DK2060628T3 - Eukaryotiske signalsekvenser til polypeptidekspression og polypeptid-display-biblioteker - Google Patents

Eukaryotiske signalsekvenser til polypeptidekspression og polypeptid-display-biblioteker

Info

Publication number
DK2060628T3
DK2060628T3 DK08163005.5T DK08163005T DK2060628T3 DK 2060628 T3 DK2060628 T3 DK 2060628T3 DK 08163005 T DK08163005 T DK 08163005T DK 2060628 T3 DK2060628 T3 DK 2060628T3
Authority
DK
Denmark
Prior art keywords
polypeptide
signal sequences
display libraries
eukaryotic signal
expression
Prior art date
Application number
DK08163005.5T
Other languages
English (en)
Inventor
Jeff Gray
Joe Buechler
Uday Kumar Veeramallu
Original Assignee
Xoma Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xoma Technology Ltd filed Critical Xoma Technology Ltd
Application granted granted Critical
Publication of DK2060628T3 publication Critical patent/DK2060628T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK08163005.5T 2002-02-13 2003-02-13 Eukaryotiske signalsekvenser til polypeptidekspression og polypeptid-display-biblioteker DK2060628T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/076,802 US7094579B2 (en) 2002-02-13 2002-02-13 Eukaryotic signal sequences for prokaryotic expression
EP03739833A EP1481059B1 (en) 2002-02-13 2003-02-13 Eukaryotic signal sequences for polypeptide expression and polypeptide display libraries

Publications (1)

Publication Number Publication Date
DK2060628T3 true DK2060628T3 (da) 2012-01-23

Family

ID=27732544

Family Applications (2)

Application Number Title Priority Date Filing Date
DK08163005.5T DK2060628T3 (da) 2002-02-13 2003-02-13 Eukaryotiske signalsekvenser til polypeptidekspression og polypeptid-display-biblioteker
DK03739833T DK1481059T3 (da) 2002-02-13 2003-02-13 Eukaryote signalsekvenser for polypeptidekspression og polypeptiddisplaybiblioteker

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK03739833T DK1481059T3 (da) 2002-02-13 2003-02-13 Eukaryote signalsekvenser for polypeptidekspression og polypeptiddisplaybiblioteker

Country Status (9)

Country Link
US (5) US7094579B2 (da)
EP (2) EP2060628B1 (da)
JP (2) JP4303596B2 (da)
AT (2) ATE533845T1 (da)
AU (1) AU2003225578B2 (da)
CA (1) CA2475929C (da)
DE (1) DE60323210D1 (da)
DK (2) DK2060628T3 (da)
WO (1) WO2003068956A1 (da)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7097840B2 (en) 2000-03-16 2006-08-29 Genentech, Inc. Methods of treatment using anti-ErbB antibody-maytansinoid conjugates
US7094579B2 (en) * 2002-02-13 2006-08-22 Xoma Technology Ltd. Eukaryotic signal sequences for prokaryotic expression
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
US8293503B2 (en) 2003-10-03 2012-10-23 Promega Corporation Vectors for directional cloning
ATE442445T1 (de) * 2003-10-03 2009-09-15 Promega Corp Rhamnose-induzierbares expressionssystem
PL1737962T3 (pl) * 2004-03-24 2011-02-28 Domantis Ltd Uniwersalny lider GAS1
EP1824961B1 (en) 2004-12-07 2016-11-02 Lonza Ltd Melibiose operon expression system
ATE466090T1 (de) 2004-12-07 2010-05-15 Lonza Ag Rhamnosepromotor-expressionssystem
US8586330B2 (en) * 2006-07-14 2013-11-19 Novozymes A/S Methods for producing secreted polypeptides having biological activity
GB0810154D0 (en) 2008-06-04 2008-07-09 Avecia Biolog Ltd Expression vector
JP2012504424A (ja) 2008-10-03 2012-02-23 ゾーマ テクノロジー リミテッド トリプルタグ配列およびその使用方法
JP5745432B2 (ja) * 2009-02-25 2015-07-08 ネクステラ アーエス シグナル配列非依存性ｐＩＸファージディスプレイ
WO2010117420A2 (en) 2009-03-30 2010-10-14 Pacific Biosciences Of California, Inc. Fret-labeled compounds and uses therefor
JP2014504503A (ja) 2010-12-28 2014-02-24 ゾーマ テクノロジー リミテッド Ｐｄｚドメインを用いた細胞表面提示
JP6161541B2 (ja) 2011-02-03 2017-07-12 ゾーマ テクノロジー リミテッド 細菌中の機能的タンパク質発現を向上させるための方法および物質
JP6362543B2 (ja) 2012-02-23 2018-07-25 ジュノ セラピューティクス ゲーエムベーハー 細胞および他の複雑な生物学的材料のクロマトグラフィーによる単離
PL2870247T3 (pl) * 2012-07-05 2019-10-31 Hoffmann La Roche Układ ekspresji i wydzielania
EP2877589B1 (en) 2012-07-26 2024-03-06 Momenta Pharmaceuticals, Inc. Glycoproteins with anti-inflammatory properties
HK1258932A1 (zh) 2015-10-22 2019-11-22 Juno Therapeutics Gmbh 用於转导的方法、反应剂盒、反应剂和设备
CN108474791B (zh) 2015-10-22 2022-07-08 朱诺治疗学有限公司 培养细胞的方法及用于该方法的试剂盒和设备
HK1258313A1 (zh) * 2015-10-23 2019-11-08 Fred Hutchinson Cancer Center 建立化学诱导的二聚化蛋白体系以调节细胞事件的方法
CN105734061B (zh) * 2016-03-25 2019-07-23 中国农业科学院生物技术研究所 从毕赤酵母中分离的鼠李糖诱导型启动子及其应用
MA49288A (fr) 2017-04-27 2020-03-04 Juno Therapeutics Gmbh Reactifs particulaires oligomères et leurs méthodes d'utilisation
EP3444269A1 (en) 2017-08-17 2019-02-20 National Research Council of Canada Systems and methods for the production of diphtheria toxin polypeptides
CA3084315A1 (en) 2017-12-11 2019-06-20 Abalone Bio, Inc. Yeast display of proteins in the periplasmic space
EP3874024A1 (en) 2018-10-31 2021-09-08 Juno Therapeutics GmbH Methods for selection and stimulation of cells and apparatus for same
US11471497B1 (en) 2019-03-13 2022-10-18 David Gordon Bermudes Copper chelation therapeutics
IT201900006656A1 (it) 2019-05-08 2020-11-08 Salvagnini Italia Spa Macchina piegatrice per lamiere metalliche
AU2021226352A1 (en) * 2020-02-25 2022-09-29 Momenta Pharmaceuticals, Inc. Enzymes for sialylation of glycans
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
US12537071B1 (en) 2020-07-22 2026-01-27 David Gordon Bermudes Bacteria having boolean control pathways expressing therapeutic proteins including immunotherapeutic cytotoxins
CN116284288A (zh) * 2023-02-01 2023-06-23 深圳大学 莱茵衣藻分泌导肽和转基因莱茵衣藻及其构建方法与应用

