|
JP5179689B2
(ja)
|
2000-02-11 |
2013-04-10 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング |
抗体ベース融合タンパク質の循環系内半減期の増強
|
|
HUP0303428A2
(hu)
|
2001-03-07 |
2004-01-28 |
Merck Patent Gmbh. |
Expressziós eljárás hibrid izotípusú antitestcsoportot tartalmazó fehérjékhez
|
|
WO2002079415A2
(en)
|
2001-03-30 |
2002-10-10 |
Lexigen Pharmaceuticals Corp. |
Reducing the immunogenicity of fusion proteins
|
|
KR100900166B1
(ko)
|
2001-05-03 |
2009-06-02 |
메르크 파텐트 게엠베하 |
재조합 종양 특이적 항체 및 이들의 용도
|
|
ATE542137T1
(de)
|
2001-12-04 |
2012-02-15 |
Merck Patent Gmbh |
Immunocytokine mit modulierter selektivität
|
|
EP2314629B2
(en)
|
2002-07-18 |
2022-11-16 |
Merus N.V. |
Recombinant production of mixtures of antibodies
|
|
USRE47770E1
(en)
|
2002-07-18 |
2019-12-17 |
Merus N.V. |
Recombinant production of mixtures of antibodies
|
|
PT1699822E
(pt)
|
2003-12-30 |
2008-07-30 |
Merck Patent Gmbh |
Proteínas de fusão de il-7
|
|
BRPI0417916A
(pt)
|
2003-12-31 |
2007-04-10 |
Merck Patent Gmbh |
proteìna de fusão de fc-eritropoietina com farmacocinética melhorada
|
|
US7670595B2
(en)
|
2004-06-28 |
2010-03-02 |
Merck Patent Gmbh |
Fc-interferon-beta fusion proteins
|
|
CN101198698B
(zh)
|
2005-03-31 |
2014-03-19 |
中外制药株式会社 |
通过调节多肽缔合制备多肽的方法
|
|
WO2007110205A2
(en)
|
2006-03-24 |
2007-10-04 |
Merck Patent Gmbh |
Engineered heterodimeric protein domains
|
|
EP2009101B1
(en)
|
2006-03-31 |
2017-10-25 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody modification method for purifying bispecific antibody
|
|
HUE028379T2
(en)
|
2006-09-29 |
2016-12-28 |
Oncomed Pharm Inc |
Preparations and procedures for the diagnosis and treatment of cancer
|
|
CN104497143B
(zh)
|
2007-03-29 |
2020-08-25 |
健玛保 |
双特异性抗体及其制造方法
|
|
US9266967B2
(en)
|
2007-12-21 |
2016-02-23 |
Hoffmann-La Roche, Inc. |
Bivalent, bispecific antibodies
|
|
US20090162359A1
(en)
|
2007-12-21 |
2009-06-25 |
Christian Klein |
Bivalent, bispecific antibodies
|
|
AU2015202560B2
(en)
*
|
2008-01-07 |
2017-06-15 |
Amgen Inc. |
Method for Making Antibody Fc-Heterodimeric Molecules Using Electrostatic Steering Effects
|
|
EP3663318A1
(en)
|
2008-01-07 |
2020-06-10 |
Amgen Inc. |
Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
|
|
AU2009240234A1
(en)
*
|
2008-04-25 |
2009-10-29 |
Merck Patent Gmbh |
Artificial protein scaffolds
|
|
JP5646457B2
(ja)
|
2008-04-29 |
2014-12-24 |
アッヴィ・インコーポレイテッド |
二重可変ドメイン免疫グロブリン及びその使用
|
|
EP3002299A1
(en)
|
2008-06-03 |
2016-04-06 |
AbbVie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
|
BRPI1014089A2
(pt)
*
|
2009-04-02 |
2016-04-19 |
Roche Glycart Ag |
anticorpos multiespecíficos que compreendem anticorpos de comprimento completo e fragmentos fab de cadeia simples
|
|
PT2417156E
(pt)
|
2009-04-07 |
2015-04-29 |
Roche Glycart Ag |
Anticorpos trivalentes, biespecíficos
|
|
SG175233A1
(en)
|
2009-04-22 |
2011-11-28 |
Merck Patent Gmbh |
Antibody fusion proteins with modified fcrn binding sites
|
|
AU2010245011B2
(en)
*
|
2009-04-27 |
2015-09-03 |
Oncomed Pharmaceuticals, Inc. |
Method for making heteromultimeric molecules
|
|
US9676845B2
(en)
|
2009-06-16 |
2017-06-13 |
Hoffmann-La Roche, Inc. |
Bispecific antigen binding proteins
|
|
MX2011013455A
(es)
|
2009-07-08 |
2012-02-13 |
Amgen Inc |
Diseño de moleculas de fc de anticuerpo estables y libres de agregacion a traves del diseño de la interfase del dominio de ch3.
|
|
WO2011028952A1
(en)
|
2009-09-02 |
2011-03-10 |
Xencor, Inc. |
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
|
|
MX2012003396A
(es)
|
2009-09-16 |
2012-04-10 |
Genentech Inc |
Complejos de proteina conteniendo helice super-enrollada y/o enlazador tether y usos de los mismos.
|
|
US8883145B2
(en)
|
2009-10-16 |
2014-11-11 |
Oncomed Pharmaceuticals, Inc. |
Methods of treatment with DLL4 antagonists and an anti-hypertensive agent
|
|
TW201138821A
(en)
*
|
2010-03-26 |
2011-11-16 |
Roche Glycart Ag |
Bispecific antibodies
|
|
JP6040148B2
(ja)
|
2010-04-20 |
2016-12-07 |
ゲンマブ エー/エス |
ヘテロ二量体抗体Fc含有タンパク質およびその産生方法
|
|
UY33492A
(es)
|
2010-07-09 |
2012-01-31 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
CA2806252C
(en)
|
2010-07-29 |
2019-05-14 |
Xencor, Inc. |
Antibodies with modified isoelectric points
|
|
US8735546B2
(en)
|
2010-08-03 |
2014-05-27 |
Abbvie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
|
RU2013110875A
(ru)
|
2010-08-24 |
2014-09-27 |
Ф.Хоффманн-Ля Рош Аг |
БИСПЕЦИФИЧЕСКИЕ АНТИТЕЛА, СОДЕРЖАЩИЕ СТАБИЛИЗИРОВАННЫЙ ДИСУЛЬФИДОМ ФРАГМЕНТ Fv
|
|
US8551479B2
(en)
|
2010-09-10 |
2013-10-08 |
Oncomed Pharmaceuticals, Inc. |
Methods for treating melanoma
|
|
PL2635607T3
(pl)
|
2010-11-05 |
2020-05-18 |
Zymeworks Inc. |
Projekt stabilnego przeciwciała heterodimerowego z mutacjami w domenie FC
|
|
US9518132B2
(en)
|
2010-11-09 |
2016-12-13 |
Altimab Therapeutics, Inc. |
Protein complexes for antigen binding and methods of use
|
|
TWI638833B
(zh)
|
2010-11-30 |
2018-10-21 |
中外製藥股份有限公司 |
細胞傷害誘導治療劑
|
|
JP5766296B2
(ja)
|
2010-12-23 |
2015-08-19 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用
|
|
EP2681239B8
(en)
|
2011-02-28 |
2015-09-09 |
F. Hoffmann-La Roche AG |
Antigen binding proteins
|
|
AR085403A1
(es)
|
2011-02-28 |
2013-09-25 |
Hoffmann La Roche |
Proteinas monovalentes que se unen a antigenos
|
|
AU2012235758B2
(en)
*
|
2011-03-25 |
2015-05-07 |
IGI Therapeutics SA |
Hetero-dimeric immunoglobulins
|
|
ES2608835T3
(es)
|
2011-04-13 |
2017-04-17 |
Bristol-Myers Squibb Company |
Proteínas de fusión Fc que comprenden nuevos enlazadores o disposiciones
|
|
AU2012245116A1
(en)
|
2011-04-20 |
2013-11-07 |
Genmab A/S |
Bispecific antibodies against HER2 and CD3
|
|
EP4520771A3
(en)
|
2011-04-20 |
2025-07-16 |
Genmab A/S |
Bispecifc antibodies against her2
|
|
WO2012158818A2
(en)
|
2011-05-16 |
2012-11-22 |
Fabion Pharmaceuticals, Inc. |
Multi-specific fab fusion proteins and methods of use
|
|
UA117901C2
(uk)
|
2011-07-06 |
2018-10-25 |
Ґенмаб Б.В. |
Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
|
|
EP2747781B1
(en)
|
2011-08-23 |
2017-11-15 |
Roche Glycart AG |
Bispecific antibodies specific for t-cell activating antigens and a tumor antigen and methods of use
|
|
GB201116092D0
(en)
|
2011-09-16 |
2011-11-02 |
Bioceros B V |
Antibodies and uses thereof
|
|
SI3485903T1
(sl)
|
2011-09-23 |
2023-02-28 |
Mereo Biopharma 5, Inc. |
Sredstva, ki vežejo VEGF/DLL4, in njihove uporabe
|
|
US10851178B2
(en)
|
2011-10-10 |
2020-12-01 |
Xencor, Inc. |
Heterodimeric human IgG1 polypeptides with isoelectric point modifications
|
|
US12466897B2
(en)
|
2011-10-10 |
2025-11-11 |
Xencor, Inc. |
Heterodimeric human IgG1 polypeptides with isoelectric point modifications
|
|
DK2771364T3
(da)
|
2011-10-27 |
2019-08-19 |
Genmab As |
Fremstilling af heterodimere proteiner
|
|
ES2732712T3
(es)
|
2011-10-31 |
2019-11-25 |
Chugai Pharmaceutical Co Ltd |
Molécula de unión a antígeno que tiene una conjugación regulada entre la cadena pesada y la cadena ligera
|
|
PL2773671T3
(pl)
|
2011-11-04 |
2022-01-24 |
Zymeworks Inc. |
Projekt stabilnego przeciwciała heterodimerycznego z mutacjami w domenie fc
|
|
ES2749349T3
(es)
|
2011-11-07 |
2020-03-19 |
Medimmune Llc |
Proteínas de unión multiespecíficas y multivalentes y usos de las mismas
|
|
PT2794905T
(pt)
|
2011-12-20 |
2020-06-30 |
Medimmune Llc |
Polipéptidos modificados para estrutura de anticorpos bispecíficos
|
|
CN104105711B
(zh)
|
2012-02-10 |
2018-11-30 |
弗·哈夫曼-拉罗切有限公司 |
单链抗体及其他异多聚体
|
|
DK2838918T3
(da)
|
2012-04-20 |
2019-08-12 |
Merus Nv |
Fremgangsmåder og midler til fremstilling af heterodimere ig-lignende molekyler
|
|
US9090694B2
(en)
|
2012-04-30 |
2015-07-28 |
Janssen Biotech, Inc. |
ST2L antibody antagonists
|
|
US9499634B2
(en)
|
2012-06-25 |
2016-11-22 |
Zymeworks Inc. |
Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells
|
|
MX2014014804A
(es)
|
2012-06-27 |
2015-02-12 |
Hoffmann La Roche |
Metodo para la elaboracion de conjugados de la region fc de anticuerpos que comprenden por lo menos una entidad de union que se une especificamente a un objetivo y usos del mismo.
|
|
EP2867253B1
(en)
|
2012-06-27 |
2016-09-14 |
F. Hoffmann-La Roche AG |
Method for selection and production of tailor-made highly selective and multi-specific targeting entities containing at least two different binding entities and uses thereof
|
|
US11180572B2
(en)
|
2012-07-06 |
2021-11-23 |
Genmab B.V. |
Dimeric protein with triple mutations
|
|
EP3632462A1
(en)
|
2012-07-06 |
2020-04-08 |
Genmab B.V. |
Dimeric protein with triple mutations
|
|
HK1215950A1
(zh)
|
2012-09-25 |
2016-09-30 |
艾科诺斯科技股份有限公司 |
异源二聚免疫球蛋白的纯化
|
|
PL2900694T3
(pl)
|
2012-09-27 |
2018-12-31 |
Merus N.V. |
Dwuswoiste przeciwciała igg jako aktywatory komórek t
|
|
JP6581505B2
(ja)
|
2012-10-03 |
2019-09-25 |
ザイムワークス,インコーポレイテッド |
重鎖および軽鎖ポリペプチドの対を定量化する方法
|
|
EP2905290B1
(en)
|
2012-10-05 |
2019-12-04 |
Kyowa Kirin Co., Ltd. |
Heterodimeric protein composition
|
|
WO2014056783A1
(en)
|
2012-10-08 |
2014-04-17 |
Roche Glycart Ag |
Fc-free antibodies comprising two fab-fragments and methods of use
|
|
US9890216B2
(en)
|
2012-10-23 |
2018-02-13 |
Board Of Regents, The University Of Texas System |
Antibodies with engineered IgG Fc domains
|
|
US9599620B2
(en)
|
2012-10-31 |
2017-03-21 |
Oncomed Pharmaceuticals, Inc. |
Methods and monitoring of treatment with a DLL4 antagonist
|
|
WO2014079000A1
(en)
*
|
2012-11-21 |
2014-05-30 |
Wuhan Yzy Biopharma Co., Ltd. |
Bispecific antibody
|
|
US9914785B2
(en)
|
2012-11-28 |
2018-03-13 |
Zymeworks Inc. |
Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
|
|
MX385344B
(es)
|
2012-11-28 |
2025-03-18 |
Zymeworks Bc Inc |
Pares de cadena pesada-cadena ligera de inmunoglobulina modificados genéticamente y usos de estos.
