DK20481A - Octapeptid med antiotensin-ii-antagoniserende virkninger fremgangsmaade til dets fremstilling samt dets anvendelse - Google Patents

Octapeptid med antiotensin-ii-antagoniserende virkninger fremgangsmaade til dets fremstilling samt dets anvendelse

Info

Publication number: DK20481A
Authority: DK; Denmark
Prior art keywords: radical; group; nitrogen atom; protective group; atom
Prior art date: 1980-01-18

Application number

DK20481A

Other languages

English (en)

Other versions

DK149777B (da

DK149777C (da

Inventor

O Nyeki

L Kisfaludy

E Karparti

L Szporny

Original Assignee

Richter Gedeon Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-01-18

Filing date

1981-01-16

Publication date

1981-07-19

1981-01-16 Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet

1981-07-19 Publication of DK20481A publication Critical patent/DK20481A/da

1986-09-29 Publication of DK149777B publication Critical patent/DK149777B/da

1987-04-21 Application granted granted Critical

1987-04-21 Publication of DK149777C publication Critical patent/DK149777C/da

Links

238000000034 method Methods 0.000 title abstract 2
230000003042 antagnostic effect Effects 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
229910052757 nitrogen Inorganic materials 0.000 abstract 12
125000004433 nitrogen atom Chemical group N* 0.000 abstract 11
125000006239 protecting group Chemical group 0.000 abstract 11
108090000765 processed proteins & peptides Proteins 0.000 abstract 9
239000002253 acid Substances 0.000 abstract 7
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 6
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 6
229940024606 amino acid Drugs 0.000 abstract 5
125000004432 carbon atom Chemical group C* 0.000 abstract 5
150000003839 salts Chemical class 0.000 abstract 5
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 4
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 4
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 4
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 4
150000001413 amino acids Chemical class 0.000 abstract 4
229910052799 carbon Inorganic materials 0.000 abstract 4
238000009833 condensation Methods 0.000 abstract 4
230000005494 condensation Effects 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000004430 oxygen atom Chemical group O* 0.000 abstract 4
125000001931 aliphatic group Chemical group 0.000 abstract 3
235000001014 amino acid Nutrition 0.000 abstract 3
125000002344 aminooxy group Chemical group [H]N([H])O[*] 0.000 abstract 3
150000002148 esters Chemical class 0.000 abstract 3
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 2
229930064664 L-arginine Natural products 0.000 abstract 2
235000014852 L-arginine Nutrition 0.000 abstract 2
229930182844 L-isoleucine Natural products 0.000 abstract 2
229930182821 L-proline Natural products 0.000 abstract 2
102000007079 Peptide Fragments Human genes 0.000 abstract 2
108010033276 Peptide Fragments Proteins 0.000 abstract 2
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Chemical compound CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 2
150000007933 aliphatic carboxylic acids Chemical class 0.000 abstract 2
229960002885 histidine Drugs 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
229960000310 isoleucine Drugs 0.000 abstract 2
102000004196 processed proteins & peptides Human genes 0.000 abstract 2
229960002429 proline Drugs 0.000 abstract 2
229960004441 tyrosine Drugs 0.000 abstract 2
229960004295 valine Drugs 0.000 abstract 2
125000005907 alkyl ester group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000004185 ester group Chemical group 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
230000009993 protective function Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/14—Angiotensins: Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Vascular Medicine (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK20481A 1980-01-18 1981-01-16 Analogifremgangsmaade til fremstilling af et octapeptid med angiotensin-ii-antagoniserende virkninger DK149777C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU8080100A HU181008B (en)	1980-01-18	1980-01-18	Process for producing angiotenzin-ii analogues of antagonistic activity containing sarcosyl-group at the 1-positon,and an alpha-hydroxy-carboxylic acid at the 8-position
HU10080		1980-01-18

Publications (3)

Publication Number	Publication Date
DK20481A true DK20481A (da)	1981-07-19
DK149777B DK149777B (da)	1986-09-29
DK149777C DK149777C (da)	1987-04-21

Family

ID=10947908

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK20481A DK149777C (da)	1980-01-18	1981-01-16	Analogifremgangsmaade til fremstilling af et octapeptid med angiotensin-ii-antagoniserende virkninger

Country Status (19)

