DK2057165T3 - Acryliske amininhibotorer af nukleosidphosphorylaser og hydrolaser - Google Patents

Acryliske amininhibotorer af nukleosidphosphorylaser og hydrolaser

Info

Publication number: DK2057165T3
Authority: DK; Denmark
Prior art keywords: hydrolases; compounds; nucleoside phosphorylases; acrylic amine; amine inhibitors
Prior art date: 2006-09-07

Application number

DK07834863.8T

Other languages

English (en)

Inventor

Shivali Ashwin Gulab

Keith Clinch

Gary Brian Evans

Richard Hubert Furneaux

Peter Michael Kelly

Vern L Schramm

Peter Charles Tyler

Anthony David Woolhouse

Original Assignee

Ind Res Ltd

Einstein Coll Med

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-09-07

Filing date

2007-09-07

Publication date

2011-06-27

2007-09-07 Application filed by Ind Res Ltd, Einstein Coll Med filed Critical Ind Res Ltd

2011-06-27 Application granted granted Critical

2011-06-27 Publication of DK2057165T3 publication Critical patent/DK2057165T3/da

Links

108010063372 N-Glycosyl Hydrolases Proteins 0.000 title abstract 3
239000003112 inhibitor Substances 0.000 title abstract 2
-1 Acrylic amine Chemical class 0.000 title 1
102000004157 Hydrolases Human genes 0.000 title 1
102100036286 Purine nucleoside phosphorylase Human genes 0.000 title 1
108010009099 nucleoside phosphorylase Proteins 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
102000010722 N-Glycosyl Hydrolases Human genes 0.000 abstract 2
102000030764 Purine-nucleoside phosphorylase Human genes 0.000 abstract 2
108700006317 Purine-nucleoside phosphorylases Proteins 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
208000035143 Bacterial infection Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
206010037075 Protozoal infections Diseases 0.000 abstract 1
210000001744 T-lymphocyte Anatomy 0.000 abstract 1
208000022362 bacterial infectious disease Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Tropical Medicine & Parasitology (AREA)
Dermatology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Transplantation (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)

DK07834863.8T 2006-09-07 2007-09-07 Acryliske amininhibotorer af nukleosidphosphorylaser og hydrolaser DK2057165T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US84286706P	2006-09-07	2006-09-07
PCT/NZ2007/000261 WO2008030119A1 (en)	2006-09-07	2007-09-07	Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases

Publications (1)

Publication Number	Publication Date
DK2057165T3 true DK2057165T3 (da)	2011-06-27

Family

ID=39157466

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK07834863.8T DK2057165T3 (da)	2006-09-07	2007-09-07	Acryliske amininhibotorer af nukleosidphosphorylaser og hydrolaser

Country Status (19)