|
|
AU2013372331A1
(en)
|
2013-01-10 |
2015-07-23 |
Genmab B.V. |
Human IgG1 Fc region variants and uses thereof
|
|
US10968276B2
(en)
|
2013-03-12 |
2021-04-06 |
Xencor, Inc. |
Optimized anti-CD3 variable regions
|
|
CA2898100C
(en)
|
2013-01-14 |
2023-10-10 |
Xencor, Inc. |
Novel heterodimeric proteins
|
|
US9701759B2
(en)
|
2013-01-14 |
2017-07-11 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US11053316B2
(en)
|
2013-01-14 |
2021-07-06 |
Xencor, Inc. |
Optimized antibody variable regions
|
|
US9605084B2
(en)
|
2013-03-15 |
2017-03-28 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US10131710B2
(en)
|
2013-01-14 |
2018-11-20 |
Xencor, Inc. |
Optimized antibody variable regions
|
|
US10487155B2
(en)
|
2013-01-14 |
2019-11-26 |
Xencor, Inc. |
Heterodimeric proteins
|
|
CA2897987A1
(en)
|
2013-01-15 |
2014-07-24 |
Xencor, Inc. |
Rapid clearance of antigen complexes using novel antibodies
|
|
ES2751735T3
(es)
|
2013-02-12 |
2020-04-01 |
Bristol Myers Squibb Co |
Métodos de replegado de proteínas a elevado pH
|
|
EP2956468B1
(en)
|
2013-02-12 |
2020-06-10 |
Bristol-Myers Squibb Company |
Tangential flow filtration based protein refolding methods
|
|
WO2014131712A1
(en)
|
2013-02-26 |
2014-09-04 |
Roche Glycart Ag |
Bispecific t cell activating antigen binding molecules
|
|
JP6499087B2
(ja)
|
2013-02-26 |
2019-04-10 |
ロシュ グリクアート アーゲー |
二重特異性t細胞活性化抗原結合分子
|
|
US10519242B2
(en)
|
2013-03-15 |
2019-12-31 |
Xencor, Inc. |
Targeting regulatory T cells with heterodimeric proteins
|
|
EP2970486B1
(en)
|
2013-03-15 |
2018-05-16 |
Xencor, Inc. |
Modulation of t cells with bispecific antibodies and fc fusions
|
|
US10858417B2
(en)
|
2013-03-15 |
2020-12-08 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US9902770B2
(en)
|
2013-03-15 |
2018-02-27 |
Janssen Biotech, Inc. |
Interferon alpha and omega antibody antagonists
|
|
US10106624B2
(en)
|
2013-03-15 |
2018-10-23 |
Xencor, Inc. |
Heterodimeric proteins
|
|
MD20180107A2
(ro)
|
2013-03-18 |
2019-06-30 |
Biocerox Products B.V. |
Anticorpi anti-CD134 (OX40) umanizaţi şi utilizarea acestora
|
|
EP2992010B1
(en)
|
2013-04-29 |
2021-03-24 |
F.Hoffmann-La Roche Ag |
Fc-receptor binding modified asymmetric antibodies and methods of use
|
|
SG10201800492PA
(en)
|
2013-04-29 |
2018-03-28 |
Hoffmann La Roche |
Human fcrn-binding modified antibodies and methods of use
|
|
SG10201810481UA
(en)
|
2013-04-29 |
2018-12-28 |
Hoffmann La Roche |
Fcrn-binding abolished anti-igf-1r antibodies and their use in the treatment of vascular eye diseases
|
|
KR102363220B1
(ko)
|
2013-07-05 |
2022-02-15 |
젠맵 에이/에스 |
인간화 또는 키메라 cd3 항체
|
|
CN105764922B
(zh)
|
2013-09-27 |
2020-07-17 |
中外制药株式会社 |
多肽异源多聚体的制备方法
|
|
RU2016115866A
(ru)
|
2013-10-11 |
2017-11-16 |
Ф. Хоффманн-Ля Рош Аг |
Мультиспецифические антитела с обменянными доменами и одинаковыми вариабельными доменами легкой цепи
|
|
PL3065774T3
(pl)
|
2013-11-06 |
2021-12-13 |
Janssen Biotech, Inc |
Przeciwciała anty-ccl17
|
|
EP4570318A3
(en)
|
2013-11-27 |
2025-10-15 |
Zymeworks BC Inc. |
Bispecific antigen-binding constructs targeting her2
|
|
MX379030B
(es)
|
2013-12-17 |
2025-03-10 |
Genentech Inc |
Anticuerpos anti-cd3 y metodos de uso
|
|
SI3083680T1
(sl)
|
2013-12-20 |
2020-06-30 |
F. Hoffmann-La Roche Ag |
Humanizirana protitelesa proti beljakovini Tau(pS422) in postopki uporabe
|
|
ES2895752T3
(es)
|
2014-01-03 |
2022-02-22 |
Hoffmann La Roche |
Anticuerpos biespecíficos anti-hapteno/anti-receptor de la barrera hematoencefálica, complejos de los mismos y su uso como lanzaderas a través de la barrera hematoencefálica
|
|
JP6557664B2
(ja)
|
2014-01-06 |
2019-08-07 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
一価の血液脳関門シャトルモジュール
|
|
EP3835318B1
(en)
|
2014-01-15 |
2025-10-29 |
F. Hoffmann-La Roche AG |
Fc-region variants with modified fcrn- and maintained protein a-binding properties
|
|
CA2935423C
(en)
|
2014-01-24 |
2023-11-07 |
Dana-Farber Cancer Institute, Inc. |
Antibody molecules to pd-1 and uses thereof
|
|
AU2015210750B2
(en)
|
2014-01-31 |
2020-08-20 |
Children's Medical Center Corporation |
Antibody molecules to TIM-3 and uses thereof
|
|
EP3786186A1
(en)
|
2014-02-28 |
2021-03-03 |
Merus N.V. |
Antibodies that bind egfr and erbb3
|
|
US9732154B2
(en)
|
2014-02-28 |
2017-08-15 |
Janssen Biotech, Inc. |
Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia
|
|
SMT202500020T1
(it)
|
2014-02-28 |
2025-03-12 |
Merus Nv |
Anticorpo che lega erbb-2 ed erbb-3
|
|
WO2015138920A1
(en)
|
2014-03-14 |
2015-09-17 |
Novartis Ag |
Antibody molecules to lag-3 and uses thereof
|
|
EP3593812A3
(en)
|
2014-03-15 |
2020-05-27 |
Novartis AG |
Treatment of cancer using chimeric antigen receptor
|
|
JP6775422B2
(ja)
|
2014-03-28 |
2020-10-28 |
ゼンコー・インコーポレイテッドXencor、 Inc. |
Cd38及びcd3に結合する二重特異性抗体
|
|
UA117289C2
(uk)
|
2014-04-02 |
2018-07-10 |
Ф. Хоффманн-Ля Рош Аг |
Мультиспецифічне антитіло
|
|
CN106164288A
(zh)
|
2014-04-02 |
2016-11-23 |
豪夫迈·罗氏有限公司 |
检测多特异性抗体轻链错配的方法
|
|
KR102568808B1
(ko)
|
2014-04-07 |
2023-08-18 |
추가이 세이야쿠 가부시키가이샤 |
면역활성화 항원 결합 분자
|
|
SG11201609370QA
(en)
|
2014-05-13 |
2016-12-29 |
Chugai Pharmaceutical Co Ltd |
T cell-redirected antigen-binding molecule for cells having immunosuppression function
|
|
BR112016027888A2
(pt)
|
2014-05-28 |
2017-10-24 |
Zymeworks Inc |
construto de polipeptídeo de ligação ao antígeno isolado, polinucleotídeo isolado ou um conjunto de polinucleotídeos isolados, vetor ou conjunto de vetores, célula isolada, composição farmacêutica, uso do construto, método para tratar um sujeito com uma doença ou distúrbio, método para obter um construto, método para preparar um construto, meio de armazenamento legível por computador, método para produzir um construto de polipeptídeo de ligação com antígeno bi-específico e método para preparar um construto de polipeptídeo de ligação com antígeno isolado
|
|
TWI713453B
(zh)
|
2014-06-23 |
2020-12-21 |
美商健生生物科技公司 |
干擾素α及ω抗體拮抗劑
|
|
CN106687476B
(zh)
|
2014-06-26 |
2020-11-13 |
豪夫迈·罗氏有限公司 |
抗brdu抗体及使用方法
|
|
AR100978A1
(es)
|
2014-06-26 |
2016-11-16 |
Hoffmann La Roche |
LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS
|
|
KR20170010863A
(ko)
|
2014-07-01 |
2017-02-01 |
화이자 인코포레이티드 |
이중특이성 이종이량체성 디아바디 및 이의 용도
|
|
EP3169706B1
(en)
|
2014-07-11 |
2019-12-04 |
Genmab A/S |
Antibodies binding axl
|
|
WO2016014530A1
(en)
|
2014-07-21 |
2016-01-28 |
Novartis Ag |
Combinations of low, immune enhancing. doses of mtor inhibitors and cars
|
|
US9777061B2
(en)
|
2014-07-21 |
2017-10-03 |
Novartis Ag |
Treatment of cancer using a CD33 chimeric antigen receptor
|
|
MY181834A
(en)
|
2014-07-21 |
2021-01-08 |
Novartis Ag |
Treatment of cancer using humanized anti-bcma chimeric antigen receptor
|
|
US11542488B2
(en)
|
2014-07-21 |
2023-01-03 |
Novartis Ag |
Sortase synthesized chimeric antigen receptors
|
|
US20170209492A1
(en)
|
2014-07-31 |
2017-07-27 |
Novartis Ag |
Subset-optimized chimeric antigen receptor-containing t-cells
|
|
RS65573B1
(sr)
|
2014-08-04 |
2024-06-28 |
Hoffmann La Roche |
Bispecifični antigen vezujući molekuli koji aktiviraju t ćelije
|
|
EP2982692A1
(en)
|
2014-08-04 |
2016-02-10 |
EngMab AG |
Bispecific antibodies against CD3epsilon and BCMA
|
|
WO2016025880A1
(en)
|
2014-08-14 |
2016-02-18 |
Novartis Ag |
Treatment of cancer using gfr alpha-4 chimeric antigen receptor
|
|
SG11201700770PA
(en)
|
2014-08-19 |
2017-03-30 |
Novartis Ag |
Anti-cd123 chimeric antigen receptor (car) for use in cancer treatment
|
|
PE20170676A1
(es)
|
2014-09-09 |
2017-05-22 |
Janssen Biotech Inc |
Terapias de combinacion con anticuerpos anti-cd38
|
|
MA40579A
(fr)
|
2014-09-12 |
2016-03-17 |
Genentech Inc |
Anticorps anti-cll-1 et immunoconjugués
|
|
ES2891332T3
(es)
|
2014-09-17 |
2022-01-27 |
Novartis Ag |
Direccionamiento a células citotóxicas con receptores quiméricos para la inmunoterapia adoptiva
|
|
MA40764A
(fr)
|
2014-09-26 |
2017-08-01 |
Chugai Pharmaceutical Co Ltd |
Agent thérapeutique induisant une cytotoxicité
|
|
CA2963692A1
(en)
|
2014-10-09 |
2016-04-14 |
Engmab Ag |
Bispecific antibodies against cd3epsilon and ror1
|
|
WO2016061142A1
(en)
|
2014-10-14 |
2016-04-21 |
Novartis Ag |
Antibody molecules to pd-l1 and uses thereof
|
|
US20160176962A1
(en)
|
2014-10-31 |
2016-06-23 |
Oncomed Pharmaceuticals, Inc. |
Combination Therapy For Treatment Of Disease
|
|
US11773166B2
(en)
|
2014-11-04 |
2023-10-03 |
Ichnos Sciences SA |
CD3/CD38 T cell retargeting hetero-dimeric immunoglobulins and methods of their production
|
|
WO2016071377A1
(en)
|
2014-11-06 |
2016-05-12 |
F. Hoffmann-La Roche Ag |
Fc-region variants with modified fcrn- and protein a-binding properties
|
|
EP3215528B1
(en)
|
2014-11-06 |
2019-08-07 |
F.Hoffmann-La Roche Ag |
Fc-region variants with modified fcrn-binding and methods of use
|
|
EP3023437A1
(en)
|
2014-11-20 |
2016-05-25 |
EngMab AG |
Bispecific antibodies against CD3epsilon and BCMA
|
|
BR112017010513A2
(pt)
|
2014-11-20 |
2018-04-03 |
F. Hoffmann-La Roche Ag |
?cadeias leves comuns e métodos de uso?
|
|
FI4141032T3
(fi)
|
2014-11-20 |
2024-07-31 |
Hoffmann La Roche |
T-solua aktivoivien bispesifisten antigeeniä sitovien molekyylien ja pd-1-akselia sitovien antagonistien yhdistelmähoito
|
|
EP3221356B1
(en)
|
2014-11-20 |
2020-09-02 |
F.Hoffmann-La Roche Ag |
T cell activating bispecific antigen binding molecules against folr1 and cd3
|
|
SG11201704283PA
(en)
|
2014-11-26 |
2017-06-29 |
Xencor Inc |
Heterodimeric antibodies that bind cd3 and tumor antigens
|
|
JP2017536830A
(ja)
|
2014-11-26 |
2017-12-14 |
ゼンコー・インコーポレイテッドXencor、 Inc. |
Cd3及びcd38に結合するヘテロ二量体抗体
|
|
US10259887B2
(en)
|
2014-11-26 |
2019-04-16 |
Xencor, Inc. |
Heterodimeric antibodies that bind CD3 and tumor antigens
|
|
US20180334490A1
(en)
|
2014-12-03 |
2018-11-22 |
Qilong H. Wu |
Methods for b cell preconditioning in car therapy
|
|
CN107001482B
(zh)
|
2014-12-03 |
2021-06-15 |
豪夫迈·罗氏有限公司 |
多特异性抗体
|
|
EA202092609A1
(ru)
|
2014-12-04 |
2021-10-29 |
Янссен Байотек, Инк. |
Антитела к cd38 для лечения острого миелолейкоза
|
|
JP6904902B2
(ja)
|
2014-12-05 |
2021-07-21 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung |
ドメイン交換抗体
|
|
EP3233907B1
(en)
|
2014-12-19 |
2021-03-03 |
Genmab A/S |
Rodent bispecific heterodimeric proteins
|
|
WO2016105450A2
(en)
|
2014-12-22 |
2016-06-30 |
Xencor, Inc. |
Trispecific antibodies
|
|
WO2016110576A1
(en)
|
2015-01-08 |
2016-07-14 |
Genmab A/S |
Bispecific antibodies against cd3 and cd20
|
|
WO2016130516A1
(en)
|
2015-02-09 |
2016-08-18 |
Research Development Foundation |
Engineered immunoglobulin fc polypeptides displaying improved complement activation
|
|
US10227411B2
(en)
|
2015-03-05 |
2019-03-12 |
Xencor, Inc. |
Modulation of T cells with bispecific antibodies and FC fusions
|
|
US11142587B2
(en)
|
2015-04-01 |
2021-10-12 |
Chugai Seiyaku Kabushiki Kaisha |
Method for producing polypeptide hetero-oligomer
|
|
MX2017012939A
(es)
|
2015-04-08 |
2018-05-22 |
Novartis Ag |
Terapias cd20, terapias cd22 y terapias de combinacion con una celula que expresa un receptor quimerico de antigeno (car) de cd19.
