ATE512968T1 - 1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazin-6- carboxamid und 2,3,4,5-tetrahydropyrrolo(1,2-a)- diazepin-7-carboxamid- derivate, ihre herstellung und therapeutische verwendung - Google Patents

1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazin-6- carboxamid und 2,3,4,5-tetrahydropyrrolo(1,2-a)- diazepin-7-carboxamid- derivate, ihre herstellung und therapeutische verwendung

Info

Publication number: ATE512968T1
Authority: AT; Austria
Prior art keywords: tetrahydropyrrolo; carboxamide; diazepine; pyrazine; preparation
Prior art date: 2007-07-27

Application number

AT08836692T

Other languages

English (en)

Inventor

Bernard Baudoin

Michel Evers

Arielle Genevois-Borella

Andreas Karlsson

Jean-Luc Malleron

Magali Mathieu

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-07-27

Filing date

2008-07-24

Publication date

2011-07-15

2007-07-27 Priority claimed from FR0705498A external-priority patent/FR2919289B1/fr

2007-07-27 Priority claimed from FR0705497A external-priority patent/FR2919288B1/fr

2008-07-24 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2011-07-15 Application granted granted Critical

2011-07-15 Publication of ATE512968T1 publication Critical patent/ATE512968T1/de

Links

CHVBEBZZBGCXQP-UHFFFAOYSA-N 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-6-carboxamide Chemical compound C1NCCN2C(C(=O)N)=CC=C21 CHVBEBZZBGCXQP-UHFFFAOYSA-N 0.000 title abstract 2
230000001225 therapeutic effect Effects 0.000 title abstract 2
229940053202 antiepileptics carboxamide derivative Drugs 0.000 title 1
UERAUKQJMDAHHP-UHFFFAOYSA-N 2,3,4,5-tetrahydro-1h-pyrrolo[1,2-a][1,4]diazepine-7-carboxamide Chemical class C1NCCCN2C(C(=O)N)=CC=C21 UERAUKQJMDAHHP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT08836692T 2007-07-27 2008-07-24 1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazin-6- carboxamid und 2,3,4,5-tetrahydropyrrolo(1,2-a)- diazepin-7-carboxamid- derivate, ihre herstellung und therapeutische verwendung ATE512968T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR0705498A FR2919289B1 (fr)	2007-07-27	2007-07-27	Derives de 2,3,4,5-tetrahydropyrrolo[1,2-a][1,4]- diazepine-7-carboxamides, leur preparation et leur application en therapeutique.
FR0705497A FR2919288B1 (fr)	2007-07-27	2007-07-27	Derives de 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-6- carboxamides, leur preparation et leur application en therapeutique.
PCT/FR2008/001096 WO2009044007A2 (fr)	2007-07-27	2008-07-24	Dérivés de 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-6-carboxamides et de 2,3,4,5-tetrahydropyrrolo[1,2-a][1,4]-diazépine-7-carboxamides, leur préparation et leur application en thérapeutique

Publications (1)

Publication Number	Publication Date
ATE512968T1 true ATE512968T1 (de)	2011-07-15

Family

ID=40526763

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08836692T ATE512968T1 (de)	2007-07-27	2008-07-24	1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazin-6- carboxamid und 2,3,4,5-tetrahydropyrrolo(1,2-a)- diazepin-7-carboxamid- derivate, ihre herstellung und therapeutische verwendung

Country Status (23)

