DK2128170T3 - Fremgangsmåde til glycosidering af colchicin og thiocolchicin - Google Patents

Fremgangsmåde til glycosidering af colchicin og thiocolchicin

Info

Publication number: DK2128170T3
Authority: DK; Denmark
Prior art keywords: thiocolchicine; glycosidation; colchicine; compounds; formula
Prior art date: 2008-05-28

Application number

DK08157069.9T

Other languages

English (en)

Inventor

Stephen Beszant

Bruno Gabetta

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-05-28

Filing date

2008-05-28

Publication date

2011-02-28

2008-05-28 Application filed by Indena Spa filed Critical Indena Spa

2011-02-28 Application granted granted Critical

2011-02-28 Publication of DK2128170T3 publication Critical patent/DK2128170T3/da

Links

238000000034 method Methods 0.000 title abstract 2
IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 title 2
229960001338 colchicine Drugs 0.000 title 1
238000005858 glycosidation reaction Methods 0.000 title 1
CMEGANPVAXDBPL-INIZCTEOSA-N n-[(7s)-1,2,3-trimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(SC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC CMEGANPVAXDBPL-INIZCTEOSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 1
239000002243 precursor Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/248—Colchicine radicals, e.g. colchicosides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
- C07C2603/34—Benzoheptalenes; Hydrogenated benzoheptalenes
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK08157069.9T 2008-05-28 2008-05-28 Fremgangsmåde til glycosidering af colchicin og thiocolchicin DK2128170T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP08157069A EP2128170B1 (en)	2008-05-28	2008-05-28	"Process for the glycosidation of colchicine and thiocolchicine"

Publications (1)

Publication Number	Publication Date
DK2128170T3 true DK2128170T3 (da)	2011-02-28

Family

ID=39637699

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK08157069.9T DK2128170T3 (da)	2008-05-28	2008-05-28	Fremgangsmåde til glycosidering af colchicin og thiocolchicin

Country Status (21)

Country	Link
US (1)	US8742080B2 (da)
EP (1)	EP2128170B1 (da)
JP (1)	JP5478612B2 (da)
KR (1)	KR101625161B1 (da)
CN (2)	CN102046644A (da)
AT (1)	ATE492556T1 (da)
AU (1)	AU2009253483B2 (da)
BR (1)	BRPI0912287A2 (da)
CA (1)	CA2725842C (da)
CO (1)	CO6290769A2 (da)
DE (1)	DE602008004113D1 (da)
DK (1)	DK2128170T3 (da)
ES (1)	ES2356494T3 (da)
HR (1)	HRP20110186T1 (da)
MX (1)	MX2010012884A (da)
PL (1)	PL2128170T3 (da)
PT (1)	PT2128170E (da)
RU (1)	RU2488589C2 (da)
SI (1)	SI2128170T1 (da)
WO (1)	WO2009143930A1 (da)
ZA (1)	ZA201008480B (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP6356684B2 (ja)	2012-11-02	2018-07-11	マレイ・アンド・プール・エンタープライゼズ・リミテッド	コルヒチン誘導体の投与による心血管イベントの処置または予防

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2112131A1 (en)	1970-11-06	1972-06-16	Roussel Uclaf	2-and 3-glucose-2-yl-demethylthiololchicines - antimitotic agents,prepared from colchicine
IT1270124B (it) *	1994-10-05	1997-04-28	Indena Spa	Derivati della colchicina e loro impiego terapeutico
IT1282584B1 (it)	1996-02-08	1998-03-31	Indena Spa	Processo di glicosidazione di derivati colchicinici e prodotti ottenuti
IT1285777B1 (it)	1996-10-07	1998-06-18	Indena Spa	Processo di biotrasformazione di composti colchicinoidi nei corrispondenti 3-glicosilderivati
FR2779147B1 (fr) *	1998-05-27	2000-06-30	Synthelabo	Derive de thiocolchicoside sa preparation et son application en therapeutique
ITMI20031144A1 (it) *	2003-06-06	2004-12-07	Indena Spa	Analoghi del colchicoside.

2008
- 2008-05-28 PL PL08157069T patent/PL2128170T3/pl unknown
- 2008-05-28 DE DE602008004113T patent/DE602008004113D1/de active Active
- 2008-05-28 ES ES08157069T patent/ES2356494T3/es active Active
- 2008-05-28 EP EP08157069A patent/EP2128170B1/en active Active
- 2008-05-28 SI SI200830169T patent/SI2128170T1/sl unknown
- 2008-05-28 AT AT08157069T patent/ATE492556T1/de active
- 2008-05-28 DK DK08157069.9T patent/DK2128170T3/da active
- 2008-05-28 PT PT08157069T patent/PT2128170E/pt unknown
2009
- 2009-04-09 AU AU2009253483A patent/AU2009253483B2/en active Active
- 2009-04-09 WO PCT/EP2009/002623 patent/WO2009143930A1/en not_active Ceased
- 2009-04-09 US US12/994,485 patent/US8742080B2/en active Active
- 2009-04-09 CN CN2009801191319A patent/CN102046644A/zh active Pending
- 2009-04-09 JP JP2011510851A patent/JP5478612B2/ja active Active
- 2009-04-09 CN CN201610052127.7A patent/CN105713054A/zh active Pending
- 2009-04-09 CA CA2725842A patent/CA2725842C/en active Active
- 2009-04-09 BR BRPI0912287-7A patent/BRPI0912287A2/pt not_active Application Discontinuation
- 2009-04-09 KR KR1020107026481A patent/KR101625161B1/ko active Active
- 2009-04-09 RU RU2010147934/04A patent/RU2488589C2/ru active
- 2009-04-09 MX MX2010012884A patent/MX2010012884A/es active IP Right Grant
2010
- 2010-11-16 CO CO10143051A patent/CO6290769A2/es active IP Right Grant
- 2010-11-25 ZA ZA2010/08480A patent/ZA201008480B/en unknown
2011
- 2011-03-14 HR HR20110186T patent/HRP20110186T1/hr unknown

Also Published As

Publication number	Publication date
ATE492556T1 (de)	2011-01-15
PL2128170T3 (pl)	2011-05-31
CN102046644A (zh)	2011-05-04
MX2010012884A (es)	2010-12-14
CA2725842A1 (en)	2009-12-03
AU2009253483A1 (en)	2009-12-03
KR101625161B1 (ko)	2016-05-27
RU2488589C2 (ru)	2013-07-27
US8742080B2 (en)	2014-06-03
CA2725842C (en)	2016-11-22
US20110130554A1 (en)	2011-06-02
EP2128170B1 (en)	2010-12-22
PT2128170E (pt)	2011-02-23
AU2009253483B2 (en)	2013-08-22
BRPI0912287A2 (pt)	2015-08-04
CN105713054A (zh)	2016-06-29
WO2009143930A1 (en)	2009-12-03
CO6290769A2 (es)	2011-06-20
ES2356494T3 (es)	2011-04-08
RU2010147934A (ru)	2012-05-27
DE602008004113D1 (de)	2011-02-03
ZA201008480B (en)	2012-02-29
KR20110010739A (ko)	2011-02-07
JP2011520995A (ja)	2011-07-21
JP5478612B2 (ja)	2014-04-23
EP2128170A1 (en)	2009-12-02
SI2128170T1 (sl)	2011-04-29
HRP20110186T1 (hr)	2011-04-30

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