DK2241575T3 - IGF-1-fusionspolypeptider og terapeutiske anvendelser deraf - Google Patents
IGF-1-fusionspolypeptider og terapeutiske anvendelser deraf Download PDFInfo
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- DK2241575T3 DK2241575T3 DK10007017.6T DK10007017T DK2241575T3 DK 2241575 T3 DK2241575 T3 DK 2241575T3 DK 10007017 T DK10007017 T DK 10007017T DK 2241575 T3 DK2241575 T3 DK 2241575T3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
Claims (13)
1. Fusionsprotein, der omfatter: (a) mindst en IGF1-polypeptidvariant-komponent; og (b) en fusions-komponent, der omfatter Fc-domænet af human IgG; hvor IGF-variant-komponenten er et humant IGF-1-protein af SEQ ID NO:1, omfattende: (i) en deletion af aminosyrer i position 1-3, 37 og 68-70 (Δ1-3, Δ37, Δ68-70); eller (ii) en deletion af aminosyrer i position 1-3, 37 og 65-70 (Δ1-3, Δ37, Δ65-70)
2. Dimer af fusionsproteinet ifølge krav 1.
3. Nukleinsyre, der koder for fusionsproteinet ifølge krav 1.
4. Vektor, der omfatter nukleinsyren ifølge krav 3.
5. Vært-vektor-system, der omfatter vektoren ifølge krav 4.
6. Vært-vektor-system ifølge krav 5, hvor værtscellen er udvalgt fra en bakterie-, gær-, insekt- og pattedyrcelle.
7. Fremgangsmåde til fremstilling af et fusionsprotein, hvilken fremgangsmåde omfatter, at man dyrker en værtscelle transfekteret med vektoren ifølge krav 4, under betingelser, der er egnede til ekspression af proteinet fra værtscellen, og indvinder det således producerede polypeptid.
8. Farmaceutisk sammensætning, der omfatter fusionsproteinet ifølge krav 1 og en farmaceutisk acceptabel bærer.
9. Fusionsprotein ifølge krav 1 til anvendelse i en terapeutisk metode til behandling af en sygdom eller tilstand udvalgt fra muskelatrofi, dværgvækst, myokardialt infarkt, osteoporose, aldersbetinget svaghed eller gebrækkelighed, sarkopeni, en sygdom eller en tilstand, der involverer tab af kropsmasse, cachexia, kongestiv hjerteinsufficiens, thalassæmi, diabetes, hy- perglykæmi og anæmi eller til behandling af et individ, der har risiko for at udvikle den sygdom eller tilstand.
10. Fusionsprotein ifølge krav 9 til anvendelse i en terapeutisk metode, hvor muskelatrofien er resultatet af denervering; degenerativ, metabolisk eller inflammatorisk neuropati; infantile og juvenile spinale muskelatrofier; autoimmun motorisk neuropati; kronisk sygdom, AIDS, faste eller rhabdomyolyse; et muskeldystrofi-syndrom; sarkopeni; immobilisering; ældning; eller som resultat af behandling med et atrofi-forårsagende middel.
11. Anvendelse af et fusionsprotein ifølge krav 1 ved fremstilling af et medikament til behandling af en sygdom eller tilstand udvalgt fra muskelatrofi, dværgvækst, myokardialt infarkt, osteoporose, aldersbetinget svaghed eller gebrækkelighed, sarkopeni, en sygdom eller tilstand, der involverer tab af kropsmasse, cachexia, kongestiv hjerteinsufficiens, thalassæmi, diabetes, hyperglykæmi og anæmi eller til behandling af et individ, der har risiko for at udvikle den sygdom eller tilstand.
