DK20388A - Anvendelse af 5-ht3-receptorantagonister til behandling af viscerale smerter - Google Patents

Anvendelse af 5-ht3-receptorantagonister til behandling af viscerale smerter

Info

Publication number: DK20388A
Authority: DK; Denmark
Prior art keywords: hydrogen; alkoxy; alkyl; visceral pain; halo
Prior art date: 1987-01-19

Application number

DK020388A

Other languages

Danish (da)

English (en)

Other versions

DK20388D0 (da

Inventor

C O Veecham Pharmaceuti Sanger

C O Beecham Pharmaceutica Marr

Original Assignee

Beecham Group Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-01-19

Filing date

1988-01-18

Publication date

1988-07-20

1988-01-18 Application filed by Beecham Group Plc filed Critical Beecham Group Plc

1988-01-18 Publication of DK20388D0 publication Critical patent/DK20388D0/da

1988-07-20 Publication of DK20388A publication Critical patent/DK20388A/da

Links

208000009935 visceral pain Diseases 0.000 title abstract 2
102000035037 5-HT3 receptors Human genes 0.000 title 1
108091005477 5-HT3 receptors Proteins 0.000 title 1
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 8
239000001257 hydrogen Substances 0.000 abstract 8
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 5
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
125000001475 halogen functional group Chemical group 0.000 abstract 3
241000124008 Mammalia Species 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000005236 alkanoylamino group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
-1 polymethylene Polymers 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Emergency Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)
Saccharide Compounds (AREA)
Crystals, And After-Treatments Of Crystals (AREA)
Polarising Elements (AREA)
Mechanical Treatment Of Semiconductor (AREA)
Processing Of Meat And Fish (AREA)
Analysing Materials By The Use Of Radiation (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)

DK020388A 1987-01-19 1988-01-18 Anvendelse af 5-ht3-receptorantagonister til behandling af viscerale smerter DK20388A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB878701022A GB8701022D0 (en)	1987-01-19	1987-01-19	Treatment

Publications (2)

Publication Number	Publication Date
DK20388D0 DK20388D0 (da)	1988-01-18
DK20388A true DK20388A (da)	1988-07-20

Family

ID=10610829

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK020388A DK20388A (da)	1987-01-19	1988-01-18	Anvendelse af 5-ht3-receptorantagonister til behandling af viscerale smerter

Country Status (12)

Country	Link
US (3)	US4845092A (de)
EP (1)	EP0279512B1 (de)
JP (1)	JP2584266B2 (de)
KR (1)	KR880009020A (de)
AT (1)	ATE135911T1 (de)
AU (1)	AU608276B2 (de)
DE (1)	DE3855144T2 (de)
DK (1)	DK20388A (de)
ES (1)	ES2085259T3 (de)
GB (1)	GB8701022D0 (de)
GR (1)	GR3019447T3 (de)
ZA (1)	ZA88266B (de)

