DK2044078T3 - Camptothecinderivater med antitumoraktivitet - Google Patents

Camptothecinderivater med antitumoraktivitet

Info

Publication number: DK2044078T3
Authority: DK; Denmark
Prior art keywords: antitumor activity; camptothecin derivatives; antitumor; derivatives; camptothecin
Prior art date: 2006-07-26

Application number

DK07786046.8T

Other languages

English (en)

Inventor

Carla Manzotti

Gabriele Fontana

Ezio Bombardelli

Arturo Battaglia

Cristian Samori

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-07-26

Filing date

2007-07-12

Publication date

2010-12-13

2007-07-12 Application filed by Indena Spa filed Critical Indena Spa

2010-12-13 Application granted granted Critical

2010-12-13 Publication of DK2044078T3 publication Critical patent/DK2044078T3/da

Links

230000000259 anti-tumor effect Effects 0.000 title abstract 2
VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title abstract 2
239000002246 antineoplastic agent Substances 0.000 abstract 1
229940041181 antineoplastic drug Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Medicinal Preparation (AREA)

DK07786046.8T 2006-07-26 2007-07-12 Camptothecinderivater med antitumoraktivitet DK2044078T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT001475A ITMI20061475A1 (it)	2006-07-26	2006-07-26	Derivati della camptotecina ad attivita antitumorale
PCT/EP2007/006218 WO2008011992A1 (en)	2006-07-26	2007-07-12	Camptothecin derivatives with antitumor activity

Publications (1)

Publication Number	Publication Date
DK2044078T3 true DK2044078T3 (da)	2010-12-13

Family

ID=38520867

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK07786046.8T DK2044078T3 (da)	2006-07-26	2007-07-12	Camptothecinderivater med antitumoraktivitet

Country Status (21)

Country	Link
US (1)	US8076351B2 (da)
EP (1)	EP2044078B1 (da)
JP (1)	JP5198447B2 (da)
KR (1)	KR101398591B1 (da)
CN (1)	CN101495484B (da)
AT (1)	ATE482216T1 (da)
AU (1)	AU2007278587B2 (da)
BR (1)	BRPI0714669B8 (da)
CA (1)	CA2659050C (da)
DE (1)	DE602007009396D1 (da)
DK (1)	DK2044078T3 (da)
ES (1)	ES2350711T3 (da)
IL (1)	IL196654A (da)
IT (1)	ITMI20061475A1 (da)
MX (1)	MX2009000903A (da)
NO (1)	NO341743B1 (da)
PL (1)	PL2044078T3 (da)
PT (1)	PT2044078E (da)
RU (1)	RU2441009C2 (da)
SI (1)	SI2044078T1 (da)
WO (1)	WO2008011992A1 (da)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2972955A (en) *	1957-03-21	1961-02-28	Richter Harald	Submersible pump
US5658920A (en) *	1991-01-16	1997-08-19	Daiichi Pharmaceutical Co., Ltd.	Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7] indolizino[1,2-B]quinoline-10,13(9H,15H)-dione compound
JP3008226B2 (ja) *	1991-01-16	2000-02-14	第一製薬株式会社	六環性化合物
US5834479A (en)	1993-03-05	1998-11-10	Mayer; David J.	Method and composition for alleviating pain
KR960029336A (ko) *	1995-01-09	1996-08-17	김충환	캄토테신 유도체, 그의 제조 방법 및 이를 함유하는 항암제
US5972955A (en) *	1995-06-06	1999-10-26	Dr. Reddy's Research Foundation	Water soluble C-ring analogues of 20(S)-camptothecin
US6177439B1 (en) *	1995-06-06	2001-01-23	Reddy's Research Foundation	Water soluble analogues of 20(S)-camptothecin
US6214836B1 (en) *	1995-06-06	2001-04-10	Dr. Reddy's Research Foundation	Water soluble analogues of 20(S)-camptothecin
PL188075B1 (pl) *	1996-06-05	2004-12-31	Reddy Cheminor	Rozpuszczalne w wodzie C-pierścieniowe analogi 20(S)-kamptotecyny, kompozycja farmaceutyczna zawierająca te związki, ich zastosowanie oraz sposób wytwarzania
WO2000066127A1 (en)	1999-05-04	2000-11-09	Bionumerik Pharmaceuticals, Inc.	Novel highly lipophilic camptothecin analogs

