DK2094728T3 - Fremgangsmåder til anvendelse for human-adapterende monoklonale antistoffer - Google Patents
Fremgangsmåder til anvendelse for human-adapterende monoklonale antistofferInfo
- Publication number
- DK2094728T3 DK2094728T3 DK07863509.1T DK07863509T DK2094728T3 DK 2094728 T3 DK2094728 T3 DK 2094728T3 DK 07863509 T DK07863509 T DK 07863509T DK 2094728 T3 DK2094728 T3 DK 2094728T3
- Authority
- DK
- Denmark
- Prior art keywords
- human
- methods
- monoclonal antibodies
- adapting
- adapting monoclonal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
- C07K16/465—Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1089—Design, preparation, screening or analysis of libraries using computer algorithms
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Microbiology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86300806P | 2006-10-26 | 2006-10-26 | |
| PCT/US2007/082516 WO2008052108A2 (en) | 2006-10-26 | 2007-10-25 | Methods for use in human-adapting monoclonal antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2094728T3 true DK2094728T3 (da) | 2013-07-01 |
Family
ID=39325420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07863509.1T DK2094728T3 (da) | 2006-10-26 | 2007-10-25 | Fremgangsmåder til anvendelse for human-adapterende monoklonale antistoffer |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8093068B2 (da) |
| EP (1) | EP2094728B1 (da) |
| JP (1) | JP5323710B2 (da) |
| DK (1) | DK2094728T3 (da) |
| ES (1) | ES2410886T3 (da) |
| PT (1) | PT2094728E (da) |
| SI (1) | SI2094728T1 (da) |
| WO (1) | WO2008052108A2 (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8399630B2 (en) | 2008-08-20 | 2013-03-19 | Centocor Ortho Biotech Inc. | Engineered anti-IL-13 antibodies, compositions, methods and uses |
| JO3437B1 (ar) | 2009-10-30 | 2019-10-20 | Esai R & D Man Co Ltd | أجسام مضادة محسنة مضادة للفراكتالكين البشري واستخداماتها |
| EP3294773A1 (en) | 2015-05-15 | 2018-03-21 | The General Hospital Corporation | Antagonistic anti-tumor necrosis factor receptor superfamily antibodies |
| JP6983075B2 (ja) | 2015-06-02 | 2021-12-17 | ノヴォ ノルディスク アー/エス | 極性の組換え延長部を有するインスリン |
| CN108136043B (zh) | 2015-10-01 | 2022-09-06 | 诺和诺德股份有限公司 | 蛋白质缀合物 |
| CN110505885A (zh) | 2017-04-05 | 2019-11-26 | 诺和诺德股份有限公司 | 寡聚体延伸的胰岛素-Fc缀合物 |
| CN112028994B (zh) * | 2020-07-30 | 2022-04-05 | 北京弘进久安生物科技有限公司 | 抗金黄色葡萄球菌肠毒素b的抗体、检测试纸及试剂盒 |
| EP4204094A1 (en) | 2020-08-27 | 2023-07-05 | Enosi Therapeutics Corporation | Methods and compositions to treat autoimmune diseases and cancer |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2724393A1 (fr) | 1994-09-12 | 1996-03-15 | Inst Nat Sante Rech Med | Obtention d'un anticorps monoclonal recombinant humanise a partir d'un anticorps monoclonal murin, sa production en cellules d'insecte, et ses utilisations |
| US20050175986A1 (en) * | 2000-05-09 | 2005-08-11 | Smit Kline Beecham Corporation | Human monoclonal antibody |
| CA2443862A1 (en) * | 2001-04-17 | 2002-10-24 | Peizhi Luo | Structure-based construction of human antibody library |
| MXPA05000511A (es) * | 2001-07-12 | 2005-09-30 | Jefferson Foote | Anticuepros super humanizados. |
| US20040067532A1 (en) * | 2002-08-12 | 2004-04-08 | Genetastix Corporation | High throughput generation and affinity maturation of humanized antibody |
| US20050048578A1 (en) * | 2003-06-26 | 2005-03-03 | Epitomics, Inc. | Methods of screening for monoclonal antibodies with desirable activity |
| EP1660186B1 (en) | 2003-08-18 | 2013-12-25 | MedImmune, LLC | Humanization of antibodies |
| WO2005035575A2 (en) * | 2003-08-22 | 2005-04-21 | Medimmune, Inc. | Humanization of antibodies |
| JP2009515516A (ja) * | 2005-11-14 | 2009-04-16 | バイオレン・インク | 推定成熟cdrのブラスティングならびにコホートライブラリの作製およびスクリーニングによる抗体の超ヒト化 |
-
2007
- 2007-10-25 PT PT78635091T patent/PT2094728E/pt unknown
- 2007-10-25 ES ES07863509T patent/ES2410886T3/es active Active
- 2007-10-25 WO PCT/US2007/082516 patent/WO2008052108A2/en not_active Ceased
- 2007-10-25 DK DK07863509.1T patent/DK2094728T3/da active
- 2007-10-25 SI SI200731225T patent/SI2094728T1/sl unknown
- 2007-10-25 EP EP07863509.1A patent/EP2094728B1/en active Active
- 2007-10-25 US US11/924,094 patent/US8093068B2/en active Active
- 2007-10-25 JP JP2009534854A patent/JP5323710B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20090137403A1 (en) | 2009-05-28 |
| PT2094728E (pt) | 2013-05-27 |
| ES2410886T3 (es) | 2013-07-03 |
| SI2094728T1 (sl) | 2013-06-28 |
| WO2008052108A2 (en) | 2008-05-02 |
| JP5323710B2 (ja) | 2013-10-23 |
| US8093068B2 (en) | 2012-01-10 |
| EP2094728B1 (en) | 2013-04-10 |
| WO2008052108A3 (en) | 2008-07-10 |
| JP2010508290A (ja) | 2010-03-18 |
| EP2094728A4 (en) | 2011-03-09 |
| EP2094728A2 (en) | 2009-09-02 |
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