DK2093232T3 - Granuleret maltitol til direkte kompression og fremgangsmåde til fremstilling heraf - Google Patents
Granuleret maltitol til direkte kompression og fremgangsmåde til fremstilling heraf Download PDFInfo
- Publication number
- DK2093232T3 DK2093232T3 DK08171504.7T DK08171504T DK2093232T3 DK 2093232 T3 DK2093232 T3 DK 2093232T3 DK 08171504 T DK08171504 T DK 08171504T DK 2093232 T3 DK2093232 T3 DK 2093232T3
- Authority
- DK
- Denmark
- Prior art keywords
- maltitol
- temperature
- granulated
- equal
- less
- Prior art date
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- 235000010449 maltitol Nutrition 0.000 title claims description 175
- 239000000845 maltitol Substances 0.000 title claims description 174
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 title claims description 160
- 229940035436 maltitol Drugs 0.000 title claims description 147
- 238000000034 method Methods 0.000 title description 37
- 238000007907 direct compression Methods 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 23
- 235000020357 syrup Nutrition 0.000 claims description 20
- 239000006188 syrup Substances 0.000 claims description 20
- 239000002245 particle Substances 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 5
- 238000004090 dissolution Methods 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 238000002844 melting Methods 0.000 claims description 4
- 230000008018 melting Effects 0.000 claims description 4
- 238000001033 granulometry Methods 0.000 claims description 3
- 238000000691 measurement method Methods 0.000 claims 2
- 240000008042 Zea mays Species 0.000 claims 1
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 claims 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims 1
- 238000000889 atomisation Methods 0.000 claims 1
- 235000009973 maize Nutrition 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 description 26
- 238000005507 spraying Methods 0.000 description 22
- 239000000203 mixture Substances 0.000 description 14
- 235000015218 chewing gum Nutrition 0.000 description 13
- 229920005862 polyol Polymers 0.000 description 13
- 150000003077 polyols Chemical class 0.000 description 13
- 239000000047 product Substances 0.000 description 11
- 239000013078 crystal Substances 0.000 description 8
- 238000005259 measurement Methods 0.000 description 8
- 238000002425 crystallisation Methods 0.000 description 7
- 230000008025 crystallization Effects 0.000 description 7
- 229940112822 chewing gum Drugs 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 235000000346 sugar Nutrition 0.000 description 6
- 238000012360 testing method Methods 0.000 description 5
- 150000001720 carbohydrates Chemical class 0.000 description 4
- 238000005243 fluidization Methods 0.000 description 4
- 235000003599 food sweetener Nutrition 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000003765 sweetening agent Substances 0.000 description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 3
- 229920001908 Hydrogenated starch hydrolysate Polymers 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 238000007906 compression Methods 0.000 description 3
- 230000006835 compression Effects 0.000 description 3
- 230000018044 dehydration Effects 0.000 description 3
- 238000006297 dehydration reaction Methods 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 238000006116 polymerization reaction Methods 0.000 description 3
- 239000000600 sorbitol Substances 0.000 description 3
- 229960002920 sorbitol Drugs 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- XJCCHWKNFMUJFE-CGQAXDJHSA-N Maltotriitol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O[C@@H]([C@H](O)[C@@H](O)CO)[C@H](O)CO)O[C@H](CO)[C@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 XJCCHWKNFMUJFE-CGQAXDJHSA-N 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000010583 slow cooling Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- LUAHEUHBAZYUOI-KVXMBEGHSA-N (2s,3r,4r,5r)-4-[(2r,3r,4r,5s,6r)-5-[(2r,3r,4r,5s,6r)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexane-1,2,3,5,6-pentol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O[C@@H]([C@H](O)[C@@H](O)CO)[C@H](O)CO)O[C@H](CO)[C@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@@H](CO)O1 LUAHEUHBAZYUOI-KVXMBEGHSA-N 0.000 description 1
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000001013 cariogenic effect Effects 0.000 description 1
- 239000012159 carrier gas Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000019219 chocolate Nutrition 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 239000000905 isomalt Substances 0.000 description 1
- 235000010439 isomalt Nutrition 0.000 description 1
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000004441 surface measurement Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
- A23B2/00—Preservation of foods or foodstuffs, in general
- A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
- A23B2/725—Preservation of foods or foodstuffs, in general by treatment with chemicals in the form of liquids or solids
- A23B2/729—Organic compounds; Microorganisms; Enzymes
- A23B2/779—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
- A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
- A23G1/32—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds
- A23G1/40—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/42—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/10—Chewing gum characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L13/00—Meat products; Meat meal; Preparation or treatment thereof
- A23L13/40—Meat products; Meat meal; Preparation or treatment thereof containing additives
- A23L13/42—Additives other than enzymes or microorganisms in meat products or meat meals
- A23L13/428—Addition of flavours, spices, colours, amino acids or their salts, peptides, vitamins, yeast extract or autolysate, nucleic acid or derivatives, organic acidifying agents or their salts or acidogens, sweeteners, e.g. sugars or sugar alcohols; Addition of alcohol-containing products
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
- A23L27/34—Sugar alcohols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/04—Disaccharides
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Inorganic Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Seasonings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Jellies, Jams, And Syrups (AREA)
Claims (6)
1. Granuleret maltitol med en koncentration på mere end eller lig med 97 %, fortrinsvis på mellem 98 og 99 %, kendetegnet ved, at det har: - et vandindhold mindre end 1 %, fortrinsvis mindre end 0,5 %, endnu mere fortrinsvis mindre end eller lig med 0,4 %, - en kompressibilitet større end eller lig med 300 N, fortrinsvis mellem 300 og 500 N, - en hygroskopicitet mindre end eller lig med 2,5 %, fortrinsvis mellem 0,15 og 2,5 %.