Country	Link
US (1)	US20100197668A1 (de)
EP (1)	EP2185561B1 (de)
JP (1)	JP2010534639A (de)
KR (1)	KR20100050485A (de)
CN (1)	CN101765601A (de)
AT (1)	ATE512968T1 (de)
AU (1)	AU2008306835A1 (de)
BR (1)	BRPI0813094A2 (de)
CA (1)	CA2694288A1 (de)
CO (1)	CO6290689A2 (de)
CY (1)	CY1112121T1 (de)
DK (1)	DK2185561T3 (de)
EA (1)	EA201070195A1 (de)
HR (1)	HRP20110650T1 (de)
MA (1)	MA31630B1 (de)
MX (1)	MX2010001076A (de)
NZ (1)	NZ582871A (de)
PL (1)	PL2185561T3 (de)
PT (1)	PT2185561E (de)
RS (1)	RS51912B (de)
SI (1)	SI2185561T1 (de)
WO (1)	WO2009044007A2 (de)
ZA (1)	ZA201000581B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2919285B1 (fr) *	2007-07-27	2012-08-31	Sanofi Aventis	Derives de 1-oxo-isoindoline-4-carboxamides et de 1-oxo- 1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur preparation et leur application en therapeutique.
FR2960876B1 (fr) *	2010-06-03	2012-07-27	Sanofi Aventis	Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique.
WO2013059215A1 (en)	2011-10-17	2013-04-25	Biotheryx, Inc.	Substituted biaryl alkyl amides
DK2809669T3 (da)	2012-02-03	2017-05-01	Sanofi Sa	Kondenserede pyrroldicarboxamider og deres anvendelse som farmaceutika
US10431748B2 (en)	2014-10-30	2019-10-01	Lg Chem, Ltd.	Cyclic compound and organic light-emitting element comprising same
WO2016100166A1 (en)	2014-12-15	2016-06-23	Bristol-Myers Squibb Company	SUBSTITUTED DIHYDRO-1H-PYRROLO[3,2-c]PYRIDIN-4(5H)-ONES AS RIPK3 INHIBITORS
CN114522668B (zh) *	2022-01-13	2023-10-13	浙江大学杭州国际科创中心	乙氧基柱[6]芳烃晶体材料在选择性吸附四氢吡咯中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2003211428A1 (en) *	2002-02-22	2003-09-09	Teijin Limited	Pyrrolopyrimidine derivative
GB0309221D0 (en) *	2003-04-23	2003-06-04	Glaxo Group Ltd	Novel compounds
GB0328900D0 (en) *	2003-12-12	2004-01-14	Glaxo Group Ltd	Novel compounds
GB0506562D0 (en) *	2005-03-31	2005-05-04	Glaxo Group Ltd	Novel compounds

2008
- 2008-07-24 KR KR1020107001731A patent/KR20100050485A/ko not_active Withdrawn
- 2008-07-24 CN CN200880100661.4A patent/CN101765601A/zh active Pending
- 2008-07-24 WO PCT/FR2008/001096 patent/WO2009044007A2/fr not_active Ceased
- 2008-07-24 RS RS20110374A patent/RS51912B/sr unknown
- 2008-07-24 HR HR20110650T patent/HRP20110650T1/hr unknown
- 2008-07-24 PL PL08836692T patent/PL2185561T3/pl unknown
- 2008-07-24 AT AT08836692T patent/ATE512968T1/de active
- 2008-07-24 SI SI200830365T patent/SI2185561T1/sl unknown
- 2008-07-24 MX MX2010001076A patent/MX2010001076A/es active IP Right Grant
- 2008-07-24 DK DK08836692.7T patent/DK2185561T3/da active
- 2008-07-24 CA CA2694288A patent/CA2694288A1/fr not_active Abandoned
- 2008-07-24 JP JP2010517449A patent/JP2010534639A/ja not_active Withdrawn
- 2008-07-24 BR BRPI0813094-9A2A patent/BRPI0813094A2/pt not_active IP Right Cessation
- 2008-07-24 AU AU2008306835A patent/AU2008306835A1/en not_active Abandoned
- 2008-07-24 EA EA201070195A patent/EA201070195A1/ru unknown
- 2008-07-24 EP EP08836692A patent/EP2185561B1/de active Active
- 2008-07-24 PT PT08836692T patent/PT2185561E/pt unknown
- 2008-07-24 NZ NZ582871A patent/NZ582871A/en not_active IP Right Cessation
2010
- 2010-01-26 CO CO10007695A patent/CO6290689A2/es not_active Application Discontinuation
- 2010-01-26 US US12/693,601 patent/US20100197668A1/en not_active Abandoned
- 2010-01-26 ZA ZA2010/00581A patent/ZA201000581B/en unknown
- 2010-02-24 MA MA32647A patent/MA31630B1/fr unknown
2011
- 2011-09-15 CY CY20111100888T patent/CY1112121T1/el unknown

Also Published As

Publication number	Publication date
PL2185561T3 (pl)	2011-11-30
NZ582871A (en)	2011-09-30
AU2008306835A1 (en)	2009-04-09
CY1112121T1 (el)	2015-11-04
SI2185561T1 (sl)	2011-10-28
JP2010534639A (ja)	2010-11-11
HRP20110650T1 (hr)	2011-10-31
CA2694288A1 (fr)	2009-04-09
PT2185561E (pt)	2011-09-07
MX2010001076A (es)	2010-03-09
EP2185561B1 (de)	2011-06-15
EA201070195A1 (ru)	2010-10-29
DK2185561T3 (da)	2011-10-10
BRPI0813094A2 (pt)	2014-12-23
KR20100050485A (ko)	2010-05-13
MA31630B1 (fr)	2010-08-02
US20100197668A1 (en)	2010-08-05
WO2009044007A3 (fr)	2009-09-17
EP2185561A2 (de)	2010-05-19
WO2009044007A2 (fr)	2009-04-09
ZA201000581B (en)	2011-04-28
RS51912B (sr)	2012-02-29
CN101765601A (zh)	2010-06-30
CO6290689A2 (es)	2011-06-20