|
|
EP3286211A1
(en)
|
2015-04-23 |
2018-02-28 |
Novartis AG |
Treatment of cancer using chimeric antigen receptor and protein kinase a blocker
|
|
CA2986594C
(en)
|
2015-05-20 |
2025-06-10 |
Tufts Medical Center, Inc. |
Anti-CD38 antibodies for the treatment of light chain amyloidosis and other CD38-positive hematological malignancies
|
|
CN104833797B
(zh)
*
|
2015-06-04 |
2017-02-01 |
武汉友芝友生物制药有限公司 |
检测双特异性抗体msbody的elisa方法及应用
|
|
TWI773646B
(zh)
|
2015-06-08 |
2022-08-11 |
美商宏觀基因股份有限公司 |
結合lag-3的分子和其使用方法
|
|
CN107847568B
(zh)
|
2015-06-16 |
2022-12-20 |
豪夫迈·罗氏有限公司 |
抗cll-1抗体和使用方法
|
|
HRP20231134T1
(hr)
|
2015-06-16 |
2024-01-05 |
F. Hoffmann - La Roche Ag |
Humanizirana i afinitetno zrela protutijela na fcrh5 i postupci za uporabu
|
|
CN107708734B
(zh)
|
2015-06-22 |
2022-01-11 |
詹森生物科技公司 |
用抗cd38抗体和生存素抑制剂联合治疗血红素恶性肿瘤
|
|
CN107810196B
(zh)
|
2015-06-24 |
2021-11-05 |
豪夫迈·罗氏有限公司 |
人源化的抗-Tau(pS422)抗体和使用方法
|
|
HRP20240338T1
(hr)
|
2015-06-24 |
2024-05-24 |
Janssen Biotech, Inc. |
Imunomodulacija i liječenje solidnih tumora s protutijelima koja se specifično vežu na cd38
|
|
ES2973885T3
(es)
|
2015-07-09 |
2024-06-24 |
Genmab As |
Anticuerpos biespecíficos y multiespecíficos y método para aislarlos
|
|
AU2016293942B2
(en)
|
2015-07-10 |
2022-06-16 |
Merus B.V. |
Human CD3 binding antibody
|
|
CA2991805A1
(en)
|
2015-07-10 |
2017-01-19 |
Genmab A/S |
Axl-specific antibody-drug conjugates for cancer treatment
|
|
PL3322727T3
(pl)
|
2015-07-15 |
2026-05-11 |
Genmab A/S |
Humanizowane lub chimeryczne przeciwciała cd3
|
|
ES2878188T3
(es)
|
2015-07-29 |
2021-11-18 |
Novartis Ag |
Terapias de combinación que comprenden moléculas de anticuerpos contra LAG-3
|
|
EP4378957A3
(en)
|
2015-07-29 |
2024-08-07 |
Novartis AG |
Combination therapies comprising antibody molecules to pd-1
|
|
WO2017019897A1
(en)
|
2015-07-29 |
2017-02-02 |
Novartis Ag |
Combination therapies comprising antibody molecules to tim-3
|
|
AU2016298227B9
(en)
|
2015-07-30 |
2019-10-31 |
Macrogenics, Inc. |
PD-1-binding molecules and methods of use thereof
|
|
EA201890434A1
(ru)
|
2015-08-05 |
2018-10-31 |
Янссен Байотек, Инк. |
Антитела к cd154 и способы их применения
|
|
ES2968074T3
(es)
|
2015-09-23 |
2024-05-07 |
Mereo Biopharma 5 Inc |
Anticuerpo bi-específico anti-VEGF/DLL4 para su uso en el tratamiento del cáncer de ovario resistente al platino
|
|
BR112018006360A2
(pt)
|
2015-09-30 |
2018-10-09 |
Janssen Biotech Inc |
anticorpos agonísticos que se ligam especificamente ao cd40 humano e métodos de uso
|
|
AR106188A1
(es)
|
2015-10-01 |
2017-12-20 |
Hoffmann La Roche |
Anticuerpos anti-cd19 humano humanizados y métodos de utilización
|
|
WO2017055393A1
(en)
|
2015-10-02 |
2017-04-06 |
F. Hoffmann-La Roche Ag |
Anti-cd3xtim-3 bispecific t cell activating antigen binding molecules
|
|
KR20180073561A
(ko)
|
2015-10-02 |
2018-07-02 |
에프. 호프만-라 로슈 아게 |
이중특이적 항-ceaxcd3 t 세포 활성화 항원 결합 분자
|
|
WO2017055392A1
(en)
|
2015-10-02 |
2017-04-06 |
F. Hoffmann-La Roche Ag |
Anti-cd3xcd44v6 bispecific t cell activating antigen binding molecules
|
|
CN108026177B
(zh)
|
2015-10-02 |
2021-11-26 |
豪夫迈·罗氏有限公司 |
双特异性抗cd19xcd3 t细胞活化性抗原结合分子
|
|
EP3356821B1
(en)
|
2015-10-02 |
2019-10-23 |
H. Hoffnabb-La Roche Ag |
Cellular based fret assay for the determination of simultaneous binding
|
|
WO2017055385A1
(en)
|
2015-10-02 |
2017-04-06 |
F. Hoffmann-La Roche Ag |
Anti-cd3xgd2 bispecific t cell activating antigen binding molecules
|
|
HK1254967A1
(zh)
|
2015-10-02 |
2019-08-02 |
豪夫迈‧罗氏有限公司 |
结合间皮素和cd3的双特异性t细胞活化性抗原结合分子
|
|
DK3356411T3
(da)
|
2015-10-02 |
2021-09-06 |
Hoffmann La Roche |
Bispecifikke antistoffer, der er specifikke for PD1 og TIM3
|
|
US20180282410A1
(en)
|
2015-10-02 |
2018-10-04 |
Hoffmann-La Roche Inc. |
Anti-cd3xrob04 bispecific t cell activating antigen binding molecules
|
|
EP3150637A1
(en)
|
2015-10-02 |
2017-04-05 |
F. Hoffmann-La Roche AG |
Multispecific antibodies
|
|
JP2018533930A
(ja)
|
2015-10-02 |
2018-11-22 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
二重特異性t細胞活性化抗原結合分子
|
|
WO2017059551A1
(en)
|
2015-10-08 |
2017-04-13 |
Zymeworks Inc. |
Antigen-binding polypeptide constructs comprising kappa and lambda light chains and uses thereof
|
|
CN108136010A
(zh)
|
2015-10-08 |
2018-06-08 |
宏观基因有限公司 |
用于治疗癌症的联合疗法
|
|
WO2017069628A2
(en)
|
2015-10-23 |
2017-04-27 |
Merus N.V. |
Binding molecules that inhibit cancer growth
|
|
CN114891102A
(zh)
|
2015-10-29 |
2022-08-12 |
豪夫迈·罗氏有限公司 |
抗变体Fc区抗体及使用方法
|
|
AU2016349152A1
(en)
*
|
2015-11-03 |
2018-06-14 |
Merck Patent Gmbh |
Bi-specific antibodies for enhanced tumor selectivity and inhibition and uses thereof
|
|
KR20250099459A
(ko)
|
2015-11-03 |
2025-07-01 |
얀센 바이오테크 인코포레이티드 |
Pd-1과 특이적으로 결합하는 항체 및 그의 용도
|
|
HUE053366T2
(hu)
|
2015-11-03 |
2021-06-28 |
Janssen Biotech Inc |
Szubkután anti-CD38-ellenanyag-készítmények és alkalmazásuk
|
|
WO2017086367A1
(ja)
|
2015-11-18 |
2017-05-26 |
中外製薬株式会社 |
免疫抑制機能を有する細胞に対するt細胞リダイレクト抗原結合分子を用いた併用療法
|
|
EP3378488A4
(en)
|
2015-11-18 |
2019-10-30 |
Chugai Seiyaku Kabushiki Kaisha |
Method for enhancing humoral immune response
|
|
BR112018011100A2
(en)
|
2015-12-01 |
2018-12-04 |
Genmab B.V. |
antibody, composition, nucleic acid construct, expression vector, host cell, method for treating an individual having a cancer, kit of parts, and use of an antibody or composition.
|
|
JP7058219B2
(ja)
|
2015-12-07 |
2022-04-21 |
ゼンコア インコーポレイテッド |
Cd3及びpsmaに結合するヘテロ二量体抗体
|
|
AU2016368469B2
(en)
|
2015-12-09 |
2023-11-02 |
F. Hoffmann-La Roche Ag |
Type II anti-CD20 antibody for reducing formation of anti-drug antibodies
|
|
EP3178848A1
(en)
|
2015-12-09 |
2017-06-14 |
F. Hoffmann-La Roche AG |
Type ii anti-cd20 antibody for reducing formation of anti-drug antibodies
|
|
JP6955507B2
(ja)
|
2015-12-14 |
2021-10-27 |
マクロジェニクス,インコーポレーテッド |
Pd‐1及びctla‐4との免疫応答性を有する二重特異性並びにその使用方法
|
|
EP3389712B1
(en)
|
2015-12-17 |
2024-04-10 |
Novartis AG |
Antibody molecules to pd-1 and uses thereof
|
|
RU2018125603A
(ru)
|
2015-12-17 |
2020-01-21 |
Новартис Аг |
Комбинация ингибитора с-мет с молекулой антитела к pd-1 и ее применения
|
|
WO2017106684A2
(en)
|
2015-12-17 |
2017-06-22 |
Janssen Biotech, Inc. |
Antibodies specifically binding hla-dr and their uses
|
|
PT3393504T
(pt)
|
2015-12-22 |
2025-12-30 |
Novartis Ag |
Recetor de antigénio quimérico (car) de mesotelina e anticorpo contra o inibidor de pd-l1 para utilização combinada em terapia anticancerígena
|
|
SG11201803989WA
(en)
|
2015-12-28 |
2018-06-28 |
Chugai Pharmaceutical Co Ltd |
Method for promoting efficiency of purification of fc region-containing polypeptide
|
|
AR107303A1
(es)
|
2016-01-08 |
2018-04-18 |
Hoffmann La Roche |
Métodos de tratamiento de cánceres positivos para ace utilizando antagonistas de unión a eje pd-1 y anticuerpos biespecíficos anti-ace / anti-cd3, uso, composición, kit
|
|
EP3405492B1
(en)
|
2016-01-21 |
2020-10-21 |
Novartis AG |
Multispecific molecules targeting cll-1
|
|
TW201730212A
(zh)
|
2016-02-17 |
2017-09-01 |
宏觀基因股份有限公司 |
Ror1-結合分子及其使用方法
|
|
CA3016287A1
(en)
|
2016-03-04 |
2017-09-08 |
Novartis Ag |
Cells expressing multiple chimeric antigen receptor (car) molecules and uses therefore
|
|
CA3016424A1
(en)
|
2016-03-14 |
2017-09-21 |
Chugai Seiyaku Kabushiki Kaisha |
Cell injury inducing therapeutic drug for use in cancer therapy
|
|
JP7034489B2
(ja)
|
2016-03-15 |
2022-03-14 |
アイタブメッド (エイチケイ) リミテッド |
多重特異性Fab融合タンパクおよびその使用
|
|
JP7082604B2
(ja)
|
2016-03-21 |
2022-06-08 |
マレンゴ・セラピューティクス,インコーポレーテッド |
多重特異性および多機能性分子ならびにその使用
|
|
LT3433280T
(lt)
|
2016-03-22 |
2023-07-10 |
F. Hoffmann-La Roche Ag |
Proteazės aktyvuojamos t ląstelei bispecifinės molekulės
|
|
US11549099B2
(en)
|
2016-03-23 |
2023-01-10 |
Novartis Ag |
Cell secreted minibodies and uses thereof
|
|
CA3020864A1
(en)
|
2016-04-15 |
2017-10-19 |
Macrogenics, Inc. |
Novel b7-h3-binding molecules, antibody drug conjugates thereof and methods of use thereof
|
|
EP3443096B1
(en)
|
2016-04-15 |
2023-03-01 |
Novartis AG |
Compositions and methods for selective expression of chimeric antigen receptors
|
|
SG10202010156XA
(en)
|
2016-04-20 |
2020-11-27 |
Regeneron Pharma |
Compositions and methods for making antibodies based on use of an expression-enhancing locus
|
|
MX2018012868A
(es)
|
2016-04-20 |
2019-03-11 |
Regeneron Pharma |
Composiciones y metodos para generar anticuerpos basado en el uso de loci potenciadores de expresion.