Country	Link
US (1)	US4330532A (da)
EP (1)	EP0034260B1 (da)
JP (1)	JPS56142251A (da)
AT (1)	ATE4197T1 (da)
AU (1)	AU541000B2 (da)
CA (1)	CA1149377A (da)
CS (1)	CS219939B2 (da)
DE (1)	DE3160608D1 (da)
DK (1)	DK149777C (da)
ES (1)	ES498583A0 (da)
FI (1)	FI73225C (da)
HU (1)	HU181008B (da)
IL (1)	IL61922A (da)
IN (1)	IN153279B (da)
NO (1)	NO151409C (da)
PH (1)	PH17196A (da)
PL (1)	PL130448B1 (da)
SU (1)	SU993816A3 (da)
YU (1)	YU42550B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5182264A (en) *	1986-03-07	1993-01-26	Schering Corporation	Angiotensin II receptor blockers as antiglaucoma agents
DE19529604A1 (de) *	1995-08-11	1997-02-13	Bayer Ag	Endoparasitizide Mittel auf Basis von Didepsipeptiden, neue Didepsipeptide und ein Verfahren zu ihrer Herstellung
US9572856B2 (en)	2009-12-16	2017-02-21	The George Washington University a Congressionally Chartered Not-for-Profit Corporation	Method of treating low blood pressure
CN105592855A (zh)	2013-04-26	2016-05-18	拉卓拉药物公司	用于治疗肾衰竭的组合物和方法
LT2986308T (lt)	2013-12-18	2020-03-25	The George Washington University, A Congressionally Chartered Not-For-Profit Corporation	Angiotenzino ii derinys hipotenzijai gydyti
AU2017205168A1 (en)	2016-01-07	2018-08-16	La Jolla Pharma, Llc	Methods for administering angiotensin II
WO2018191678A1 (en)	2017-04-14	2018-10-18	La Jolla Pharmaceutical Company	Methods for administering angiotensin ii

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3947575A (en) *	1969-06-30	1976-03-30	E. R. Squibb & Sons, Inc.	Peptides as argiotensin converting enzyme inhibitors
DE2323322A1 (de) *	1973-05-09	1974-11-28	Hoechst Ag	Neue peptide mit blutdrucksenkender wirkung und verfahren zu ihrer herstellung
US3923770A (en) *	1974-05-10	1975-12-02	Francis Merlin Bumpus	{8 Me{hd 2{b Gly{hu 1{b , Ile{hu 8{b {9 -Anziotensin II as an angiotensin antagonist
US3923769A (en) *	1974-05-10	1975-12-02	Francis Merlin Bumpus	{8 N-Me-Ile{40 ,Ile{hu 8{b {9 -Angiotensin II as an angiotensin antagonist
US3915948A (en) *	1974-08-05	1975-10-28	Morton Norwich Products Inc	Sarcosyl-L-arginyl-L-valyl-L-tyrosyl-L-valyl-L-histidyl-L-proline
DE2457463A1 (de) *	1974-12-05	1976-06-10	Hoechst Ag	Neue peptide mit blutdrucksenkender wirkung und verfahren zu ihrer herstellung
US3975365A (en) *	1975-01-27	1976-08-17	G. D. Searle & Co.	Inhibitory octapeptides angiotensin II
US3976770A (en) *	1975-02-10	1976-08-24	Francis Merlin Bumpus	Sar'-(OMe)Thr8 Angiotensin II as an angiotensin II antagonist
HU177133B (en) *	1977-07-18	1981-07-28	Richter Gedeon Vegyeszet	Process for preparing angiotensin ii analogues containing alpha- amino-oxy-acid in position 1 with angiotensin ii antagonist activity
HU177134B (en) *	1977-07-18	1981-07-28	Richter Gedeon Vegyeszet	Process for preparing angiotensin ii analogues containing alpha-hydroxy-acid in position 1 with angiotensin ii antagonist activity

1980
- 1980-01-18 HU HU8080100A patent/HU181008B/hu not_active IP Right Cessation
1981
- 1981-01-06 US US06/222,765 patent/US4330532A/en not_active Expired - Fee Related
- 1981-01-13 PH PH25083A patent/PH17196A/en unknown
- 1981-01-15 PL PL1981229223A patent/PL130448B1/pl unknown
- 1981-01-16 CA CA000368683A patent/CA1149377A/en not_active Expired
- 1981-01-16 SU SU813233003A patent/SU993816A3/ru active
- 1981-01-16 DK DK20481A patent/DK149777C/da active
- 1981-01-16 YU YU93/81A patent/YU42550B/xx unknown
- 1981-01-16 CS CS81323A patent/CS219939B2/cs unknown
- 1981-01-16 NO NO810149A patent/NO151409C/no unknown
- 1981-01-16 AU AU66276/81A patent/AU541000B2/en not_active Ceased
- 1981-01-16 FI FI810123A patent/FI73225C/fi not_active IP Right Cessation
- 1981-01-16 IL IL61922A patent/IL61922A/xx unknown
- 1981-01-16 ES ES498583A patent/ES498583A0/es active Granted
- 1981-01-17 JP JP463381A patent/JPS56142251A/ja active Pending
- 1981-01-17 IN IN53/CAL/81A patent/IN153279B/en unknown
- 1981-01-19 AT AT81100357T patent/ATE4197T1/de active
- 1981-01-19 EP EP81100357A patent/EP0034260B1/de not_active Expired
- 1981-01-19 DE DE8181100357T patent/DE3160608D1/de not_active Expired

