DK2155228T3 - Polypeptidinhibitorer af HSP27-kinase og anvendelser herfor - Google Patents

Polypeptidinhibitorer af HSP27-kinase og anvendelser herfor

Info

Publication number
DK2155228T3
DK2155228T3 DK07836118.5T DK07836118T DK2155228T3 DK 2155228 T3 DK2155228 T3 DK 2155228T3 DK 07836118 T DK07836118 T DK 07836118T DK 2155228 T3 DK2155228 T3 DK 2155228T3
Authority
DK
Denmark
Prior art keywords
applications
kinase polypeptide
polypeptide inhibitors
hsp27 kinase
hsp27
Prior art date
Application number
DK07836118.5T
Other languages
English (en)
Inventor
Alyssa Panitch
Brandon Seal
Brian Ward
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Application granted granted Critical
Publication of DK2155228T3 publication Critical patent/DK2155228T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK07836118.5T 2007-01-10 2007-07-16 Polypeptidinhibitorer af HSP27-kinase og anvendelser herfor DK2155228T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88013707P 2007-01-10 2007-01-10
PCT/US2007/016246 WO2008085191A1 (en) 2007-01-10 2007-07-16 Polypeptide inhibitors of hsp27 kinase and uses therefor

Publications (1)

Publication Number Publication Date
DK2155228T3 true DK2155228T3 (da) 2014-07-07

Family

ID=39608928

Family Applications (3)

Application Number Title Priority Date Filing Date
DK13001411.1T DK2617431T3 (da) 2007-01-10 2007-07-16 Polypeptidinhibitorer af HSP27-kinase og anvendelser derfor
DK13001412.9T DK2606903T3 (da) 2007-01-10 2007-07-16 Polypeptidinhibitorer af HSP27-kinase og anvendelser herfor
DK07836118.5T DK2155228T3 (da) 2007-01-10 2007-07-16 Polypeptidinhibitorer af HSP27-kinase og anvendelser herfor

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK13001411.1T DK2617431T3 (da) 2007-01-10 2007-07-16 Polypeptidinhibitorer af HSP27-kinase og anvendelser derfor
DK13001412.9T DK2606903T3 (da) 2007-01-10 2007-07-16 Polypeptidinhibitorer af HSP27-kinase og anvendelser herfor

Country Status (7)