|
|
SG11201809620UA
(en)
|
2016-05-02 |
2018-11-29 |
Hoffmann La Roche |
The contorsbody - a single chain target binder
|
|
AR108377A1
(es)
|
2016-05-06 |
2018-08-15 |
Medimmune Llc |
Proteínas de unión biespecíficas y sus usos
|
|
CN109478421B
(zh)
|
2016-05-25 |
2024-07-09 |
豪夫迈·罗氏有限公司 |
剂量方案设计相关的材料与方法
|
|
EP3252078A1
(en)
|
2016-06-02 |
2017-12-06 |
F. Hoffmann-La Roche AG |
Type ii anti-cd20 antibody and anti-cd20/cd3 bispecific antibody for treatment of cancer
|
|
CN110603266A
(zh)
|
2016-06-02 |
2019-12-20 |
豪夫迈·罗氏有限公司 |
用于治疗癌症的ii型抗cd20抗体和抗cd20/cd3双特异性抗体
|
|
US20210177896A1
(en)
|
2016-06-02 |
2021-06-17 |
Novartis Ag |
Therapeutic regimens for chimeric antigen receptor (car)- expressing cells
|
|
MA45255A
(fr)
|
2016-06-14 |
2019-04-17 |
Xencor Inc |
Anticorps inhibiteurs de points de contrôle bispécifiques
|
|
KR20190020341A
(ko)
|
2016-06-28 |
2019-02-28 |
젠코어 인코포레이티드 |
소마토스타틴 수용체 2에 결합하는 이종이량체 항체
|
|
US20190233533A1
(en)
|
2016-06-28 |
2019-08-01 |
Umc Utrecht Holding B.V. |
Treatment Of IgE-Mediated Diseases With Antibodies That Specifically Bind CD38
|
|
AU2017290389B2
(en)
|
2016-07-01 |
2024-09-26 |
Resolve Therapeutics, Llc |
Optimized binuclease fusions and methods
|
|
CN109415435B
(zh)
|
2016-07-04 |
2024-01-16 |
豪夫迈·罗氏有限公司 |
新型抗体形式
|
|
UA128304C2
(uk)
|
2016-07-14 |
2024-06-05 |
Ґенмаб А/С |
Мультиспецифічне антитіло до cd40 і cd137
|
|
SG11201900344YA
(en)
|
2016-07-15 |
2019-02-27 |
Novartis Ag |
Treatment and prevention of cytokine release syndrome using a chimeric antigen receptor in combination with a kinase inhibitor
|
|
CN110214150A
(zh)
|
2016-07-28 |
2019-09-06 |
诺华股份有限公司 |
嵌合抗原受体和pd-1抑制剂的组合疗法
|
|
EP3490590A2
(en)
|
2016-08-01 |
2019-06-05 |
Novartis AG |
Treatment of cancer using a chimeric antigen receptor in combination with an inhibitor of a pro-m2 macrophage molecule
|
|
KR102050463B1
(ko)
|
2016-08-10 |
2019-11-29 |
아주대학교산학협력단 |
항체 중쇄불변부위 이종이중체 (heterodimeric Fc)에 융합된 사이토카인 (heterodimeric Fc-fused cytokine) 및 이를 포함하는 약제학적 조성물
|
|
JP7009448B2
(ja)
|
2016-08-12 |
2022-02-10 |
ヤンセン バイオテツク,インコーポレーテツド |
強化されたアゴニスト活性を有する、Fcが遺伝子操作を受けた抗TNFRスーパーファミリーメンバー抗体及びその使用方法
|
|
MA45919A
(fr)
|
2016-08-12 |
2019-06-19 |
Janssen Biotech Inc |
Conception d'anticorps modifiés et d'autres molécules contenant un domaine fc présentant des fonctions d'agonisme et d'effecteur améliorées
|
|
US10793632B2
(en)
|
2016-08-30 |
2020-10-06 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
PL3512882T3
(pl)
*
|
2016-09-14 |
2022-01-10 |
Merck Patent Gmbh |
Przeciwciała anty-c-met i ich koniugaty przeciwciał z lekami do efektywnej inhibicji nowotworów
|
|
JP7525261B2
(ja)
|
2016-09-20 |
2024-07-30 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング |
診断用抗pd-l1抗体およびその使用
|
|
CN109791149A
(zh)
|
2016-09-30 |
2019-05-21 |
豪夫迈·罗氏有限公司 |
用于功能分析多特异性分子的基于spr的双重结合测定法
|
|
US10882918B2
(en)
|
2016-09-30 |
2021-01-05 |
Hoffmann-La Roche Inc. |
Bispecific T cell activating antigen binding molecules
|
|
WO2018067992A1
(en)
|
2016-10-07 |
2018-04-12 |
Novartis Ag |
Chimeric antigen receptors for the treatment of cancer
|
|
BR112019007281A2
(pt)
|
2016-10-14 |
2019-07-09 |
Xencor Inc |
proteína heterodimérica, composições de ácido nucleico e de vetor de expressão, vetor de expressão, célula hospedeira, e, métodos para produzir proteína heterodimérica e para tratar câncer em um paciente
|
|
JP7277363B2
(ja)
|
2016-11-01 |
2023-05-18 |
ジェンマブ ビー.ブイ. |
ポリペプチド変異体およびその使用
|
|
KR20190074300A
(ko)
|
2016-11-15 |
2019-06-27 |
제넨테크, 인크. |
항-cd20/항-cd3 이중특이적 항체에 의한 치료를 위한 투약
|
|
TW201829463A
(zh)
|
2016-11-18 |
2018-08-16 |
瑞士商赫孚孟拉羅股份公司 |
抗hla-g抗體及其用途
|
|
WO2018095932A1
(en)
|
2016-11-22 |
2018-05-31 |
Merck Patent Gmbh |
Monoclonal antibody directed to fgfr1
|
|
AU2017382234B2
(en)
|
2016-12-23 |
2025-01-30 |
Macrogenics, Inc. |
ADAM9-binding molecules, and methods of use thereof
|
|
EP3574005B1
(en)
|
2017-01-26 |
2021-12-15 |
Novartis AG |
Cd28 compositions and methods for chimeric antigen receptor therapy
|
|
KR20190113870A
(ko)
|
2017-02-02 |
2019-10-08 |
메르크 파텐트 게엠베하 |
항체 도메인의 바람직한 페어링
|
|
AU2018218345B2
(en)
|
2017-02-10 |
2025-04-03 |
Genmab B.V. |
Polypeptide variants and uses thereof
|
|
WO2018151820A1
(en)
|
2017-02-16 |
2018-08-23 |
Elstar Therapeutics, Inc. |
Multifunctional molecules comprising a trimeric ligand and uses thereof
|
|
JP7556687B2
(ja)
*
|
2017-02-24 |
2024-09-26 |
中外製薬株式会社 |
薬学的組成物、抗原結合分子、治療方法、およびスクリーニング方法
|
|
CN110382529B
(zh)
|
2017-03-02 |
2024-03-08 |
诺华股份有限公司 |
工程化的异源二聚体蛋白质
|
|
PT3592769T
(pt)
|
2017-03-09 |
2024-07-31 |
Genmab As |
Anticorpos contra pd-l1
|
|
RU2750721C2
(ru)
|
2017-03-10 |
2021-07-01 |
Ф. Хоффманн-Ля Рош Аг |
Способ получения мультиспецифических антител
|
|
JP7165717B2
(ja)
|
2017-03-15 |
2022-11-04 |
パンディオン・オペレーションズ・インコーポレイテッド |
標的免疫寛容
|
|
US11780925B2
(en)
|
2017-03-31 |
2023-10-10 |
Merus N.V. |
ErbB-2 and ErbB3 binding bispecific antibodies for use in the treatment of cells that have an NRG1 fusion gene
|
|
SG11201908772TA
(en)
|
2017-03-31 |
2019-10-30 |
Genmab Holding B V |
Bispecific anti-cd37 antibodies, monoclonal anti-cd37 antibodies and methods of use thereof
|
|
KR20200020662A
(ko)
|
2017-04-03 |
2020-02-26 |
온콜로지, 인크. |
면역-종양학 제제와 함께 ps-표적화 항체를 사용하여 암을 치료하는 방법
|
|
EP4201953A1
(en)
|
2017-04-03 |
2023-06-28 |
F. Hoffmann-La Roche AG |
Immunoconjugates of an anti-pd-1 antibody with a mutant il-2 or with il-15
|
|
SG11201909218RA
(en)
|
2017-04-03 |
2019-11-28 |
Hoffmann La Roche |
Antibodies binding to steap-1
|
|
JP7148539B2
(ja)
|
2017-04-03 |
2022-10-05 |
エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト |
免疫抱合体
|
|
SG11201909154SA
(en)
|
2017-04-05 |
2019-10-30 |
Hoffmann La Roche |
Bispecific antibodies specifically binding to pd1 and lag3
|
|
CA3058279A1
(en)
|
2017-04-13 |
2018-10-18 |
F.Hoffmann-La Roche Ag |
An interleukin-2 immunoconjugate, a cd40 agonist, and optionally a pd-1 axis binding antagonist for use in methods of treating cancer
|
|
US20200055948A1
(en)
|
2017-04-28 |
2020-02-20 |
Novartis Ag |
Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
|
|
US20200179511A1
(en)
|
2017-04-28 |
2020-06-11 |
Novartis Ag |
Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
|
|
US12195551B2
(en)
|
2017-05-17 |
2025-01-14 |
Merus N.V. |
Combination of an ErbB-2/ErbB-3 bispecific antibody with endocrine therapy for breast cancer
|
|
AU2018273914A1
(en)
|
2017-05-24 |
2019-11-14 |
Pandion Operations, Inc. |
Targeted immunotolerance
|
|
WO2018222901A1
(en)
|
2017-05-31 |
2018-12-06 |
Elstar Therapeutics, Inc. |
Multispecific molecules that bind to myeloproliferative leukemia (mpl) protein and uses thereof
|
|
MX2019014407A
(es)
|
2017-06-07 |
2020-02-05 |
Genmab Bv |
Anticuerpos terapeuticos basados en hexameros de inmunoglobulina g (igg) mutados.
|
|
GB201709970D0
(en)
|
2017-06-22 |
2017-08-09 |
Kymab Ltd |
Bispecific antigen-binding molecules
|
|
US11312783B2
(en)
|
2017-06-22 |
2022-04-26 |
Novartis Ag |
Antibody molecules to CD73 and uses thereof
|
|
US20200223924A1
(en)
|
2017-06-27 |
2020-07-16 |
Novartis Ag |
Dosage regimens for anti-tim-3 antibodies and uses thereof
|
|
AU2018291497A1
(en)
|
2017-06-30 |
2020-01-16 |
Xencor, Inc. |
Targeted heterodimeric Fc fusion proteins containing IL-15/IL-15Ra and antigen binding domains
|
|
AR112603A1
(es)
|
2017-07-10 |
2019-11-20 |
Lilly Co Eli |
Anticuerpos biespecíficos inhibidores de punto de control
|
|
EP3652209A2
(en)
|
2017-07-11 |
2020-05-20 |
Compass Therapeutics LLC |
Agonist antibodies that bind human cd137 and uses thereof
|
|
KR20200031659A
(ko)
|
2017-07-20 |
2020-03-24 |
노파르티스 아게 |
항-lag-3 항체의 투여 요법 및 그의 용도
|
|
IL272159B2
(en)
|
2017-08-04 |
2026-03-01 |
Genmab As |
PD-L1 and CD137 binding agents and their use
|
|
SI3665198T1
(sl)
|
2017-08-09 |
2025-06-30 |
Merus N.V. |
Protitelesa, ki vežejo egfr in cmet
|
|
WO2019035938A1
(en)
|
2017-08-16 |
2019-02-21 |
Elstar Therapeutics, Inc. |
MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF
|
|
US10947295B2
(en)
|
2017-08-22 |
2021-03-16 |
Sanabio, Llc |
Heterodimers of soluble interferon receptors and uses thereof
|
|
EP3676281A1
(en)
|
2017-08-30 |
2020-07-08 |
Ares Trading S.A. |
Method for purifying proteins
|
|
BR112020005742A2
(pt)
|
2017-09-21 |
2020-10-13 |
Umc Utrecht Holding B.V. |
anticorpo anti-gd2 para o tratamento de neuroblastoma
|
|
WO2019057805A1
(en)
|
2017-09-21 |
2019-03-28 |
Merck Patent Gmbh |
FUSION PROTEIN COMPRISING A FRACTION FGF-18
|
|
MX2020003497A
(es)
|
2017-10-20 |
2020-07-22 |
Hoffmann La Roche |
Metodo para generar anticuerpos multiespecificos a partir de anticuerpos monoespecificos.
|
|
AU2018358883B2
(en)
|
2017-10-30 |
2025-09-25 |
F. Hoffmann-La Roche Ag |
Method for in vivo generation of multispecific antibodies from monospecific antibodies
|
|
US11718679B2
(en)
|
2017-10-31 |
2023-08-08 |
Compass Therapeutics Llc |
CD137 antibodies and PD-1 antagonists and uses thereof
|
|
IL272747B2
(en)
|
2017-11-01 |
2025-04-01 |
Hoffmann La Roche |
Bispecific antibodies 1 + 2
|
|
EP3704150A1
(en)
|
2017-11-01 |
2020-09-09 |
F. Hoffmann-La Roche AG |
The compbody - a multivalent target binder
|
|
PL3704146T3
(pl)
|
2017-11-01 |
2022-03-07 |
F. Hoffmann-La Roche Ag |
Przeciwciało Contorsbody trifab
|
|
EP3703746A1
(en)
|
2017-11-01 |
2020-09-09 |
F. Hoffmann-La Roche AG |
Novel tnf family ligand trimer-containing antigen binding molecules
|
|
AU2018366199A1
(en)
|
2017-11-08 |
2020-05-28 |
Xencor, Inc. |
Bispecific and monospecific antibodies using novel anti-PD-1 sequences
|
|
US10981992B2
(en)
|
2017-11-08 |
2021-04-20 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
CN111655288A
(zh)
|
2017-11-16 |
2020-09-11 |
诺华股份有限公司 |
组合疗法
|
|
EP3713961A2
(en)
|
2017-11-20 |
2020-09-30 |
Compass Therapeutics LLC |
Cd137 antibodies and tumor antigen-targeting antibodies and uses thereof
|
|
USRE50550E1
(en)
|
2017-12-06 |
2025-08-26 |
Pandion Operations, Inc. |
IL-2 muteins and uses thereof
|
|
US10946068B2
(en)
|
2017-12-06 |
2021-03-16 |
Pandion Operations, Inc. |
IL-2 muteins and uses thereof
|
|
US10174091B1
(en)
|
2017-12-06 |
2019-01-08 |
Pandion Therapeutics, Inc. |
IL-2 muteins
|
|
JP2021505637A
(ja)
|
2017-12-12 |
2021-02-18 |
マクロジェニクス,インコーポレーテッド |
二重特異性cd16結合分子、及び疾患の治療におけるその使用
|
|
AU2018390418B2
(en)
|
2017-12-19 |
2023-12-21 |
Xencor, Inc. |
Engineered IL-2 Fc fusion proteins
|
|
BR112020011469A2
(pt)
|
2017-12-21 |
2020-11-24 |
F. Hoffmann-La Roche Ag |
anticorpos, molécula de ligação ao antígeno biespecífica, um ou mais polinucleotídeos isolados, um ou mais vetores, célula hospedeira, método para produzir um anticorpo, composição farmacêutica, uso do anticorpo, método de tratamento de uma doença e invenção
|
|
CN111491951B
(zh)
|
2017-12-22 |
2024-05-24 |
豪夫迈·罗氏有限公司 |
通过疏水相互作用色谱法耗尽轻链错配的抗体变体
|
|
WO2019139987A1
(en)
|
2018-01-09 |
2019-07-18 |
Elstar Therapeutics, Inc. |
Calreticulin binding constructs and engineered t cells for the treatment of diseases
|
|
EP3737949A1
(en)
|
2018-01-12 |
2020-11-18 |
Genzyme Corporation |
Methods for the quantitation of polypeptides
|
|
US12398209B2
(en)
|
2018-01-22 |
2025-08-26 |
Janssen Biotech, Inc. |
Methods of treating cancers with antagonistic anti-PD-1 antibodies
|
|
MA51666A
(fr)
|
2018-01-24 |
2020-12-02 |
Genmab Bv |
Variants polypeptidiques et leurs utilisations
|
|
AU2019215031C1
(en)
|
2018-01-31 |
2026-02-26 |
Novartis Ag |
Combination therapy using a chimeric antigen receptor
|
|
WO2019154776A1
(en)
|
2018-02-06 |
2019-08-15 |
F. Hoffmann-La Roche Ag |
Treatment of ophthalmologic diseases
|
|
AR115360A1
(es)
|
2018-02-08 |
2021-01-13 |
Genentech Inc |
Moléculas de unión al antígeno y métodos de uso
|
|
TWI829667B
(zh)
|
2018-02-09 |
2024-01-21 |
瑞士商赫孚孟拉羅股份公司 |
結合gprc5d之抗體
|
|
EP3753956A4
(en)
|
2018-02-14 |
2021-12-22 |
Chugai Seiyaku Kabushiki Kaisha |
ANTIGIBONDING MOLECULE AND COMBINATION
|
|
SG11202007572VA
(en)
|
2018-02-15 |
2020-09-29 |
Macrogenics Inc |
Variant cd3-binding domains and their use in combination therapies for the treatment of disease
|
|
CR20250347A
(es)
|
2018-03-12 |
2025-09-23 |
Genmab As |
ANTICUERPOS QUE SE UNEN A 5T4 (Divisional 2020-0463)
|
|
EP3765516A2
(en)
|
2018-03-14 |
2021-01-20 |
Elstar Therapeutics, Inc. |
Multifunctional molecules and uses thereof
|
|
US12152073B2
(en)
|
2018-03-14 |
2024-11-26 |
Marengo Therapeutics, Inc. |
Multifunctional molecules that bind to calreticulin and uses thereof
|
|
AU2019247415A1
(en)
|
2018-04-04 |
2020-10-22 |
Xencor, Inc. |
Heterodimeric antibodies that bind fibroblast activation protein
|
|
US20210147547A1
(en)
|
2018-04-13 |
2021-05-20 |
Novartis Ag |
Dosage Regimens For Anti-Pd-L1 Antibodies And Uses Thereof
|
|
JP2021520829A
(ja)
|
2018-04-18 |
2021-08-26 |
ゼンコア インコーポレイテッド |
IL−15/IL−15RA Fc融合タンパク質およびTIM−3抗原結合ドメインを含む、TIM−3標的化ヘテロ二量体融合タンパク質
|
|
AR114789A1
(es)
|
2018-04-18 |
2020-10-14 |
Hoffmann La Roche |
Anticuerpos anti-hla-g y uso de los mismos
|
|
JP7516254B2
(ja)
|
2018-04-18 |
2024-07-16 |
ゼンコア インコーポレイテッド |
Il-15/il-15raヘテロ二量体fc融合タンパク質およびその使用