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JP2828653B2 (ja) *	1989-04-13	1998-11-25	東ソー株式会社	接着性の改良されたポリフェニレンスルフィド樹脂組成物
IE913621A1 (en) *	1990-10-17	1992-04-22	Beecham Group Plc	Novel treatment
HU211081B (en) *	1990-12-18	1995-10-30	Sandoz Ag	Process for producing indole derivatives as serotonin antagonists and pharmaceutical compositions containing the same
GB9214184D0 (en) *	1992-07-03	1992-08-12	Smithkline Beecham Plc	Pharmaceuticals
US5399562A (en) *	1994-02-04	1995-03-21	G. D. Searle & Co.	Indolones useful as serotonergic agents
GB9721139D0 (en)	1997-10-07	1997-12-03	Glaxo Group Ltd	Medicaments
AU3422800A (en) *	1999-02-18	2000-09-04	Novartis Ag	Use of 5-ht3 receptor antagonists
US20040048874A1 (en) *	2001-05-22	2004-03-11	Bardsley Hazel Judith	New therapeutic use of 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine
GB0216027D0 (en) *	2002-07-10	2002-08-21	Arachnova Therapeutics Ltd	New therapeutic use
AR036040A1 (es)	2001-06-12	2004-08-04	Upjohn Co	Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen
AR036041A1 (es)	2001-06-12	2004-08-04	Upjohn Co	Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen
DE60218493D1 (de) *	2001-09-12	2007-04-12	Pharmacia & Upjohn Co Llc	Substituierte 7-aza-ä2.2.1übicycloheptane für die behandlung von krankheiten
CA2462453C (en)	2001-10-02	2009-07-28	Pharmacia & Upjohn Company	Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease
US6849620B2 (en)	2001-10-26	2005-02-01	Pfizer Inc	N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease
MXPA04004373A (es)	2001-11-09	2004-08-11	Upjohn Co	Compuestos heterociclicos condensados con fenilo azabiciclo para el tratamiento de enfermedades.
CA2476681A1 (en) *	2002-02-19	2003-08-28	Bruce N. Rogers	Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease
CA2476624A1 (en) *	2002-02-19	2003-08-28	Pharmacia & Upjohn Company	Azabicyclic compounds for the treatment of disease
MXPA05003317A (es)	2002-09-25	2005-07-05	Memory Pharm Corp	Indazoles, benzotiazoles y benzoisotiazoles asi como preparacion y usos de los mismos.
WO2004039815A2 (en) *	2002-11-01	2004-05-13	Pharmacia & Upjohn Company Llc	Compounds having both alpha7 nachr agonist and 5ht antagonist activity for treatment of cns diseases
JP2006516977A (ja) *	2003-01-13	2006-07-13	ダイノゲンファーマシューティカルズ，インコーポレイテッド	悪心、嘔吐、レッチング、またはそれらの任意の組み合わせの治療方法
MXPA05007381A (es) *	2003-01-13	2006-02-10	Dynogen Pharmaceuticals Inc	Metodo para el tratamiento de transtornos funcionales del intestino.
WO2005041988A1 (en) *	2003-10-22	2005-05-12	University Of Florida	Method and composition for pain amelioration
RU2389729C2 (ru)	2003-12-22	2010-05-20	Мемори Фармасьютиклз Корпорейшн	1н-индазолы, 1, 2-бензизоксазолы и 1, 2-бензизотиазолы, их получение и применение
TW200533348A (en) *	2004-02-18	2005-10-16	Theravance Inc	Indazole-carboxamide compounds as 5-ht4 receptor agonists
US7820690B2 (en)	2004-03-19	2010-10-26	Solvay Pharmaceuticals Gmbh	Method of treating or inhibiting a non-digestive tract derived abdominal disorder associated with pain using a 5-HT, receptor antagonist
EP1727527A1 (de) *	2004-03-19	2006-12-06	Solvay Pharmaceuticals GmbH	Verwendung eines 5-ht3-rezeptorantagonisten zur herstellung eines medikaments zur behandlung schmerzhafter nicht vom verdauungstrakt herrührender abdominalerkrankungen
EP1735306A2 (de)	2004-03-25	2006-12-27	Memory Pharmaceuticals Corporation	Indazole, benzothiazole, benzoisothiazole, benzisoxazole und deren herstellung und verwendungen
US8309575B2 (en)	2004-04-07	2012-11-13	Theravance, Inc.	Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) *	2004-04-07	2011-11-01	Theravance Inc	Quinolinone-carboxamide compounds as 5-ht4 recepto
US7728006B2 (en) *	2004-04-07	2010-06-01	Theravance, Inc.	Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
CA2567977A1 (en)	2004-04-22	2006-01-05	Memory Pharmaceutical Corporation	Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof
NZ551712A (en) *	2004-05-07	2010-07-30	Memory Pharm Corp	1H-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparations and uses thereof
EP1807423B1 (de) *	2004-11-05	2009-05-20	Theravance, Inc.	Chinolinon-carboxamid-verbindungen
ATE441646T1 (de) *	2004-11-05	2009-09-15	Theravance Inc	5-ht4-rezeptoragonistenverbindungen
AU2005316739A1 (en) *	2004-12-13	2006-06-22	Galileo Pharmaceuticals, Inc.	Spiro derivatives as lipoxygenase inhibitors
ATE469897T1 (de) *	2004-12-22	2010-06-15	Theravance Inc	Indazolcarbonsäureamidverbindungen
CA2591817A1 (en)	2004-12-22	2006-06-29	Memory Pharmaceuticals Corporation	Nicotinic alpha-7 receptor ligands and preparation and uses thereof
US20060160905A1 (en) *	2005-01-18	2006-07-20	Bergeron Raymond J Jr	Compositions and methods for inhibiting pain
NZ560828A (en) *	2005-03-02	2011-01-28	Theravance Inc	Quinolinone compounds as 5-HT4 receptor agonists
WO2006105117A2 (en) *	2005-03-28	2006-10-05	Dynogen Pharmaceuticals, Inc.	Method of treating disorders and conditions using peripherally-restricted antagonists and inhibitors
US8106066B2 (en)	2005-09-23	2012-01-31	Memory Pharmaceuticals Corporation	Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof

