BRPI0821743A2 - derivados de piridazinona - Google Patents

derivados de piridazinona

Info

Publication number: BRPI0821743A2
Authority: BR; Brazil
Prior art keywords: pyridazinone derivatives; pyridazinone; derivatives
Prior art date: 2007-12-21

Application number

BRPI0821743A

Other languages

English (en)

Inventor

Andree Blaukat

Dieter Dorsch

Frank Stieber

Oliver Schadt

Original Assignee

Merck Patent Ges Mit Berschränkter Haftung

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-21

Filing date

2008-11-25

Publication date

2015-09-22

2008-11-25 Application filed by Merck Patent Ges Mit Berschränkter Haftung filed Critical Merck Patent Ges Mit Berschränkter Haftung

2015-09-22 Publication of BRPI0821743A2 publication Critical patent/BRPI0821743A2/pt

2020-03-10 Publication of BRPI0821743B1 publication Critical patent/BRPI0821743B1/pt

2021-05-25 Publication of BRPI0821743B8 publication Critical patent/BRPI0821743B8/pt

Links

AAILEWXSEQLMNI-UHFFFAOYSA-N 1h-pyridazin-6-one Chemical class OC1=CC=CN=N1 AAILEWXSEQLMNI-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Immunology (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Hematology (AREA)
Obesity (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Physical Education & Sports Medicine (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Vascular Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Transplantation (AREA)
Pulmonology (AREA)
Reproductive Health (AREA)
Oncology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BRPI0821743A 2007-12-21 2008-11-25 derivados de piridazinona, e seu uso BRPI0821743B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE102007061963.6		2007-12-21
DE102007061963A DE102007061963A1 (de)	2007-12-21	2007-12-21	Pyridazinonderivate
PCT/EP2008/009970 WO2009083076A1 (de)	2007-12-21	2008-11-25	2-benzylpyridazinonderivate als met-kinasehemmer

Publications (3)

Publication Number	Publication Date
BRPI0821743A2 true BRPI0821743A2 (pt)	2015-09-22
BRPI0821743B1 BRPI0821743B1 (pt)	2020-03-10
BRPI0821743B8 BRPI0821743B8 (pt)	2021-05-25

Family

ID=40262707

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0821743A BRPI0821743B8 (pt)	2007-12-21	2008-11-25	derivados de piridazinona, e seu uso

Country Status (30)

Country	Link
US (2)	US8557813B2 (pt)
EP (1)	EP2220070B1 (pt)
JP (1)	JP5443381B2 (pt)
KR (1)	KR101606945B1 (pt)
CN (1)	CN101903374B (pt)
AR (1)	AR069843A1 (pt)
AT (1)	ATE506358T1 (pt)
AU (1)	AU2008342339B2 (pt)
BR (1)	BRPI0821743B8 (pt)
CA (1)	CA2710092C (pt)
CL (1)	CL2008003854A1 (pt)
CO (1)	CO6220964A2 (pt)
CY (1)	CY1111556T1 (pt)
DE (2)	DE102007061963A1 (pt)
DK (1)	DK2220070T3 (pt)
EA (1)	EA021362B1 (pt)
EC (1)	ECSP10010361A (pt)
ES (1)	ES2362472T3 (pt)
HR (1)	HRP20110441T1 (pt)
IL (1)	IL206394A (pt)
MY (1)	MY155719A (pt)
NZ (1)	NZ586894A (pt)
PE (1)	PE20091527A1 (pt)
PL (1)	PL2220070T3 (pt)
PT (1)	PT2220070E (pt)
SI (1)	SI2220070T1 (pt)
TW (1)	TWI433845B (pt)
UA (1)	UA100540C2 (pt)
WO (1)	WO2009083076A1 (pt)
ZA (1)	ZA201005166B (pt)

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2007
- 2007-12-21 DE DE102007061963A patent/DE102007061963A1/de not_active Withdrawn
2008
- 2008-11-25 DK DK08865961.0T patent/DK2220070T3/da active
- 2008-11-25 PT PT08865961T patent/PT2220070E/pt unknown
- 2008-11-25 BR BRPI0821743A patent/BRPI0821743B8/pt not_active IP Right Cessation
- 2008-11-25 KR KR1020107016204A patent/KR101606945B1/ko not_active Expired - Fee Related
- 2008-11-25 ES ES08865961T patent/ES2362472T3/es active Active
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- 2008-12-19 PE PE2008002158A patent/PE20091527A1/es not_active Application Discontinuation
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Also Published As

Publication number	Publication date
ECSP10010361A (es)	2010-08-31
CN101903374A (zh)	2010-12-01
TWI433845B (zh)	2014-04-11
MY155719A (en)	2015-11-30
CA2710092C (en)	2016-08-23
JP2011506500A (ja)	2011-03-03
KR101606945B1 (ko)	2016-03-28
US8557813B2 (en)	2013-10-15
ATE506358T1 (de)	2011-05-15
CL2008003854A1 (es)	2010-01-22
DK2220070T3 (da)	2011-07-04
AU2008342339A1 (en)	2009-07-09
PT2220070E (pt)	2011-07-21
CY1111556T1 (el)	2015-10-07
WO2009083076A1 (de)	2009-07-09
AR069843A1 (es)	2010-02-24
EP2220070A1 (de)	2010-08-25
IL206394A0 (en)	2010-12-30
EA021362B1 (ru)	2015-06-30
CN101903374B (zh)	2013-12-18
US20130190311A1 (en)	2013-07-25
TW200932740A (en)	2009-08-01
PE20091527A1 (es)	2009-09-25
HRP20110441T1 (hr)	2011-07-31
KR20100099732A (ko)	2010-09-13
US8859547B2 (en)	2014-10-14
ES2362472T3 (es)	2011-07-06
DE102007061963A1 (de)	2009-06-25
ZA201005166B (en)	2011-03-30
HK1151291A1 (en)	2012-01-27
DE502008003317D1 (de)	2011-06-01
NZ586894A (en)	2012-02-24
UA100540C2 (en)	2013-01-10
EA201001005A1 (ru)	2011-02-28
CO6220964A2 (es)	2010-11-19
EP2220070B1 (de)	2011-04-20
BRPI0821743B8 (pt)	2021-05-25
PL2220070T3 (pl)	2011-08-31
AU2008342339B2 (en)	2013-10-03
BRPI0821743B1 (pt)	2020-03-10
IL206394A (en)	2015-10-29
CA2710092A1 (en)	2009-07-09
SI2220070T1 (sl)	2011-09-30
US20100273796A1 (en)	2010-10-28
JP5443381B2 (ja)	2014-03-19

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