|
|
AR115052A1
(es)
|
2018-04-18 |
2020-11-25 |
Hoffmann La Roche |
Anticuerpos multiespecíficos y utilización de los mismos
|
|
KR20210003813A
(ko)
|
2018-04-18 |
2021-01-12 |
젠코어 인코포레이티드 |
IL-15/IL-15Rα Fc-융합 단백질 및 LAG-3 항원 결합 도메인을 함유하는 LAG-3 표적화 이종이량체 융합 단백질
|
|
CA3097593A1
(en)
|
2018-04-18 |
2019-10-24 |
Xencor, Inc. |
Pd-1 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and pd-1 antigen binding domains and uses thereof
|
|
EP3784351A1
(en)
|
2018-04-27 |
2021-03-03 |
Novartis AG |
Car t cell therapies with enhanced efficacy
|
|
AU2019264217B2
(en)
|
2018-05-03 |
2026-03-05 |
Genmab B.V. |
Antibody variant combinations and uses thereof
|
|
SG11202011306TA
(en)
|
2018-05-16 |
2020-12-30 |
Janssen Biotech Inc |
Bcma/cd3 and gprdc5d/cd3 bispecific antibodies for use in cancer therapy
|
|
HRP20240756T1
(hr)
|
2018-05-18 |
2024-09-13 |
Daiichi Sankyo Co., Ltd. |
Anti-muc1-eksatekan antitijelo-lijek konjugat
|
|
WO2019226658A1
(en)
|
2018-05-21 |
2019-11-28 |
Compass Therapeutics Llc |
Multispecific antigen-binding compositions and methods of use
|
|
WO2019226617A1
(en)
|
2018-05-21 |
2019-11-28 |
Compass Therapeutics Llc |
Compositions and methods for enhancing the killing of target cells by nk cells
|
|
CR20200564A
(es)
|
2018-05-24 |
2021-06-21 |
Janssen Biotech Inc |
Anticuerpos anti-tmeff2 monoespecificos y multiespecificos y sus usos
|
|
CN112912397B
(zh)
|
2018-05-24 |
2025-03-14 |
詹森生物科技公司 |
抗cd3抗体及其用途
|
|
MA52777A
(fr)
|
2018-05-24 |
2021-04-14 |
Janssen Biotech Inc |
Agents de liaison psma et utilisations correspondantes
|
|
WO2019227003A1
(en)
|
2018-05-25 |
2019-11-28 |
Novartis Ag |
Combination therapy with chimeric antigen receptor (car) therapies
|
|
US20210214459A1
(en)
|
2018-05-31 |
2021-07-15 |
Novartis Ag |
Antibody molecules to cd73 and uses thereof
|
|
AU2019284911B2
(en)
|
2018-06-13 |
2026-04-09 |
Novartis Ag |
BCMA chimeric antigen receptors and uses thereof
|
|
KR20210035173A
(ko)
|
2018-06-19 |
2021-03-31 |
아타르가, 엘엘씨 |
보체 성분 5에 대한 항체분자 및 이의 용도
|
|
US12275797B2
(en)
|
2018-06-22 |
2025-04-15 |
Genmab Holding B.V. |
Anti-CD37 antibodies and anti-CD20 antibodies, compositions and methods of use thereof
|
|
WO2020010250A2
(en)
|
2018-07-03 |
2020-01-09 |
Elstar Therapeutics, Inc. |
Anti-tcr antibody molecules and uses thereof
|
|
AR116109A1
(es)
|
2018-07-10 |
2021-03-31 |
Novartis Ag |
Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
|
|
BR112020026432A2
(pt)
|
2018-07-13 |
2021-03-23 |
Genmab A/S |
variante de anticorpo, ácido nucleico isolado, vetor de expressão, ácido nucleico, combinação de ácidos nucleicos, veículo de dispensação, célula hospedeira recombinante, métodos para produção de uma variante de um anticorpo, para aumentar pelo menos uma função efetora de um anticorpo parental e para tratar uma doença, anticorpo, composição, composição farmacêutica, e, variante de anticorpo para uso
|
|
MA53123A
(fr)
|
2018-07-13 |
2021-05-19 |
Genmab As |
Thérapie à médiation par trogocytose utilisant des anticorps cd38
|
|
JP2021531306A
(ja)
|
2018-07-25 |
2021-11-18 |
アドバンスド アクセラレーター アプリケーションズ エスエー |
神経内分泌腫瘍の処置の方法
|
|
EP3845558A4
(en)
|
2018-08-29 |
2022-05-18 |
Chugai Seiyaku Kabushiki Kaisha |
ANTIBODY HALF-MOLECULE AND METHODS FOR INHIBITION OF HOMODIMER FORMATION OF ANTIBODY HALF-MOLECULE
|
|
CN113166197A
(zh)
|
2018-08-29 |
2021-07-23 |
默克生物发展联合股份公司 |
新纯化方法
|
|
GB2576914A
(en)
|
2018-09-06 |
2020-03-11 |
Kymab Ltd |
Antigen-binding molecules comprising unpaired variable domains produced in mammals
|
|
US12460000B2
(en)
|
2018-09-07 |
2025-11-04 |
Itabmed (Hk) Limited |
Anti-CD19 and anti-CD3 bispecific antigen binding proteins and uses thereof
|
|
AU2019349662A1
(en)
|
2018-09-24 |
2021-04-29 |
The Medical College Of Wisconsin, Inc. |
System and method for the development of cd30 bispecific antibodies for immunotherapy of cd30+ malignancies
|
|
SG11202103192RA
(en)
|
2018-10-03 |
2021-04-29 |
Xencor Inc |
Il-12 heterodimeric fc-fusion proteins
|
|
US20240252635A1
(en)
|
2018-10-04 |
2024-08-01 |
Genmab Holding B.V. |
Pharmaceutical compositions comprising bispecific anti-cd37 antibodies
|
|
CR20210239A
(es)
|
2018-10-12 |
2021-12-15 |
Xencor Inc |
Proteínas de fusión de il-15/il-15ralfa-fc dirigidas a pd-1 y usos de las mismas en terapias combinadas
|
|
CA3117212A1
(en)
|
2018-10-23 |
2020-04-30 |
Dragonfly Therapeutics, Inc. |
Heterodimeric fc-fused proteins
|
|
SG11202103064YA
(en)
|
2018-10-29 |
2021-05-28 |
Hoffmann La Roche |
Antibody formulation
|
|
KR20210087959A
(ko)
|
2018-11-02 |
2021-07-13 |
유니버시티 오브 워싱톤 |
직교 단백질 이종이량체
|
|
AU2019375014A1
(en)
|
2018-11-06 |
2021-05-27 |
Genmab A/S |
Antibody formulation
|
|
WO2020102387A1
(en)
|
2018-11-13 |
2020-05-22 |
Compass Therapeutics Llc |
Multispecific binding constructs against checkpoint molecules and uses thereof
|
|
CA3121699A1
(en)
|
2018-12-05 |
2020-06-11 |
Morphosys Ag |
Multispecific antigen-binding molecules
|
|
TWI874341B
(zh)
|
2018-12-18 |
2025-03-01 |
美商健生生物科技公司 |
產生異二聚體抗體之方法
|
|
GB201820687D0
(en)
|
2018-12-19 |
2019-01-30 |
Kymab Ltd |
Antagonists
|
|
JP2022514280A
(ja)
|
2018-12-20 |
2022-02-10 |
ノバルティス アーゲー |
Mdm2阻害剤のための延長低用量レジメン
|
|
CN113438961A
(zh)
|
2018-12-20 |
2021-09-24 |
Xencor股份有限公司 |
含有IL-15/IL-15Rα和NKG2D抗原结合结构域的靶向异二聚体Fc融合蛋白
|
|
WO2020128972A1
(en)
|
2018-12-20 |
2020-06-25 |
Novartis Ag |
Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives
|
|
US20220064327A1
(en)
|
2018-12-21 |
2022-03-03 |
Kymab Limited |
Fixaxfx bispecific antibody with common light chain
|
|
CN118271445A
(zh)
|
2018-12-21 |
2024-07-02 |
豪夫迈·罗氏有限公司 |
与cd3结合的抗体
|
|
EP3902823A1
(en)
|
2018-12-24 |
2021-11-03 |
Sanofi |
Multispecific binding proteins with mutant fab domains
|
|
WO2020132810A1
(en)
|
2018-12-24 |
2020-07-02 |
Generon (Shanghai) Corporation Ltd. |
Multispecific antigen binding proteins capable of binding cd19 and cd3, and use thereof
|
|
MA54601A
(fr)
|
2018-12-24 |
2022-03-30 |
Sanofi Sa |
Nouvelles protéines de liaison multi-spécifiques à base de pseudofab
|
|
US20220073630A1
(en)
|
2018-12-28 |
2022-03-10 |
Hoffmann-La Roche, Inc. |
A peptide-mhc-i-antibody fusion protein for therapeutic use in a patient with amplified immune response
|
|
JP2022516964A
(ja)
*
|
2019-01-07 |
2022-03-03 |
シャタック ラボ,インコーポレイテッド |
ガンマデルタt細胞を調節するためのヘテロ二量体タンパク質
|
|
TWI852977B
(zh)
|
2019-01-10 |
2024-08-21 |
美商健生生物科技公司 |
前列腺新抗原及其用途
|
|
PH12021551676A1
(en)
|
2019-01-18 |
2022-03-07 |
Janssen Biotech Inc |
Gprc5d chimeric antigen receptors and cells expressing the same
|
|
US10871640B2
(en)
|
2019-02-15 |
2020-12-22 |
Perkinelmer Cellular Technologies Germany Gmbh |
Methods and systems for automated imaging of three-dimensional objects
|
|
BR112021015672A2
(pt)
|
2019-02-15 |
2021-10-05 |
Novartis Ag |
Derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona substituída e usos dos mesmos
|
|
ES3032659T3
(en)
|
2019-02-15 |
2025-07-23 |
Novartis Ag |
3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
|
|
JP7706373B2
(ja)
|
2019-02-21 |
2025-07-11 |
マレンゴ・セラピューティクス,インコーポレーテッド |
カルレティキュリンに結合する多機能性分子およびその使用
|
|
EP3927745A1
(en)
|
2019-02-21 |
2021-12-29 |
Marengo Therapeutics, Inc. |
Multifunctional molecules that bind to t cells and uses thereof to treat autoimmune disorders
|
|
GB2597851B
(en)
|
2019-02-21 |
2024-05-29 |
Marengo Therapeutics Inc |
Antibody molecules that bind to NKP30 and uses thereof
|
|
AU2020226904B2
(en)
|
2019-02-21 |
2025-05-01 |
Marengo Therapeutics, Inc. |
Anti-TCR antibody molecules and uses thereof
|
|
AU2020226893B2
(en)
|
2019-02-21 |
2025-02-27 |
Marengo Therapeutics, Inc. |
Multifunctional molecules that bind to T cell related cancer cells and uses thereof
|
|
US20220088075A1
(en)
|
2019-02-22 |
2022-03-24 |
The Trustees Of The University Of Pennsylvania |
Combination therapies of egfrviii chimeric antigen receptors and pd-1 inhibitors
|
|
SG11202108311RA
(en)
|
2019-02-26 |
2021-09-29 |
Janssen Biotech Inc |
Combination therapies and patient stratification with bispecific anti-egfr/c-met antibodies
|
|
WO2020180726A1
(en)
|
2019-03-01 |
2020-09-10 |
Xencor, Inc. |
Heterodimeric antibodies that bind enpp3 and cd3
|
|
CN114096559B
(zh)
|
2019-03-27 |
2026-03-20 |
蒂嘉特克斯公司 |
工程化iga抗体及其使用方法
|
|
JP7412440B2
(ja)
|
2019-03-29 |
2024-01-12 |
エフ. ホフマン-ラ ロシュ アーゲー |
アビド結合多重特異性抗体を作製する方法
|
|
WO2020200941A1
(en)
|
2019-03-29 |
2020-10-08 |
F. Hoffmann-La Roche Ag |
Spr-based binding assay for the functional analysis of multivalent molecules
|
|
JP2022527790A
(ja)
|
2019-03-29 |
2022-06-06 |
アターガ,エルエルシー |
抗fgf23抗体分子
|
|
AR118720A1
(es)
|
2019-04-19 |
2021-10-27 |
Janssen Biotech Inc |
Métodos para tratar el cáncer de próstata con un anticuerpo anti-psma / cd3
|
|
JP7688584B2
(ja)
|
2019-04-25 |
2025-06-04 |
エフ. ホフマン-ラ ロシュ アーゲー |
ポリペプチド鎖の交換により活性化される治療用多重特異性ポリペプチド
|
|
WO2020216883A1
(en)
|
2019-04-25 |
2020-10-29 |
F. Hoffmann-La Roche Ag |
Activatable therapeutic multispecific polypeptides with extended half-life
|
|
CN113728002B
(zh)
|
2019-04-25 |
2024-11-12 |
豪夫迈·罗氏有限公司 |
通过多肽链交换产生抗体衍生的多肽
|
|
AU2020267504A1
(en)
|
2019-05-08 |
2021-12-02 |
Janssen Biotech, Inc. |
Materials and methods for modulating T cell mediated immunity
|
|
US20220315661A1
(en)
|
2019-05-09 |
2022-10-06 |
Genmab B.V. |
Dosage regimens for a combination of anti-dr5 antibodies for use in treating cancer
|
|
EP3969907B1
(en)
|
2019-05-13 |
2025-09-24 |
F. Hoffmann-La Roche AG |
Interference-suppressed pharmacokinetic immunoassay
|
|
US11850248B2
(en)
|
2019-05-14 |
2023-12-26 |
Yuhan Corporation |
Therapies with 3rd generation EGFR tyrosine kinase inhibitors
|
|
PH12021552798A1
(en)
|
2019-05-14 |
2022-09-19 |
Janssen Biotech Inc |
Combination therapies with bispecific anti-egfr/c-met antibodies and 3rd generation egfr tyrosine kinase inhibitors
|
|
CA3141327A1
(en)
|
2019-05-20 |
2020-11-26 |
Pandion Operations, Inc. |
Madcam targeted immunotolerance
|
|
JP2022533254A
(ja)
*
|
2019-05-24 |
2022-07-21 |
プロヴィヴァ セラピューティクス (ホン コン) リミテッド |
Il-2組成物およびその使用方法
|
|
BR112021025425A2
(pt)
|
2019-06-19 |
2022-02-01 |
Hoffmann La Roche |
Método para produzir uma célula de mamífero recombinante e uso de mrna de recombinase cre
|
|
HUE071032T2
(hu)
|
2019-06-26 |
2025-07-28 |
Hoffmann La Roche |
Emlõs sejtvonalak SIRT-1 gén kiiktatásával
|
|
TW202115115A
(zh)
|
2019-07-02 |
2021-04-16 |
瑞士商赫孚孟拉羅股份公司 |
免疫結合物
|
|
PH12021552960A1
(en)
|
2019-07-10 |
2022-07-25 |
Chugai Pharmaceutical Co Ltd |
Claudin-6 binding molecules and uses thereof
|
|
AR119393A1
(es)
|
2019-07-15 |
2021-12-15 |
Hoffmann La Roche |
Anticuerpos que se unen a nkg2d
|
|
TWI894157B
(zh)
|
2019-07-26 |
2025-08-21 |
美商健生生物科技公司 |
包含血管舒緩素相關肽酶2抗原結合域之蛋白質及其用途
|
|
JP2022543551A
(ja)
|
2019-07-31 |
2022-10-13 |
エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト |
Gprc5dに結合する抗体
|
|
CN119192386A
(zh)
|
2019-07-31 |
2024-12-27 |
豪夫迈·罗氏有限公司 |
与gprc5d结合的抗体
|
|
BR112022002540A2
(pt)
|
2019-08-15 |
2022-06-14 |
Janssen Biotech Inc |
Materiais e métodos para fragmentos variáveis de cadeia única aprimorados
|
|
TW202128757A
(zh)
|
2019-10-11 |
2021-08-01 |
美商建南德克公司 |
具有改善之特性的 PD-1 標靶 IL-15/IL-15Rα FC 融合蛋白
|
|
CA3158298A1
(en)
|
2019-10-21 |
2021-04-29 |
Novartis Ag |
Combination therapies with venetoclax and tim-3 inhibitors
|
|
TW202128191A
(zh)
|
2019-10-21 |
2021-08-01 |
瑞士商諾華公司 |
Tim-3抑制劑及其用途
|
|
EP4055046A1
(en)
|
2019-11-06 |
2022-09-14 |
Genmab B.V. |
Antibody variant combinations and uses thereof
|
|
EP4061837A1
(en)
|
2019-11-18 |
2022-09-28 |
Janssen Biotech, Inc. |
Anti-cd79 chimeric antigen receptors, car-t cells, and uses thereof
|
|
EP4065158A2
(en)
|
2019-11-26 |
2022-10-05 |
Novartis AG |
Chimeric antigen receptors binding bcma and cd19 and uses thereof
|
|
BR112022011357A2
(pt)
|
2019-12-13 |
2022-08-23 |
Genentech Inc |
Anticorpos isolado, um ou mais ácidos nucleicos isolados, um ou mais vetores, uma ou mais células hospedeiras, composição, kit, uso do anticorpo, métodos para produzir o anticorpo e método para tratar ou retardar a progressão de um câncer ly6g6d positivo
|
|
JP7296467B2
(ja)
|
2019-12-18 |
2023-06-22 |
エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト |
Hla-a2/mage-a4に結合する抗体
|
|
WO2021122733A1
(en)
|
2019-12-18 |
2021-06-24 |
F. Hoffmann-La Roche Ag |
Bispecific anti-ccl2 antibodies
|
|
KR20220116257A
(ko)
|
2019-12-20 |
2022-08-22 |
노파르티스 아게 |
골수섬유증 및 골수이형성 증후군을 치료하기 위한, 데시타빈 또는 항 pd-1 항체 스파르탈리주맙을 포함하거나 또는 포함하지 않는, 항 tim-3 항체 mbg453 및 항 tgf-베타 항체 nis793의 조합물
|
|
EP4085251B1
(en)
|
2020-01-02 |
2024-07-31 |
F. Hoffmann-La Roche AG |
Method for determining the amount of a therapeutic antibody in the brain
|
|
AU2020416273A1
(en)
|
2020-01-03 |
2022-07-28 |
Marengo Therapeutics, Inc. |
Anti-TCR antibody molecules and uses thereof
|
|
WO2021138407A2
(en)
|
2020-01-03 |
2021-07-08 |
Marengo Therapeutics, Inc. |
Multifunctional molecules that bind to cd33 and uses thereof
|
|
MX2022008050A
(es)
|
2020-01-16 |
2022-07-27 |
Genmab As |
Formulaciones de anticuerpos anti cumulo de diferenciacion 38 (cd38) y usos de las mismas.
