DK2061897T3 - Fed-batch-fermenteringsproces med høj celledensitet til fremstilling af rekombinant protein - Google Patents

Fed-batch-fermenteringsproces med høj celledensitet til fremstilling af rekombinant protein Download PDF

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Publication number
DK2061897T3
DK2061897T3 DK07836299.3T DK07836299T DK2061897T3 DK 2061897 T3 DK2061897 T3 DK 2061897T3 DK 07836299 T DK07836299 T DK 07836299T DK 2061897 T3 DK2061897 T3 DK 2061897T3
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DK
Denmark
Prior art keywords
recombinant protein
fermentation process
batch fermentation
produce recombinant
density fatty
Prior art date
Application number
DK07836299.3T
Other languages
English (en)
Inventor
Wei-Qiang Willie Sun
Earl Pursell
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Application granted granted Critical
Publication of DK2061897T3 publication Critical patent/DK2061897T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK07836299.3T 2006-07-27 2007-07-21 Fed-batch-fermenteringsproces med høj celledensitet til fremstilling af rekombinant protein DK2061897T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83347906P 2006-07-27 2006-07-27
PCT/US2007/016917 WO2008013943A2 (en) 2006-07-27 2007-07-21 High-cell density fed-batch fermentation process for producing recombinant protein

Publications (1)

Publication Number Publication Date
DK2061897T3 true DK2061897T3 (da) 2020-06-02

Family

ID=38982103

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07836299.3T DK2061897T3 (da) 2006-07-27 2007-07-21 Fed-batch-fermenteringsproces med høj celledensitet til fremstilling af rekombinant protein

Country Status (20)

Country Link
US (3) US8632995B2 (da)
EP (2) EP2061897B1 (da)
JP (2) JP2009544321A (da)
KR (1) KR101419958B1 (da)
CN (2) CN101535493A (da)
AU (1) AU2007277081B2 (da)
BR (1) BRPI0715360B8 (da)
CA (1) CA2657135C (da)
DK (1) DK2061897T3 (da)
ES (1) ES2788001T3 (da)
HK (1) HK1217969A1 (da)
HU (1) HUE048973T2 (da)
IL (1) IL196496A (da)
MX (1) MX2009000813A (da)
PL (1) PL2061897T3 (da)
PT (1) PT2061897T (da)
RU (1) RU2451070C2 (da)
SG (1) SG174013A1 (da)
SI (1) SI2061897T1 (da)
WO (1) WO2008013943A2 (da)

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MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
SG174013A1 (en) 2006-07-27 2011-09-29 Wyeth Corp High-cell density fed-batch fermentation process for producing recombinant protein
AR064642A1 (es) 2006-12-22 2009-04-15 Wyeth Corp Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi
RU2580620C2 (ru) 2010-08-23 2016-04-10 ВАЙЕТ ЭлЭлСи СТАБИЛЬНЫЕ КОМПОЗИЦИИ АНТИГЕНОВ Neisseria meningitidis rLP2086
WO2012032489A1 (en) 2010-09-10 2012-03-15 Wyeth Llc Non-lipidated variants of neisseria meningitidis orf2086 antigens
US9347080B2 (en) * 2011-01-31 2016-05-24 Novozymes A/S Use of browned glucose as a feed substrate
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
CA2865745C (en) 2012-03-09 2018-01-09 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
CN108410788A (zh) * 2012-03-12 2018-08-17 韩美科学株式会社 高密度培养大肠杆菌细胞的方法
US9802987B2 (en) 2013-03-08 2017-10-31 Pfizer Inc. Immunogenic fusion polypeptides
RU2662968C2 (ru) 2013-09-08 2018-07-31 Пфайзер Инк. Иммуногенная композиция против neisseria meningitidis (варианты)
RU2561467C1 (ru) * 2014-04-24 2015-08-27 Сергей Михайлович Юдин Способ получения препарата для повышения мясной и молочной продуктивности сельскохозяйственных животных (варианты) и препарат, полученный на его основе
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US10322304B2 (en) * 2015-01-29 2019-06-18 Sandy Kronenberg Nasal air filter
AU2016221318B2 (en) 2015-02-19 2020-06-25 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US20200087390A1 (en) 2016-12-21 2020-03-19 Amgen Inc. Anti-tnf alpha antibody formulations
US10183070B2 (en) 2017-01-31 2019-01-22 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
EP4034157A1 (en) 2019-09-27 2022-08-03 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
WO2021087404A1 (en) * 2019-10-30 2021-05-06 Future Fields Cellular Agriculture and Research LTD. Method for producing recombinant proteins in insects
US20250101484A1 (en) * 2023-09-27 2025-03-27 Pharmaessentia Corporation Method to increase drug substance yield
CN117510596A (zh) * 2023-11-13 2024-02-06 中山迈托姆生物技术有限公司 一种大肠杆菌高密度表达犬瘟热抗原的发酵工艺及其应用