2. Granuleret maltitol ifølge krav 1, kendetegnet ved, at det har en tilsyneladende massefylde, som bestemt ifølge den målemetode, der anbefales i den Europæiske Farmakopé (EF 5.0 bind 1, 01/2005: 20915 afsnit 2.9.15. TILSYNELADENDE RUMVÆGT; udstyr ifølge figur 2.9.15.-1), mellem 0,30 og 0,90 g/ml, fortrinsvis mellem 0,40 og 0,80 g/ml.
3. Granuleret maltitol ifølge et af kravene 1 og 2, kendetegnet ved, at det har en fri strømning, som bestemt ifølge den målemetode, der anbefales i den Europæiske Farmakopé (EF 5.0 bind 1, 01/2005: 20916 afsnit 2.9.16. STRØMNING; udstyr ifølge figur 2.9.16.-2), på mellem 5 og 12 sekunder.
4. Granuleret maltitol ifølge et hvilket som et af kravene 1 til 3, kendetegnet ved, at det har en opløsningshastighed i vand mindre end eller lig med 40 sekunder, fortrinsvis mindre end eller lig med 35 sekunder, endnu mere fortrinsvis mindre end eller lig med 30 sekunder.
5. Granuleret maltitol ifølge et hvilket som et af kravene 1 til 4, kendetegnet ved, at det har en gennemsnitlig volumendiameter, målt ved laserdiffraktions-granulometri ved hjælp af et tørprocesmodul, mellem 200 og 500 pm, fortrinsvis mellem 250 og 400 pm.
6. Fremgangsmåde til fremstilling af granuleret maltitol ifølge et hvilket som helst af kravene 1 til 5, kendetegnet ved, at den omfatter følgende trin: a) fremstilling af en maltitolsirup med et tørstofindhold under 50 vægt-%, fortrinsvis mellem 20 og 45 vægt-%, og med en koncentration af maltitol større end eller lig med 70 vægt-%, fortrinsvis mellem 75 og 95 vægt-%, b) indførelse i en granulator med luftfluidiseret leje af et pulverformet leje af krystalliseret maltitol med en koncentration mindst lig med 99 vægt-% og med en gennemsnitlig diameter mellem 30 og 100 pm, c) indstilling af temperaturen af indgangsluften til granulatoren på en værdi mellem 100 og 120 °C og hastigheden af fluidiseringsluften på en værdi mellem 1 og 2 m/s, d) fin forstøvning af maltitolsiruppen fra trin a) i granulatoren ved en temperatur mellem 35 og 45 °C, fortrinsvis ved en temperatur af størrelsesordenen 40 °C på det pulverformede leje i bevægelse af partikler af krystalliseret maltitol fra trin b), idet lejet har en temperatur mellem 30 og 60 °C, idet massen af lejet konstant udgør mindst 2,5 gange massen af pulveriseret sirup, e) tørring ved forøgelse af temperaturen af luften i granulatoren, når den fine forstøvning af siruppen er afsluttet, til en temperatur under maltitols smeltetemperatur, fortrinsvis til en temperatur under 130 °C, mere fortrinsvis til en temperatur af størrelsesordenen 120 °C, indtil temperaturen af lejet ligger mellem 70 og 80 °C, fortrinsvis af størrelsesordenen 75 °C, f) afkøling af det således opnåede granulerede maltitol til en temperatur på højst 25 °C, fortrinsvis til en temperatur af størrelsesordenen 20 °C, og opsamling af det således opnåede granulerede maltitol.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0760174A FR2925499B1 (fr) | 2007-12-20 | 2007-12-20 | Maltitol granule pour compression directe et son procede de preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2093232T3 true DK2093232T3 (da) | 2015-09-14 |
Family
ID=39632468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08171504.7T DK2093232T3 (da) | 2007-12-20 | 2008-12-12 | Granuleret maltitol til direkte kompression og fremgangsmåde til fremstilling heraf |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8232388B2 (da) |
