DK2198037T3 - Kemo-enzymatisk peptidsyntese ved hjælp af C-terminal ester-interkonvertering - Google Patents

Kemo-enzymatisk peptidsyntese ved hjælp af C-terminal ester-interkonvertering

Info

Publication number
DK2198037T3
DK2198037T3 DK08838478.9T DK08838478T DK2198037T3 DK 2198037 T3 DK2198037 T3 DK 2198037T3 DK 08838478 T DK08838478 T DK 08838478T DK 2198037 T3 DK2198037 T3 DK 2198037T3
Authority
DK
Denmark
Prior art keywords
terminal
ester
peptide
optionally
protected
Prior art date
Application number
DK08838478.9T
Other languages
English (en)
Inventor
Peter Jan Leonard Mario Quaedflieg
Timo Nuijens
Harold Monro Moody
Van Theodorus Johannes Godfried Maria Dooren
Claudia Cusan
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Application granted granted Critical
Publication of DK2198037T3 publication Critical patent/DK2198037T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/222—Phenylalanine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
DK08838478.9T 2007-10-12 2008-10-09 Kemo-enzymatisk peptidsyntese ved hjælp af C-terminal ester-interkonvertering DK2198037T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07020031 2007-10-12
PCT/EP2008/063574 WO2009047311A1 (en) 2007-10-12 2008-10-09 Chemo-enzymatic peptide synthesis via c-terminal ester interconversion

Publications (1)

Publication Number Publication Date
DK2198037T3 true DK2198037T3 (da) 2012-05-29

Family

ID=39149330

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08838478.9T DK2198037T3 (da) 2007-10-12 2008-10-09 Kemo-enzymatisk peptidsyntese ved hjælp af C-terminal ester-interkonvertering

Country Status (7)

Country Link
US (1) US8450084B2 (da)
EP (1) EP2198037B1 (da)
JP (1) JP2011500010A (da)
CN (1) CN101821400B (da)
AT (1) ATE544864T1 (da)
DK (1) DK2198037T3 (da)
WO (1) WO2009047311A1 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA019536B1 (ru) * 2008-11-19 2014-04-30 ДСМ АйПи АССЕТС Б.В. Синтез пептидов с использованием энзиматической активации и конденсации
JP2014505059A (ja) 2011-01-18 2014-02-27 ジェネラル アトミクス ヒドロラーゼ酵素基質およびその使用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4856184B2 (ja) * 2005-10-20 2012-01-18 ディーエスエム アイピー アセッツ ビー．ブイ． オリゴペプチドアミドからオリゴペプチドアルキルエステルへの酵素転化
ATE461208T1 (de) * 2006-01-17 2010-04-15 Organon Nv Selektive enzymatische hydrolyse von c-terminalen tert-butyl-peptidestern

Also Published As

Publication number Publication date
CN101821400B (zh) 2014-02-19
ATE544864T1 (de) 2012-02-15
EP2198037A1 (en) 2010-06-23
US8450084B2 (en) 2013-05-28
JP2011500010A (ja) 2011-01-06
CN101821400A (zh) 2010-09-01
WO2009047311A1 (en) 2009-04-16
EP2198037B1 (en) 2012-02-08
US20100311113A1 (en) 2010-12-09

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DK2198037T3 (da) Kemo-enzymatisk peptidsyntese ved hjælp af C-terminal ester-interkonvertering