Country Link
US (3) US8536303B2 (da)
EP (3) EP2155228B1 (da)
AU (1) AU2007342674B2 (da)
CA (2) CA2689296C (da)
DK (3) DK2617431T3 (da)
ES (3) ES2594281T3 (da)
WO (1) WO2008085191A1 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080293640A1 (en) * 2007-01-10 2008-11-27 Arizona Board of Regents, A body Corporate, of the State of Arizona, acting for and on behalf of Polypeptide inhibitors of HSP27 kinase and uses therefor
ES2594281T3 (es) 2007-01-10 2016-12-19 Purdue Research Foundation Inhibidores polipeptídicos de HSP27 quinasa y usos de los mismos
US9034815B2 (en) * 2007-01-10 2015-05-19 Moerae Matrix, Inc Polypeptide for treating or preventing adhesions
JP5703466B2 (ja) 2007-08-07 2015-04-22 パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ キナーゼ阻害薬およびその使用
KR20180090396A (ko) 2008-01-18 2018-08-10 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 체액 내에서 질병 또는 병태의 시그너쳐의 검출 방법
AU2013202108B2 (en) * 2008-12-10 2015-12-24 Purdue Research Foundation Cell-permeant peptide-based inhibitor of kinases
BRPI0922448A2 (pt) * 2008-12-10 2021-02-17 Purdue Research Foundation inibidor com base em peptídeo penetrante celular de quinases
WO2011017132A2 (en) * 2009-07-27 2011-02-10 Purdue Research, Foundation Mk2 inhibitor compositions and methods to enhance neurite outgrowth, neuroprotection, and nerve regeneration
EP2575855A4 (en) * 2010-05-24 2014-03-12 Moerae Matrix Inc METHOD FOR TREATING OR PREVENTING VASCULAR GRAFT BREAKAGE
EP2596134B1 (en) 2010-07-23 2020-04-08 President and Fellows of Harvard College Methods of detecting diseases or conditions using phagocytic cells
EP4303584A3 (en) 2010-07-23 2024-04-03 President and Fellows of Harvard College Methods for detecting signatures of disease or conditions in bodily fluids
CA2806293A1 (en) 2010-07-23 2012-01-26 President And Fellows Of Harvard College Methods of detecting autoimmune or immune-related diseases or conditions
WO2012012717A1 (en) 2010-07-23 2012-01-26 President And Fellows Of Harvard College Methods of detecting prenatal or pregnancy-related diseases or conditions
US9890200B2 (en) * 2011-04-12 2018-02-13 Moerae Matrix, Inc. Compositions and methods for preventing or treating diseases, conditions, or processes characterized by aberrant fibroblast proliferation and extracellular matrix deposition
CA3042808A1 (en) * 2011-04-12 2012-10-18 Moerae Matrix, Inc. Compositions and methods for preventing or treating diseases, conditions, or processes characterized by aberrant fibroblast proliferation and extracellular matrix deposition
CA2747509C (en) 2011-05-12 2017-07-18 Oncogenex Technologies Inc. Treatment of pulmonary and pleural fibrosis using hsp27 inhibitors
WO2013134636A1 (en) 2012-03-09 2013-09-12 Purdue Research Foundation Compositions and methods for delivery of kinase inhibiting peptides
US20140072613A1 (en) * 2012-09-10 2014-03-13 Cynthia Lander Compositions and Methods for Treating Cutaneous Scarring
EP2965077B1 (en) 2013-03-09 2022-07-13 Harry Stylli Methods of detecting cancer
EP2965086A4 (en) 2013-03-09 2017-02-08 Harry Stylli Methods of detecting prostate cancer
US10336788B2 (en) * 2014-04-17 2019-07-02 Moerae Matrix, Inc. Inhibition of cardiac fibrosis in myocardial infarction
EP4428251A3 (en) 2014-09-11 2024-12-18 Immunis.AI, Inc. Methods of detecting prostate cancer
BR112017010238A2 (pt) * 2014-11-17 2018-02-06 Moerae Matrix, Inc. composições e métodos para prevenir ou tratar doenças, condições ou processos caracterizados por proliferação de fibroblastos e a deposição aberrante de matriz extracelular
CN107406489A (zh) 2015-01-08 2017-11-28 莫伊莱麦屈克斯公司 Mk2抑制剂肽的制剂
MX2017011633A (es) * 2015-03-12 2017-11-02 Moerae Matrix Inc Uso de composiciones que contienen peptido inhibidor de mk2 para tratar cancer de pulmon de celulas no pequeñas con las mismas.
US11946927B2 (en) 2016-03-14 2024-04-02 Musidora Biotechnology Llc Process and system for identifying individuals having a high risk of inflammatory bowel disease and a method of treatment
US10295527B2 (en) 2016-03-14 2019-05-21 Bruce Yacyshyn Process and system for predicting responders and non-responders to mesalamine treatment of ulcerative colitis
US20210015905A1 (en) * 2017-09-01 2021-01-21 Excel Med, Llc Pharmaceutical composition for treating keloid and uses thereof
CN115851946B (zh) * 2022-11-24 2023-09-01 中山大学孙逸仙纪念医院 CaMK I作为治疗靶点在制备胰腺癌治疗药物中的应用

