DK2096167T3 - Aptamer mod midkin og anvendelse deraf - Google Patents

Aptamer mod midkin og anvendelse deraf

Info

Publication number
DK2096167T3
DK2096167T3 DK07831829.2T DK07831829T DK2096167T3 DK 2096167 T3 DK2096167 T3 DK 2096167T3 DK 07831829 T DK07831829 T DK 07831829T DK 2096167 T3 DK2096167 T3 DK 2096167T3
Authority
DK
Denmark
Prior art keywords
midkin
aptamer against
aptamer
against midkin
Prior art date
Application number
DK07831829.2T
Other languages
English (en)
Inventor
Shin Miyakawa
Masatoshi Fujiwara
Yoshikazu Nakamura
Takashi Matsui
Sadatoshi Sakuma
Original Assignee
Ribomic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ribomic Inc filed Critical Ribomic Inc
Application granted granted Critical
Publication of DK2096167T3 publication Critical patent/DK2096167T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/16Aptamers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/317Chemical structure of the backbone with an inverted bond, e.g. a cap structure
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/3212'-O-R Modification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/3222'-R Modification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/35Nature of the modification
    • C12N2310/351Conjugate
    • C12N2310/3515Lipophilic moiety, e.g. cholesterol

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK07831829.2T 2006-11-14 2007-11-14 Aptamer mod midkin og anvendelse deraf DK2096167T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006308482 2006-11-14
PCT/JP2007/072099 WO2008059877A1 (en) 2006-11-14 2007-11-14 Aptamer against midkine and use thereof

Publications (1)

Publication Number Publication Date
DK2096167T3 true DK2096167T3 (da) 2013-02-04

Family

ID=39401681

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07831829.2T DK2096167T3 (da) 2006-11-14 2007-11-14 Aptamer mod midkin og anvendelse deraf

Country Status (26)

Country Link
US (1) US8080649B2 (da)
EP (1) EP2096167B1 (da)
JP (1) JP5190573B2 (da)
KR (1) KR101516024B1 (da)
CN (1) CN101573446B (da)
AU (1) AU2007320401B2 (da)
BR (1) BRPI0718913A2 (da)
CA (1) CA2669523C (da)
CO (1) CO6190535A2 (da)
CY (1) CY1113679T1 (da)
DK (1) DK2096167T3 (da)
ES (1) ES2397715T3 (da)
HR (1) HRP20130012T1 (da)
IL (1) IL198705A (da)
MX (1) MX2009005148A (da)
MY (1) MY147374A (da)
NO (1) NO342010B1 (da)
NZ (1) NZ577396A (da)
PL (1) PL2096167T3 (da)
PT (1) PT2096167E (da)
RU (1) RU2460794C2 (da)
SI (1) SI2096167T1 (da)
TW (1) TWI481713B (da)
UA (1) UA100847C2 (da)
WO (1) WO2008059877A1 (da)
ZA (1) ZA200903562B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007055378A1 (ja) 2005-11-14 2007-05-18 Cell Signals Inc. 調節性t細胞の機能異常に基づく疾患の治療方法及び予防方法
KR101694559B1 (ko) 2008-09-24 2017-01-09 가부시키가이샤 리보믹 Ngf에 대한 압타머 및 이의 용도
JP6041373B2 (ja) * 2010-02-01 2016-12-07 Necソリューションイノベータ株式会社 TNF−αに結合するアプタマー分子
TWI500425B (zh) 2010-03-24 2015-09-21 Ribomic Inc 對ngf之適體及其用途
US9320690B2 (en) 2010-12-20 2016-04-26 Colgate-Palmolive Company Gelatin encapsulated oral care composition containing hydrophilic active, hydrophobic structuring agent and oil carrier
ES2687154T3 (es) * 2011-09-28 2018-10-23 Ribomic Inc. Aptámero para NGF y sus aplicaciones
JP6020888B2 (ja) * 2012-06-29 2016-11-02 国立大学法人名古屋大学 エポキシエイコサトリエン酸関連疾患の予防又は治療
US9506070B2 (en) 2012-11-21 2016-11-29 Ribomic Inc. Aptamer against midkine and applications thereof
RU2549704C1 (ru) * 2014-03-26 2015-04-27 Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) Рнк-аптамер, обладающий способностью узнавать характерные для рассеянного склероза аутоантитела
EP3478843B1 (en) 2016-07-01 2021-08-04 Somalogic, Inc. Oligonucleotides comprising modified nucleosides
KR101985300B1 (ko) * 2016-07-19 2019-06-03 삼성전자주식회사 미드카인 저해제를 포함하는 뇌종양 치료 또는 예방용 약학 조성물
SG11202012933QA (en) * 2018-06-29 2021-01-28 Ribomic Inc Aptamer preparation
CN109536505B (zh) * 2018-12-07 2021-11-09 暨南大学 鬼臼毒素的核酸适配体及其应用
WO2020124095A1 (en) * 2018-12-14 2020-06-18 Board Of Regents, The University Of Texas System Aka Dna aptamers and use thereof for the treatment of cancer
WO2020241493A1 (ja) * 2019-05-24 2020-12-03 株式会社リボミック 骨形成や骨代謝の異常に関連する疾患の治療薬

