DK2133330T3 - Atropisomer af pyrrolderivat - Google Patents

Atropisomer af pyrrolderivat

Info

Publication number
DK2133330T3
DK2133330T3 DK08740010.7T DK08740010T DK2133330T3 DK 2133330 T3 DK2133330 T3 DK 2133330T3 DK 08740010 T DK08740010 T DK 08740010T DK 2133330 T3 DK2133330 T3 DK 2133330T3
Authority
DK
Denmark
Prior art keywords
atropisomes
pyrrole derivative
pyrrole
derivative
Prior art date
Application number
DK08740010.7T
Other languages
English (en)
Inventor
Noriyuki Hayashi
Kazumasa Aoki
Hiroyuki Tsuruoka
Juri Yoshida
Yusuke Asoh
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Application granted granted Critical
Publication of DK2133330T3 publication Critical patent/DK2133330T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK08740010.7T 2007-04-09 2008-04-08 Atropisomer af pyrrolderivat DK2133330T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007101938 2007-04-09
PCT/JP2008/056907 WO2008126831A1 (ja) 2007-04-09 2008-04-08 ピロール誘導体のアトロプ異性体

Publications (1)

Publication Number Publication Date
DK2133330T3 true DK2133330T3 (da) 2014-03-31

Family

ID=39863928

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08740010.7T DK2133330T3 (da) 2007-04-09 2008-04-08 Atropisomer af pyrrolderivat

Country Status (14)

Country Link
US (2) US8524918B2 (da)
EP (1) EP2133330B1 (da)
JP (1) JP5363312B2 (da)
KR (2) KR101477579B1 (da)
CN (1) CN101679243B (da)
BR (1) BRPI0809656B8 (da)
CA (1) CA2683059C (da)
DK (1) DK2133330T3 (da)
ES (1) ES2448498T3 (da)
IL (1) IL201261A0 (da)
PL (1) PL2133330T3 (da)
PT (1) PT2133330E (da)
TW (1) TWI444185B (da)
WO (1) WO2008126831A1 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8642640B2 (en) 2008-10-08 2014-02-04 Exelixis, Inc. 1-phenylpyrrole derivatives
AU2009302371B2 (en) 2008-10-08 2015-02-12 Exelixis, Inc. Atropisomers of (hydroxyalkyl) pyrrole derivatives
WO2010098286A1 (ja) * 2009-02-25 2010-09-02 第一三共株式会社 ミネラルコルチコイド受容体拮抗薬を含有する医薬
ES2436633T3 (es) * 2009-03-26 2014-01-03 Poxel Procedimiento para la separación de enantiómeros de dihidro-1,3,5-triazinas racémicas por cristalización preferencial
CA2958625C (en) * 2013-04-10 2019-05-28 Daiichi Sankyo Company, Limited Crystal of pyrrole derivative and method for producing the same
EP3025711B1 (en) * 2013-07-23 2020-11-18 Daiichi Sankyo Company, Limited Medicine for preventing or treating hypertension
CN105473552B (zh) * 2013-08-27 2017-11-10 第一三共株式会社 用于产生吡咯衍生物及其中间体的方法
SI3160948T1 (sl) 2014-06-30 2020-06-30 Astrazeneca Ab Amidi benzoksazinona, kot modulatorji receptorja mineralokortikoida
BR112017015788B1 (pt) * 2015-01-26 2023-05-16 Daiichi Sankyo Company, Limited Composição sólida, e, método de fabricação para uma composição sólida
CN105985295B (zh) * 2015-02-17 2018-11-20 华润赛科药业有限责任公司 一种旋光纯的硫代乙酸类化合物
CN105622531A (zh) * 2015-04-03 2016-06-01 南京明德新药研发股份有限公司 轴手性异构体及其制备方法和制药用途
US20180280414A1 (en) 2015-10-13 2018-10-04 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of choroidal neovascularisation
EP3434284A4 (en) * 2016-03-24 2019-11-13 Daiichi Sankyo Company, Limited MEDICINE FOR THE TREATMENT OF KIDNEY DISEASE
EP3490606B8 (en) 2016-07-26 2024-04-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Antagonist of mineralocorticoid receptor for the treatment of osteoarthritis
CN112707854B (zh) * 2019-10-25 2022-03-15 年衍药业(珠海)有限公司 吡咯酰胺类化合物及其用途
WO2021180818A1 (en) 2020-03-11 2021-09-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of determining whether a subject has or is at risk of having a central serous chorioretinopathy
CA3213094A1 (en) * 2021-03-30 2022-10-06 Qiao ZONG Crystalline form of pyrrole amide compound, preparation method therefor and use thereof
AU2022264993A1 (en) * 2021-04-26 2023-11-09 Sunshine Lake Pharma Co., Ltd. Preparation method for pyrrole amide compound
WO2023031277A1 (en) 2021-08-31 2023-03-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of ocular rosacea
CN115784961B (zh) * 2021-09-10 2026-03-31 上海鼎雅药物化学科技有限公司 埃沙西林酮及其中间体的合成方法
CN119306644A (zh) * 2023-07-12 2025-01-14 广东东阳光药业股份有限公司 制备吡咯甲酸化合物的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323208B1 (en) 1997-09-05 2001-11-27 Pfizer Inc Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones
MXPA04002438A (es) * 2001-09-24 2004-06-29 Bayer Pharmaceuticals Corp Preparacion y uso de derivados de pirroll para el tratamiento de la obesidad.
US6939968B2 (en) 2002-12-23 2005-09-06 Bristol-Myers Squibb Company Atropisomers of 3-substituted-4-arylquinolin-2-one derivatives
DE10354060A1 (de) * 2003-11-19 2005-06-02 Merck Patent Gmbh Pyrrolderivate
US8026237B2 (en) * 2004-07-30 2011-09-27 Exelixis, Inc. Pyrrole derivatives as pharmaceutical agents
CA2593156C (en) * 2005-01-10 2015-05-05 Exelixis, Inc. Heterocyclic carboxamide compounds as steroid nuclear receptors ligands