Also Published As

Publication number	Publication date
US4330532A (en)	1982-05-18
ES8201129A1 (es)	1981-12-01
CS219939B2 (en)	1983-03-25
PL229223A1 (da)	1982-03-01
ATE4197T1 (de)	1983-08-15
FI73225B (fi)	1987-05-29
NO151409B (no)	1984-12-27
HU181008B (en)	1983-05-30
EP0034260B1 (de)	1983-07-20
IN153279B (da)	1984-06-23
NO810149L (no)	1981-07-20
PL130448B1 (en)	1984-08-31
AU6627681A (en)	1981-07-23
DK149777B (da)	1986-09-29
IL61922A0 (en)	1981-02-27
CA1149377A (en)	1983-07-05
DK149777C (da)	1987-04-21
JPS56142251A (en)	1981-11-06
YU42550B (en)	1988-10-31
NO151409C (no)	1985-04-10
AU541000B2 (en)	1984-12-13
FI810123L (fi)	1981-07-19
EP0034260A1 (de)	1981-08-26
SU993816A3 (ru)	1983-01-30
YU9381A (en)	1983-09-30
IL61922A (en)	1984-01-31
DE3160608D1 (en)	1983-08-25
PH17196A (en)	1984-06-19
ES498583A0 (es)	1981-12-01
FI73225C (fi)	1987-09-10

Publication	Publication Date	Title
DK163120C (da)	1992-06-15	Analogifremgangsmaade til fremstilling af substituerede acylderivater af 1,2,3,4-tetrahydroisoquinolin-3-carboxylsyre (s,s,s) eller et farmaceutisk acceptabelt salt deraf
ATE552340T1 (de)	2012-04-15	Hepatitis c virus genotypsequenzen sowie ihre verwendung als behandlungs- und nachweismitteln
DK0397420T3 (da)	1995-08-21	Enzymatisk fjernelse af en aminoterminal proteinsekvens
AU541000B2 (en)	1984-12-13	Octapeptide of angiotensin-02 antagonizing effects
PT76333A (en)	1983-04-01	Process for preparing dipeptide sweetener-metal complexes
EP0192988A3 (en)	1989-03-15	Process for solubilization, purification and characterization of protein from insoluble protein aggregates or complexes and compositions of matter therefrom
ATE116348T1 (de)	1995-01-15	Verfahren zur zubereitung beständiger bitumen- polymermischungen.
EP0384341A3 (en)	1991-11-27	New proline derivatives
KR870002145A (ko)	1987-03-30	아미노산 유도체의 제조방법
HU896606D0 (en)	1990-02-28	Process for the preparation of aminoacid derivatives inhibiting enzymes and pharmaceutical compositions thereof
DK117883D0 (da)	1983-03-11	Fremgangsmade til fremstilling af insuliner ud fra praeproinsulinanaloge
KR910000791A (ko)	1991-01-30	뉴로키닌 a 길항제
IE820292L (en)	1982-08-10	Process for removing an n-formyl group from dipeptides
DE59813491D1 (de)	2006-05-24	Verfahren zur Herstellung eines eine Hyaluronidase enthaltenden Präparats
ZA806328B (en)	1981-10-28	Method of using motility increasing peptides
JPS57108053A (en)	1982-07-05	Tripeptide and its derivative
SE8202414L (sv)	1982-10-24	Metod for framstellning av oligopeptider bestaende av lysinyl-och tryptofanylrester
DK584489D0 (da)	1989-11-21	Fremgangsmaade til fremstilling af tripeptider
KR830007080A (ko)	1983-10-14	무식욕유발성 펩티드류의 제조방법
JPS5461170A (en)	1979-05-17	Preparation of coerulein and its analogs
JPS57212194A (en)	1982-12-27	Hepatic basic protein and its preparation
ES447686A1 (es)	1977-06-16	Procedimiento para la preparacion de tripeptidos derivados de la l-prolina.
JPS5762245A (en)	1982-04-15	Novel preparation of cargtosin
ES8104193A1 (es)	1981-04-01	Procedimiento para la obtencion de aminoacidos a partir de hidrolizados de proteinas
DK37882A (da)	1983-07-29	Fremgangsmaade til fremstilling af ((1-benzyl-1h-indazol-3-yl)oxy)-eddikesyresalt med lysin