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5660985A (en) 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
JP3842304B2 (ja) 1992-10-08 2006-11-08 喬 村松 癌の診断、治療薬
AU756279B2 (en) 1997-07-14 2003-01-09 Medical Therapies Limited Agents comprising Midkine or its inhibitor as active ingredient
CA2341638C (en) 1998-08-24 2010-05-11 Meiji Milk Products Co., Ltd. Use of a midkine inhibitor
US6858390B2 (en) * 1998-12-31 2005-02-22 Ingeneus Corporation Aptamers containing sequences of nucleic acid or nucleic acid analogues bound homologously, or in novel complexes
JP2000354487A (ja) 1999-06-15 2000-12-26 Takashi Muramatsu ミッドカイン受容体
JP4768440B2 (ja) 2003-03-06 2011-09-07 セルミド リミテッド 開腹手術後の癒着の予防剤
WO2004085642A1 (ja) 2003-03-27 2004-10-07 Takashi Muramatsu 関節炎関連遺伝子及びこれの関節炎検査等への利用
JP3940097B2 (ja) * 2003-05-20 2007-07-04 株式会社リボミック 翻訳開始因子eIF4Eに結合するリガンド
JP2007297282A (ja) 2004-08-13 2007-11-15 Cell Signals Inc 子宮内膜症の発生の際にミッドカインによって起こる影響
JP2006141305A (ja) * 2004-11-22 2006-06-08 Univ Of Tokyo 翻訳開始因子eIF4Gに結合するリボ核酸
JP2006211905A (ja) * 2005-02-01 2006-08-17 Univ Of Tokyo 腫瘍壊死因子受容体ファミリータンパク質に結合する核酸リガンド
JP2006308482A (ja) 2005-04-28 2006-11-09 Sanyo Electric Co Ltd 検出装置

Also Published As

Publication number Publication date
CN101573446B (zh) 2013-07-17
KR101516024B1 (ko) 2015-04-29
IL198705A (en) 2014-11-30
ES2397715T3 (es) 2013-03-08
RU2009122476A (ru) 2010-12-20
CY1113679T1 (el) 2016-06-22
TWI481713B (zh) 2015-04-21
HK1135729A1 (en) 2010-06-11
WO2008059877A1 (en) 2008-05-22
CO6190535A2 (es) 2010-08-19
HRP20130012T1 (hr) 2013-01-31
JP5190573B2 (ja) 2013-04-24
PL2096167T3 (pl) 2013-03-29
SI2096167T1 (sl) 2013-02-28
NO20092280L (no) 2009-08-14
BRPI0718913A2 (pt) 2013-12-10
KR20090097879A (ko) 2009-09-16
CA2669523A1 (en) 2008-05-22
NZ577396A (en) 2011-12-22
MX2009005148A (es) 2009-08-24
US8080649B2 (en) 2011-12-20
AU2007320401B2 (en) 2012-12-06
EP2096167A1 (en) 2009-09-02
CA2669523C (en) 2016-06-21
US20100004432A1 (en) 2010-01-07
RU2460794C2 (ru) 2012-09-10
CN101573446A (zh) 2009-11-04
MY147374A (en) 2012-11-30
JPWO2008059877A1 (ja) 2010-03-04
TW200831668A (en) 2008-08-01
EP2096167B1 (en) 2012-10-17
ZA200903562B (en) 2010-07-28
IL198705A0 (en) 2011-08-01
PT2096167E (pt) 2013-01-25
EP2096167A4 (en) 2009-11-11
UA100847C2 (uk) 2013-02-11
AU2007320401A1 (en) 2008-05-22
NO342010B1 (no) 2018-03-12

Similar Documents

Publication Publication Date Title
DK2170827T3 (da) Indolin-2-oner og aza-indolin-2-oner
DK2001556T3 (da) Thioninium-forbindelser og anvendelse deraf
EP2069496A4 (en) IMPROVED SELEX AND PHOTOSELEX
DK2185552T3 (da) Dipeptoid-prodrugs og anvendelse heraf
DK2118140T3 (da) Humancytomegalovirus-neutraliserende antistoffer og anvendelse deraf
DK3338790T3 (da) Oligopeptid-forbindelser og anvendelser deraf
DK2081955T3 (da) Metastinderivater og anvendelse deraf
DK3263589T5 (da) Peptidsekvenser og sammensætninger
BRPI0907231A2 (pt) pirrolpirimidinas e pirrolpiridinas
DK1954140T3 (da) Glycerollevulinatketaler og deres anvendelse
DE602007010795D1 (de) Blattsauger und -häcksler
DK2160401T3 (da) Fusionsmolekyler og il-15-varianter
DK2185164T3 (da) Sammensætning og terapeutisk antitumorvaccine
DK2349430T3 (da) KATETERISERINGANORDNING og -kit
DK2041138T3 (da) Pyrroltriazinkinase-inhibitorer
DK2079485T3 (da) Phenylpropionamidforbindelser og anvendelsen deraf
DK2024375T3 (da) Cyclopropyl-kondenserede indolobenzazepin-HCV-NS5B-hæmmere
DK2376791T3 (da) Afstandsindretning og fastgørelsesindretning med afstandsindretning
DK3020729T3 (da) Antistoffer mod human il-22 og anvendelser deraf
DK2049571T3 (da) Bindingsmidler, der er målrettet mod PDGFR-ALFA, og anvendelser deraf
DK2038275T3 (da) Ny pyridazinforbindelse og anvendelse heraf
DK1894567T3 (da) Ledsagende farmaceutiske midler og anvendelse deraf
DK2190991T3 (da) SDF-1-Bindende nucleinsyrer og anvendelsen deraf
DK2160336T3 (da) Forbindelsesmekanisme og fremgangsmåde
EP2147554A4 (en) DEVICE AND METHOD FOR DECODING BIT TRAIN