Also Published As

Publication number Publication date
IL201261A0 (en) 2010-05-31
PL2133330T3 (pl) 2014-06-30
KR20140048337A (ko) 2014-04-23
CN101679243B (zh) 2012-09-26
EP2133330B1 (en) 2014-01-01
WO2008126831A1 (ja) 2008-10-23
JP5363312B2 (ja) 2013-12-11
US20100093826A1 (en) 2010-04-15
US8754118B2 (en) 2014-06-17
KR101477579B1 (ko) 2014-12-30
BRPI0809656B8 (pt) 2021-05-25
TW200901968A (en) 2009-01-16
BRPI0809656B1 (pt) 2019-07-09
ES2448498T3 (es) 2014-03-14
JPWO2008126831A1 (ja) 2010-07-22
CA2683059C (en) 2012-09-25
CN101679243A (zh) 2010-03-24
CA2683059A1 (en) 2008-10-23
BRPI0809656A2 (pt) 2014-10-07
PT2133330E (pt) 2014-03-31
EP2133330A1 (en) 2009-12-16
US20140024696A1 (en) 2014-01-23
KR20090127421A (ko) 2009-12-11
EP2133330A4 (en) 2010-08-11
US8524918B2 (en) 2013-09-03
HK1139942A1 (en) 2010-09-30
TWI444185B (zh) 2014-07-11

Similar Documents

Publication Publication Date Title
CY2022017I2 (el) Παραγωγα πυριδαζινονης
CY2024031I1 (el) Παραγωγο 4-πυριμιδινοσουλφαμιδης
PL2133330T3 (pl) Atropoizomer pochodnej pirolu
DK2099973T3 (da) Udfoldning af gabion
DK2318390T3 (da) Pyrrolforbindelser
EP2226315A4 (en) 2-aminoquinazoline DERIVATIVE
DK2111555T3 (da) Diagnosticering af præeklampsi
EP2376493A4 (en) DIHYDROPYRIMIDOPYRIMIDINDERIVAT
EP2380877A4 (en) PYRIDINE-3-CARBONSÄUREAMIDDERIVAT
EP2266989A4 (en) HETEROCYCLIC DERIVATIVES
BRPI0923497A2 (pt) derivados de piridazinona
EP2194045A4 (en) Substituted pyrazole derivative
BRPI0812247A2 (pt) Derivados de piridazinona
EP2120569A4 (en) SPIROCHROMANONDERIVATE
EP2331543A4 (en) 3-deazaneplanocin DERIVATIVES
BRPI0821743A2 (pt) derivados de piridazinona
BRPI0911161A2 (pt) derivado de piridazinona
EP2336132A4 (en) MORPHOLINPURINDERIVAT
DK2364166T3 (da) Undertrykkelse af cancer
EP2239253A4 (en) NOVEL PHENYLPYRROL DERIVATIVE
EP2252582A4 (en) pyrrolidine
DK2358714T3 (da) Alkylcyclohexylethere af dihydrotetraazabenzoazulener
ATE545635T1 (de) Substituierte n-oxidpyrazinderivate
EP2341044A4 (en) CYCLOALKYLAMINDERIVAT
EP2177522A4 (en) NEW CARBAPE DERIVATIVES