DK2278030T3 - Fremgangsmåder til undersøgelse og genetisk analyse af populationer - Google Patents

Fremgangsmåder til undersøgelse og genetisk analyse af populationer Download PDF

Info

Publication number
DK2278030T3
DK2278030T3 DK10012384.3T DK10012384T DK2278030T3 DK 2278030 T3 DK2278030 T3 DK 2278030T3 DK 10012384 T DK10012384 T DK 10012384T DK 2278030 T3 DK2278030 T3 DK 2278030T3
Authority
DK
Denmark
Prior art keywords
dna
sample
unknown
marker
rrna
Prior art date
Application number
DK10012384.3T
Other languages
English (en)
Inventor
Matthew Ashby
Original Assignee
Taxon Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taxon Biosciences Inc filed Critical Taxon Biosciences Inc
Application granted granted Critical
Publication of DK2278030T3 publication Critical patent/DK2278030T3/da

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/20—Sequence assembly
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C12Q1/683—Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/40—Population genetics; Linkage disequilibrium
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/21—Hydrocarbon

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Ecology (AREA)
  • Physiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Claims (12)

1. Fremgangsmåde til konstruktion af en markørdiversitetsprofil- (MDP) database, hvilken fremgangsmåde omfatter følgende trin: a) sekvensering af en flerhed af rRNA-markører fra en prøve, hvor prøver omfatter en mikrobiel population, og hvor hver rRNA-markør omfatter et mikrobielt rRNA-gens polymorfe sekvens, og hvor flerheden af rRNA-markører tilvejebringer en præcis repræsentation af prøvens mikrobielle struktur; b) bestemmelse af abundansen, i prøven, af hver af flerheden af rRNA-markører; c) transduktion af abundansen af hver rRNA-markør til et elektrisk udgangssignal; d) lagring af de elektriske udgangssignaler frembragt i trin c) i en matrixdatastruktur og associering i strukturen af hvert udgangssignal med den tilsvarende sekvens af rRNA-markøren, hvorfra abundansudgangssignalet var transduceret; e) tilvejebringelse af abundanser af ét eller flere prøveparametre, der er forbundet med prøven; f) transduktion af abundanseme af hvert prøveparameter til et elektrisk udgangssignal; g) lagring af de elektriske udgangssignaler frembragt i trin f) i en matrixdatastruktur og associering i strukturen af hvert udgangssignal med prøveparameteret, hvorfra abundansudgangssignalet var transduceret; h) betegnelse af de elektriske udgangssignaler frembragt i trin c) svarende til flerheden af rRNA-markørabundanser og de elektriske udgangssignaler frembragt i trin f) svarende til den ene eller flere prøveparameterabundanser, som en MDP; og i) gentagelse af trin a-h for en flerhed af andre prøver, og betegnelse af flerheden af MDP’er laget i datastrukturen som en MDP-database.
2. Fremgangsmåde ifølge krav 1, hvor rRNA-markørabundansen er en abundans i forhold til den totale abundans af flerheden af rRNA-markører i prøven.
3. Fremgangsmåde ifølge krav 1 eller 2, hvor det mikrobielle rRNA-gen er et 16S Rrna-gen.
4. Fremgangsmåde ifølge krav 1 eller 2, hvor det mikrobielle rRNA-gens polymorfe sekvens er fra intergen-området mellem et 16S rRNA-gen og et 23S rRNA-gen.
5. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 4, hvor prøven er udvalgt fra gruppen bestående af: en jordprøve, en klippeprøve, en vandprøve, en luftprøve, en carbonhydridprøve, en petroleumsprøve og en biofilmprøve.
6. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 5, hvor prøven er opnået fra gmppen bestående af: petroleum, carbonhydrider, et oliereservoir, et gasreservoir, jord, klippe, vand, luft, en bygning og en vej.
7. Fremgangsmåde ifølge krav 6, hvor prøveparameteret er udvalgt fra gruppen bestående af: petroleum, carbonhydrider, olie, gas, en uorganisk forbindelse, et mineral, pH, temperatur og saltholdighed.
8. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 4, hvor prøven er opnået fra gruppen bestående af: et menneske, en plante, et dyr, en fødevare, en cellekultur eller en vævskultur.
9. Fremgangsmåde ifølge krav 8, hvor prøveparameteret er udvalgt fra gmppen bestående af: en akut sygdomstilstand, en kronisk sygdomstilstand, en fysiologisk tilstand og et udviklingstrin.
10. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 4, hvor prøveparameteret er tid, og hvor flerheden af prøver omfatter et tidsforløb.
11. Fremgangsmåde ifølge krav 10, hvor flerheden af prøver omfatter et tidsforløb, der kan anvendes til overvågning af miljømæssige afhjælpningsforanstaltninger eller oliefeltsproduktion.
12. MDP-database, der er opbygget og lagret i hukommelsen på en computer ifølge fremgangsmåden ifølge et hvilket som helst af kravene 1 til 11.
DK10012384.3T 2000-04-10 2001-04-10 Fremgangsmåder til undersøgelse og genetisk analyse af populationer DK2278030T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19606300P 2000-04-10 2000-04-10
US19625800P 2000-04-11 2000-04-11
EP10152284.5A EP2206791B1 (en) 2000-04-10 2001-04-10 Methods for the survey and genetic analysis of populations