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
DE3852304T3 (de) 1987-03-02 1999-07-01 Enzon Labs Inc., Piscataway, N.J. Organismus als Träger für "Single Chain Antibody Domain (SCAD)".
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9011861D0 (en) 1990-05-26 1990-07-18 Beecham Group Plc Novel compounds
US5723286A (en) 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
CA2109602C (en) 1990-07-10 2002-10-01 Gregory P. Winter Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
DE4022940A1 (de) 1990-07-19 1992-01-23 Bosch Gmbh Robert Einrichtung zur temperatursteuerung eines messwiderstands
US5401629A (en) 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
IL99552A0 (en) 1990-09-28 1992-08-18 Ixsys Inc Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof
ES2113940T3 (es) 1990-12-03 1998-05-16 Genentech Inc Metodo de enriquecimiento para variantes de proteinas con propiedades de union alteradas.
AU662148B2 (en) 1991-04-10 1995-08-24 Scripps Research Institute, The Heterodimeric receptor libraries using phagemids
DE4122598C1 (da) * 1991-07-08 1992-07-30 Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts, 6900 Heidelberg, De
EP0605522B1 (en) 1991-09-23 1999-06-23 Medical Research Council Methods for the production of humanized antibodies
US5470997A (en) 1992-04-06 1995-11-28 Biosite Diagnostics Incorporated Amphetamine derivatives and protein and polypeptide amphetamine derivative conjugates and labels
US6057098A (en) 1997-04-04 2000-05-02 Biosite Diagnostics, Inc. Polyvalent display libraries
US6555310B1 (en) * 1997-04-04 2003-04-29 Biosite Diagnostics, Inc. Polyclonal libraries
EP0985033A4 (en) 1997-04-04 2005-07-13 Biosite Inc POLYVALENT AND POLYCLONAL LIBRARIES
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
JP3374052B2 (ja) 1997-07-28 2003-02-04 株式会社堀場製作所 オゾン測定装置
US5932445A (en) 1997-11-07 1999-08-03 Incyte Pharmaceuticals, Inc. Signal peptide-containing proteins
US6545140B1 (en) * 1998-07-13 2003-04-08 University Of Georgia Research Foundation, Inc. DNA encoding an avian beta-defensin and uses thereof
ATE323766T1 (de) 1999-02-12 2006-05-15 Amgen Inc Glykosylierte leptinzusammensetzungen und zugehörige verfahren
US6794132B2 (en) 1999-10-02 2004-09-21 Biosite, Inc. Human antibodies
US7094579B2 (en) 2002-02-13 2006-08-22 Xoma Technology Ltd. Eukaryotic signal sequences for prokaryotic expression
DE20207301U1 (de) 2002-05-10 2002-12-19 Eichler-Stahlberg, Alke, 93059 Regensburg Expressionssystem für synthetische Gene in Mikroalgen
CN103929153B (zh) 2013-01-11 2016-12-28 北大方正集团有限公司 一种倍频处理方法和装置

Also Published As

Publication number Publication date
CA2475929C (en) 2013-01-15
EP1481059A4 (en) 2006-02-01
US8476040B2 (en) 2013-07-02
CA2475929A1 (en) 2003-08-21
US7094579B2 (en) 2006-08-22
DE60323210D1 (en) 2008-10-09
ATE533845T1 (de) 2011-12-15
JP2005517407A (ja) 2005-06-16
US20030162249A1 (en) 2003-08-28
EP1481059B1 (en) 2008-08-27
US20110224102A1 (en) 2011-09-15
WO2003068956A1 (en) 2003-08-21
US7977068B2 (en) 2011-07-12
EP1481059A1 (en) 2004-12-01
JP2009131286A (ja) 2009-06-18
JP4303596B2 (ja) 2009-07-29
US20100009857A1 (en) 2010-01-14
US20080214411A1 (en) 2008-09-04
US7972811B2 (en) 2011-07-05
EP2060628A1 (en) 2009-05-20
DK1481059T3 (da) 2009-01-12
ATE406439T1 (de) 2008-09-15
JP5190963B2 (ja) 2013-04-24
US20030228660A1 (en) 2003-12-11
EP2060628B1 (en) 2011-11-16
US7396661B2 (en) 2008-07-08
AU2003225578B2 (en) 2008-04-03
AU2003225578A1 (en) 2003-09-04

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