Country	Link
US (1)	US8853224B2 (da)
EP (2)	EP2057165B1 (da)
JP (1)	JP5388067B2 (da)
KR (1)	KR101433621B1 (da)
CN (1)	CN101528749B (da)
AT (1)	ATE502038T1 (da)
AU (1)	AU2007293774C1 (da)
CA (1)	CA2662628C (da)
CY (1)	CY1111507T1 (da)
DE (1)	DE602007013252D1 (da)
DK (1)	DK2057165T3 (da)
ES (1)	ES2362805T3 (da)
HR (1)	HRP20110408T1 (da)
NZ (1)	NZ575365A (da)
PL (1)	PL2057165T3 (da)
PT (1)	PT2057165E (da)
RS (1)	RS51864B (da)
SI (1)	SI2057165T1 (da)
WO (1)	WO2008030119A1 (da)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1539783B1 (en)	2002-08-21	2011-04-13	Albert Einstein College Of Medicine Of Yeshiva University	Inhibitors of nucleoside phosphorylases and nucleosidases
NZ533360A (en)	2004-06-04	2007-02-23	Ind Res Ltd	Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
US8541567B2 (en)	2005-07-27	2013-09-24	Albert Einstein College Of Medicine Of Yeshiva University	Transition state structure of 5′-methylthioadenosine/s-adenosylhomocysteine nucleosidases
US8394950B2 (en)	2006-02-22	2013-03-12	Industrial Research Limited	Analogues of coformycin and their use for treating protozoan parasite infections
JP2009527550A (ja)	2006-02-24	2009-07-30	アルバートアインシュタインカレッジオブメディシンオブイエシバユニバーシティ	癌を処置する方法
CA2662626C (en)	2006-09-07	2016-07-26	Industrial Research Limited	Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
WO2008079028A1 (en)	2006-12-22	2008-07-03	Industrial Research Limited	Azetidine analogues of nucleosidase and phosphorylase inhibitors
US20090247750A1 (en) *	2008-03-28	2009-10-01	Biocryst Pharmaceuticals, Inc.	Process for preparing nucleoside analogs
US20110190265A1 (en) *	2008-09-22	2011-08-04	Schramm Vern L	Methods and compositions for treating bacterial infections by inhibiting quorum sensing
EP2454263B1 (en)	2009-07-17	2018-06-13	Albert Einstein College of Medicine, Inc.	3-hydroxypyrrolidine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
AR077898A1 (es)	2009-08-26	2011-09-28	Nycomed Gmbh	Metilpirrolopirimidincarboxamidas
WO2011047320A2 (en)	2009-10-16	2011-04-21	Rib-X Pharmaceuticals, Inc.	Antimicrobial compounds and methods of making and using the same
US9216979B2 (en)	2009-10-16	2015-12-22	Melinta Therapeutics, Inc.	Antimicrobial compounds and methods of making and using the same
KR101972992B1 (ko)	2009-10-16	2019-04-29	멜린타 서브시디어리 코프.	항미생물성 화합물 및 이의 제조 방법 및 사용 방법
DK2898885T3 (da)	2010-10-15	2018-02-05	Biocryst Pharm Inc	Pyrrolopyrimidinderivater til anvendelse i behandling af virusinfektioner
US9290501B2 (en)	2010-11-29	2016-03-22	Albert Einstein College Of Medicine, Inc.	Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase
ES2675856T3 (es) *	2010-11-30	2018-07-13	Connora Technologies, Inc.	Agentes nuevos para resinas epóxicas retrabajables
KR20140065378A (ko)	2011-04-15	2014-05-29	멜린타 테라퓨틱스, 인크.	항미생물 화합물 및 그의 제조 방법과 사용 방법
WO2012150866A1 (en) *	2011-05-03	2012-11-08	Industrial Research Limited	Phosphoribosyltransferase inhibitors and uses thereof
DK2741765T3 (da)	2011-08-10	2016-06-13	Adocia	Injicerbar opløsning af i det mindste én type basal-insulin
US9198971B2 (en)	2012-01-09	2015-12-01	Adocia	Injectable solution at pH 7 comprising at least one basal insulin the pI of which is between 5.8 and 8.5 and a substituted co-polyamino acid
JP6063571B2 (ja)	2012-08-07	2017-01-18	アルバートアインシュタインカレッジオブメディシン，インコーポレイティド	ヘリコバクター・ピロリ感染の治療
US20150314003A2 (en)	2012-08-09	2015-11-05	Adocia	Injectable solution at ph 7 comprising at least one basal insulin the isoelectric point of which is between 5.8 and 8.5 and a hydrophobized anionic polymer
FR3001895B1 (fr)	2013-02-12	2015-07-03	Adocia	Solution injectable a ph7 comprenant au moins une insuline basale dont le point isoelectrique est compris en 5,8 et 8,5 et un compose anionique porteur de charges carboxylates et de radicaux hydrophobes
US9452217B2 (en)	2013-06-22	2016-09-27	Nitor Therapeutics	Methods for potentiating immune response for the treatment of infectious diseases and cancer
NO2865735T3 (da)	2013-07-12	2018-07-21
ES2859102T3 (es)	2013-07-12	2021-10-01	Gilead Sciences Inc	Compuestos de carbamoilpiridona policíclica y su uso para el tratamiento de infecciones por VIH
KR20160070066A (ko)	2013-09-09	2016-06-17	멜린타 테라퓨틱스, 인크.	항균 화합물, 및 이의 제조 방법 및 이용 방법
EP3038623A4 (en)	2013-09-09	2017-04-19	Melinta Therapeutics, Inc.	Antimicrobial compounds and methods of making and using the same
HK1232071A1 (zh)	2014-02-12	2018-01-05	Albert Einstein College Of Medicine, Inc.	使用mtan抑制剂治疗h.pylori感染
CA2979342A1 (en)	2015-03-11	2016-09-15	Melinta Therapeutics, Inc.	Antimicrobial compounds and methods of making and using the same
JP7046015B2 (ja)	2016-03-06	2022-04-01	バイオクライストファーマシューティカルズ，インコーポレイテッド	ジカウイルス感染の治療のための方法及び組成物
MX2018010466A (es)	2016-03-15	2019-01-14	Shionogi & Co	Metodo de produccion para derivados de fenoxietanol.
WO2017193016A1 (en)	2016-05-06	2017-11-09	Melinta Therapeutics, Inc.	Antimicrobials and methods of making and using same
CN113045484B (zh) *	2019-12-27	2024-01-26	南京药石科技股份有限公司	一种2-氨基-2-(1-甲基-4-哌啶基)丙烷-1-醇的制备方法
CN111320634A (zh) *	2020-04-14	2020-06-23	浙江工业大学	一种乙酰氧取代的吡咯并[2,3-d]嘧啶衍生物的制备方法
GB202218782D0 (en)	2022-12-13	2023-01-25	Mehrling Thomas	Purine nucleoside phosphorylase inhibitor for metabolic syndrome

