DK2462098T3 - Fremgangsmåde til fremstillingen af derivater af 1-(2-halobiphenyl-4-yl)-cyclopropancarboxylsyre - Google Patents

Fremgangsmåde til fremstillingen af derivater af 1-(2-halobiphenyl-4-yl)-cyclopropancarboxylsyre

Info

Publication number
DK2462098T3
DK2462098T3 DK10742083.8T DK10742083T DK2462098T3 DK 2462098 T3 DK2462098 T3 DK 2462098T3 DK 10742083 T DK10742083 T DK 10742083T DK 2462098 T3 DK2462098 T3 DK 2462098T3
Authority
DK
Denmark
Prior art keywords
halobiphenyl
derivatives
procedure
preparation
cyclopropancarboxylic acid
Prior art date
Application number
DK10742083.8T
Other languages
English (en)
Inventor
Fausto Pivetti
Maria Gioia Fornaretto
Marco Re
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Application granted granted Critical
Publication of DK2462098T3 publication Critical patent/DK2462098T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/14—Preparation of carboxylic acid nitriles by reaction of cyanides with halogen-containing compounds with replacement of halogen atoms by cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/54—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals combined with metals, oxides or hydroxides provided for in groups B01J23/02 - B01J23/36
    • B01J23/56—Platinum group metals
    • B01J23/58—Platinum group metals with alkali- or alkaline earth metals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
DK10742083.8T 2009-08-04 2010-07-22 Fremgangsmåde til fremstillingen af derivater af 1-(2-halobiphenyl-4-yl)-cyclopropancarboxylsyre DK2462098T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09167206 2009-08-04
PCT/EP2010/004481 WO2011015287A2 (en) 2009-08-04 2010-07-22 Process for the preparation of derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid

Publications (1)

Publication Number Publication Date
DK2462098T3 true DK2462098T3 (da) 2013-11-25

Family

ID=41479261

Family Applications (1)

Application Number Title Priority Date Filing Date
DK10742083.8T DK2462098T3 (da) 2009-08-04 2010-07-22 Fremgangsmåde til fremstillingen af derivater af 1-(2-halobiphenyl-4-yl)-cyclopropancarboxylsyre

Country Status (21)

Country Link
US (1) US9056818B2 (da)
EP (1) EP2462098B1 (da)
JP (2) JP5996428B2 (da)
KR (1) KR101737653B1 (da)
CN (1) CN102596879B (da)
AU (1) AU2010281069B2 (da)
BR (1) BR112012002500A2 (da)
CA (1) CA2769960C (da)
DK (1) DK2462098T3 (da)
ES (1) ES2437163T3 (da)
HR (1) HRP20140032T1 (da)
IL (1) IL217886A (da)
MX (1) MX2012001411A (da)
MY (1) MY152980A (da)
PT (1) PT2462098E (da)
RU (1) RU2540076C2 (da)
SG (1) SG178239A1 (da)
SI (1) SI2462098T1 (da)
UA (1) UA106619C2 (da)
WO (1) WO2011015287A2 (da)
ZA (1) ZA201200821B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2133322A1 (en) * 2008-06-11 2009-12-16 CHIESI FARMACEUTICI S.p.A. Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid
SI2462098T1 (sl) * 2009-08-04 2014-01-31 Chiesi Farmaceutici S.P.A. Postopek priprave derivatov 1-(2-halobifenil-4-il)-ciklopropankarboksilne kisline
WO2011120778A1 (en) 2010-04-01 2011-10-06 Chiesi Farmaceutici S.P.A. Novel polymorphs and salts
US8975438B2 (en) * 2011-07-13 2015-03-10 Hoffmann-La Roche Inc. Process for the preparation of cyclohexanecarboxylic acid derivatives
US9592210B2 (en) 2011-12-22 2017-03-14 Chiesi Farmaceutici S.P.A. 1-phenylalkanecarboxylic acid derivatives for the treatment of cognitive impairment
CN104169251A (zh) 2012-04-04 2014-11-26 奇斯药制品公司 用于治疗神经退行性疾病的1-(2-卤代-联苯-4-基)-烷羧酸的衍生物
EP2818460A1 (en) * 2013-06-24 2014-12-31 ZaCh System S.p.A. Cyclopropanation of substituted phenylacetonitriles or phenyl acetates
RU2015153818A (ru) * 2013-06-24 2017-06-21 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Усовершенствованный способ получения производных 1-(2-фтор[1, 1-бифенил]-4-ил)-циклопропанкарбоновой кислоты
WO2023034184A1 (en) 2021-08-31 2023-03-09 Cerespir Incorporated Co-crystals

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE409176T1 (de) * 2003-02-21 2008-10-15 Chiesi Farma Spa 1-phenylalkancarbonsäurederivate zur behandlung neurodegenerativer erkrankungen
ITMI20030311A1 (it) * 2003-02-21 2004-08-22 Chiesi Farma Spa Acidi 2-fenil-2-dialchil-acetici per il trattamento della malattia di alzheimer.
JP2005047842A (ja) * 2003-07-31 2005-02-24 Mitsubishi Chemicals Corp 有機化合物の製造方法
EP1650183A1 (en) * 2004-10-21 2006-04-26 Cellzome Ag (Benzyloxy-biphenyl) acetic acids and derivatives thereof and their use in therapy
US20090291988A1 (en) * 2005-06-14 2009-11-26 Renata Oballa Reversible Inhibitors of Monoamine Oxidase A and B
US8193237B2 (en) * 2007-01-15 2012-06-05 Santen Pharmaceutical Co., Ltd. Indole derivative having IκB kinase β inhibitory activity
EP2133322A1 (en) 2008-06-11 2009-12-16 CHIESI FARMACEUTICI S.p.A. Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid
SI2462098T1 (sl) * 2009-08-04 2014-01-31 Chiesi Farmaceutici S.P.A. Postopek priprave derivatov 1-(2-halobifenil-4-il)-ciklopropankarboksilne kisline

Also Published As

Publication number Publication date
WO2011015287A2 (en) 2011-02-10
AU2010281069B2 (en) 2015-09-10
JP6001112B2 (ja) 2016-10-05
MY152980A (en) 2014-12-15
SG178239A1 (en) 2012-03-29
JP2013501010A (ja) 2013-01-10
ES2437163T3 (es) 2014-01-09
CN102596879B (zh) 2015-01-28
WO2011015287A3 (en) 2011-03-31
CN102596879A (zh) 2012-07-18
JP2015131824A (ja) 2015-07-23
EP2462098B1 (en) 2013-10-23
HK1168588A1 (en) 2013-01-04
AU2010281069A1 (en) 2012-02-23
RU2012104795A (ru) 2013-09-10
SI2462098T1 (sl) 2014-01-31
MX2012001411A (es) 2012-03-29
JP5996428B2 (ja) 2016-09-21
BR112012002500A2 (pt) 2018-03-13
KR101737653B1 (ko) 2017-05-18
KR20120050977A (ko) 2012-05-21
UA106619C2 (uk) 2014-09-25
HRP20140032T1 (hr) 2014-02-14
IL217886A0 (en) 2012-03-29
CA2769960C (en) 2017-04-18
US20110039934A1 (en) 2011-02-17
EP2462098A2 (en) 2012-06-13
IL217886A (en) 2014-11-30
US9056818B2 (en) 2015-06-16
ZA201200821B (en) 2013-05-29
RU2540076C2 (ru) 2015-01-27
CA2769960A1 (en) 2011-02-10
PT2462098E (pt) 2013-12-04

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