DK2139892T3 - Substituerede pyrimidodiazepiner nyttige som PLK1-inhibitorer - Google Patents

Substituerede pyrimidodiazepiner nyttige som PLK1-inhibitorer

Info

Publication number: DK2139892T3
Authority: DK; Denmark
Prior art keywords: pyrimidodiazepines; substituted; useful; plk1 inhibitors; plk1
Prior art date: 2007-03-22

Application number

DK08717594.9T

Other languages

English (en)

Inventor

Jianping Cai

Shaoqing Chen

Xin-Jie Chu

Kang Le

Kin-Chun Thomas Luk

Peter Michael Wovkulich

Original Assignee

Takeda Pharmaceutical

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-03-22

Filing date

2008-03-11

Publication date

2011-12-12

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39415299&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2139892(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-03-11 Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical

2011-12-12 Application granted granted Critical

2011-12-12 Publication of DK2139892T3 publication Critical patent/DK2139892T3/da

Links

OHXQYFCNXHGKPJ-UHFFFAOYSA-N 1h-pyrimido[5,4-c]diazepine Chemical class N1N=CC=CC2=NC=NC=C12 OHXQYFCNXHGKPJ-UHFFFAOYSA-N 0.000 title 1
102100031463 Serine/threonine-protein kinase PLK1 Human genes 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
108010056274 polo-like kinase 1 Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

DK08717594.9T 2007-03-22 2008-03-11 Substituerede pyrimidodiazepiner nyttige som PLK1-inhibitorer DK2139892T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US91935807P	2007-03-22	2007-03-22
PCT/EP2008/052847 WO2008113711A1 (en)	2007-03-22	2008-03-11	Substituted pyrimidodiazepines useful as plk1 inhibitors

Publications (1)

Publication Number	Publication Date
DK2139892T3 true DK2139892T3 (da)	2011-12-12

Family

ID=39415299

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK08717594.9T DK2139892T3 (da)	2007-03-22	2008-03-11	Substituerede pyrimidodiazepiner nyttige som PLK1-inhibitorer

Country Status (23)

Country	Link
US (1)	US7517873B2 (da)
EP (1)	EP2139892B1 (da)
JP (1)	JP5087640B2 (da)
KR (1)	KR101157848B1 (da)
CN (2)	CN102746175B (da)
AR (1)	AR065794A1 (da)
AT (1)	ATE524472T1 (da)
AU (1)	AU2008228303B2 (da)
BR (1)	BRPI0809088A2 (da)
CA (1)	CA2680757A1 (da)
CL (1)	CL2008000785A1 (da)
CY (1)	CY1112102T1 (da)
DK (1)	DK2139892T3 (da)
ES (1)	ES2371832T3 (da)
HR (1)	HRP20110807T1 (da)
IL (1)	IL200617A (da)
MX (1)	MX2009010034A (da)
PE (1)	PE20120495A1 (da)
PL (1)	PL2139892T3 (da)
PT (1)	PT2139892E (da)
SI (1)	SI2139892T1 (da)
TW (1)	TWI363629B (da)
WO (1)	WO2008113711A1 (da)

Families Citing this family (35)

