DK2247577T4 - Fremgangsmåde til regioselektiv syntese af 1-alkyl-3-haloalkyl-pyrazol-4-carboxylsyrederivater - Google Patents
Fremgangsmåde til regioselektiv syntese af 1-alkyl-3-haloalkyl-pyrazol-4-carboxylsyrederivater Download PDFInfo
- Publication number
- DK2247577T4 DK2247577T4 DK09715350.6T DK09715350T DK2247577T4 DK 2247577 T4 DK2247577 T4 DK 2247577T4 DK 09715350 T DK09715350 T DK 09715350T DK 2247577 T4 DK2247577 T4 DK 2247577T4
- Authority
- DK
- Denmark
- Prior art keywords
- pyrazole
- haloalkyl
- alkyl
- procedure
- carboxylic acid
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/72—Hydrazones
- C07C251/74—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C251/76—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/72—Hydrazones
- C07C251/86—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/10—Hydrazines
- C07C243/12—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms
- C07C243/16—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C243/18—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/72—Hydrazones
- C07C251/74—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C251/78—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
- C07C251/80—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08151891A EP2133341A1 (de) | 2008-02-25 | 2008-02-25 | Verfahren zur regioselektiven Synthese von 1-Alkyl-3-haloalkyl-pyrazol-4-carbonsäure-Derivaten |
| PCT/EP2009/000958 WO2009106230A2 (de) | 2008-02-25 | 2009-02-12 | Verfahren zur regioselektiven synthese von 1-alkyl-3-haloalkyl-pyrazol-4-carbonsäur e-derivaten |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK2247577T3 DK2247577T3 (da) | 2016-02-15 |
| DK2247577T4 true DK2247577T4 (da) | 2022-07-18 |
Family
ID=39590527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09715350.6T DK2247577T4 (da) | 2008-02-25 | 2009-02-12 | Fremgangsmåde til regioselektiv syntese af 1-alkyl-3-haloalkyl-pyrazol-4-carboxylsyrederivater |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8629288B2 (da) |
| EP (2) | EP2133341A1 (da) |
| JP (2) | JP5756293B2 (da) |
| KR (1) | KR101656690B1 (da) |
| CN (2) | CN102026981B (da) |
| BR (2) | BRPI0908891A2 (da) |
| CA (1) | CA2716381C (da) |
| DK (1) | DK2247577T4 (da) |
| ES (1) | ES2561038T5 (da) |
| IL (1) | IL207151A0 (da) |
| MX (2) | MX2010008553A (da) |
| MY (2) | MY156546A (da) |
| RU (2) | RU2498977C9 (da) |
| TW (1) | TWI458712B (da) |
| WO (1) | WO2009106230A2 (da) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009021987A1 (en) | 2007-08-16 | 2009-02-19 | Solvay (Société Anonyme) | Process for the preparation of esters of 4-fluorosubstituted 3-oxo-alcanoic acids |
| EP2133341A1 (de) * | 2008-02-25 | 2009-12-16 | Bayer CropScience AG | Verfahren zur regioselektiven Synthese von 1-Alkyl-3-haloalkyl-pyrazol-4-carbonsäure-Derivaten |
| EP2100883A1 (de) * | 2008-03-10 | 2009-09-16 | Bayer CropScience AG | Verfahren zur regioselektiven Synthese von 1-Alkyl-3-haloalkyl-pyrazol-4carbonsäure-Derivaten |
| DK2288597T3 (da) * | 2008-05-05 | 2015-01-26 | Basf Se | Fremgangsmåde til fremstilling af 1,3,4-substituerede pyrazolforbindelser |