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Publication number	Priority date	Publication date	Assignee	Title
CA1220141A (en) *	1981-06-13	1987-04-07	John R. Fozard	Treatment of migraine with tropyl benzoate derivatives
FR2531083B1 (fr) *	1982-06-29	1986-11-28	Sandoz Sa	Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
JPS5936675A (ja) *	1982-07-13	1984-02-28	サンド・アクチエンゲゼルシヤフト	二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド
FR2557110B1 (fr) *	1983-12-23	1989-11-24	Sandoz Sa	Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments
DE3587151T2 (de) *	1984-12-20	1993-07-15	Sandoz Ag	Behandlung von gastrointestinalkrankheiten durch anwendung von 5-ht3-antagonisten.
EP0201165B1 (de) *	1985-03-14	1994-07-20	Beecham Group Plc	Arzneimittel zur Behandlung von Emesis
DE3650772T2 (de) *	1985-04-27	2003-04-03	F. Hoffmann-La Roche Ag, Basel	Derivate von Indazole-3-carboxamide und -3-carboxylsäure
GB8510752D0 (en) *	1985-04-27	1985-06-05	Beecham Group Plc	Compounds
GB8525913D0 (en) *	1985-10-21	1985-11-27	Beecham Group Plc	Compounds
EP0220011A3 (de) *	1985-10-12	1990-01-03	Beecham Group Plc	Verwendung von Azabicycloalkylbenzamiden zur Behandlung von Magen-Darmbewegungskrankheiten, Migräne, Emesis, Migränekopfschmerzen, Trigeminusneuralgie und Arhythmie
DE3687980T2 (de) *	1986-01-07	1993-06-17	Beecham Group Plc	Indolderivate mit einer azabicyclischen seitenkette, verfahren zu ihrer herstellung, zwischenprodukte und pharmazeutische zusammensetzungen.
EP0235878A3 (de) *	1986-01-16	1989-06-14	Beecham Group Plc	Neue Verbindungen

1987
- 1987-01-19 GB GB878701022A patent/GB8701022D0/en active Pending
1988
- 1988-01-15 ZA ZA88266A patent/ZA88266B/xx unknown
- 1988-01-18 ES ES88300376T patent/ES2085259T3/es not_active Expired - Lifetime
- 1988-01-18 DK DK020388A patent/DK20388A/da not_active Application Discontinuation
- 1988-01-18 AT AT88300376T patent/ATE135911T1/de not_active IP Right Cessation
- 1988-01-18 DE DE3855144T patent/DE3855144T2/de not_active Expired - Fee Related
- 1988-01-18 EP EP88300376A patent/EP0279512B1/de not_active Expired - Lifetime
- 1988-01-18 JP JP63008215A patent/JP2584266B2/ja not_active Expired - Lifetime
- 1988-01-18 KR KR1019880000325A patent/KR880009020A/ko not_active Withdrawn
- 1988-01-18 AU AU10355/88A patent/AU608276B2/en not_active Ceased
- 1988-01-19 US US07/145,537 patent/US4845092A/en not_active Expired - Fee Related
1989
- 1989-05-05 US US07/348,051 patent/US4942160A/en not_active Expired - Fee Related
1990
- 1990-05-07 US US07/520,108 patent/US5063231A/en not_active Expired - Fee Related
1996
- 1996-03-28 GR GR960400649T patent/GR3019447T3/el unknown

