DK2185561T3 - Derivater af 1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazin-6-carboxamid og 2,3,4,5-tetrahydroprrolo(1,2-a)-diazepin-7-carboxamid, fremstilling deraf og terapeutisk anvendelse deraf - Google Patents

Derivater af 1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazin-6-carboxamid og 2,3,4,5-tetrahydroprrolo(1,2-a)-diazepin-7-carboxamid, fremstilling deraf og terapeutisk anvendelse deraf

Info

Publication number: DK2185561T3
Authority: DK; Denmark
Prior art keywords: carboxamide; tetrahydropyrrolo; diazepine; pyrazine; derivatives
Prior art date: 2007-07-27

Application number

DK08836692.7T

Other languages

English (en)

Inventor

Bernard Baudoin

Michel Evers

Arielle Genevois-Borella

Andreas Karlsson

Jean-Luc Malleron

Magali Mathieu

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-07-27

Filing date

2008-07-24

Publication date

2011-10-10

2007-07-27 Priority claimed from FR0705498A external-priority patent/FR2919289B1/fr

2007-07-27 Priority claimed from FR0705497A external-priority patent/FR2919288B1/fr

2008-07-24 Application filed by Sanofi Sa filed Critical Sanofi Sa

2011-10-10 Application granted granted Critical

2011-10-10 Publication of DK2185561T3 publication Critical patent/DK2185561T3/da

Links

CHVBEBZZBGCXQP-UHFFFAOYSA-N 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-6-carboxamide Chemical class C1NCCN2C(C(=O)N)=CC=C21 CHVBEBZZBGCXQP-UHFFFAOYSA-N 0.000 title abstract 2
230000001225 therapeutic effect Effects 0.000 title abstract 2
UERAUKQJMDAHHP-UHFFFAOYSA-N 2,3,4,5-tetrahydro-1h-pyrrolo[1,2-a][1,4]diazepine-7-carboxamide Chemical class C1NCCCN2C(C(=O)N)=CC=C21 UERAUKQJMDAHHP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Psychiatry (AREA)
Emergency Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK08836692.7T 2007-07-27 2008-07-24 Derivater af 1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazin-6-carboxamid og 2,3,4,5-tetrahydroprrolo(1,2-a)-diazepin-7-carboxamid, fremstilling deraf og terapeutisk anvendelse deraf DK2185561T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR0705498A FR2919289B1 (fr)	2007-07-27	2007-07-27	Derives de 2,3,4,5-tetrahydropyrrolo[1,2-a][1,4]- diazepine-7-carboxamides, leur preparation et leur application en therapeutique.
FR0705497A FR2919288B1 (fr)	2007-07-27	2007-07-27	Derives de 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-6- carboxamides, leur preparation et leur application en therapeutique.
PCT/FR2008/001096 WO2009044007A2 (fr)	2007-07-27	2008-07-24	Dérivés de 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-6-carboxamides et de 2,3,4,5-tetrahydropyrrolo[1,2-a][1,4]-diazépine-7-carboxamides, leur préparation et leur application en thérapeutique

Publications (1)

Publication Number	Publication Date
DK2185561T3 true DK2185561T3 (da)	2011-10-10

Family

ID=40526763

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK08836692.7T DK2185561T3 (da)	2007-07-27	2008-07-24	Derivater af 1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazin-6-carboxamid og 2,3,4,5-tetrahydroprrolo(1,2-a)-diazepin-7-carboxamid, fremstilling deraf og terapeutisk anvendelse deraf

Country Status (23)

