DK217380A - Fremgangsmaade til fremstilling af 3-allyl-7,8-dihydroxy-6-halogen-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzapin-derivater - Google Patents

Fremgangsmaade til fremstilling af 3-allyl-7,8-dihydroxy-6-halogen-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzapin-derivater

Info

Publication number: DK217380A
Authority: DK; Denmark
Prior art keywords: compounds; tetrahydro; dihydroxy; hydroxyphenyl; allyl
Prior art date: 1979-05-25

Application number

DK217380A

Other languages

English (en)

Other versions

DK154833C (da

DK154833B (da

Inventor

J Weinstock

Original Assignee

Smithkline Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-05-25

Filing date

1980-05-19

Publication date

1980-11-26

1980-05-19 Application filed by Smithkline Corp filed Critical Smithkline Corp

1980-11-26 Publication of DK217380A publication Critical patent/DK217380A/da

1988-12-27 Publication of DK154833B publication Critical patent/DK154833B/da

1989-05-16 Application granted granted Critical

1989-05-16 Publication of DK154833C publication Critical patent/DK154833C/da

Links

-1 4-HYDROXYPHENYL Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 5
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 4
150000003839 salts Chemical class 0.000 abstract 2
230000006179 O-acylation Effects 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
208000006218 bradycardia Diseases 0.000 abstract 1
230000036471 bradycardia Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
230000002526 effect on cardiovascular system Effects 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
229940124550 renal vasodilator Drugs 0.000 abstract 1

Classifications

- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
- H04N3/00—Scanning details of television systems; Combination thereof with generation of supply voltages
- H04N3/10—Scanning details of television systems; Combination thereof with generation of supply voltages by means not exclusively optical-mechanical
- H04N3/16—Scanning details of television systems; Combination thereof with generation of supply voltages by means not exclusively optical-mechanical by deflecting electron beam in cathode-ray tube, e.g. scanning corrections
- H04N3/26—Modifications of scanning arrangements to improve focusing
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Multimedia (AREA)
Signal Processing (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Other In-Based Heterocyclic Compounds (AREA)

DK217380A 1979-05-25 1980-05-19 Analogifremgangsmaade til fremstilling af 3-allyl-7,8-dihydroxy-6-halogen-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepin-derivater DK154833C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/042,680 US4251525A (en)	1979-05-25	1979-05-25	3-Allyl-7,8-dihydroxy-6-halo-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives
US4268079		1979-05-25

Publications (3)

Publication Number	Publication Date
DK217380A true DK217380A (da)	1980-11-26
DK154833B DK154833B (da)	1988-12-27
DK154833C DK154833C (da)	1989-05-16

Family

ID=21923200

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK217380A DK154833C (da)	1979-05-25	1980-05-19	Analogifremgangsmaade til fremstilling af 3-allyl-7,8-dihydroxy-6-halogen-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepin-derivater

Country Status (26)

Country	Link
US (1)	US4251525A (da)
EP (1)	EP0020107B1 (da)
JP (1)	JPS55157569A (da)
KR (1)	KR840001212B1 (da)
AT (1)	ATE1448T1 (da)
AU (1)	AU534783B2 (da)
CS (1)	CS216929B2 (da)
DD (1)	DD151162A5 (da)
DE (1)	DE3060753D1 (da)
DK (1)	DK154833C (da)
ES (1)	ES491620A0 (da)
FI (1)	FI66599C (da)
GR (1)	GR68523B (da)
HU (1)	HU180582B (da)
IE (1)	IE49815B1 (da)
IL (1)	IL60144A (da)
IN (1)	IN154373B (da)
MX (1)	MX6526E (da)
NO (1)	NO146025C (da)
NZ (1)	NZ193767A (da)
PH (1)	PH15922A (da)
PL (1)	PL124374B1 (da)
PT (1)	PT71262A (da)
SU (1)	SU982539A3 (da)
YU (1)	YU140580A (da)
ZA (1)	ZA802325B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4340601A (en) *	1980-07-08	1982-07-20	Smithkline Corporation	Dopaminergic isoquinolines
US4328153A (en) *	1980-07-17	1982-05-04	Smith Kline Corporation	Dopaminergic benzazepines
CA2098446A1 (en) *	1992-09-30	1994-03-31	Eckard Weber	2,5-dihydro-2,5-dioxo-1h-azepines and 2,5-dihydro-2-oxo-1h-azepines and the use thereof as excitatory amino acid and glycine receptor antagonists
US7585493B2 (en)	2001-05-24	2009-09-08	Alexza Pharmaceuticals, Inc.	Thin-film drug delivery article and method of use
US7090830B2 (en) *	2001-05-24	2006-08-15	Alexza Pharmaceuticals, Inc.	Drug condensation aerosols and kits
US7645442B2 (en)	2001-05-24	2010-01-12	Alexza Pharmaceuticals, Inc.	Rapid-heating drug delivery article and method of use
US7458374B2 (en)	2002-05-13	2008-12-02	Alexza Pharmaceuticals, Inc.	Method and apparatus for vaporizing a compound
US7766013B2 (en) *	2001-06-05	2010-08-03	Alexza Pharmaceuticals, Inc.	Aerosol generating method and device
US20070122353A1 (en)	2001-05-24	2007-05-31	Hale Ron L	Drug condensation aerosols and kits
US20040105818A1 (en) *	2002-11-26	2004-06-03	Alexza Molecular Delivery Corporation	Diuretic aerosols and methods of making and using them
US7913688B2 (en) *	2002-11-27	2011-03-29	Alexza Pharmaceuticals, Inc.	Inhalation device for producing a drug aerosol
US20040234699A1 (en)	2003-05-21	2004-11-25	Alexza Molecular Delivery Corporation	Methods of controlling uniformity of substrate temperature and self-contained heating unit and drug-supply unit employing same
US7540286B2 (en) *	2004-06-03	2009-06-02	Alexza Pharmaceuticals, Inc.	Multiple dose condensation aerosol devices and methods of forming condensation aerosols
EP2246086A3 (en) *	2004-08-12	2012-11-21	Alexza Pharmaceuticals, Inc.	Aerosol drug delivery device incorporating percussively activated heating unit
US20100006092A1 (en) *	2004-08-12	2010-01-14	Alexza Pharmaceuticals, Inc.	Aerosol Drug Delivery Device Incorporating Percussively Activated Heat Packages
EP2121088B1 (en)	2007-03-09	2016-07-13	Alexza Pharmaceuticals, Inc.	Heating unit for use in a drug delivery device
US12214118B2 (en)	2018-02-02	2025-02-04	Alexza Pharmaceuticals, Inc.	Electrical condensation aerosol device