Also Published As

Publication number	Publication date
US5063231A (en)	1991-11-05
AU1035588A (en)	1988-07-21
EP0279512A3 (de)	1992-09-16
DK20388D0 (da)	1988-01-18
GB8701022D0 (en)	1987-02-18
US4845092A (en)	1989-07-04
ZA88266B (en)	1988-11-30
ES2085259T3 (es)	1996-06-01
EP0279512A2 (de)	1988-08-24
EP0279512B1 (de)	1996-03-27
DE3855144T2 (de)	1996-08-22
AU608276B2 (en)	1991-03-28
ATE135911T1 (de)	1996-04-15
JP2584266B2 (ja)	1997-02-26
DE3855144D1 (de)	1996-05-02
GR3019447T3 (en)	1996-06-30
KR880009020A (ko)	1988-09-13
US4942160A (en)	1990-07-17
JPS63215627A (ja)	1988-09-08

Legal Events

Date	Code	Title	Description
1997-09-15	AHB	Application shelved due to non-payment

Publication	Publication Date	Title
DK20388A (da)	1988-07-20	Anvendelse af 5-ht3-receptorantagonister til behandling af viscerale smerter
PE46899A1 (es)	1999-06-24	Derivados de n-fenil-sulfonamida
IL95440A0 (en)	1991-06-30	Substituted urea compounds,their preparation and pharmaceutical compositions containing them
DK359289D0 (da)	1989-07-19	4-oxoquinolin-3-carboxylsyrederivater og fremgangsmaade til fremstilling deraf samt deres anvendelse
AR240929A2 (es)	1991-03-27	"n-piridinsulfonil-n'-piridinil-y-triazinil-ureas procedimiento parasu preparacion, intermediarios para uso exclusivo en dicho procedimiento, y composiciones que contienen dichas ureas"
PE1591A1 (es)	1991-03-16	Procedimiento para la preparacion de agentes tiazoles antifungicos
DE3860960D1 (de)	1990-12-13	Arylcyclobutylalkylamin-derivat zur behandlung von morbus parkinson.
DE68914292D1 (de)	1994-05-11	Zusammensetzung zur Behandlung von ischämischen Störungen in Organen.
DE69129998D1 (de)	1998-09-24	Pyrimidindionderivate, deren Herstellung und Verwendung
FR2619111B1 (fr)	1991-01-11	Derives de (piperidinyl-4)methyl-2 tetrahydro-1,2,3,4 9h-pyrido (3,4-b) indole, leur preparation et leur application en therapeutique
ES2132284T3 (es)	1999-08-16	Derivados de carbamato de 2-(piperidin-4-il, piridin-4-il y tetrahidropiridin-4-il)-benzofurano-7, su preparacion y su uso como inhibidores de acetilcolinesterasa.
ZA89389B (en)	1989-10-25	Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia
DK322588A (da)	1989-02-01	Cycloalkylamider af 6-substituerede (8beta)-1-alkylergoliner og fremgangsmaade til fremstilling af saadanne forbindelser
EP0882721A4 (de)	1999-12-22	4-substituierte 2,7-dideoxy-7-fluoro-2,3-didehydro-sialsäuren
DK40890D0 (da)	1990-02-16	Substituerede urinstofforbindelser, deres fremstilling og anvendelse
MY106786A (en)	1995-07-31	Novel antiviral tetrahydroimidazo [1,4] benzodiazepin -2- (thi)ones
ATE229328T1 (de)	2002-12-15	Venlafaxin und seine analoga zum herbeiführen einer verbesserung der kognitiven funktionen
DE3569111D1 (en)	1989-05-03	Derivatives of n-(2-pyrrolidinylmethyl)-benzamide, process for their preparation, intermediates and a pharmaceutical preparation
MX9702028A (es)	1997-09-30	Antagonistas de bradiquinina heterociclicos, sustituidos con fluoroalquilo y fluoroalcoxi, procedimientos para su preparacion y su utilizacion.
JO1621B1 (en)	1991-11-27	Therapeutic agents