Publications (1)

Publication Number Publication Date
DK2278030T3 true DK2278030T3 (da) 2017-07-24

Family

ID=26891630

Family Applications (3)

Application Number Title Priority Date Filing Date
DK10012061.7T DK2278029T3 (da) 2000-04-10 2001-04-10 Fremgangsmåder til undersøgelse og genetisk analyse af populationer
DK10152284.5T DK2206791T3 (da) 2000-04-10 2001-04-10 Fremgangsmåder til undersøgelse og genetisk analyse af populationer
DK10012384.3T DK2278030T3 (da) 2000-04-10 2001-04-10 Fremgangsmåder til undersøgelse og genetisk analyse af populationer

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK10012061.7T DK2278029T3 (da) 2000-04-10 2001-04-10 Fremgangsmåder til undersøgelse og genetisk analyse af populationer
DK10152284.5T DK2206791T3 (da) 2000-04-10 2001-04-10 Fremgangsmåder til undersøgelse og genetisk analyse af populationer

Country Status (7)

Country Link
US (8) US6613520B2 (da)
EP (4) EP2278029B1 (da)
AU (1) AU2001253310A1 (da)
CA (1) CA2405629C (da)
DK (3) DK2278029T3 (da)
ES (1) ES2632538T3 (da)
WO (1) WO2001077392A2 (da)