|
|
EP4090762A1
(en)
|
2020-01-17 |
2022-11-23 |
Becton, Dickinson and Company |
Methods and compositions for single cell secretomics
|
|
US20230058489A1
(en)
|
2020-01-17 |
2023-02-23 |
Novartis Ag |
Combination comprising a tim-3 inhibitor and a hypomethylating agent for use in treating myelodysplastic syndrome or chronic myelomonocytic leukemia
|
|
CN115697388A
(zh)
|
2020-01-30 |
2023-02-03 |
优莫佳生物制药股份有限公司 |
双特异性转导增强子
|
|
WO2021155916A1
(en)
|
2020-02-04 |
2021-08-12 |
BioNTech SE |
Treatment involving antigen vaccination and binding agents binding to pd-l1 and cd137
|
|
JP7783182B2
(ja)
|
2020-02-12 |
2025-12-09 |
ヤンセン バイオテツク,インコーポレーテツド |
c-METエクソン14スキッピング変異を有する患者の治療
|
|
TW202144389A
(zh)
|
2020-02-14 |
2021-12-01 |
美商健生生物科技公司 |
在多發性骨髓瘤中表現之新抗原及其用途
|
|
TW202144388A
(zh)
|
2020-02-14 |
2021-12-01 |
美商健生生物科技公司 |
在卵巢癌中表現之新抗原及其用途
|
|
WO2021168079A1
(en)
|
2020-02-21 |
2021-08-26 |
Pandion Operations, Inc. |
Tissue targeted immunotolerance with a cd39 effector
|
|
MX2022010685A
(es)
|
2020-02-27 |
2022-09-23 |
Novartis Ag |
Metodos de produccion de celulas que expresan receptores de antigeno quimericos.
|
|
KR20230051617A
(ko)
|
2020-03-13 |
2023-04-18 |
얀센 바이오테크 인코포레이티드 |
Siglec-3/cd33을 결합시키기 위한 물질 및 방법
|
|
EP4121456A1
(en)
|
2020-03-18 |
2023-01-25 |
Genmab A/S |
Antibodies binding to b7h4
|
|
WO2021190980A1
(en)
|
2020-03-22 |
2021-09-30 |
Quadrucept Bio Limited |
Multimers for viral strain evolution
|
|
US20230242671A1
(en)
|
2020-03-25 |
2023-08-03 |
Eli Lilly And Company |
Multispecific binding proteins and methods of developing the same
|
|
EP4126942A1
(en)
*
|
2020-03-30 |
2023-02-08 |
Sanofi |
Split ch2 domains
|
|
BR112022020753A2
(pt)
|
2020-04-15 |
2022-12-20 |
Voyager Therapeutics Inc |
Compostos de ligação a tau
|
|
MX2022012541A
(es)
|
2020-04-15 |
2022-11-07 |
Hoffmann La Roche |
Inmunoconjugados.
|
|
KR20230028242A
(ko)
|
2020-04-24 |
2023-02-28 |
마렝고 테라퓨틱스, 인크. |
T 세포 관련 암 세포에 결합하는 다중기능성 분자 및 그것의 용도
|
|
EP4142722A1
(en)
|
2020-04-30 |
2023-03-08 |
Bristol-Myers Squibb Company |
Methods of treating cytokine-related adverse events
|
|
BR112022022730A2
(pt)
|
2020-05-08 |
2023-02-14 |
Genmab As |
Método para tratar um linfoma não hodgkin de células b em um indivíduo humano
|
|
CA3177288A1
(en)
|
2020-05-11 |
2021-11-18 |
F.Hoffmann-La Roche Ag |
Combination therapy with modified pbmcs and an immunoconjugate
|
|
WO2021231976A1
(en)
|
2020-05-14 |
2021-11-18 |
Xencor, Inc. |
Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3
|
|
CA3184189A1
(en)
|
2020-05-27 |
2021-12-02 |
Janssen Biotech, Inc. |
Proteins comprising cd3 antigen binding domains and uses thereof
|
|
US20230310629A1
(en)
|
2020-06-03 |
2023-10-05 |
Merck Patent Gmbh |
Bispecific antibody-drug conjugates targeting egfr and muc1 and uses thereof
|
|
AR122658A1
(es)
|
2020-06-19 |
2022-09-28 |
Hoffmann La Roche |
Anticuerpos que se unen a cd3
|
|
WO2021255146A1
(en)
|
2020-06-19 |
2021-12-23 |
F. Hoffmann-La Roche Ag |
Antibodies binding to cd3 and cea
|
|
TWI852680B
(zh)
|
2020-06-19 |
2024-08-11 |
瑞士商赫孚孟拉羅股份公司 |
與 cd3 及 cd19 結合之抗體
|
|
MX2022015203A
(es)
|
2020-06-19 |
2023-01-05 |
Hoffmann La Roche |
Moleculas de union al dominio fc de activacion inmunitaria.
|
|
MX2022015887A
(es)
|
2020-06-19 |
2023-01-24 |
Hoffmann La Roche |
Anticuerpos que se unen a cd3 y folr1.
|
|
CN115916199A
(zh)
|
2020-06-23 |
2023-04-04 |
诺华股份有限公司 |
包含3-(1-氧代异吲哚啉-2-基)哌啶-2,6-二酮衍生物的给药方案
|
|
WO2022009052A2
(en)
|
2020-07-06 |
2022-01-13 |
Janssen Biotech, Inc. |
Prostate neoantigens and their uses
|
|
US11524998B2
(en)
|
2020-07-16 |
2022-12-13 |
Novartis Ag |
Anti-betacellulin antibodies, fragments thereof, and multi-specific binding molecules
|
|
EP4185388A1
(en)
|
2020-07-23 |
2023-05-31 |
Genmab B.V. |
A combination of anti-dr5 antibodies and an immunomodulatory imide drug for use in treating multiple myeloma
|
|
WO2022026592A2
(en)
|
2020-07-28 |
2022-02-03 |
Celltas Bio, Inc. |
Antibody molecules to coronavirus and uses thereof
|
|
US11827708B2
(en)
|
2020-07-29 |
2023-11-28 |
Janssen Biotech, Inc. |
Proteins comprising HLA-G antigen binding domains and their uses
|
|
US20230271940A1
(en)
|
2020-08-03 |
2023-08-31 |
Novartis Ag |
Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
|
|
EP4192859A1
(en)
|
2020-08-06 |
2023-06-14 |
BioNTech SE |
Binding agents for coronavirus s protein
|
|
CA3192204A1
(en)
|
2020-08-19 |
2022-02-24 |
Xencor, Inc. |
Anti-cd28 and/or anti-b7h3 compositions
|
|
US12528869B2
(en)
|
2020-08-25 |
2026-01-20 |
Janssen Biotech, Inc. |
Treatment of non-small cell lung cancer with EGFR mutations
|
|
CN116249718A
(zh)
|
2020-08-26 |
2023-06-09 |
马伦戈治疗公司 |
结合至钙网蛋白的多功能性分子及其用途
|
|
GB2616354A
(en)
|
2020-08-26 |
2023-09-06 |
Marengo Therapeutics Inc |
Methods of detecting TRBC1 or TRBC2
|
|
KR20230074144A
(ko)
|
2020-08-26 |
2023-05-26 |
마렝고 테라퓨틱스, 인크. |
NKp30에 결합하는 항체 분자 및 이의 용도
|
|
WO2022043557A1
(en)
|
2020-08-31 |
2022-03-03 |
Advanced Accelerator Applications International Sa |
Method of treating psma-expressing cancers
|
|
EP4204020A1
(en)
|
2020-08-31 |
2023-07-05 |
Advanced Accelerator Applications International S.A. |
Method of treating psma-expressing cancers
|
|
JP2023539525A
(ja)
|
2020-09-02 |
2023-09-14 |
ジェンマブ エー/エス |
抗体療法
|
|
EP4210746A1
(en)
|
2020-09-10 |
2023-07-19 |
Genmab A/S |
Bispecific antibodies against cd3 and cd20 for treating chronic lymphocytic leukemia
|
|
US20240034812A1
(en)
|
2020-09-10 |
2024-02-01 |
Genmab A/S |
Bispecific antibody against cd3 and cd20 in combination therapy for treating diffuse large b-cell lymphoma
|
|
JP2023544254A
(ja)
|
2020-09-14 |
2023-10-23 |
ストロ バイオファーマ, インコーポレイテッド |
無細胞タンパク質合成系を用いた抗体の大規模産生方法
|
|
AU2021347580A1
(en)
|
2020-09-24 |
2023-04-06 |
F. Hoffmann-La Roche Ag |
Mammalian cell lines with gene knockout
|
|
KR20230080437A
(ko)
|
2020-10-02 |
2023-06-07 |
젠맵 에이/에스 |
Ror2에 결합할 수 있는 항체 및 ror2 및 cd3에 결합하는 이중특이적 항체
|
|
EP4228693A4
(en)
|
2020-10-13 |
2024-12-18 |
Janssen Biotech, Inc. |
BIOTECHNOLOGICALLY ENGINEERED T-CELL-MEDIATED IMMUNITY, MATERIALS AND OTHER METHODS FOR MODULATING A CLUSTER OF DIFFERENTIATION IV AND/OR VIII
|
|
KR20230110523A
(ko)
|
2020-10-22 |
2023-07-24 |
얀센 바이오테크 인코포레이티드 |
델타-유사 리간드 3(dll3) 항원 결합 영역을 포함하는 단백질 및 그의 용도
|
|
US12024559B2
(en)
|
2020-10-23 |
2024-07-02 |
Asher Biotherapeutics, Inc. |
Fusions with CD8 antigen binding molecules for modulating immune cell function
|
|
TW202233674A
(zh)
|
2020-10-28 |
2022-09-01 |
美商健生生物科技公司 |
用於調節δγ鏈介導之免疫的組成物及方法
|
|
TWI874719B
(zh)
|
2020-11-04 |
2025-03-01 |
美商建南德克公司 |
用抗cd20/抗cd3雙特異性抗體進行治療之給藥
|
|
KR20230095113A
(ko)
|
2020-11-04 |
2023-06-28 |
제넨테크, 인크. |
항-cd20/항-cd3 이중특이적 항체들과 항-cd79b 항체 약물 접합체들을 이용한 치료를 위한 투약
|
|
AU2021374590A1
(en)
|
2020-11-04 |
2023-06-01 |
Genentech, Inc. |
Subcutaneous dosing of anti-cd20/anti-cd3 bispecific antibodies
|
|
JP2023547499A
(ja)
|
2020-11-06 |
2023-11-10 |
ノバルティス アーゲー |
抗体Fc変異体
|
|
JP7853992B2
(ja)
|
2020-11-10 |
2026-04-30 |
上海齊魯制藥研究中心有限公司 |
クローディン18a2及びcd3に対する二重特異性抗体及びその使用
|
|
MX2023005609A
(es)
|
2020-11-13 |
2023-05-29 |
Novartis Ag |
Terapias de combinacion con celulas que expresan receptores quimericos para el antigeno (car).