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CA2695753A1 (en) *	2007-08-15	2009-02-19	Vertex Pharmaceuticals Incorporated	Compounds useful as protein kinases inhibitors
WO2009042711A1 (en) *	2007-09-25	2009-04-02	Takeda Pharmaceutical Company Limited	Polo-like kinase inhibitors
EP2205603B1 (en)	2007-09-28	2014-01-15	Cyclacel Limited	Pyrimidine derivatives as protein kinase inhibitors
WO2009067547A1 (en) *	2007-11-19	2009-05-28	Takeda Pharmaceutical Company Limited	Polo-like kinase inhibitors
TWI490214B (zh)	2008-05-30	2015-07-01	艾德克上野股份有限公司	苯或噻吩衍生物及該等作為ｖａｐ－１抑制劑之用途
JP2011527667A (ja)	2008-06-18	2011-11-04	武田薬品工業株式会社	ハロ置換ピリミドジアゼピン
ES2467108T3 (es)	2008-12-09	2014-06-11	Gilead Sciences, Inc.	Moduladores de receptores tipo toll
EP2379559B1 (en)	2009-01-06	2017-10-25	Dana-Farber Cancer Institute, Inc.	Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders
RS57869B1 (sr)	2009-06-17	2018-12-31	Vertex Pharma	Inhibitori replikacije virusa gripa
NO2477987T3 (da)	2009-09-14	2018-06-09
AU2011343642A1 (en)	2010-12-16	2013-05-02	Vertex Pharmaceuticals Incorporated	Inhibitors of influenza viruses replication
UA118010C2 (uk)	2011-08-01	2018-11-12	Вертекс Фармасьютікалз Інкорпорейтед	Інгібітори реплікації вірусів грипу
WO2014145909A2 (en)	2013-03-15	2014-09-18	Dana-Farber Cancer Institute, Inc.	Pyrimido-diazepinone compounds and methods of treating disorders
AU2014292888B2 (en)	2013-07-25	2018-03-22	Dana-Farber Cancer Institute, Inc.	Inhibitors of transcription factors and uses thereof
TWI652014B (zh) *	2013-09-13	2019-03-01	美商艾佛艾姆希公司	雜環取代之雙環唑殺蟲劑
RS59144B1 (sr)	2013-11-13	2019-09-30	Vertex Pharma	Inhibitori replikacije virusa influence
HRP20181272T1 (hr)	2013-11-13	2018-10-05	Vertex Pharmaceuticals Incorporated	Postupci priprave inhibitora replikacije virusa influence
WO2015117087A1 (en)	2014-01-31	2015-08-06	Dana-Farber Cancer Institute, Inc.	Uses of diazepane derivatives
CA2936865A1 (en)	2014-01-31	2015-08-06	Dana-Farber Cancer Institute, Inc.	Diaminopyrimidine benzenesulfone derivatives and uses thereof
PT3166607T (pt)	2014-07-11	2022-12-07	Gilead Sciences Inc	Moduladores de receptores de tipo toll para o tratamento do vih
CN106715437A (zh)	2014-08-08	2017-05-24	达纳-法伯癌症研究所股份有限公司	二氮杂环庚烷衍生物及其用途
BR112017005100A2 (pt)	2014-09-16	2017-12-05	Gilead Sciences Inc	métodos de preparação de moduladores de receptores do tipo toll
CA2960436C (en)	2014-09-16	2021-01-05	Gilead Sciences, Inc.	Solid forms of a toll-like receptor modulator
JP6857617B2 (ja)	2015-05-13	2021-04-14	バーテックスファーマシューティカルズインコーポレイテッドＶｅｒｔｅｘＰｈａｒｍａｃｅｕｔｉｃａｌｓＩｎｃｏｒｐｏｒａｔｅｄ	インフルエンザウイルスの複製の阻害剤
JP6704416B2 (ja)	2015-05-13	2020-06-03	バーテックスファーマシューティカルズインコーポレイテッドＶｅｒｔｅｘＰｈａｒｍａｃｅｕｔｉｃａｌｓＩｎｃｏｒｐｏｒａｔｅｄ	インフルエンザウイルスの複製の阻害剤を調製する方法
US10702527B2 (en)	2015-06-12	2020-07-07	Dana-Farber Cancer Institute, Inc.	Combination therapy of transcription inhibitors and kinase inhibitors
HK1256417A1 (zh)	2015-09-11	2019-09-20	达纳-法伯癌症研究所股份有限公司	氰基噻吩并三唑并二氮杂环庚三烯及其用途
RU2018112953A (ru)	2015-09-11	2019-10-14	Дана-Фарбер Кэнсер Инститьют, Инк.	Ацетамидтиенотриазолодиазепины и пути их применения
MX2018006499A (es)	2015-11-25	2018-08-01	Dana Farber Cancer Inst Inc	Inhibidores de bromodominio bivalentes y usos de los mismos.
US11155556B2 (en) *	2016-04-07	2021-10-26	Dana-Farber Cancer Institute, Inc.	Pyrimido-diazepinone kinase scaffold compounds and methods for treating PI3K-mediated disorders
AU2020356484A1 (en)	2019-09-27	2022-03-17	Dana-Farber Cancer Institute, Inc.	ERK5 degraders as therapeutics in cancer and inflammatory diseases
US20230158158A1 (en) *	2020-03-27	2023-05-25	Uppthera	Pyrazolo quinazoline derivative compounds inducing selective degradation of plk1
WO2022145989A1 (ko) *	2020-12-31	2022-07-07	(주) 업테라	선택적 plk1 억제제로서의 피리미도디아제핀 유도체
EP4157849A4 (en) *	2021-08-10	2024-12-11	Uppthera, Inc.	NOVEL PLK1 DEGRADATION-INDUCING COMPOUND
GB202313514D0 (en)	2023-09-05	2023-10-18	Cambridge Entpr Ltd	Treatment of inflammatory diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL354241A1 (en)	1999-09-17	2003-12-29	Abbott Gmbh & Co.Kgabbott Gmbh & Co.Kg	Kinase inhibitors as therapeutic agents
PT1427730E (pt)	2001-09-04	2006-11-30	Boehringer Ingelheim Pharma	Novas di-hidropteridinonas, processo para sua preparação e sua utilização como medicamento
TW200804389A (en) *	2006-02-14	2008-01-16	Vertex Pharma	Dihydrodiazepines useful as inhibitors of protein kinases
TW200808325A (en) *	2006-07-06	2008-02-16	Astrazeneca Ab	Novel compounds