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0920777A (ja)	1995-06-30	1997-01-21	Nippon Paper Ind Co Ltd	新規なプリンヌクレオシド誘導体、その製造方法及びその誘導体を有効成分とする酵素阻害剤
AU1739097A (en)	1996-02-23	1997-09-10	Albert Einstein College Of Medicine Of Yeshiva University	Enzyme detection/assay method and substrates
US5985848A (en)	1997-10-14	1999-11-16	Albert Einstein College Of Medicine Of Yeshiva University	Inhibitors of nucleoside metabolism
US6228741B1 (en)	1998-01-13	2001-05-08	Texas Instruments Incorporated	Method for trench isolation of semiconductor devices
SI1165564T1 (sl)	1999-04-08	2009-08-31	Ind Res Ltd	Postopek priprave inhibitorjev metabolizma nukleozidov
US6448799B1 (en) *	1999-09-30	2002-09-10	Hitachi Electronics Engineering Co., Ltd.	Timing adjustment method and apparatus for semiconductor IC tester
US7109331B2 (en)	2000-08-29	2006-09-19	Industrial Research Limited	5H-pyrrolo[3,2-d]pyrimidine nucleoside metabolism inhibitors
US6458799B1 (en)	2000-08-31	2002-10-01	Biocryst Pharmaceuticals, Inc.	Deazaguanine analog, preparation thereof and use thereof
JP2002296365A (ja) *	2001-03-29	2002-10-09	Seiko Epson Corp	電子機器、電子制御式機械時計、電子機器の制御方法
TW200306191A (en)	2002-02-22	2003-11-16	Teijin Ltd	Pyrrolopyrimidine derivatives
US7098334B2 (en)	2002-03-25	2006-08-29	Industrial Research Limited	4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
EP1539783B1 (en)	2002-08-21	2011-04-13	Albert Einstein College Of Medicine Of Yeshiva University	Inhibitors of nucleoside phosphorylases and nucleosidases
GB0301736D0 (en)	2003-01-24	2003-02-26	Xenova Ltd	Pharmaceutical compounds
NZ523970A (en)	2003-02-04	2005-02-25	Ind Res Ltd	Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
NZ533360A (en)	2004-06-04	2007-02-23	Ind Res Ltd	Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
WO2006014913A2 (en)	2004-07-27	2006-02-09	Biocryst Pharmaceuticals, Inc.	Inhibitors of 5'-methylthioadenosine phosphorylase and 5'methylthioadenosine/s-adenosylhomocysteine nucleosidase
NZ540160A (en)	2005-05-20	2008-03-28	Einstein Coll Med	Inhibitors of nucleoside phosphorylases
US8541567B2 (en)	2005-07-27	2013-09-24	Albert Einstein College Of Medicine Of Yeshiva University	Transition state structure of 5′-methylthioadenosine/s-adenosylhomocysteine nucleosidases
NZ544187A (en)	2005-12-15	2008-07-31	Ind Res Ltd	Deazapurine analogs of 1'-aza-l-nucleosides
CA2633484A1 (en)	2005-12-23	2007-06-28	Novartis Ag	Condensed heterocyclic compounds useful as dpp-iv inhibitors
JP2009528996A (ja)	2006-02-24	2009-08-13	インダストリアルリサーチリミテッド	ヌクレオシドホスホリラーゼ及びヌクレオシダーゼの阻害剤を用いて疾患を処置する方法
JP2009527550A (ja)	2006-02-24	2009-07-30	アルバートアインシュタインカレッジオブメディシンオブイエシバユニバーシティ	癌を処置する方法
CA2662626C (en)	2006-09-07	2016-07-26	Industrial Research Limited	Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
EP2066671A1 (en)	2006-09-26	2009-06-10	Albert Einstein College Of Medicine Of Yeshiva University	Transition state structure of human 5'-methylthioadenosine phosphorylase
WO2008079028A1 (en)	2006-12-22	2008-07-03	Industrial Research Limited	Azetidine analogues of nucleosidase and phosphorylase inhibitors
WO2009082247A1 (en)	2007-12-21	2009-07-02	Industrial Research Limited	Process for preparing immucillins having a methylene link
US20110190265A1 (en)	2008-09-22	2011-08-04	Schramm Vern L	Methods and compositions for treating bacterial infections by inhibiting quorum sensing
EP2454263B1 (en)	2009-07-17	2018-06-13	Albert Einstein College of Medicine, Inc.	3-hydroxypyrrolidine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase

