ATE512968T1 - 1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazin-6- carboxamid und 2,3,4,5-tetrahydropyrrolo(1,2-a)- diazepin-7-carboxamid- derivate, ihre herstellung und therapeutische verwendung - Google Patents

1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazin-6- carboxamid und 2,3,4,5-tetrahydropyrrolo(1,2-a)- diazepin-7-carboxamid- derivate, ihre herstellung und therapeutische verwendung

Info

Publication number: ATE512968T1
Authority: AT; Austria
Prior art keywords: tetrahydropyrrolo; carboxamide; diazepine; pyrazine; preparation
Prior art date: 2007-07-27

Application number

AT08836692T

Other languages

English (en)

Inventor

Bernard Baudoin

Michel Evers

Arielle Genevois-Borella

Andreas Karlsson

Jean-Luc Malleron

Magali Mathieu

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-07-27

Filing date

2008-07-24

Publication date

2011-07-15

2007-07-27 Priority claimed from FR0705497A external-priority patent/FR2919288B1/fr

2007-07-27 Priority claimed from FR0705498A external-priority patent/FR2919289B1/fr

2008-07-24 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2011-07-15 Application granted granted Critical

2011-07-15 Publication of ATE512968T1 publication Critical patent/ATE512968T1/de

Links

CHVBEBZZBGCXQP-UHFFFAOYSA-N 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-6-carboxamide Chemical compound C1NCCN2C(C(=O)N)=CC=C21 CHVBEBZZBGCXQP-UHFFFAOYSA-N 0.000 title abstract 2
230000001225 therapeutic effect Effects 0.000 title abstract 2
229940053202 antiepileptics carboxamide derivative Drugs 0.000 title 1
UERAUKQJMDAHHP-UHFFFAOYSA-N 2,3,4,5-tetrahydro-1h-pyrrolo[1,2-a][1,4]diazepine-7-carboxamide Chemical class C1NCCCN2C(C(=O)N)=CC=C21 UERAUKQJMDAHHP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT08836692T 2007-07-27 2008-07-24 1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazin-6- carboxamid und 2,3,4,5-tetrahydropyrrolo(1,2-a)- diazepin-7-carboxamid- derivate, ihre herstellung und therapeutische verwendung ATE512968T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR0705497A FR2919288B1 (fr)	2007-07-27	2007-07-27	Derives de 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-6- carboxamides, leur preparation et leur application en therapeutique.
FR0705498A FR2919289B1 (fr)	2007-07-27	2007-07-27	Derives de 2,3,4,5-tetrahydropyrrolo[1,2-a][1,4]- diazepine-7-carboxamides, leur preparation et leur application en therapeutique.
PCT/FR2008/001096 WO2009044007A2 (fr)	2007-07-27	2008-07-24	Dérivés de 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-6-carboxamides et de 2,3,4,5-tetrahydropyrrolo[1,2-a][1,4]-diazépine-7-carboxamides, leur préparation et leur application en thérapeutique

Publications (1)

Publication Number	Publication Date
ATE512968T1 true ATE512968T1 (de)	2011-07-15

Family

ID=40526763

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08836692T ATE512968T1 (de)	2007-07-27	2008-07-24	1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazin-6- carboxamid und 2,3,4,5-tetrahydropyrrolo(1,2-a)- diazepin-7-carboxamid- derivate, ihre herstellung und therapeutische verwendung

Country Status (23)