| BR112013032988A2 (pt) | 2011-06-21 | 2016-08-16 | Bayer Ip Gmbh | método para a produção de pirazolilcarboxanilidas |
| CH706864B1 (de) * | 2011-06-22 | 2016-03-31 | Central Glass Co Ltd | Verfahren zur Herstellung einer Pyrazol-Verbindung. |
| EP2623496A1 (de) | 2012-02-01 | 2013-08-07 | Bayer CropScience AG | Verfahren zur Herstellung von 3,5-bis (fluoralkyl)-pyrazol-4-carbonsäure-Derivaten und 3,5-bis(fluoralkyl)-pyrazolen |
| EP2644598A1 (en) | 2012-03-30 | 2013-10-02 | Solvay Sa | Method for the manufacture of heterocycles |
| EP2644593A1 (en) * | 2012-03-30 | 2013-10-02 | Solvay Sa | Dialkoxymethyl oxobutyric acid esters, their manufacture and use |
| WO2013171102A1 (en) | 2012-05-16 | 2013-11-21 | Solvay Sa | Manufacture of 1-substituted methylidene compounds |
| EP2671874B1 (en) | 2012-06-06 | 2016-01-13 | Solvay Sa | Preparation of esters of 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylic acids |
| EP2671873A1 (en) | 2012-06-06 | 2013-12-11 | Solvay Sa | Method for the cyclization of hydrazinoacrylic acid derivatives |
| US8871947B2 (en) | 2013-02-04 | 2014-10-28 | KingChem LLC | Preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid ester |
| EP2999694B1 (en) * | 2013-05-22 | 2017-05-17 | Bayer CropScience Aktiengesellschaft | Process for preparing 3,5-bis(fluoroalkyl)pyrazole derivatives from alpha,alpha -dihaloamines |
| JP6518654B2 (ja) | 2013-05-22 | 2019-05-22 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | ３，５−ビス（フルオロアルキル）ピラゾール誘導体の製造方法 |
| CN103360313A (zh) * | 2013-07-12 | 2013-10-23 | 雅本化学股份有限公司 | 3-氟代烷基-1-取代吡唑-4-羧酸及其制备方法 |
| TWI647215B (zh) * | 2013-11-11 | 2019-01-11 | 德商拜耳作物科學股份有限公司 | 自α,α－二鹵胺製備３,５－雙鹵烷基吡唑衍生物之方法 |
| WO2015085464A1 (en) | 2013-12-09 | 2015-06-18 | King Chem, Llc | Process for preparing alkyl 3-difluoromethyl-1-methyl-1h-pyrazole-4-carboxylate and its analogs |
| JP6431088B2 (ja) * | 2014-03-24 | 2018-11-28 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | α，α−ジハロアミン類およびケチミン類からの３，５−ビス（ハロアルキル）ピラゾール誘導体の製造方法 |
| EP3015458A1 (en) | 2014-11-03 | 2016-05-04 | Bayer CropScience AG | Process for preparing 3,5-bis(haloalkyl)pyrazole derivatives from a,a-dihaloamines and ketimines |
| EP3154947B1 (en) | 2014-06-11 | 2018-03-28 | Bayer CropScience Aktiengesellschaft | Process for preparing 3,5-bis(haloalkyl)pyrazoles via acylation of ketimines |
| BR112016028702B1 (pt) | 2014-06-11 | 2021-05-04 | Bayer Cropscience Aktiengesellschaft | processo para preparação de derivados de 3,5-bis(haloalquil)pirazole via acilação de hidrazonas |
| CN105541716B (zh) * | 2015-03-26 | 2024-02-23 | Ａｇｃ株式会社 | 吡唑衍生物的制造方法 |
| KR20180021798A (ko) | 2015-06-26 | 2018-03-05 | 바이엘 크롭사이언스 악티엔게젤샤프트 | α,α-디할로알킬아민 및 케트이민으로부터 할로알콕시- 및 할로알킬티오 그룹을 가지는 치환된 피라졸의 제조방법 |
| CN106467492B (zh) * | 2015-08-14 | 2019-12-17 | 联化科技(盐城)有限公司 | 多氟甲基吡唑类化合物的制备方法、中间体及制备方法 |
| JP2019507136A (ja) * | 2016-02-18 | 2019-03-14 | ソルヴェイ（ソシエテ アノニム） | カルボキサミドの製造方法 |
| JP2019524765A (ja) * | 2016-08-02 | 2019-09-05 | ソルヴェイ（ソシエテ アノニム） | ピラゾールカルボン酸および誘導体の製造に有用なヒドラジニル化合物の製造、ヒドラジニル化合物ならびにその使用 |
| CN109689629B (zh) | 2016-09-21 | 2022-11-29 | 拜耳作物科学股份公司 | 制备3-氟烷基-5-吡唑羧酸酯和3-氟烷基-5-吡唑羧酸的方法 |