|
|
WO2022128716A1
(en)
|
2020-12-17 |
2022-06-23 |
Merck Patent Gmbh |
Pharmaceutical composition comprising a bispecific anti-muc1/egfr antibody-drug conjugate
|
|
CR20230263A
(es)
|
2020-12-17 |
2023-08-21 |
Hoffmann La Roche |
Anticuerpos anti-hla-g y uso de estos
|
|
CN116601175A
(zh)
|
2020-12-18 |
2023-08-15 |
豪夫迈·罗氏有限公司 |
用于靶向疗法的前体蛋白和试剂盒
|
|
CN116670282A
(zh)
|
2020-12-22 |
2023-08-29 |
豪夫迈·罗氏有限公司 |
靶向xbp1的寡核苷酸
|
|
MX2023007846A
(es)
|
2021-01-06 |
2023-07-07 |
Hoffmann La Roche |
Tratamiento conjunto que usa un anticuerpo biespecifico contra pd1-lag3 y un anticuerpo biespecifico de linfocitos t cd20.
|
|
WO2022148853A1
(en)
|
2021-01-11 |
2022-07-14 |
F. Hoffmann-La Roche Ag |
Immunoconjugates
|
|
KR20230137393A
(ko)
|
2021-01-28 |
2023-10-04 |
얀센 바이오테크 인코포레이티드 |
Psma 결합 단백질 및 이의 용도
|
|
EP4284510A1
(en)
|
2021-01-29 |
2023-12-06 |
Novartis AG |
Dosage regimes for anti-cd73 and anti-entpd2 antibodies and uses thereof
|
|
US11639396B2
(en)
|
2021-02-16 |
2023-05-02 |
Janssen Biotech, Inc. |
Antibody binding to a linker peptide
|
|
WO2022175217A1
(en)
|
2021-02-18 |
2022-08-25 |
F. Hoffmann-La Roche Ag |
Method for resolving complex, multistep antibody interactions
|
|
WO2022184659A1
(en)
|
2021-03-01 |
2022-09-09 |
Quadrucept Bio Limited |
Antibody domains & multimers
|
|
KR20230156079A
(ko)
|
2021-03-09 |
2023-11-13 |
젠코어 인코포레이티드 |
Cd3과 cldn6에 결합하는 이종이량체 항체
|
|
JP2024509920A
(ja)
|
2021-03-09 |
2024-03-05 |
ヤンセン バイオテツク,インコーポレーテツド |
Egfr活性化変異を欠くがんの治療
|
|
US11859012B2
(en)
|
2021-03-10 |
2024-01-02 |
Xencor, Inc. |
Heterodimeric antibodies that bind CD3 and GPC3
|
|
WO2022189667A1
(en)
|
2021-03-12 |
2022-09-15 |
Genmab A/S |
Non-activating antibody variants
|
|
WO2022201053A1
(en)
|
2021-03-24 |
2022-09-29 |
Janssen Biotech, Inc. |
Proteins comprising cd3 antigen binding domains and uses thereof
|
|
CA3214259A1
(en)
|
2021-03-24 |
2022-09-29 |
Janssen Biotech, Inc. |
Antibody targeting cd22 and cd79b
|
|
CN116897159A
(zh)
|
2021-03-31 |
2023-10-17 |
江苏恒瑞医药股份有限公司 |
截短的taci多肽及其融合蛋白和用途
|
|
TW202304979A
(zh)
|
2021-04-07 |
2023-02-01 |
瑞士商諾華公司 |
抗TGFβ抗體及其他治療劑用於治療增殖性疾病之用途
|
|
JP2024515591A
(ja)
|
2021-04-08 |
2024-04-10 |
マレンゴ・セラピューティクス,インコーポレーテッド |
Tcrに結合する多機能性分子およびその使用
|
|
JP7642857B2
(ja)
|
2021-04-22 |
2025-03-10 |
広東菲鵬制▲薬▼股▲ふん▼有限公司 |
二重特異性多機能性融合ポリペプチド
|
|
WO2022228705A1
(en)
|
2021-04-30 |
2022-11-03 |
F. Hoffmann-La Roche Ag |
Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate
|
|
AU2021443863A1
(en)
|
2021-04-30 |
2023-10-26 |
F. Hoffmann-La Roche Ag |
Dosing for treatment with anti-cd20/anti-cd3 bispecific antibody
|
|
AR125815A1
(es)
|
2021-05-07 |
2023-08-16 |
Genmab As |
Composiciones farmacéuticas que comprenden anticuerpos biespecíficos que se unen a b7h4 y cd3
|
|
CA3218542A1
(en)
|
2021-05-12 |
2022-11-17 |
Hua Ying |
Antigen binding molecule specifically binding to rankl and ngf, and medical use thereof
|
|
CA3219388A1
(en)
|
2021-05-14 |
2022-11-17 |
Jiangsu Hengrui Pharmaceuticals Co., Ltd. |
Antigen-binding molecule
|
|
KR20240007171A
(ko)
|
2021-05-14 |
2024-01-16 |
제넨테크, 인크. |
모수네투주맙 및 폴라투주맙 베도틴을 이용한 cd20 양성 증식성 장애의 치료 방법
|
|
AR125874A1
(es)
|
2021-05-18 |
2023-08-23 |
Novartis Ag |
Terapias de combinación
|
|
TW202309094A
(zh)
|
2021-05-18 |
2023-03-01 |
美商健生生物科技公司 |
用於識別癌症患者以進行組合治療之方法
|
|
GB2638094B
(en)
|
2021-05-19 |
2026-03-04 |
Asher Biotherapeutics Inc |
IL-21 Polypeptides And Targeted Constructs
|
|
WO2022263501A1
(en)
|
2021-06-18 |
2022-12-22 |
F. Hoffmann-La Roche Ag |
Bispecific anti-ccl2 antibodies
|
|
WO2022268740A1
(en)
|
2021-06-21 |
2022-12-29 |
Genmab A/S |
Combination dosage regime of cd137 and pd-l1 binding agents
|
|
CA3223534A1
(en)
|
2021-07-02 |
2023-01-05 |
Genentech, Inc. |
Methods and compositions for treating cancer
|
|
MX2024000501A
(es)
|
2021-07-14 |
2024-01-31 |
Jiangsu Hengrui Pharmaceuticals Co Ltd |
Molecula de union a antigeno que se une especificamente a hgfr y egfr, y su uso farmaceutico.
|
|
EP4373859A1
(en)
|
2021-07-22 |
2024-05-29 |
F. Hoffmann-La Roche AG |
Heterodimeric fc domain antibodies
|
|
US20250101103A1
(en)
|
2021-07-27 |
2025-03-27 |
Morphosys Ag |
Combinations of antigen binding molecules
|
|
KR20240038008A
(ko)
|
2021-07-28 |
2024-03-22 |
에프. 호프만-라 로슈 아게 |
암 치료 방법 및 조성물
|
|
US20230109496A1
(en)
|
2021-09-06 |
2023-04-06 |
Genmab B.V. |
Antibodies capable of binding to cd27, variants thereof and uses thereof
|
|
AU2022344595A1
(en)
|
2021-09-13 |
2024-05-02 |
Janssen Biotech, Inc |
CD33 X Vδ2 MULTISPECIFIC ANTIBODIES FOR THE TREATMENT OF CANCER
|
|
EP4405396A2
(en)
|
2021-09-20 |
2024-07-31 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of her2 positive cancer
|
|
JP2024534531A
(ja)
|
2021-09-23 |
2024-09-20 |
江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司 |
抗klb抗体及び使用
|
|
US20250019455A1
(en)
|
2021-09-24 |
2025-01-16 |
Pharmaceutica Nv |
Proteins comprising cd20 binding domains, and uses thereof
|
|
TW202323304A
(zh)
|
2021-09-30 |
2023-06-16 |
大陸商江蘇恆瑞醫藥股份有限公司 |
抗il23抗體融合蛋白及用途
|
|
AR127298A1
(es)
|
2021-10-08 |
2024-01-10 |
Genmab As |
Anticuerpos que se unen a cd30 y cd3
|
|
CN118139648A
(zh)
|
2021-10-14 |
2024-06-04 |
豪夫迈·罗氏有限公司 |
用于治疗癌症的替代的PD1-IL7v免疫缀合物
|
|
AU2022362681A1
(en)
|
2021-10-14 |
2024-04-04 |
F. Hoffmann-La Roche Ag |
New interleukin-7 immunoconjugates
|
|
WO2023081705A1
(en)
|
2021-11-03 |
2023-05-11 |
Janssen Biotech, Inc. |
Methods of treating cancers and enhancing efficacy of bcmaxcd3 bispecific antibodies
|
|
EP4433506A1
(en)
|
2021-11-16 |
2024-09-25 |
Genentech, Inc. |
Methods and compositions for treating systemic lupus erythematosus (sle) with mosunetuzumab
|
|
US20250034559A1
(en)
|
2021-11-17 |
2025-01-30 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of tau-related disorders
|
|
MX2024006205A
(es)
|
2021-11-22 |
2024-08-19 |
Janssen Biotech Inc |
Composiciones que comprenden agentes de unión multiespecíficos potenciados para una respuesta inmunitaria.
|
|
JP2024544607A
(ja)
|
2021-11-25 |
2024-12-03 |
エフ. ホフマン-ラ ロシュ アーゲー |
少量の抗体副産物の定量
|
|
US20230183360A1
(en)
|
2021-12-09 |
2023-06-15 |
Janssen Biotech, Inc. |
Use of Amivantamab to Treat Colorectal Cancer
|
|
AR127887A1
(es)
|
2021-12-10 |
2024-03-06 |
Hoffmann La Roche |
Anticuerpos que se unen a cd3 y plap
|
|
CN118574855B
(zh)
|
2022-02-07 |
2026-05-12 |
江苏恒瑞医药股份有限公司 |
特异性结合psma和cd3的抗原结合分子及其医药用途
|
|
TW202342548A
(zh)
|
2022-02-07 |
2023-11-01 |
美商威特拉公司 |
抗獨特型(anti-idiotype)抗體分子及其用途
|
|
TW202342057A
(zh)
|
2022-02-07 |
2023-11-01 |
美商健生生物科技公司 |
用於減少用egfr/met雙特異性抗體治療之患者的輸注相關反應之方法
|
|
MX2024009715A
(es)
|
2022-02-11 |
2024-08-19 |
Jiangsu Hengrui Pharmaceuticals Co Ltd |
Inmunoconjugado y su uso del mismo.