2008
- 2008-03-11 WO PCT/EP2008/052847 patent/WO2008113711A1/en not_active Ceased
- 2008-03-11 CA CA002680757A patent/CA2680757A1/en not_active Abandoned
- 2008-03-11 HR HR20110807T patent/HRP20110807T1/hr unknown
- 2008-03-11 DK DK08717594.9T patent/DK2139892T3/da active
- 2008-03-11 PT PT08717594T patent/PT2139892E/pt unknown
- 2008-03-11 MX MX2009010034A patent/MX2009010034A/es active IP Right Grant
- 2008-03-11 ES ES08717594T patent/ES2371832T3/es active Active
- 2008-03-11 BR BRPI0809088-2A patent/BRPI0809088A2/pt not_active IP Right Cessation
- 2008-03-11 PL PL08717594T patent/PL2139892T3/pl unknown
- 2008-03-11 EP EP08717594A patent/EP2139892B1/en not_active Not-in-force
- 2008-03-11 KR KR1020097019761A patent/KR101157848B1/ko not_active Expired - Fee Related
- 2008-03-11 JP JP2009553997A patent/JP5087640B2/ja not_active Expired - Fee Related
- 2008-03-11 SI SI200830445T patent/SI2139892T1/sl unknown
- 2008-03-11 AU AU2008228303A patent/AU2008228303B2/en not_active Ceased
- 2008-03-11 AT AT08717594T patent/ATE524472T1/de active
- 2008-03-11 CN CN201210030872.3A patent/CN102746175B/zh not_active Expired - Fee Related
- 2008-03-11 CN CN2008800088890A patent/CN101636399B/zh not_active Expired - Fee Related
- 2008-03-18 CL CL2008000785A patent/CL2008000785A1/es unknown
- 2008-03-19 US US12/051,000 patent/US7517873B2/en not_active Expired - Fee Related
- 2008-03-19 AR ARP080101142A patent/AR065794A1/es unknown
- 2008-03-19 TW TW097109660A patent/TWI363629B/zh not_active IP Right Cessation
- 2008-03-19 PE PE2011001933A patent/PE20120495A1/es not_active Application Discontinuation
2009
- 2009-08-27 IL IL200617A patent/IL200617A/en not_active IP Right Cessation
2011
- 2011-11-30 CY CY20111101174T patent/CY1112102T1/el unknown