Families Citing this family (225)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110166040A1 (en) * 1997-09-05 2011-07-07 Ibis Biosciences, Inc. Compositions for use in identification of strains of e. coli o157:h7
DK2278029T3 (da) 2000-04-10 2016-10-03 Taxon Biosciences Inc Fremgangsmåder til undersøgelse og genetisk analyse af populationer
WO2002010438A2 (en) * 2000-07-28 2002-02-07 The Johns Hopkins University Serial analysis of transcript expression using long tags
US7054828B2 (en) * 2000-12-20 2006-05-30 International Business Machines Corporation Computer method for using sample data to predict future population and domain behaviors
US7718354B2 (en) 2001-03-02 2010-05-18 Ibis Biosciences, Inc. Methods for rapid identification of pathogens in humans and animals
US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
US20040121309A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in blood, bodily fluids, and bodily tissues
WO2004060278A2 (en) 2002-12-06 2004-07-22 Isis Pharmaceuticals, Inc. Methods for rapid identification of pathogens in humans and animals
US20030027135A1 (en) 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
US8073627B2 (en) 2001-06-26 2011-12-06 Ibis Biosciences, Inc. System for indentification of pathogens
KR20050008651A (ko) * 2002-03-05 2005-01-21 솔렉사 리미티드 표현형과 관련된 게놈 와이드 서열 변형을 검출하는 방법
US7323306B2 (en) * 2002-04-01 2008-01-29 Brookhaven Science Associates, Llc Genome signature tags
US8383342B2 (en) 2002-04-24 2013-02-26 The University Of North Carolina At Greensboro Compositions, products, methods and systems to monitor water and other ecosystems
US9126165B1 (en) 2002-04-24 2015-09-08 The University Of North Carolina At Greensboro Nucleic acid arrays to monitor water and other ecosystems
US7135310B2 (en) * 2002-04-24 2006-11-14 The Regents Of The University Of California Method to amplify variable sequences without imposing primer sequences
US8048623B1 (en) 2002-04-24 2011-11-01 The University Of North Carolina At Greensboro Compositions, products, methods and systems to monitor water and other ecosystems
US20040161767A1 (en) * 2002-06-28 2004-08-19 Baldwin Brett R. Detection and quantification of aromatic oxygenase genes by real-time PCR
GB0220798D0 (en) * 2002-09-06 2002-10-16 Statoil Asa Identification tool for hydrocarbon zones
NL1022152C2 (nl) * 2002-12-12 2004-06-18 Tno Procescontrole gebaseerd op analyse van microbiele populaties.
US20040177011A1 (en) * 2003-03-06 2004-09-09 Ramsay Jimmie A. Food contamination tracking system
EP1613772B1 (en) * 2003-04-14 2009-06-03 Bedrijfslaboratorium voor Grond- en Gewasonderzoek B.V. Method for determining soil condition
US8046171B2 (en) 2003-04-18 2011-10-25 Ibis Biosciences, Inc. Methods and apparatus for genetic evaluation
US8057993B2 (en) 2003-04-26 2011-11-15 Ibis Biosciences, Inc. Methods for identification of coronaviruses
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US8158354B2 (en) 2003-05-13 2012-04-17 Ibis Biosciences, Inc. Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US20050026188A1 (en) * 2003-05-30 2005-02-03 Van Kessel Andrew G. Methods of identifying, characterizing and comparing organism communities
US7205111B2 (en) * 2003-07-24 2007-04-17 Marshfield Clinic Rapid identification of bacteria from positive blood cultures
US20100129811A1 (en) * 2003-09-11 2010-05-27 Ibis Biosciences, Inc. Compositions for use in identification of pseudomonas aeruginosa
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US20120122102A1 (en) 2003-09-11 2012-05-17 Rangarajan Sampath Compositions for use in identification of bacteria
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8222005B2 (en) * 2003-09-17 2012-07-17 Agency For Science, Technology And Research Method for gene identification signature (GIS) analysis
US8163895B2 (en) 2003-12-05 2012-04-24 Ibis Biosciences, Inc. Compositions for use in identification of orthopoxviruses
US7666592B2 (en) 2004-02-18 2010-02-23 Ibis Biosciences, Inc. Methods for concurrent identification and quantification of an unknown bioagent
US8119336B2 (en) 2004-03-03 2012-02-21 Ibis Biosciences, Inc. Compositions for use in identification of alphaviruses