Country	Link
US (1)	US20100197668A1 (de)
EP (1)	EP2185561B1 (de)
JP (1)	JP2010534639A (de)
KR (1)	KR20100050485A (de)
CN (1)	CN101765601A (de)
AT (1)	ATE512968T1 (de)
AU (1)	AU2008306835A1 (de)
BR (1)	BRPI0813094A2 (de)
CA (1)	CA2694288A1 (de)
CO (1)	CO6290689A2 (de)
CY (1)	CY1112121T1 (de)
DK (1)	DK2185561T3 (de)
EA (1)	EA201070195A1 (de)
HR (1)	HRP20110650T1 (de)
MA (1)	MA31630B1 (de)
MX (1)	MX2010001076A (de)
NZ (1)	NZ582871A (de)
PL (1)	PL2185561T3 (de)
PT (1)	PT2185561E (de)
RS (1)	RS51912B (de)
SI (1)	SI2185561T1 (de)
WO (1)	WO2009044007A2 (de)
ZA (1)	ZA201000581B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2919285B1 (fr) *	2007-07-27	2012-08-31	Sanofi Aventis	Derives de 1-oxo-isoindoline-4-carboxamides et de 1-oxo- 1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur preparation et leur application en therapeutique.
FR2960876B1 (fr) *	2010-06-03	2012-07-27	Sanofi Aventis	Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique.
AU2012326361B2 (en)	2011-10-17	2017-08-03	Biotheryx, Inc.	Substituted biaryl alkyl amides
ES2623167T3 (es) *	2012-02-03	2017-07-10	Sanofi	Pirroldicarboxamidas condensadas y su uso como productos farmacéuticos
WO2016068478A2 (ko) *	2014-10-30	2016-05-06	주식회사 엘지화학	고리 화합물 및 이를 포함하는 유기 발광 소자
US10301306B2 (en)	2014-12-15	2019-05-28	Bristol-Myers Squibb Company	Substituted dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones as RIPK3 inhibitors
CN114522668B (zh) *	2022-01-13	2023-10-13	浙江大学杭州国际科创中心	乙氧基柱[6]芳烃晶体材料在选择性吸附四氢吡咯中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2477117A1 (en) *	2002-02-22	2003-08-28	Teijin Limited	Pyrrolopyrimidine derivative
GB0309221D0 (en) *	2003-04-23	2003-06-04	Glaxo Group Ltd	Novel compounds
GB0328900D0 (en) *	2003-12-12	2004-01-14	Glaxo Group Ltd	Novel compounds
GB0506562D0 (en) *	2005-03-31	2005-05-04	Glaxo Group Ltd	Novel compounds

2008
- 2008-07-24 HR HR20110650T patent/HRP20110650T1/hr unknown
- 2008-07-24 KR KR1020107001731A patent/KR20100050485A/ko not_active Withdrawn
- 2008-07-24 BR BRPI0813094-9A2A patent/BRPI0813094A2/pt not_active IP Right Cessation
- 2008-07-24 SI SI200830365T patent/SI2185561T1/sl unknown
- 2008-07-24 CN CN200880100661.4A patent/CN101765601A/zh active Pending
- 2008-07-24 AU AU2008306835A patent/AU2008306835A1/en not_active Abandoned
- 2008-07-24 NZ NZ582871A patent/NZ582871A/en not_active IP Right Cessation
- 2008-07-24 PL PL08836692T patent/PL2185561T3/pl unknown
- 2008-07-24 AT AT08836692T patent/ATE512968T1/de active
- 2008-07-24 JP JP2010517449A patent/JP2010534639A/ja not_active Withdrawn
- 2008-07-24 CA CA2694288A patent/CA2694288A1/fr not_active Abandoned
- 2008-07-24 MX MX2010001076A patent/MX2010001076A/es active IP Right Grant
- 2008-07-24 WO PCT/FR2008/001096 patent/WO2009044007A2/fr not_active Ceased
- 2008-07-24 DK DK08836692.7T patent/DK2185561T3/da active
- 2008-07-24 EP EP08836692A patent/EP2185561B1/de active Active
- 2008-07-24 RS RS20110374A patent/RS51912B/sr unknown
- 2008-07-24 EA EA201070195A patent/EA201070195A1/ru unknown
- 2008-07-24 PT PT08836692T patent/PT2185561E/pt unknown
2010
- 2010-01-26 US US12/693,601 patent/US20100197668A1/en not_active Abandoned
- 2010-01-26 CO CO10007695A patent/CO6290689A2/es not_active Application Discontinuation
- 2010-01-26 ZA ZA2010/00581A patent/ZA201000581B/en unknown
- 2010-02-24 MA MA32647A patent/MA31630B1/fr unknown
2011
- 2011-09-15 CY CY20111100888T patent/CY1112121T1/el unknown

Also Published As

Publication number	Publication date
BRPI0813094A2 (pt)	2014-12-23
EP2185561A2 (de)	2010-05-19
NZ582871A (en)	2011-09-30
HRP20110650T1 (hr)	2011-10-31
US20100197668A1 (en)	2010-08-05
KR20100050485A (ko)	2010-05-13
SI2185561T1 (sl)	2011-10-28
PL2185561T3 (pl)	2011-11-30
CN101765601A (zh)	2010-06-30
WO2009044007A3 (fr)	2009-09-17
CY1112121T1 (el)	2015-11-04
CA2694288A1 (fr)	2009-04-09
AU2008306835A1 (en)	2009-04-09
EA201070195A1 (ru)	2010-10-29
MA31630B1 (fr)	2010-08-02
JP2010534639A (ja)	2010-11-11
MX2010001076A (es)	2010-03-09
PT2185561E (pt)	2011-09-07
CO6290689A2 (es)	2011-06-20
WO2009044007A2 (fr)	2009-04-09
EP2185561B1 (de)	2011-06-15
DK2185561T3 (da)	2011-10-10
RS51912B (sr)	2012-02-29
ZA201000581B (en)	2011-04-28