| EP (1) | EP2093232B1 (da) |
| JP (1) | JP5748390B2 (da) |
| KR (1) | KR101557162B1 (da) |
| CN (1) | CN101463054B (da) |
| BR (1) | BRPI0819340B8 (da) |
| CA (1) | CA2647157C (da) |
| DK (1) | DK2093232T3 (da) |
| ES (1) | ES2546115T3 (da) |
| FR (1) | FR2925499B1 (da) |
| MX (1) | MX2008016495A (da) |
| PL (1) | PL2093232T3 (da) |
| RU (1) | RU2483753C2 (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150091191A (ko) | 2004-08-25 | 2015-08-07 | 미츠비시 쇼지 푸드테크 가부시키가이샤 | 고결되기 어려운 결정성 말티톨분말 및 그 제조방법 |
| JP6189080B2 (ja) * | 2012-04-25 | 2017-08-30 | 上野製薬株式会社 | 終末糖化産物生成抑制剤 |
| JP6088848B2 (ja) * | 2013-02-22 | 2017-03-01 | フロイント産業株式会社 | 賦形剤造粒物及びその製造方法、並びに錠剤 |
| BR112017001000B1 (pt) * | 2014-07-21 | 2021-11-30 | Roquette Freres | Método para a fabricação de grânulos de d-alulose, grânulos de d-alulose, uso dos referidos grânulos, composição diretamente compressível, comprimido e método para a fabricação do referido comprimido |
| CN107087702A (zh) * | 2016-02-17 | 2017-08-25 | 罗盖特公司 | 增强的风味释放口香糖组合物 |
| CN108721631A (zh) * | 2018-06-13 | 2018-11-02 | 沈惠 | 一种蔗糖细颗粒及其制备方法、设备与应用 |
| CN109438188A (zh) * | 2018-11-16 | 2019-03-08 | 浙江华康药业股份有限公司 | 一种颗粒山梨醇及其制备方法 |
| CN113974124B (zh) * | 2021-12-17 | 2023-08-11 | 浙江华康药业股份有限公司 | 一种颗粒麦芽糖醇的制备方法 |
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-
2007
- 2007-12-20 FR FR0760174A patent/FR2925499B1/fr active Active
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2008
- 2008-12-12 PL PL08171504T patent/PL2093232T3/pl unknown
- 2008-12-12 ES ES08171504.7T patent/ES2546115T3/es active Active
- 2008-12-12 EP EP08171504.7A patent/EP2093232B1/fr active Active
- 2008-12-12 DK DK08171504.7T patent/DK2093232T3/da active
- 2008-12-17 CA CA2647157A patent/CA2647157C/fr active Active
- 2008-12-18 BR BRPI0819340A patent/BRPI0819340B8/pt not_active IP Right Cessation
- 2008-12-19 JP JP2008324628A patent/JP5748390B2/ja active Active
- 2008-12-19 MX MX2008016495A patent/MX2008016495A/es active IP Right Grant
- 2008-12-19 RU RU2008150539/15A patent/RU2483753C2/ru active
- 2008-12-19 KR KR1020080129883A patent/KR101557162B1/ko not_active Expired - Fee Related
- 2008-12-22 CN CN2008101878681A patent/CN101463054B/zh not_active Expired - Fee Related
- 2008-12-22 US US12/341,689 patent/US8232388B2/en active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| US20090163700A1 (en) | 2009-06-25 |
| EP2093232A1 (fr) | 2009-08-26 |
| BRPI0819340B8 (pt) | 2021-05-25 |
| ES2546115T3 (es) | 2015-09-18 |
| CA2647157A1 (fr) | 2009-06-20 |
| CA2647157C (fr) | 2016-03-22 |
| US8232388B2 (en) | 2012-07-31 |
| RU2483753C2 (ru) | 2013-06-10 |
| HK1135109A1 (en) | 2010-05-28 |
| US20120259103A1 (en) | 2012-10-11 |
| KR20090067100A (ko) | 2009-06-24 |
| BRPI0819340A2 (pt) | 2011-01-11 |
| FR2925499A1 (fr) | 2009-06-26 |
| US8518185B2 (en) | 2013-08-27 |
| PL2093232T3 (pl) | 2015-11-30 |
| JP5748390B2 (ja) | 2015-07-15 |
| FR2925499B1 (fr) | 2010-02-12 |
| KR101557162B1 (ko) | 2015-10-02 |
| MX2008016495A (es) | 2009-06-30 |
| CN101463054A (zh) | 2009-06-24 |
| JP2009148262A (ja) | 2009-07-09 |
| BRPI0819340B1 (pt) | 2020-09-29 |
| EP2093232B1 (fr) | 2015-06-10 |
| RU2008150539A (ru) | 2010-06-27 |
| CN101463054B (zh) | 2013-05-08 |
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