Legal Events

Date

Code

Title

Description

2012-02-15

UEP

Publication of translation of european patent specification

Ref document number: 2185561

Country of ref document: EP

Publication	Publication Date	Title
ATE467633T1 (de)	2010-05-15	2-aryl-6-phenylimidazoä1,2-aüpyridin-derivate, ihre herstellung und therapeutische verwendung
TW200800968A (en)	2008-01-01	Sulfoximine-substituted pyrimidines, processes for production thereof and use thereof as drugs
WO2009002423A3 (en)	2009-04-23	Polycyclic guanine derivatives and use thereof
CL2011000116A1 (es)	2011-06-17	Compuestos derivados de imidazo[1,2-a]piridina; procedimiento de preparacion; composicion farmaceutica; compuestos intermediarios; y uso en el tratamiento del cancer.
ATE512970T1 (de)	2011-07-15	Dimere von artemisininderivaten, deren herstellung und deren therapeutische verwendung
JO2682B1 (en)	2013-03-03	Derivatives of alkynil-8.1-naphthayridone, preparations thereof and therapeutic use thereof
ATE502035T1 (de)	2011-04-15	2-amido-4-phenylthiazol-derivate, ihre herstellung und ihre therapeutische verwendung
MX2012007896A (es)	2012-08-01	Derivados de piridino-piridinonas arilsulfonamidas, su preparacion y su uso en terapeutica.
ATE540023T1 (de)	2012-01-15	Neuartige 3-aminoalkyl-1,3-dihydro-2h-indol-2-on- derivate, ihre herstellung und therapeutische verwendung
CO5660287A2 (es)	2006-07-31	Derivados de tetrahidrocarbazol y su uso farmaceutico
ZA201000581B (en)	2011-04-28	1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-6-carboxamide and 2,3,4,5-tetrahydropyrrolo[1,2-a][1,4]-diazepine-7-carboxamide derivatives,preparation and therapeutic use thereof
DE602005019743D1 (de)	2010-04-15	Oxopiperidinderivate, ihre herstellung und therapeutische verwendung
WO2008104473A3 (en)	2008-11-06	Pyrazolopyriidine derivatives and their use as kinase inhibitors
MX2008011576A (es)	2008-09-22	Compuestos de imidazo[2,1-b]tiazol sustituidos y su uso para la produccion de farmacos.
WO2006066950A3 (de)	2006-08-17	Tricyclische aminoalkohole, verfahren zu ihrer herstellung und ihre verwendung als entzündungshemmer
ATE520654T1 (de)	2011-09-15	Polypyrrol-derivate, ihre herstellung und ihre therapeutische verwendung
DE502006004182D1 (de)	2009-08-20	Substituierte 5,6,7,8-tetrahydro-imidazoä1 ,2-aüpyridin-2-ylamin-verbindungen und deren verwendung zur herstellung von arzneimitteln
ATE499351T1 (de)	2011-03-15	Aryl- und heteroaryl-ethyl-acylguanidinderivate, ihre herstellung und ihre therapeutische anwendung
TW200745102A (en)	2007-12-16	Pyrido[2,3-d]pyrimidine derivatives, preparation thereof, therapeutic use thereof
SV2006002220A (es)	2006-03-15	Derivados de alquiliden-tetrahidronaftaleno, procedimiento para su preparacion y su uso como antiinflamatorios ref. p-sv-78.836/cd
ATE549339T1 (de)	2012-03-15	Derivate von pyrrolopyridin-2-carboxamiden, ihre herstellung und ihre therapeutische anwendung
MY150428A (en)	2014-01-30	Tricyclic n-heteroaryl-carboxamide derivatives, preparation thereof and therapeutic use of same
ATE407126T1 (de)	2008-09-15	Herstellung von (s)-4-fluormethyl-dihydro-furan-2-on
DE602006015675D1 (de)	2010-09-02	6-heteroarylpyridoindolon-derivate, ihre herstellung und ihre therapeutische anwendung
WO2007121883A3 (de)	2007-12-21	1,4:3,6-dianhydromannitol-derivate und deren verwendung