|
|
CN118660910A
(zh)
|
2022-03-14 |
2024-09-17 |
江苏恒瑞医药股份有限公司 |
特异性结合gprc5d和cd3的抗原结合分子及其医药用途
|
|
WO2023174521A1
(en)
|
2022-03-15 |
2023-09-21 |
Genmab A/S |
Binding agents binding to epcam and cd137
|
|
EP4493585A1
(en)
|
2022-03-17 |
2025-01-22 |
Astrazeneca AB |
Methods for purifying bispecific antibodies
|
|
WO2023180353A1
(en)
|
2022-03-23 |
2023-09-28 |
F. Hoffmann-La Roche Ag |
Combination treatment of an anti-cd20/anti-cd3 bispecific antibody and chemotherapy
|
|
JP2025510232A
(ja)
|
2022-03-29 |
2025-04-14 |
エヌジーエム バイオファーマシューティカルス,インコーポレーテッド |
Ilt3及びcd3結合剤及びその使用方法
|
|
CA3255366A1
(en)
|
2022-04-13 |
2023-10-19 |
F. Hoffmann-La Roche Ag |
Pharmaceutical compositions based on bispecific anti-CD20/anti-CD3 antibodies and methods of use
|
|
WO2023202967A1
(en)
|
2022-04-19 |
2023-10-26 |
F. Hoffmann-La Roche Ag |
Improved production cells
|
|
WO2023209568A1
(en)
|
2022-04-26 |
2023-11-02 |
Novartis Ag |
Multispecific antibodies targeting il-13 and il-18
|
|
CA3253038A1
(en)
|
2022-05-12 |
2023-11-16 |
Genmab A/S |
LIAISON AGENTS CAPABLE OF BINDING TO CD27 IN POLYTHERAPY
|
|
CN119365215A
(zh)
|
2022-05-12 |
2025-01-24 |
健玛保 |
在组合疗法中能够结合cd27的结合剂
|
|
EP4522757A2
(en)
|
2022-05-13 |
2025-03-19 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of her2 positive cancer
|
|
CN119630690A
(zh)
|
2022-06-03 |
2025-03-14 |
豪夫迈·罗氏有限公司 |
改进的生产细胞
|
|
EP4545564A4
(en)
|
2022-06-23 |
2026-01-14 |
Jiangsu Hengrui Pharmaceuticals Co Ltd |
Antigen-binding molecule specifically binding to DLL3 and CD3, and its pharmaceutical use
|
|
MA71324A
(fr)
|
2022-06-30 |
2025-04-30 |
Janssen Biotech, Inc. |
Utilisation d'un anticorps anti-egfr/anti-met pour traiter le cancer gastrique ou oesophagien
|
|
JP2025528068A
(ja)
|
2022-08-03 |
2025-08-26 |
ボイジャー セラピューティクス インコーポレイテッド |
血液脳関門を通過させるための組成物及び方法
|
|
CN119546645A
(zh)
|
2022-08-05 |
2025-02-28 |
江苏恒瑞医药股份有限公司 |
特异性结合gucy2c和cd3的抗原结合分子及其医药用途
|
|
CN120019071A
(zh)
|
2022-09-15 |
2025-05-16 |
沃雅戈治疗公司 |
Tau结合化合物
|
|
TW202430211A
(zh)
|
2022-10-10 |
2024-08-01 |
瑞士商赫孚孟拉羅股份公司 |
Gprc5d tcb及imid之組合療法
|
|
TW202423970A
(zh)
|
2022-10-10 |
2024-06-16 |
瑞士商赫孚孟拉羅股份公司 |
Gprc5d tcb及cd38抗體之組合療法
|
|
TW202423969A
(zh)
|
2022-10-10 |
2024-06-16 |
瑞士商赫孚孟拉羅股份公司 |
Gprc5d tcb及蛋白酶體抑制劑之組合療法
|
|
EP4602371A1
(en)
|
2022-10-12 |
2025-08-20 |
F. Hoffmann-La Roche AG |
Method for classifying cells
|
|
WO2024089551A1
(en)
|
2022-10-25 |
2024-05-02 |
Janssen Biotech, Inc. |
Msln and cd3 binding agents and methods of use thereof
|
|
US20250382378A1
(en)
|
2022-10-31 |
2025-12-18 |
Genmab A/S |
Cd38 antibodies and uses thereof
|
|
WO2024094017A1
(zh)
|
2022-11-01 |
2024-05-10 |
上海齐鲁制药研究中心有限公司 |
一种针对磷脂酰肌醇蛋白聚糖3的双特异性抗体及其应用
|
|
IL320562A
(en)
|
2022-11-02 |
2025-07-01 |
Janssen Biotech Inc |
Cancer treatment methods
|
|
WO2024100170A1
(en)
|
2022-11-11 |
2024-05-16 |
F. Hoffmann-La Roche Ag |
Antibodies binding to hla-a*02/foxp3
|
|
EP4619428A1
(en)
|
2022-11-15 |
2025-09-24 |
F. Hoffmann-La Roche AG |
Antigen binding molecules
|
|
WO2024104988A1
(en)
|
2022-11-15 |
2024-05-23 |
F. Hoffmann-La Roche Ag |
Recombinant binding proteins with activatable effector domain
|
|
WO2024107752A2
(en)
|
2022-11-15 |
2024-05-23 |
Onestone Therapeutics Llc |
Compositions and methods for immunomodulatory bifunctional fusion molecules
|
|
CN120077072A
(zh)
|
2022-11-29 |
2025-05-30 |
江苏恒瑞医药股份有限公司 |
Cldn18.2/4-1bb结合蛋白及其医药用途
|
|
EP4651886A1
(en)
|
2023-01-20 |
2025-11-26 |
F. Hoffmann-La Roche AG |
Immunoconjugates
|
|
CN120569410A
(zh)
|
2023-01-25 |
2025-08-29 |
豪夫迈·罗氏有限公司 |
与csf1r和cd3结合的抗体
|
|
TW202436339A
(zh)
|
2023-01-31 |
2024-09-16 |
瑞士商赫孚孟拉羅股份公司 |
治療選自非小細胞肺癌或三陰性乳癌的癌症之用途
|
|
WO2024163009A1
(en)
|
2023-01-31 |
2024-08-08 |
Genentech, Inc. |
Methods and compositions for treating urothelial bladder cancer
|
|
WO2024168061A2
(en)
|
2023-02-07 |
2024-08-15 |
Ayan Therapeutics Inc. |
Antibody molecules binding to sars-cov-2
|
|
TW202434647A
(zh)
|
2023-02-21 |
2024-09-01 |
大陸商江蘇恆瑞醫藥股份有限公司 |
Il-36r結合蛋白及其醫藥用途
|
|
JP2026510318A
(ja)
|
2023-03-06 |
2026-04-02 |
エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト |
抗EGFRvIII/抗CD3抗体と腫瘍標的化4-1BBアゴニストの併用療法
|
|
JP2026508945A
(ja)
|
2023-03-13 |
2026-03-13 |
ヤンセン バイオテツク,インコーポレーテツド |
二重特異性抗EGFR/c-Met抗体と抗PD-1抗体との併用療法
|
|
JP2026510584A
(ja)
|
2023-03-13 |
2026-04-08 |
エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト |
Pd1-lag3二重特異性抗体およびhla-g t細胞二重特異性抗体を用いる併用療法
|
|
WO2024208777A1
(en)
|
2023-04-03 |
2024-10-10 |
F. Hoffmann-La Roche Ag |
All-in-one agonistic antibodies
|
|
CN120917044A
(zh)
|
2023-04-03 |
2025-11-07 |
豪夫迈·罗氏有限公司 |
激动性拆分型抗体
|
|
CN121240884A
(zh)
|
2023-04-05 |
2025-12-30 |
根马布股份公司 |
包含与cd30和cd3结合的抗体的药用组合物
|
|
WO2024213040A1
(zh)
|
2023-04-11 |
2024-10-17 |
浙江博锐生物制药有限公司 |
抗ror1抗体及其药物偶联物
|
|
WO2024231320A1
(en)
|
2023-05-08 |
2024-11-14 |
F. Hoffmann-La Roche Ag |
Targeted interferon alpha fusion proteins and methods of use
|
|
US12410258B2
(en)
|
2023-05-12 |
2025-09-09 |
Ganmab A/S |
Antibodies capable of binding to OX40, variants thereof and uses thereof
|
|
EP4713356A1
(en)
|
2023-05-16 |
2026-03-25 |
F. Hoffmann-La Roche AG |
Pd-1-regulated il-2 immunocytokine and uses thereof
|
|
CA3228195A1
(en)
|
2023-05-23 |
2025-06-30 |
Janssen Biotech, Inc. |
Methods for treatment of non-small cell lung cancer (nsclc)
|
|
CN119143869A
(zh)
|
2023-06-16 |
2024-12-17 |
复旦大学 |
乙肝病毒表面抗体及其应用
|
|
WO2024263904A1
(en)
|
2023-06-23 |
2024-12-26 |
Genentech, Inc. |
Methods for treatment of liver cancer
|
|
WO2024263195A1
(en)
|
2023-06-23 |
2024-12-26 |
Genentech, Inc. |
Methods for treatment of liver cancer
|
|
WO2025003280A1
(en)
|
2023-06-30 |
2025-01-02 |
Genmab A/S |
Antibodies binding to fibroblast activation protein alpha and death receptor 4
|
|
US12319747B2
(en)
|
2023-07-03 |
2025-06-03 |
Medicovestor, Inc. |
Methods of using anti-SP17 immunotherapeutics
|
|
US12624097B2
(en)
|
2023-07-03 |
2026-05-12 |
Medicovestor, Inc. |
Nucleic acids, vectors, and cells that encode anti-Sp17 antibodies and other Sp17 binding proteins
|
|
CN121712799A
(zh)
|
2023-07-26 |
2026-03-20 |
豪夫迈·罗氏有限公司 |
与cd3结合的抗体
|
|
CN121925428A
(zh)
|
2023-07-30 |
2026-04-24 |
詹森生物科技公司 |
结合突变钙网蛋白的分子及其用途
|
|
KR20260051068A
(ko)
|
2023-08-07 |
2026-04-15 |
얀센 바이오테크 인코포레이티드 |
Enpp3 및 cd3 결합제 및 이의 사용 방법
|
|
TW202523349A
(zh)
|
2023-08-07 |
2025-06-16 |
美商健生生物科技公司 |
Gucy2c抗體及其用途
|
|
AU2024321510A1
(en)
|
2023-08-07 |
2026-03-26 |
Janssen Biotech, Inc. |
Stabilized cd3 antigen binding agents and methods of use thereof
|
|
CN121666400A
(zh)
|
2023-08-09 |
2026-03-13 |
豪夫迈·罗氏有限公司 |
单特异性和多特异性抗trem2抗体、其方法和用途
|
|
CN121693516A
(zh)
|
2023-08-09 |
2026-03-17 |
豪夫迈·罗氏有限公司 |
单特异性和多特异性抗trem2抗体、其方法及用途
|
|
WO2025036892A1
(en)
|
2023-08-14 |
2025-02-20 |
Morphosys Ag |
Cycat halfbody molecules comprising sterically occluding moieties
|
|
WO2025036910A1
(en)
|
2023-08-15 |
2025-02-20 |
Merck Patent Gmbh |
Novel c-met binders and uses thereof
|
|
KR20260054696A
(ko)
|
2023-08-16 |
2026-04-22 |
상하이 맙젠 바이오텍 리미티드 |
면역접합체를 포함하는 약학적 조성물 및 이의 용도
|
|
WO2025042742A1
(en)
|
2023-08-18 |
2025-02-27 |
Bristol-Myers Squibb Company |
Compositions comprising antibodies that bind bcma and cd3 and methods of treatment
|
|
AU2024337472A1
(en)
|
2023-09-05 |
2026-04-16 |
Janssen Biotech, Inc. |
Methods of treating non-small cell lung cancer
|
|
WO2025056180A1
(en)
|
2023-09-15 |
2025-03-20 |
BioNTech SE |
Methods of treatment using agents binding to epcam and cd137 in combination with pd-1 axis binding antagonists
|
|
WO2025079020A1
(en)
|
2023-10-12 |
2025-04-17 |
Janssen Biotech, Inc. |
First line treatment in egfr exon 20 insertion-mutated advanced non-small cell lung cancer
|
|
WO2025082777A1
(en)
|
2023-10-17 |
2025-04-24 |
Morphosys Ag |
Dual-targeting of muc16 and mesothelin co-expressing tumor cells by functional complementation of cycat® halfbody molecules
|
|
US12364777B2
(en)
|
2023-10-20 |
2025-07-22 |
Medicovestor, Inc. |
Homodimeric antibodies for use in treating cancers and methods of use
|
|
WO2025114541A1
(en)
|
2023-11-30 |
2025-06-05 |
Genmab A/S |
Antibodies capable of binding to ox40 in combination therapy
|
|
WO2025122634A1
(en)
|
2023-12-05 |
2025-06-12 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of tau-related disorders
|
|
WO2025126102A1
(en)
|
2023-12-12 |
2025-06-19 |
Janssen Biotech, Inc. |
Enpp3 × cd3 bispecific antibodies and use thereof
|
|
WO2025125386A1
(en)
|
2023-12-14 |
2025-06-19 |
F. Hoffmann-La Roche Ag |
Antibodies that bind to folr1 and methods of use
|
|
US12121587B1
(en)
|
2023-12-26 |
2024-10-22 |
Medicovestor, Inc. |
Dimeric antibodies
|
|
US12600795B2
(en)
|
2023-12-26 |
2026-04-14 |
Medicovestor, Inc. |
Oligomeric IgG for immunotherapeutics and diagnostics
|
|
US12116410B1
(en)
|
2023-12-26 |
2024-10-15 |
Medicovestor, Inc. |
Methods of manufacturing dimeric antibodies
|
|
TW202547867A
(zh)
|
2024-01-16 |
2025-12-16 |
美商健生生物科技公司 |
使用阿米維單抗治療結腸直腸癌
|
|
EP4716552A1
(en)
|
2024-01-22 |
2026-04-01 |
Janssen Biotech, Inc. |
Use of amivantamab to treat head and neck cancer
|
|
US12258396B1
(en)
|
2024-02-02 |
2025-03-25 |
Medicovestor, Inc. |
Methods of using immunotherapeutics that bind folate receptor alpha
|
|
US12240900B1
(en)
|
2024-02-02 |
2025-03-04 |
Medicovestor, Inc. |
Nucleic acids, vectors, and cells that encode antibodies and other proteins that bind folate receptor alpha
|
|
US12378314B1
(en)
|
2024-02-02 |
2025-08-05 |
Medicovestor, Inc. |
Proteins that bind folate receptor alpha including fully-human antibodies
|
|
WO2025181189A1
(en)
|
2024-03-01 |
2025-09-04 |
F. Hoffmann-La Roche Ag |
Antibodies binding to cd3
|
|
WO2025191459A1
(en)
|
2024-03-11 |
2025-09-18 |
Janssen Biotech, Inc. |
Use of bispecific anti-egfr/c-met antibodies to treat solid tumors
|
|
WO2025202147A1
(en)
|
2024-03-27 |
2025-10-02 |
F. Hoffmann-La Roche Ag |
Interleukin-7 immunoconjugates
|
|
WO2025219504A1
(en)
|
2024-04-19 |
2025-10-23 |
F. Hoffmann-La Roche Ag |
Treatment of ophthalmologic diseases
|
|
US20260041768A1
(en)
|
2024-05-03 |
2026-02-12 |
Janssen Biotech, Inc. |
Methods for treating multiple myeloma with car-t cells and bispecific antibodies
|
|
WO2025233825A1
(en)
|
2024-05-06 |
2025-11-13 |
Janssen Pharmaceutica Nv |
Enrichment of cells expressing a bird linker
|
|
WO2025237931A1
(en)
|
2024-05-15 |
2025-11-20 |
F. Hoffmann-La Roche Ag |
Recombinant binding proteins with conditionally activatable t cell and nk cell recruiting effector domains
|
|
WO2026003224A2
(en)
|
2024-06-26 |
2026-01-02 |
Iomx Therapeutics Ag |
Bispecific antigen binding proteins (abp) targeting immune checkpoint molecules and both leukocyte immunoglobulin-like receptor subfamily b1 (lilrb1) and lilrb2; combinations and uses thereof
|
|
WO2026011013A1
(en)
|
2024-07-02 |
2026-01-08 |
Epibiologics, Inc. |
Binding agents and uses thereof
|
|
WO2026036047A1
(en)
|
2024-08-08 |
2026-02-12 |
Altus Enterprises, Inc. |
Antibody molecules to fixa and fx and uses thereof
|
|
WO2026038160A1
(en)
|
2024-08-13 |
2026-02-19 |
Janssen Biotech, Inc. |
Methods for reducing infusion-related reactions in patients treated with egfr/met bispecific antibodies
|
|
CA3278557A1
(en)
|
2024-08-13 |
2026-03-01 |
Janssen Biotech, Inc. |
Methods for reducing dermatologic adverse events in patients treated with egfr/met bispecific antibodies
|
|
WO2026042017A1
(en)
|
2024-08-19 |
2026-02-26 |
Janssen Biotech, Inc. |
Amivantamab in combination with lazertinib for the treatment of non-small cell lung cancer (nsclc)
|
|
WO2026041568A1
(en)
|
2024-08-20 |
2026-02-26 |
F. Hoffmann-La Roche Ag |
Antibodies binding to cd3 and dotam
|
|
WO2026044177A1
(en)
|
2024-08-23 |
2026-02-26 |
Janssen Biotech, Inc. |
Methods of treatment with gprc5d antibodies with enhanced effector function
|
|
WO2026050572A2
(en)
|
2024-08-29 |
2026-03-05 |
Marengo Therapeutics, Inc. |
Multifunctional molecules binding to tcr and uses thereof
|
|
WO2026052654A1
(en)
|
2024-09-03 |
2026-03-12 |
F. Hoffmann-La Roche Ag |
Cytokine receptor agonist
|
|
WO2026052652A1
(en)
|
2024-09-03 |
2026-03-12 |
F. Hoffmann-La Roche Ag |
Cytokine receptor agonist
|
|
WO2026058155A1
(en)
|
2024-09-11 |
2026-03-19 |
Novartis Ag |
Antibodies targeting il-31
|
|
WO2026073816A1
(en)
|
2024-09-25 |
2026-04-09 |
Centre Hospitalier Universitaire Vaudois |
Potency-tuned cd70 ligands, targeted chimeric antigen receptors (cars) and methods for cancer
|
|
WO2026068864A1
(en)
|
2024-09-30 |
2026-04-02 |
BioNTech SE |
Engineered ch1 and cl domains for the prevention of chain mispairing
|
|
WO2026073840A1
(en)
|
2024-10-01 |
2026-04-09 |
F. Hoffmann-La Roche Ag |
Antibodies that bind to cd3 and uses therefor
|
|
WO2026078231A1
(en)
|
2024-10-11 |
2026-04-16 |
T-Therapeutics Limited |
Soluble non-aggregating immune ligand
|
|
WO2026090160A2
(en)
|
2024-10-22 |
2026-04-30 |
Gilead Sciences, Inc. |
Cd4-targeted il-15 molecules and methods of use
|