2007
- 2007-09-07 NZ NZ575365A patent/NZ575365A/en unknown
- 2007-09-07 CA CA2662628A patent/CA2662628C/en active Active
- 2007-09-07 WO PCT/NZ2007/000261 patent/WO2008030119A1/en not_active Ceased
- 2007-09-07 DE DE602007013252T patent/DE602007013252D1/de active Active
- 2007-09-07 EP EP07834863A patent/EP2057165B1/en active Active
- 2007-09-07 AT AT07834863T patent/ATE502038T1/de active
- 2007-09-07 PL PL07834863T patent/PL2057165T3/pl unknown
- 2007-09-07 SI SI200730602T patent/SI2057165T1/sl unknown
- 2007-09-07 KR KR1020097006628A patent/KR101433621B1/ko active Active
- 2007-09-07 US US12/310,708 patent/US8853224B2/en active Active
- 2007-09-07 EP EP11158228A patent/EP2395005A1/en not_active Withdrawn
- 2007-09-07 DK DK07834863.8T patent/DK2057165T3/da active
- 2007-09-07 PT PT07834863T patent/PT2057165E/pt unknown
- 2007-09-07 HR HR20110408T patent/HRP20110408T1/hr unknown
- 2007-09-07 JP JP2009527314A patent/JP5388067B2/ja active Active
- 2007-09-07 AU AU2007293774A patent/AU2007293774C1/en active Active
- 2007-09-07 CN CN2007800402949A patent/CN101528749B/zh active Active
- 2007-09-07 RS RS20110192A patent/RS51864B/sr unknown
- 2007-09-07 ES ES07834863T patent/ES2362805T3/es active Active
2011
- 2011-05-31 CY CY20111100525T patent/CY1111507T1/el unknown

Also Published As

Publication number	Publication date
DE602007013252D1 (de)	2011-04-28
NZ575365A (en)	2012-02-24
PT2057165E (pt)	2011-05-12
JP5388067B2 (ja)	2014-01-15
ATE502038T1 (de)	2011-04-15
HRP20110408T1 (hr)	2011-06-30
KR101433621B1 (ko)	2014-08-27
CA2662628C (en)	2016-02-09
EP2057165A4 (en)	2009-09-02
CN101528749A (zh)	2009-09-09
CA2662628A1 (en)	2008-03-13
AU2007293774B2 (en)	2013-07-04
HK1131612A1 (en)	2010-01-29
KR20090069281A (ko)	2009-06-30
EP2395005A1 (en)	2011-12-14
EP2057165B1 (en)	2011-03-16
WO2008030119A1 (en)	2008-03-13
RS51864B (sr)	2012-02-29
EP2057165A1 (en)	2009-05-13
JP2010502696A (ja)	2010-01-28
CY1111507T1 (el)	2015-08-05
ES2362805T3 (es)	2011-07-13
CN101528749B (zh)	2013-07-31
SI2057165T1 (sl)	2011-07-29
PL2057165T3 (pl)	2011-08-31
WO2008030119A9 (en)	2009-09-24
US8853224B2 (en)	2014-10-07
AU2007293774C1 (en)	2014-12-18
US20110130412A1 (en)	2011-06-02
AU2007293774A1 (en)	2008-03-13

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