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4160765A (en) *	1976-11-17	1979-07-10	Smithkline Corporation	Method for 6-bromination of 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
ZA777444B (en) *	1977-01-19	1978-10-25	Smithkline Corp	Alkylthio-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines having dopaminergic activity
US4104379A (en) *	1977-01-19	1978-08-01	Smithkline Corporation	Substituted 1-alkylthiophenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
US4108989A (en) *	1977-04-01	1978-08-22	Smithkline Corporation	2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diones
US4171359A (en) *	1978-04-12	1979-10-16	Smithkline Corporation	Benz-tetrasubstituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines

1979
- 1979-05-25 US US06/042,680 patent/US4251525A/en not_active Expired - Lifetime
1980
- 1980-04-18 ZA ZA00802325A patent/ZA802325B/xx unknown
- 1980-05-16 IN IN359/DEL/80A patent/IN154373B/en unknown
- 1980-05-16 JP JP6585780A patent/JPS55157569A/ja active Pending
- 1980-05-19 DK DK217380A patent/DK154833C/da not_active IP Right Cessation
- 1980-05-19 HU HU80801241A patent/HU180582B/hu not_active IP Right Cessation
- 1980-05-19 FI FI801612A patent/FI66599C/fi not_active IP Right Cessation
- 1980-05-19 AU AU58520/80A patent/AU534783B2/en not_active Expired
- 1980-05-19 PH PH24043A patent/PH15922A/en unknown
- 1980-05-19 PT PT71262A patent/PT71262A/pt unknown
- 1980-05-19 NZ NZ193767A patent/NZ193767A/xx unknown
- 1980-05-20 NO NO801497A patent/NO146025C/no unknown
- 1980-05-20 ES ES491620A patent/ES491620A0/es active Granted
- 1980-05-21 IE IE1063/80A patent/IE49815B1/en not_active IP Right Cessation
- 1980-05-22 GR GR62031A patent/GR68523B/el unknown
- 1980-05-22 IL IL60144A patent/IL60144A/xx unknown
- 1980-05-22 PL PL1980224415A patent/PL124374B1/pl unknown
- 1980-05-23 DE DE8080301716T patent/DE3060753D1/de not_active Expired
- 1980-05-23 SU SU802927002A patent/SU982539A3/ru active
- 1980-05-23 MX MX808838U patent/MX6526E/es unknown
- 1980-05-23 DD DD80221356A patent/DD151162A5/de not_active IP Right Cessation
- 1980-05-23 EP EP80301716A patent/EP0020107B1/en not_active Expired
- 1980-05-23 CS CS803658A patent/CS216929B2/cs unknown
- 1980-05-23 YU YU01405/80A patent/YU140580A/xx unknown
- 1980-05-23 AT AT80301716T patent/ATE1448T1/de not_active IP Right Cessation
- 1980-05-24 KR KR1019800002048A patent/KR840001212B1/ko not_active Expired

Also Published As

Publication number	Publication date
EP0020107B1 (en)	1982-08-11
SU982539A3 (ru)	1982-12-15
NO146025B (no)	1982-04-05
JPS55157569A (en)	1980-12-08
DE3060753D1 (en)	1982-10-07
AU534783B2 (en)	1984-02-16
DK154833C (da)	1989-05-16
IN154373B (da)	1984-10-20
NO801497L (no)	1980-11-26
DK154833B (da)	1988-12-27
NO146025C (no)	1982-07-14
KR840001212B1 (ko)	1984-08-21
EP0020107A1 (en)	1980-12-10
YU140580A (en)	1983-02-28
FI66599B (fi)	1984-07-31
IE801063L (en)	1980-11-25
ES8104235A1 (es)	1981-04-16
PL124374B1 (en)	1983-01-31
FI801612A7 (fi)	1980-11-26
GR68523B (da)	1982-01-11
ZA802325B (en)	1981-08-26
IL60144A0 (en)	1980-07-31
PL224415A1 (da)	1981-02-13
PH15922A (en)	1983-04-22
CS216929B2 (en)	1982-12-31
NZ193767A (en)	1982-12-21
ES491620A0 (es)	1981-04-16
AU5852080A (en)	1980-11-27
HU180582B (en)	1983-03-28
MX6526E (es)	1985-06-28
FI66599C (fi)	1984-11-12
US4251525A (en)	1981-02-17
KR830002715A (ko)	1983-05-30
PT71262A (en)	1980-06-01
DD151162A5 (de)	1981-10-08
IL60144A (en)	1984-09-30
IE49815B1 (en)	1985-12-25
ATE1448T1 (de)	1982-08-15

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Legal Events

Date	Code	Title	Description
2000-06-05	PUP	Patent expired