| EP3728198A1 (en) * | 2017-12-22 | 2020-10-28 | Solvay Sa | Process for the manufacture of pyrazole carboxylic derivatives and precursors thereof |
| KR20200103744A (ko) * | 2017-12-22 | 2020-09-02 | 솔베이(소시에떼아노님) | 이미늄 화합물의 제조 방법 및 피라졸 유도체 제조에서의 이의 응용 |
| KR20210022048A (ko) | 2018-06-18 | 2021-03-02 | 바이엘 악티엔게젤샤프트 | 이치환된 3-피라졸 카르복실레이트, 및 에놀레이트의 아실화를 통한 그의 제조 방법 |
| WO2020093715A1 (en) | 2018-11-07 | 2020-05-14 | Fujian Yongjing Technology Co., Ltd | New process for manufacture of pyrazoles or pyrimidones |
| CN112480007B (zh) * | 2020-12-08 | 2022-11-18 | 宿迁市科莱博生物化学有限公司 | 一种1，3-二甲基-1h-吡唑-4-羧酸的合成方法 |
| CN114195678A (zh) * | 2021-12-24 | 2022-03-18 | 江苏七洲绿色科技研究院有限公司 | 一种中间体、其制备方法及用其制备3-二氟甲基-1-甲基吡唑-4-甲酸乙酯的方法 |
| CN114195715B (zh) * | 2021-12-31 | 2024-05-10 | 福建永晶科技股份有限公司 | 1-甲基-3-二氟甲基-4-吡唑酸和1-甲基-3-三氟甲基-4-吡唑酸的制备方法 |
| CN117447401B (zh) * | 2023-12-26 | 2024-04-19 | 山东国邦药业有限公司 | 一种二氟吡唑酸的合成方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20000035081A (ko) | 1998-11-10 | 2000-06-26 | 마크 에스. 아들러 | 2-(트리할로아세틸)-3-(치환된 아미노)-2-프로페노에이트 제조방법 |
| DE10215292A1 (de) * | 2002-02-19 | 2003-08-28 | Bayer Cropscience Ag | Disubstitutierte Pyrazolylcarbocanilide |
| DE10349500A1 (de) | 2003-10-23 | 2005-06-02 | Bayer Cropscience Ag | Verfahren zum Herstellen von 2-Dihalogenacyl-3-amino-acrylsäureestern und 3-Dihalogenmethyl-pyrazol-4-carbonsäureestern |
| EA010851B1 (ru) * | 2004-10-21 | 2008-12-30 | Зингента Партисипейшнс Аг | Способ получения пиразолов |
| CN101133031B (zh) * | 2005-02-25 | 2010-07-21 | 财团法人相模中央化学研究所 | 1-取代-3-氟代烷基吡唑-4-羧酸酯的制造方法 |
| DE102006039909A1 (de) | 2006-08-25 | 2008-03-13 | Bayer Cropscience Ag | Verfahren zum Herstellen von 3-Dihalomethyl-pyrazol-4-carbonsäurederivaten |
| DE102007005296A1 (de) * | 2007-02-02 | 2008-08-07 | Bayer Cropscience Ag | Verfahren zum Herstellen von Dihaloacetessigsäurealkylestern |
| EP2008996A1 (en) * | 2007-06-27 | 2008-12-31 | Syngeta Participations AG | Process for the production of pyrazoles |
| EP2133341A1 (de) * | 2008-02-25 | 2009-12-16 | Bayer CropScience AG | Verfahren zur regioselektiven Synthese von 1-Alkyl-3-haloalkyl-pyrazol-4-carbonsäure-Derivaten |
| EP2100883A1 (de) * | 2008-03-10 | 2009-09-16 | Bayer CropScience AG | Verfahren zur regioselektiven Synthese von 1-Alkyl-3-haloalkyl-pyrazol-4carbonsäure-Derivaten |
| DK2288597T3 (da) * | 2008-05-05 | 2015-01-26 | Basf Se | Fremgangsmåde til fremstilling af 1,3,4-substituerede pyrazolforbindelser |
-
2008
- 2008-02-25 EP EP08151891A patent/EP2133341A1/de not_active Ceased
-
2009
- 2009-02-12 MX MX2010008553A patent/MX2010008553A/es active IP Right Grant
- 2009-02-12 RU RU2010139278/04A patent/RU2498977C9/ru active
- 2009-02-12 WO PCT/EP2009/000958 patent/WO2009106230A2/de not_active Ceased
- 2009-02-12 KR KR1020107020058A patent/KR101656690B1/ko active Active
- 2009-02-12 DK DK09715350.6T patent/DK2247577T4/da active
- 2009-02-12 BR BRPI0908891-1A patent/BRPI0908891A2/pt not_active Application Discontinuation
- 2009-02-12 JP JP2010547083A patent/JP5756293B2/ja active Active
- 2009-02-12 MX MX2015009067A patent/MX344084B/es unknown
- 2009-02-12 CN CN200980106024.2A patent/CN102026981B/zh active Active