Also Published As

Publication number	Publication date
PE20120495A1 (es)	2012-05-12
CY1112102T1 (el)	2015-11-04
CN101636399B (zh)	2012-04-18
IL200617A0 (en)	2010-05-17
SI2139892T1 (sl)	2011-12-30
AU2008228303A1 (en)	2008-09-25
EP2139892A1 (en)	2010-01-06
CA2680757A1 (en)	2008-09-25
PL2139892T3 (pl)	2012-03-30
ES2371832T3 (es)	2012-01-10
WO2008113711A1 (en)	2008-09-25
CN101636399A (zh)	2010-01-27
EP2139892B1 (en)	2011-09-14
PT2139892E (pt)	2011-11-21
TW200843781A (en)	2008-11-16
AU2008228303B2 (en)	2012-04-19
KR101157848B1 (ko)	2012-07-11
US20080234255A1 (en)	2008-09-25
BRPI0809088A2 (pt)	2014-09-09
MX2009010034A (es)	2009-10-12
IL200617A (en)	2014-02-27
TWI363629B (en)	2012-05-11
HRP20110807T1 (hr)	2011-12-31
HK1139936A1 (en)	2010-09-30
AR065794A1 (es)	2009-07-01
KR20090119913A (ko)	2009-11-20
CN102746175B (zh)	2014-01-15
US7517873B2 (en)	2009-04-14
JP5087640B2 (ja)	2012-12-05
CL2008000785A1 (es)	2009-03-27
ATE524472T1 (de)	2011-09-15
CN102746175A (zh)	2012-10-24
JP2010521514A (ja)	2010-06-24

Publication	Publication Date	Title
DK2139892T3 (da)	2011-12-12	Substituerede pyrimidodiazepiner nyttige som PLK1-inhibitorer
DK2086939T3 (da)	2010-10-11	Pyridiacarboxamid som II-beta-HSDI-inhibitorer
CY2017016I2 (el)	2017-07-12	Αναστολεις πρωτεασωματος
HUS1900016I1 (hu)	2019-04-29	C7-fluorral helyettesített tetraciklin vegyületek
DK2383271T3 (da)	2013-10-07	Aminoquinoloner som GSK-3-inhibitorer
DK2331547T3 (da)	2014-11-03	Pyrrolopyrimidinforbindelser som CDK-inhibitorer
DK2069324T3 (da)	2013-09-02	Fusioneret aminopyridin som hsp90-inhibitorer
DK2220070T3 (da)	2011-07-04	2-benzylpyridazinonderivater som Met-kinaseinhibitorer
DK2421825T3 (da)	2014-02-03	Azetidinyldiamider som monoacylglycerollipase-inhibitorer
DK2125748T3 (da)	2011-08-01	Acylaminopyrazol som FGFR inhibitorer
DK2102205T3 (da)	2010-12-06	Pyridopyrazinderivater anvendelige som herbicidale forbindelser
ATE502948T1 (de)	2011-04-15	Substituierte bicyclolactamverbindungen
DK2300465T3 (da)	2019-06-24	Imidazopyridinderivater som hæmmere af receptortyrosinkinaser
BRPI0813500A2 (pt)	2015-01-06	Compostos antivirais
DK2389382T3 (da)	2013-07-08	Aminoheterocykliske forbindelser anvendt som pde9-inhibitorer
BRPI0821086A2 (pt)	2014-10-07	Compostos inseticidas
DK2125792T3 (da)	2011-03-07	Purinderivater som immunomodulatorer
DK1926722T3 (da)	2011-12-19	Substituerede benzimidazoler som kinaseinhibitorer
BRPI0918602A2 (pt)	2015-12-15	composto (i)
BRPI0811264A2 (pt)	2014-11-04	Compostos
DK1937671T3 (da)	2010-04-26	Benzimidazolthiophenforbindelser som PLK-inhibitorer
BRPI0809996A2 (pt)	2014-10-14	Compostos
BRPI0814424A2 (pt)	2015-01-06	Compostos heterociclila
BRPI0815181A2 (pt)	2015-03-31	Compostos
EP2177529A4 (en)	2011-04-20	NEW SECRETASE HEMMER