | 1998-05-04 | 2000-01-18 | Wirostko; Emil | Antibiotic treatment of age-related macular degeneration |
| US20020102581A1 (en) | 1999-02-19 | 2002-08-01 | Hageman Gregory S. | Diagnostics and therapeutics for ocular disorders |
| US20030149997A1 (en) * | 1999-02-19 | 2003-08-07 | Hageman Gregory S. | Diagnostics and therapeutics for arterial wall disruptive disorders |
| US7108982B1 (en) * | 1999-02-19 | 2006-09-19 | University Of Iowa Research Foundation | Diagnostics and the therapeutics for macular degeneration |
| EP1161686A2 (en) | 1999-03-05 | 2001-12-12 | University Of Iowa Research Foundation | Diagnostics and therapeutics for drusen associated ocular disorders |
| US7011952B2 (en) * | 2000-02-22 | 2006-03-14 | University Of Iowa Research Foundation | Diagnostics and therapeutics for macular degeneration-related disorders |
| JP4764590B2 (ja) | 2000-04-29 | 2011-09-07 | ユニバーシティー オブ アイオワ リサーチ ファウンデーション | 黄班変性関連疾患の診断および治療 |
| TW201716437A (zh) * | 2006-11-02 | 2017-05-16 | 建南德克公司 | 人類化之抗-因子d抗體及其用途 |
| EP2158330A2 (en) * | 2007-05-11 | 2010-03-03 | Tufts Medical Center | Polynucleotides associated with age-related macular degeneration and methods for evaluating patient risk |
| AR066660A1 (es) * | 2007-05-23 | 2009-09-02 | Genentech Inc | Prevencion y tratamiento de condiciones del ojo asociadas con su complemento |
-
2001
- 2001-04-30 JP JP2001581122A patent/JP4764590B2/ja not_active Expired - Fee Related
- 2001-04-30 EP EP08162987.5A patent/EP2026073B1/en not_active Expired - Lifetime
- 2001-04-30 EP EP01934962A patent/EP1287364B1/en not_active Expired - Lifetime
- 2001-04-30 DK DK01934962T patent/DK1287364T3/da active
- 2001-04-30 AT AT01934962T patent/ATE412185T1/de not_active IP Right Cessation
- 2001-04-30 ES ES01934962T patent/ES2316446T3/es not_active Expired - Lifetime
- 2001-04-30 WO PCT/US2001/013971 patent/WO2001084149A2/en not_active Ceased
- 2001-04-30 DK DK08162987.5T patent/DK2026073T3/da active
- 2001-04-30 AU AU6110301A patent/AU6110301A/xx active Pending
- 2001-04-30 AU AU2001261103A patent/AU2001261103B2/en not_active Ceased
- 2001-04-30 US US09/845,745 patent/US20020015957A1/en not_active Abandoned
- 2001-04-30 CA CA002407715A patent/CA2407715C/en not_active Expired - Fee Related
- 2001-04-30 DE DE60136272T patent/DE60136272D1/de not_active Expired - Lifetime
-
2003
- 2003-04-18 US US10/419,305 patent/US7351524B2/en not_active Expired - Lifetime
-
2006
- 2006-05-30 US US11/443,696 patent/US20060263819A1/en not_active Abandoned
-
2010
- 2010-09-23 US US12/889,311 patent/US20110182908A1/en not_active Abandoned
-
2018
- 2018-02-15 US US15/897,609 patent/US20180335436A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001261103B2 (en) | 2007-08-23 |
| US20060263819A1 (en) | 2006-11-23 |
| WO2001084149A3 (en) | 2002-07-18 |
| ATE412185T1 (de) | 2008-11-15 |
| EP1287364B1 (en) | 2008-10-22 |
| CA2407715C (en) | 2009-03-24 |
| US20110182908A1 (en) | 2011-07-28 |
| DE60136272D1 (de) | 2008-12-04 |
| WO2001084149A2 (en) | 2001-11-08 |
| JP2003535581A (ja) | 2003-12-02 |
| EP1287364A2 (en) | 2003-03-05 |
| US20020015957A1 (en) | 2002-02-07 |
| US7351524B2 (en) | 2008-04-01 |
| EP2026073A1 (en) | 2009-02-18 |
| EP2026073B1 (en) | 2016-03-30 |
| AU6110301A (en) | 2001-11-12 |
| JP4764590B2 (ja) | 2011-09-07 |
| US20030207309A1 (en) | 2003-11-06 |
| ES2316446T3 (es) | 2009-04-16 |
| US20180335436A1 (en) | 2018-11-22 |
| DK1287364T3 (da) | 2009-03-02 |
| CA2407715A1 (en) | 2001-11-08 |
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