12. Anvendelse ifølge krav 11, hvor muskelatrofien er som defineret i krav 10.
13. Fusionsprotein ifølge krav 1 til anvendelse i en fremgangsmåde til behandling af menneske- eller dyrekroppen.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64222905P | 2005-01-07 | 2005-01-07 | |
| US65658305P | 2005-02-25 | 2005-02-25 | |
| EP06717668A EP1833847B1 (en) | 2005-01-07 | 2006-01-06 | Igf-1 fusion polypeptides and therapeutic uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2241575T3 true DK2241575T3 (da) | 2015-08-24 |
Family
ID=42634965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10007017.6T DK2241575T3 (da) | 2005-01-07 | 2006-01-06 | IGF-1-fusionspolypeptider og terapeutiske anvendelser deraf |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US7396918B2 (da) |
| EP (2) | EP1833847B1 (da) |
| JP (1) | JP4988599B2 (da) |
| AT (1) | ATE517120T1 (da) |
| AU (1) | AU2006203882B2 (da) |
| CA (1) | CA2594023C (da) |
| DK (1) | DK2241575T3 (da) |
| ES (1) | ES2541810T3 (da) |
| HU (1) | HUE027645T2 (da) |
| PL (2) | PL1833847T3 (da) |
| PT (1) | PT2241575E (da) |
| WO (1) | WO2006074390A2 (da) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7521211B2 (en) | 2005-04-05 | 2009-04-21 | Regeneron Pharmaceuticals, Inc | IGF-1 and IGF-2 chimeric polypeptides and therapeutic uses thereof |
| CL2007001614A1 (es) * | 2006-06-09 | 2008-08-08 | Novartis Ag | Polipeptido que comprende una proteina del precursor del factor de crecimiento tipo insulina, igf-1 humana, en la cual la escision del peptido e mediante una proteasa se reduce a traves de la modificacion de la proteina del precursor; y su uso para t |
| AU2007291501B2 (en) * | 2006-08-31 | 2012-07-12 | F. Hoffmann-La Roche Ag | Method for the production of insulin-like growth factor-I |
| CL2007002502A1 (es) | 2006-08-31 | 2008-05-30 | Hoffmann La Roche | Variantes del factor de crecimiento similar a insulina-1 humano (igf-1) pegilados en lisina; metodo de produccion; proteina de fusion que la comprende; y su uso para tratar la enfermedad de alzheimer. |
| GB0715213D0 (en) * | 2007-08-06 | 2007-09-12 | Asterlon Ltd | Igf-1 |
| HRP20170698T1 (hr) * | 2008-05-07 | 2017-09-22 | Biomarin Pharmaceutical Inc. | Lizosomski usmjereni peptidi i njihove uporabe |
| US8685403B2 (en) | 2009-01-30 | 2014-04-01 | The Regents Of The University Of California | Insulin-like growth factor signaling and integrin |
| US7963705B2 (en) * | 2009-02-24 | 2011-06-21 | Avago Technologies Fiber Ip (Singapore) Pte. Ltd. | Molded interconnect device (MID) optical connector with metal retaining clip |
| TWI490371B (zh) | 2009-07-28 | 2015-07-01 | Industrie De Nora Spa | 電解應用上的電極及其製法以及在電極表面上陽極釋氧之電解法和電冶法 |
| BR112012029611A2 (pt) | 2010-05-21 | 2017-07-25 | Merrimack Pharmaceuticals Inc | proteína de fusão biespecífica, composição farmacêutica, método de tratamento de dano ao tecido em um indivíduo, método de promoção da regeração ou sobrevivência do tecido em um indivíduo e molécula de ácido nucleico |
| US20130274235A1 (en) * | 2010-10-08 | 2013-10-17 | The General Hospital Corporation | Treatment of motor neuron disease |
| CN102618575A (zh) * | 2011-09-16 | 2012-08-01 | 江苏普罗赛生物技术有限公司 | 哺乳动物细胞大规模生产重组人IGF1-Fc融合蛋白的实验技术 |
| JP6499080B2 (ja) * | 2012-12-18 | 2019-04-10 | ノバルティス アーゲー | 安定化されたインスリン様成長因子ポリペプチド |
| WO2014097113A2 (en) * | 2012-12-18 | 2014-06-26 | Novartis Ag | Production of therapeutic proteins in genetically modified mammalian cells |
| US10076384B2 (en) | 2013-03-08 | 2018-09-18 | Symple Surgical, Inc. | Balloon catheter apparatus with microwave emitter |
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2006
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- 2006-01-06 US US11/327,555 patent/US7396918B2/en not_active Expired - Lifetime
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- 2006-01-06 HU HUE10007017A patent/HUE027645T2/en unknown
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- 2006-01-06 WO PCT/US2006/000495 patent/WO2006074390A2/en not_active Ceased
- 2006-01-06 AT AT06717668T patent/ATE517120T1/de active
- 2006-01-06 EP EP06717668A patent/EP1833847B1/en not_active Expired - Lifetime
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| WO2006074390A2 (en) | 2006-07-13 |
| US8158581B2 (en) | 2012-04-17 |
| HUE027645T2 (en) | 2016-10-28 |
| AU2006203882B2 (en) | 2011-05-12 |
| PL2241575T3 (pl) | 2015-12-31 |
| US7396918B2 (en) | 2008-07-08 |
| US20060166328A1 (en) | 2006-07-27 |
| WO2006074390A3 (en) | 2007-01-11 |
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| EP1833847A2 (en) | 2007-09-19 |
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