DK2049571T3 - Bindingsmidler, der er målrettet mod PDGFR-ALFA, og anvendelser deraf - Google Patents

Bindingsmidler, der er målrettet mod PDGFR-ALFA, og anvendelser deraf

Info

Publication number
DK2049571T3
DK2049571T3 DK07873957.0T DK07873957T DK2049571T3 DK 2049571 T3 DK2049571 T3 DK 2049571T3 DK 07873957 T DK07873957 T DK 07873957T DK 2049571 T3 DK2049571 T3 DK 2049571T3
Authority
DK
Denmark
Prior art keywords
alfa
applications
binding agents
agents targeting
targeting pdgfr
Prior art date
Application number
DK07873957.0T
Other languages
English (en)
Inventor
Naomi Laing
Gadi Gazit-Bornstein
Jaspal Singh Kang
Ian Foltz
Xiaodong Yang
Susan Ann Cartlidge
David Charles Blakey
Laura Taylor
Original Assignee
Medlmmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medlmmune Ltd filed Critical Medlmmune Ltd
Application granted granted Critical
Publication of DK2049571T3 publication Critical patent/DK2049571T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK07873957.0T 2006-08-03 2007-08-02 Bindingsmidler, der er målrettet mod PDGFR-ALFA, og anvendelser deraf DK2049571T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83564706P 2006-08-03 2006-08-03
PCT/US2007/075117 WO2008112003A2 (en) 2006-08-03 2007-08-02 Targeted binding agents directed to pdgfr-alpha and uses thereof

Publications (1)

Publication Number Publication Date
DK2049571T3 true DK2049571T3 (da) 2013-04-29

Family

ID=39146823

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07873957.0T DK2049571T3 (da) 2006-08-03 2007-08-02 Bindingsmidler, der er målrettet mod PDGFR-ALFA, og anvendelser deraf

Country Status (23)

Country Link
US (3) US20090324601A1 (da)
EP (3) EP2049571B1 (da)
JP (1) JP5437804B2 (da)
KR (1) KR101531422B1 (da)
CN (2) CN103588881A (da)
AR (1) AR062268A1 (da)
AU (1) AU2007348940B2 (da)
BR (1) BRPI0715223A2 (da)
CA (1) CA2657898A1 (da)
CL (1) CL2007002225A1 (da)
DK (1) DK2049571T3 (da)
ES (1) ES2402380T3 (da)
IL (2) IL196209A (da)
MX (2) MX2009001021A (da)
NO (1) NO20090069L (da)
NZ (2) NZ596381A (da)
PL (1) PL2049571T3 (da)
PT (1) PT2049571E (da)
SI (1) SI2049571T1 (da)
TW (1) TWI503329B (da)
UY (1) UY30525A1 (da)
WO (1) WO2008112003A2 (da)
ZA (1) ZA200900461B (da)

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JP2013177317A (ja) * 2010-06-24 2013-09-09 Meneki Seibutsu Kenkyusho:Kk 抗ｐｄｇｆ受容体抗体
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DK2771037T3 (da) * 2011-10-28 2016-11-14 Fredax Ab Terapeutiske midler og anvendelser deraf
CN105017420B (zh) * 2012-02-17 2019-05-28 西雅图基因公司 针对整联蛋白αvβ6的抗体和使用该抗体治疗癌症
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CN109134655B (zh) * 2018-11-28 2019-02-26 上海复宏汉霖生物技术股份有限公司 一种抗PDGFRα的单克隆抗体及其制备方法和应用
KR20210095781A (ko) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물
CN121194990A (zh) * 2023-04-04 2025-12-23 泰利斯制药(创新)有限公司 用于对表达PDGFRα的癌症进行成像的试剂和方法
WO2024207069A1 (en) * 2023-04-04 2024-10-10 Telix Pharmaceuticals (Innovations) Pty Ltd Reagents and methods for imaging cancers expressing pdgfralpha
WO2024207070A1 (en) * 2023-04-04 2024-10-10 Telix Pharmaceuticals (Innovations) Pty Ltd Methods of treating cancers expressing pdgfralpha
KR20250175319A (ko) * 2023-04-04 2025-12-16 테릭스 파마슈티컬스 (이노베이션스) 피티와이 엘티디 Pdgfr알파를 발현하는 암을 치료하는 방법
WO2025101767A1 (en) * 2023-11-08 2025-05-15 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Immuno-targeting the ectopic phosphorylation sites of pdgfra generated by man2a1-fer fusion in hepatocellular carcinoma

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JP5437804B2 (ja) 2014-03-12
EP2420514A1 (en) 2012-02-22
AR062268A1 (es) 2008-10-29
HK1128481A1 (en) 2009-10-30
IL222833A0 (en) 2012-12-31
US20090324601A1 (en) 2009-12-31
EP2420513A1 (en) 2012-02-22
EP2049571A2 (en) 2009-04-22
JP2010500872A (ja) 2010-01-14
NZ596381A (en) 2013-03-28
AU2007348940B2 (en) 2012-06-28
UY30525A1 (es) 2008-02-29
IL196209A0 (en) 2011-08-01
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KR101531422B1 (ko) 2015-06-26
SI2049571T1 (sl) 2013-05-31
IL196209A (en) 2013-03-24
CN103588881A (zh) 2014-02-19
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AU2007348940A1 (en) 2008-09-18
US8697664B2 (en) 2014-04-15
CA2657898A1 (en) 2008-09-18
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