- 2009-02-12 US US12/919,365 patent/US8629288B2/en active Active
- 2009-02-12 MY MYPI2010003885A patent/MY156546A/en unknown
- 2009-02-12 CN CN201410483954.2A patent/CN104277001A/zh active Pending
- 2009-02-12 EP EP09715350.6A patent/EP2247577B2/de active Active
- 2009-02-12 CA CA2716381A patent/CA2716381C/en active Active
- 2009-02-12 ES ES09715350T patent/ES2561038T5/es active Active
- 2009-02-12 BR BR122016027233-8A patent/BR122016027233B1/pt active IP Right Grant
- 2009-02-12 MY MYPI2015000498A patent/MY170036A/en unknown
- 2009-02-24 TW TW098105720A patent/TWI458712B/zh active
-
2010
- 2010-07-22 IL IL207151A patent/IL207151A0/en active IP Right Grant
-
2013
- 2013-03-14 US US13/803,622 patent/US8592605B2/en active Active
- 2013-07-24 RU RU2013134651A patent/RU2661192C2/ru active
-
2014
- 2014-11-07 JP JP2014227243A patent/JP2015071615A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2247577T4 (da) | Fremgangsmåde til regioselektiv syntese af 1-alkyl-3-haloalkyl-pyrazol-4-carboxylsyrederivater | |
| DK2257532T3 (da) | Fremgangsmåde til regioselektiv syntese af 1-alkyl-3-haloalkyl-pyrazol-4-carboxylsyrederivater | |
| DK2310437T3 (da) | Fremgangsmåde til kontinuerlig fremstilling af polyestere | |
| DK2542685T3 (da) | Fremgangsmåde til enzymatisk syntese af fedtsyre-alkylestere | |
| DK2231606T3 (da) | Fremgangsmåder til fremstilling af cycloalkylcarboxamidopyridinbenzoesyrer | |
| DK3192500T3 (da) | Sammensætninger til kontinuerlig indgivelse af dopa-decarboxylasehæmmere | |
| DK3550016T3 (da) | Sammensætninger til saccharificering af cellulosemateriale | |
| DK2352721T3 (da) | Hidtil ukendt fremgangsmåde til fremstilling af aminosyrederivater | |
| SMT201300114T1 (it) | Derivati di piridazina come inibitori di smo | |
| ZA201203615B (en) | Derivatives of 1-amino-2-cyclobutylethylboronic acid | |
| DK2593449T3 (da) | Fremgangsmåde til syntese af benzothiadiazolforbindelse | |
| DK2513063T3 (da) | Fremgangsmåde til fremstilling af 1-alkyl-/1-aryl-5-pyrazolcarboxylsyrederivater | |
| DK3284820T3 (da) | Fremgangsmåde til behandling af pyropheophytin-holdige sammensætninger | |
| DK1884507T3 (da) | Fremgangsmåde til fremstilling af glycerol | |
| DK3214083T3 (da) | Fremgangsmåde til fremstilling af quinolonforbindelser | |
| DK2462098T3 (da) | Fremgangsmåde til fremstillingen af derivater af 1-(2-halobiphenyl-4-yl)-cyclopropancarboxylsyre | |
| EP2326657A4 (en) | SYNTHESIS OF A GLATIRAMERACETATE | |
| BR112012002971A2 (pt) | preparação regioseletiva de derivados 2-amino-5-trifluorometil-pirmidinas | |
| DK2462108T3 (da) | Fremgangsmåde til fremstilling af pyrazolcarboxylsyreamider | |
| DK2516359T3 (da) | Fremgangsmåde til fremstilling af ethylbenzen | |
| DK2245001T3 (da) | Fremgangsmåde til fremstilling af 2-fluoracyl-3-amino-acrylsyrederivater | |
| DK2403364T3 (da) | Fremgangsmåde til fremstilling af opløsninger af astaxanthin-derivater | |
| CU23884B1 (es) | Derivados de dibenzotiazepina | |
| DK2310012T3 (da) | Fremgangsmåde til fremstilling af substituerede pyrimidinderivater | |
| DK2493860T3 (da) | Fremgangsmåde til fremstilling af 4-sulfinylpyrazolderivater |