2006
- 2006-07-26 IT IT001475A patent/ITMI20061475A1/it unknown
2007
- 2007-07-12 JP JP2009521136A patent/JP5198447B2/ja not_active Expired - Fee Related
- 2007-07-12 EP EP07786046A patent/EP2044078B1/en active Active
- 2007-07-12 MX MX2009000903A patent/MX2009000903A/es active IP Right Grant
- 2007-07-12 PT PT07786046T patent/PT2044078E/pt unknown
- 2007-07-12 PL PL07786046T patent/PL2044078T3/pl unknown
- 2007-07-12 AT AT07786046T patent/ATE482216T1/de active
- 2007-07-12 ES ES07786046T patent/ES2350711T3/es active Active
- 2007-07-12 KR KR1020097001674A patent/KR101398591B1/ko not_active Expired - Fee Related
- 2007-07-12 BR BRPI0714669A patent/BRPI0714669B8/pt not_active IP Right Cessation
- 2007-07-12 SI SI200730441T patent/SI2044078T1/sl unknown
- 2007-07-12 WO PCT/EP2007/006218 patent/WO2008011992A1/en not_active Ceased
- 2007-07-12 DE DE602007009396T patent/DE602007009396D1/de active Active
- 2007-07-12 AU AU2007278587A patent/AU2007278587B2/en not_active Ceased
- 2007-07-12 US US12/374,799 patent/US8076351B2/en not_active Expired - Fee Related
- 2007-07-12 DK DK07786046.8T patent/DK2044078T3/da active
- 2007-07-12 CA CA2659050A patent/CA2659050C/en not_active Expired - Fee Related
- 2007-07-12 CN CN2007800282970A patent/CN101495484B/zh not_active Expired - Fee Related
- 2007-07-12 RU RU2009102229/04A patent/RU2441009C2/ru active
2009
- 2009-01-22 IL IL196654A patent/IL196654A/en active IP Right Grant
- 2009-01-23 NO NO20090350A patent/NO341743B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
US8076351B2 (en)	2011-12-13
SI2044078T1 (sl)	2011-01-31
BRPI0714669B1 (pt)	2020-11-17
ATE482216T1 (de)	2010-10-15
CA2659050C (en)	2014-09-23
IL196654A (en)	2015-03-31
PT2044078E (pt)	2010-11-18
BRPI0714669B8 (pt)	2021-05-25
KR101398591B1 (ko)	2014-05-27
US20100063082A1 (en)	2010-03-11
ES2350711T3 (es)	2011-01-26
NO341743B1 (no)	2018-01-15
ITMI20061475A1 (it)	2008-01-27
EP2044078B1 (en)	2010-09-22
IL196654A0 (en)	2009-11-18
JP5198447B2 (ja)	2013-05-15
KR20090040304A (ko)	2009-04-23
CA2659050A1 (en)	2008-01-31
WO2008011992A8 (en)	2009-02-19
HK1135693A1 (en)	2010-06-11
PL2044078T3 (pl)	2011-03-31
BRPI0714669A2 (pt)	2013-04-24
RU2009102229A (ru)	2010-07-27
WO2008011992A1 (en)	2008-01-31
DE602007009396D1 (en)	2010-11-04
MX2009000903A (es)	2009-02-04
AU2007278587B2 (en)	2012-11-01
EP2044078A1 (en)	2009-04-08
CN101495484B (zh)	2011-12-28
CN101495484A (zh)	2009-07-29
RU2441009C2 (ru)	2012-01-27
JP2010500970A (ja)	2010-01-14
AU2007278587A1 (en)	2008-01-31
NO20090350L (no)	2009-01-23

Publication	Publication Date	Title
NO20090251L (no)	2009-01-16	Camptotecinderivater med antitumoraktivitet
TNSN08326A1 (en)	2009-12-29	Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments
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BRPI0821115A2 (pt)	2015-06-16	Composto derivado de aminotriazol, medicamento, composição farmacêutica e uso do composto
IL193772A0 (en)	2009-08-03	4-oxoquinoline derivatives,methods for the preparation thereof and pharmaceutical compositions containing the same
MY149854A (en)	2013-10-31	Novel aminoalcohol-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments
WO2009071689A3 (de)	2009-07-23	5-halogen-substituierte oxindol-derivate und ihre verwendung zur behandlung von vasopressin-abhängigen erkrankungen
UA91848C2 (ru)	2010-09-10	Применение соединений диосметина в лечении и предотвращении тромботическим патологиям
SG148192A1 (en)	2008-12-31	Azabenzimidazole derivatives, their manufacture and use as anti-cancer agents
WO2006097617A3 (fr)	2006-12-28	Nouveaux derives dihydropyrimidines et leur utilisation comme agents anti-cancereux
SE0300457D0 (sv)	2003-02-19	Novel compounds
NO20090252L (no)	2009-01-16	Camptotecinderivater med antitumoraktivitet
CY1110787T1 (el)	2015-06-10	Νεα μορφινικα παραγωγα
GEP20115158B (en)	2011-02-10	Use of ivabradine for obtaining medicaments intended for the treatment of endothelial dysfunction
UY30235A1 (es)	2007-10-31	Inhibidores de la adenilato ciclasa soluble
DK2044078T3 (da)	2010-12-13	Camptothecinderivater med antitumoraktivitet
GB0615105D0 (en)	2006-09-06	Novel compounds
NO20085267L (no)	2009-02-23	Derivater av 2-alkoksy -3,4,5-trihydroksy-alkyl amider, fremstilling og anvendelse derav, samt sammensetninger inneholdende samme
UY30236A1 (es)	2007-10-31	Inhibidores de la adenilato ciclasa soluble
UY30237A1 (es)	2007-10-31	Inhibidores de la adenilato ciclasa soluble
GB0620619D0 (en)	2006-11-29	Novel compounds
MX2009009178A (es)	2009-09-04	Bis-fosforatos de bazedoxifeno.