Legal Events

Date

Code

Title

Description

2012-02-15

UEP

Publication of translation of european patent specification

Ref document number: 2185561

Country of ref document: EP

Publication	Publication Date	Title
ATE467633T1 (de)	2010-05-15	2-aryl-6-phenylimidazoä1,2-aüpyridin-derivate, ihre herstellung und therapeutische verwendung
TW200800968A (en)	2008-01-01	Sulfoximine-substituted pyrimidines, processes for production thereof and use thereof as drugs
MY153921A (en)	2015-04-15	Aminopyrazole derivatives
UY31236A1 (es)	2009-03-02	Derivados de la 6-cicloamino-3-(piridazin-4-il)imidazo[1,2-b]-piridazina, su preparacion y su aplicacion en terapéutica
WO2009002423A3 (en)	2009-04-23	Polycyclic guanine derivatives and use thereof
DE602005006815D1 (de)	2008-06-26	2-carbamid-4-phenylthiazol-derivate, deren herstellung und therapeutische verwendung
WO2007021937A3 (en)	2007-07-12	Unsaturated heterocyclic derivatives
ATE512970T1 (de)	2011-07-15	Dimere von artemisininderivaten, deren herstellung und deren therapeutische verwendung
ATE512968T1 (de)	2011-07-15	1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazin-6- carboxamid und 2,3,4,5-tetrahydropyrrolo(1,2-a)- diazepin-7-carboxamid- derivate, ihre herstellung und therapeutische verwendung
ATE502035T1 (de)	2011-04-15	2-amido-4-phenylthiazol-derivate, ihre herstellung und ihre therapeutische verwendung
TNSN07440A1 (en)	2009-03-17	Derivatives of pyrido [2,3 -d] pyrimidine, the preparation thereof, and the therapeutic application of the same
ATE540023T1 (de)	2012-01-15	Neuartige 3-aminoalkyl-1,3-dihydro-2h-indol-2-on- derivate, ihre herstellung und therapeutische verwendung
WO2008104473A3 (en)	2008-11-06	Pyrazolopyriidine derivatives and their use as kinase inhibitors
CO5660287A2 (es)	2006-07-31	Derivados de tetrahidrocarbazol y su uso farmaceutico
DE602005019743D1 (de)	2010-04-15	Oxopiperidinderivate, ihre herstellung und therapeutische verwendung
MX2008011576A (es)	2008-09-22	Compuestos de imidazo[2,1-b]tiazol sustituidos y su uso para la produccion de farmacos.
WO2006066950A3 (de)	2006-08-17	Tricyclische aminoalkohole, verfahren zu ihrer herstellung und ihre verwendung als entzündungshemmer
ATE520654T1 (de)	2011-09-15	Polypyrrol-derivate, ihre herstellung und ihre therapeutische verwendung
DE502006004182D1 (de)	2009-08-20	Substituierte 5,6,7,8-tetrahydro-imidazoä1 ,2-aüpyridin-2-ylamin-verbindungen und deren verwendung zur herstellung von arzneimitteln
SV2006002220A (es)	2006-03-15	Derivados de alquiliden-tetrahidronaftaleno, procedimiento para su preparacion y su uso como antiinflamatorios ref. p-sv-78.836/cd
ATE549339T1 (de)	2012-03-15	Derivate von pyrrolopyridin-2-carboxamiden, ihre herstellung und ihre therapeutische anwendung
MY150428A (en)	2014-01-30	Tricyclic n-heteroaryl-carboxamide derivatives, preparation thereof and therapeutic use of same
ATE407126T1 (de)	2008-09-15	Herstellung von (s)-4-fluormethyl-dihydro-furan-2-on
ATE524468T1 (de)	2011-09-15	Derivate aus n-phenyl-imidazo-(1,2-a)-pyridin-2- carboxamiden, ihre herstellung sowie ihre therapeutische anwendung
WO2007121883A3 (de)	2007-12-21	1,4:3,6-dianhydromannitol-derivate und deren verwendung