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1521000A (en) 1975-06-13 1978-08-09 Syntex Puerto Rico Inc Inhalation device
US4227522A (en) 1978-09-05 1980-10-14 Syntex Puerto Rico, Inc. Inhalation device
US4192309A (en) 1978-09-05 1980-03-11 Syntex Puerto Rico, Inc. Inhalation device with capsule opener
NO160330C (no) 1982-10-08 1989-04-12 Glaxo Group Ltd Anordning for aa administrere medikamenter til pasienter og medikamentpakning for anordningen.
US4778054A (en) 1982-10-08 1988-10-18 Glaxo Group Limited Pack for administering medicaments to patients
US4811731A (en) 1985-07-30 1989-03-14 Glaxo Group Limited Devices for administering medicaments to patients
US5175144A (en) * 1988-11-29 1992-12-29 The Johns Hopkins University Method of retarding the progression of chronic renal failure
JPH05963A (ja) 1990-04-13 1993-01-08 Toray Ind Inc ポリペプチド類組成物
WO1991016057A1 (en) 1990-04-18 1991-10-31 University Of Utah COLONIC-TARGETED ORAL DRUG-DOSAGE FORMS BASED ON CROSSLINKED HYDROGELS CONTAINING AZOBONDS AND EXHIBITING pH-DEPENDENT SWELLING
EP0672159B1 (en) 1992-04-24 2005-12-28 Sri International Homologous sequence targeting in eukaryotic cells
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
EP0733059B1 (en) 1993-12-09 2000-09-13 Thomas Jefferson University Compounds and methods for site-directed mutations in eukaryotic cells
CA2314267A1 (en) 1997-12-10 1999-06-17 Washington University Anti-pathogen system and methods of use thereof
US7041814B1 (en) 1998-02-18 2006-05-09 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to Enterobacter cloacae for diagnostics and therapeutics
US7601685B2 (en) 1998-08-27 2009-10-13 Eidgenossische Technische Hochschule Zurich Growth factor modified protein matrices for tissue engineering
US7615373B2 (en) 1999-02-25 2009-11-10 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed collagen and tissue engineering
US20020009491A1 (en) 2000-02-14 2002-01-24 Rothbard Jonathan B. Compositions and methods for enhancing drug delivery across biological membranes and tissues
US7056533B2 (en) 2000-08-15 2006-06-06 Surmodics, Inc. Medicament incorporation matrix
WO2002058721A1 (en) * 2000-12-08 2002-08-01 Baylor College Of Medicine Trem-1 splice variant for use in modifying immune responses
AU2002226061B2 (en) 2001-01-18 2007-08-02 The Board Of Trustees Of The Leland Stanford Junior University Peptides for activation and inhibition of delta PKC
DE10118774A1 (de) * 2001-04-17 2002-10-31 Jerini Ag Verfahren zur Bestimmung der Substratspezifität einer enzymatischen Aktivität und Vorrichtung hierzu
US7361352B2 (en) * 2001-08-15 2008-04-22 Acambis, Inc. Influenza immunogen and vaccine
EP2301563A3 (en) 2001-08-23 2011-08-10 Board Of Regents Arizona HSP20 peptides
US20030134810A1 (en) 2001-10-09 2003-07-17 Chris Springate Methods and compositions comprising biocompatible materials useful for the administration of therapeutic agents
EP1476200A4 (en) 2002-02-21 2008-08-13 Univ Rockefeller COMPOSITION AND METHOD FOR REGULATING CALCIUM DEPENDENT SIGNALING IN THE BRAIN
US20040005686A1 (en) * 2002-03-07 2004-01-08 Pharmacia Corporation Crystalline structure of human MAPKAP kinase-2
WO2003084481A2 (en) 2002-04-01 2003-10-16 Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University Biological affinity based delivery systems
CA2494577A1 (en) 2002-08-02 2004-02-12 Wyeth Mk2 interacting proteins
US20040209897A1 (en) 2002-12-20 2004-10-21 Pharmacia Corporation Mitogen activated protein kinase-activated protein kinase-2 inhibiting compounds
EP1594526B1 (en) 2003-02-21 2006-07-12 Arizona Board Of Regents Use of hsp20 for promoting wound healing and/or reducing scar formation
IL156429A0 (en) 2003-06-12 2004-01-04 Peptor Ltd Cell permeable conjugates of peptides for inhibition of protein kinases
AU2004281838B2 (en) 2003-10-17 2008-01-31 Arizona Board Of Regents Novel heat shock protein 20-related polypeptides and uses therefor
ATE427499T1 (de) * 2004-05-21 2009-04-15 Inst Systems Biology Zusammensetzungen und verfahren zur quantifizierung von serumglykoproteinen
EP1771183B1 (en) 2004-07-23 2014-09-03 The Trustees of The University of Pennsylvania Antimicrobial copolymers and uses thereof
AU2005304638A1 (en) * 2004-11-12 2006-05-18 Massachusetts Institute Of Technology Methods and compositions for treating cellular proliferative diseases
US8008093B2 (en) * 2004-12-02 2011-08-30 The University Of North Carolina At Chapel Hill Inhibition of Hsp27 phosphorylation for the treatment of blistering disorders
US7252729B2 (en) 2004-12-29 2007-08-07 Owens-Corning Fiberglas Technology Inc. Polymer/WUCS mat for use in sheet molding compounds
EP1869169A4 (en) 2005-03-29 2015-11-04 Univ California REGULATION OF THE DESTINATION OF STEM CELLS BY ADJUSTABLE NETWORK
WO2006113667A1 (en) 2005-04-15 2006-10-26 University Of Arizona Therapeutic peptides for the treatment of metastatic cancer
AT502695A1 (de) 2005-10-20 2007-05-15 Voest Alpine Ind Anlagen Verfahren zur herstellung einer strangführungsrolle, eine nach dem verfahren hergestellte strangführungsrolle und deren verwendung
DK1948259T3 (da) 2005-10-26 2017-04-10 Genesis Tech Ltd Acellulær bioabsorberbare vævsregenereringsmatrixer produceret ved inkubering af acellulære blodprodukter
AU2006308989A1 (en) 2005-11-01 2007-05-10 The Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University Novel protein transduction domains and uses therefor
WO2007062060A2 (en) 2005-11-22 2007-05-31 Ted Reid Methods and compositions using substance p to promote wound healing
MX2009000359A (es) 2006-07-12 2009-05-08 Univ Arizona Metodos paratratar y limitar trastornos fibroticos y queloides.
US20080293640A1 (en) 2007-01-10 2008-11-27 Arizona Board of Regents, A body Corporate, of the State of Arizona, acting for and on behalf of Polypeptide inhibitors of HSP27 kinase and uses therefor
ES2594281T3 (es) 2007-01-10 2016-12-19 Purdue Research Foundation Inhibidores polipeptídicos de HSP27 quinasa y usos de los mismos
US9034815B2 (en) * 2007-01-10 2015-05-19 Moerae Matrix, Inc Polypeptide for treating or preventing adhesions
JP5703466B2 (ja) * 2007-08-07 2015-04-22 パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ キナーゼ阻害薬およびその使用
US20090269406A1 (en) 2008-04-02 2009-10-29 Alyssa Panitch Therapeutic uses of biocompatible biogel compositions
BRPI0922448A2 (pt) 2008-12-10 2021-02-17 Purdue Research Foundation inibidor com base em peptídeo penetrante celular de quinases
WO2011017132A2 (en) 2009-07-27 2011-02-10 Purdue Research, Foundation Mk2 inhibitor compositions and methods to enhance neurite outgrowth, neuroprotection, and nerve regeneration
EP2575855A4 (en) * 2010-05-24 2014-03-12 Moerae Matrix Inc METHOD FOR TREATING OR PREVENTING VASCULAR GRAFT BREAKAGE
CA3042808A1 (en) 2011-04-12 2012-10-18 Moerae Matrix, Inc. Compositions and methods for preventing or treating diseases, conditions, or processes characterized by aberrant fibroblast proliferation and extracellular matrix deposition