Country	Link
US (1)	US20100197668A1 (da)
EP (1)	EP2185561B1 (da)
JP (1)	JP2010534639A (da)
KR (1)	KR20100050485A (da)
CN (1)	CN101765601A (da)
AT (1)	ATE512968T1 (da)
AU (1)	AU2008306835A1 (da)
BR (1)	BRPI0813094A2 (da)
CA (1)	CA2694288A1 (da)
CO (1)	CO6290689A2 (da)
CY (1)	CY1112121T1 (da)
DK (1)	DK2185561T3 (da)
EA (1)	EA201070195A1 (da)
HR (1)	HRP20110650T1 (da)
MA (1)	MA31630B1 (da)
MX (1)	MX2010001076A (da)
NZ (1)	NZ582871A (da)
PL (1)	PL2185561T3 (da)
PT (1)	PT2185561E (da)
RS (1)	RS51912B (da)
SI (1)	SI2185561T1 (da)
WO (1)	WO2009044007A2 (da)
ZA (1)	ZA201000581B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2919285B1 (fr) *	2007-07-27	2012-08-31	Sanofi Aventis	Derives de 1-oxo-isoindoline-4-carboxamides et de 1-oxo- 1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur preparation et leur application en therapeutique.
FR2960876B1 (fr) *	2010-06-03	2012-07-27	Sanofi Aventis	Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique.
JP6254088B2 (ja)	2011-10-17	2017-12-27	バイオセリックス，インコーポレイテッド	置換ビアリールアルキルアミド
UY34610A (es)	2012-02-03	2013-09-30	Sanofi Sa	Pirroldicarboxamidas condensadas y su uso como agentes farmacéuticos.
JP6414793B2 (ja) *	2014-10-30	2018-10-31	エルジー・ケム・リミテッド	環化合物およびこれを含む有機発光素子
US10301306B2 (en)	2014-12-15	2019-05-28	Bristol-Myers Squibb Company	Substituted dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones as RIPK3 inhibitors
CN114522668B (zh) *	2022-01-13	2023-10-13	浙江大学杭州国际科创中心	乙氧基柱[6]芳烃晶体材料在选择性吸附四氢吡咯中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2477117A1 (en) *	2002-02-22	2003-08-28	Teijin Limited	Pyrrolopyrimidine derivative
GB0309221D0 (en) *	2003-04-23	2003-06-04	Glaxo Group Ltd	Novel compounds
GB0328900D0 (en) *	2003-12-12	2004-01-14	Glaxo Group Ltd	Novel compounds
GB0506562D0 (en) *	2005-03-31	2005-05-04	Glaxo Group Ltd	Novel compounds

2008
- 2008-07-24 NZ NZ582871A patent/NZ582871A/en not_active IP Right Cessation
- 2008-07-24 HR HR20110650T patent/HRP20110650T1/hr unknown
- 2008-07-24 BR BRPI0813094-9A2A patent/BRPI0813094A2/pt not_active IP Right Cessation
- 2008-07-24 JP JP2010517449A patent/JP2010534639A/ja not_active Withdrawn
- 2008-07-24 SI SI200830365T patent/SI2185561T1/sl unknown
- 2008-07-24 KR KR1020107001731A patent/KR20100050485A/ko not_active Withdrawn
- 2008-07-24 AT AT08836692T patent/ATE512968T1/de active
- 2008-07-24 AU AU2008306835A patent/AU2008306835A1/en not_active Abandoned
- 2008-07-24 CN CN200880100661.4A patent/CN101765601A/zh active Pending
- 2008-07-24 WO PCT/FR2008/001096 patent/WO2009044007A2/fr not_active Ceased
- 2008-07-24 DK DK08836692.7T patent/DK2185561T3/da active
- 2008-07-24 CA CA2694288A patent/CA2694288A1/fr not_active Abandoned
- 2008-07-24 EA EA201070195A patent/EA201070195A1/ru unknown
- 2008-07-24 EP EP08836692A patent/EP2185561B1/fr active Active
- 2008-07-24 PT PT08836692T patent/PT2185561E/pt unknown
- 2008-07-24 PL PL08836692T patent/PL2185561T3/pl unknown
- 2008-07-24 MX MX2010001076A patent/MX2010001076A/es active IP Right Grant
- 2008-07-24 RS RS20110374A patent/RS51912B/sr unknown
2010
- 2010-01-26 ZA ZA2010/00581A patent/ZA201000581B/en unknown
- 2010-01-26 US US12/693,601 patent/US20100197668A1/en not_active Abandoned
- 2010-01-26 CO CO10007695A patent/CO6290689A2/es not_active Application Discontinuation
- 2010-02-24 MA MA32647A patent/MA31630B1/fr unknown
2011
- 2011-09-15 CY CY20111100888T patent/CY1112121T1/el unknown

Also Published As

Publication number	Publication date
US20100197668A1 (en)	2010-08-05
JP2010534639A (ja)	2010-11-11
CA2694288A1 (fr)	2009-04-09
SI2185561T1 (sl)	2011-10-28
PT2185561E (pt)	2011-09-07
EP2185561B1 (fr)	2011-06-15
WO2009044007A2 (fr)	2009-04-09
WO2009044007A3 (fr)	2009-09-17
NZ582871A (en)	2011-09-30
CY1112121T1 (el)	2015-11-04
HRP20110650T1 (hr)	2011-10-31
ZA201000581B (en)	2011-04-28
PL2185561T3 (pl)	2011-11-30
BRPI0813094A2 (pt)	2014-12-23
AU2008306835A1 (en)	2009-04-09
MA31630B1 (fr)	2010-08-02
EA201070195A1 (ru)	2010-10-29
CN101765601A (zh)	2010-06-30
MX2010001076A (es)	2010-03-09
KR20100050485A (ko)	2010-05-13
ATE512968T1 (de)	2011-07-15
CO6290689A2 (es)	2011-06-20
EP2185561A2 (fr)	2010-05-19
RS51912B (sr)	2012-02-29

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