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US5681718A (en) 1986-03-14 1997-10-28 Celltech Limited Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof
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AR005035A1 (es) * 1995-12-11 1999-04-07 Merck Patent Ges Mit Beschränkter Haftung Procedimiento para preparar proteinas recombinantes en e. coli, mediante fermentacion con gran concentracion de celulas.
JP2001500015A (ja) 1996-09-06 2001-01-09 トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア Ｔ７ポリメラーゼを利用する組換えアデノ随伴ウイルスの誘導可能な製造方法
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MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
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KR101098897B1 (ko) * 2002-12-13 2011-12-26 지모제넥틱스, 인코포레이티드 원핵생물 숙주 내 ｉｌ-21 생산
DE10305774A1 (de) * 2003-02-06 2004-08-26 Consortium für elektrochemische Industrie GmbH Verfahren zur fermentativen Herstellung von L-Methionin
BRPI0409459A (pt) * 2003-04-16 2006-05-02 Wyeth Corp novas composições imunogênicas para a prevenção e tratamento de doença meningocócica
CN100384998C (zh) * 2003-11-11 2008-04-30 浙江大学 重组鹅白细胞介素-2蛋白的制备方法及其用途
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SG174013A1 (en) 2006-07-27 2011-09-29 Wyeth Corp High-cell density fed-batch fermentation process for producing recombinant protein

Also Published As

Publication number Publication date
CN105463045A (zh) 2016-04-06
US20080026425A1 (en) 2008-01-31
US20160289725A1 (en) 2016-10-06
BRPI0715360B1 (pt) 2021-01-19
HK1217969A1 (zh) 2017-01-27
EP2061897A4 (en) 2012-03-07
IL196496A0 (en) 2011-08-01
WO2008013943A2 (en) 2008-01-31
WO2008013943A3 (en) 2009-04-02
HUE048973T2 (hu) 2020-09-28
JP2014064583A (ja) 2014-04-17
US8632995B2 (en) 2014-01-21
JP5925175B2 (ja) 2016-05-25
PT2061897T (pt) 2020-05-08
US9279000B2 (en) 2016-03-08
JP2009544321A (ja) 2009-12-17
EP3705579A1 (en) 2020-09-09
SG174013A1 (en) 2011-09-29
RU2008152445A (ru) 2010-09-10
AU2007277081A1 (en) 2008-01-31
US10301663B2 (en) 2019-05-28
BRPI0715360B8 (pt) 2022-01-04
RU2451070C2 (ru) 2012-05-20
KR101419958B1 (ko) 2014-07-16
AU2007277081B2 (en) 2014-02-06
CA2657135A1 (en) 2008-01-31
BRPI0715360A2 (pt) 2013-06-18
IL196496A (en) 2016-05-31
ES2788001T3 (es) 2020-10-20
EP2061897A2 (en) 2009-05-27
CN101535493A (zh) 2009-09-16
US20140113329A1 (en) 2014-04-24
KR20090034375A (ko) 2009-04-07
EP2061897B1 (en) 2020-03-25
SI2061897T1 (sl) 2020-07-31
MX2009000813A (es) 2009-02-03
PL2061897T3 (pl) 2020-09-07
CA2657135C (en) 2016-03-15

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