Also Published As

Publication number Publication date
WO2008085191A1 (en) 2008-07-17
CA2689296C (en) 2015-11-17
CA2898230A1 (en) 2008-07-17
DK2617431T3 (da) 2017-07-10
CA2898230C (en) 2018-04-24
EP2155228B1 (en) 2014-04-02
US9493508B2 (en) 2016-11-15
ES2594281T3 (es) 2016-12-19
EP2606903A1 (en) 2013-06-26
US20140112947A1 (en) 2014-04-24
CA2689296A1 (en) 2008-07-17
EP2617431A2 (en) 2013-07-24
AU2007342674B2 (en) 2013-09-19
US8536303B2 (en) 2013-09-17
US9649354B2 (en) 2017-05-16
US20170072009A1 (en) 2017-03-16
AU2007342674A1 (en) 2008-07-17
US20090196927A1 (en) 2009-08-06
EP2617431B1 (en) 2017-04-12
EP2155228A4 (en) 2010-06-16
EP2155228A1 (en) 2010-02-24
EP2617431A3 (en) 2013-12-11
DK2606903T3 (da) 2016-12-05
ES2476842T3 (es) 2014-07-15
EP2606903B1 (en) 2016-09-14
ES2624196T3 (es) 2017-07-13

Similar Documents

Publication Publication Date Title
DK2155228T3 (da) Polypeptidinhibitorer af HSP27-kinase og anvendelser herfor
HUS2200052I1 (hu) Imidazotriazinok és imidazopirimidinek mint kinázgátlók
HUS2300039I1 (hu) PSMA-kötõ szerek és alkalmazásaik
IL280173A (en) Inhibitors of brutons tyrosine kinase
DK2209806T3 (da) Anti-hepcidin-antistoffer og anvendelser deraf
DK2142529T3 (da) Trpv1-antagonister og anvendelser deraf
DK2059535T3 (da) Prlr-specifikt antistof og anvendelser deraf
CY2019009I2 (el) Αναστολεις πρωτεϊνικων κινασων
DK2147096T3 (da) Modificerede faktor-VII-polypeptider og anvendelser deraf
DK2068887T3 (da) SP35-antistoffer og anvendelser heraf
DK2234985T3 (da) 4-(4-cyano-2-thioaryl)-dihydropyrimidinoner og deres anvendelse
DK2118140T3 (da) Humancytomegalovirus-neutraliserende antistoffer og anvendelse deraf
DK2124999T3 (da) Activin-actrii antagonister og anvendelser til behandling af anæmi
DK2170287T3 (da) Mikropartikler omfattende PCL og anvendelser deraf
DK2120604T3 (da) Fremgangsmåde til fraktionering af havre, produkter derved opnået, og anvendelser deraf
PL2152701T3 (pl) Związki fenyloaminopirymidyny i ich zastosowania
DK2222675T3 (da) 5-anilinoimidazopyridiner og fremgangsmåder til deres anvendelse
DK2173378T3 (da) Komplekser af il-15 og il-15ralfa og anvendelser deraf
DK2012839T3 (da) Hidtil ukendte antimikrobielle substrater og anvendelser deraf
DK1846445T3 (da) PYY-agonister og anvendelser deraf
DK2012773T3 (da) Lægemidler og anvendelser deraf
DK2913344T3 (da) Specifikke bindingsproteiner og anvendelser deraf
DK3124497T3 (da) Rationelt designede syntetiske antistofbiblioteker og anvendelser deraf
DK1994055T3 (da) Anti-5t4-antistoffer og anvendelser deraf
DK1997081T3 (da) Indretning og fremgangsmåde til opbevaring og udlevering af pengesedler