JP4810533B2 (ja) 2004-05-24 2011-11-09 アイビス バイオサイエンシズ インコーポレイティッド ディジタルスレショルド化による選択的イオン濾過作用を用いた質量分光測定法
US20050266411A1 (en) 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
US8084207B2 (en) 2005-03-03 2011-12-27 Ibis Bioscience, Inc. Compositions for use in identification of papillomavirus
US20060205040A1 (en) 2005-03-03 2006-09-14 Rangarajan Sampath Compositions for use in identification of adventitious viruses
DK1907571T3 (da) 2005-06-15 2017-08-21 Complete Genomics Inc Nukleinsyreanalyse ved hjælp af tilfældige blandinger af ikke-overlappende fragmenter
US8026084B2 (en) 2005-07-21 2011-09-27 Ibis Biosciences, Inc. Methods for rapid identification and quantitation of nucleic acid variants
GB0525523D0 (en) * 2005-12-15 2006-01-25 Macaulay Land Use Res Inst Genetic process
WO2007081385A2 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
US8088582B2 (en) 2006-04-06 2012-01-03 Ibis Biosciences, Inc. Compositions for the use in identification of fungi
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
WO2007133710A2 (en) 2006-05-11 2007-11-22 Raindance Technologies, Inc. Microfluidic devices and methods of use thereof
US20080124707A1 (en) * 2006-06-09 2008-05-29 Agency For Science, Technology And Research Nucleic acid concatenation
WO2008143627A2 (en) 2006-09-14 2008-11-27 Ibis Biosciences, Inc. Targeted whole genome amplification method for identification of pathogens
WO2008130394A2 (en) * 2006-11-30 2008-10-30 The Regents Of The University Of California Array for detecting microbes
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
JP5680304B2 (ja) 2007-02-23 2015-03-04 アイビス バイオサイエンシズ インコーポレイティッド 迅速な法医学的ｄｎａ分析法
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US20080281819A1 (en) * 2007-05-10 2008-11-13 The Research Foundation Of State University Of New York Non-random control data set generation for facilitating genomic data processing
US20100291544A1 (en) * 2007-05-25 2010-11-18 Ibis Biosciences, Inc. Compositions for use in identification of strains of hepatitis c virus
US9598724B2 (en) 2007-06-01 2017-03-21 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
US20110045456A1 (en) * 2007-06-14 2011-02-24 Ibis Biosciences, Inc. Compositions for use in identification of adventitious contaminant viruses
GB2451287A (en) * 2007-07-26 2009-01-28 Envirogene Ltd Identification of hydrocarbon deposits through detection of a microbial polynucleotide
US8592150B2 (en) 2007-12-05 2013-11-26 Complete Genomics, Inc. Methods and compositions for long fragment read sequencing
US20110097704A1 (en) * 2008-01-29 2011-04-28 Ibis Biosciences, Inc. Compositions for use in identification of picornaviruses
US9074244B2 (en) 2008-03-11 2015-07-07 Affymetrix, Inc. Array-based translocation and rearrangement assays
US20110177515A1 (en) * 2008-05-30 2011-07-21 Ibis Biosciences, Inc. Compositions for use in identification of francisella
WO2009148995A2 (en) * 2008-06-02 2009-12-10 Ibis Biosciences, Inc. Compositions for use in identification of adventitious viruses
EP4047367A1 (en) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Method for detecting target analytes with droplet libraries
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
CA2735250A1 (en) * 2008-07-30 2010-02-04 Nippon Steel Kankyo Engineering Co., Ltd. Universal nucleic acid probe set and method for utilization thereof
EP2347254A2 (en) 2008-09-16 2011-07-27 Ibis Biosciences, Inc. Sample processing units, systems, and related methods
EP2349549B1 (en) 2008-09-16 2012-07-18 Ibis Biosciences, Inc. Mixing cartridges, mixing stations, and related kits, and system
EP2344893B1 (en) 2008-09-16 2014-10-15 Ibis Biosciences, Inc. Microplate handling systems and methods
US20110189687A1 (en) * 2008-10-02 2011-08-04 Ibis Bioscience, Inc. Compositions for use in identification of members of the bacterial genus mycoplasma
US20110200985A1 (en) * 2008-10-02 2011-08-18 Rangarajan Sampath Compositions for use in identification of herpesviruses
US20110183344A1 (en) * 2008-10-03 2011-07-28 Rangarajan Sampath Compositions for use in identification of clostridium difficile
WO2010039763A2 (en) * 2008-10-03 2010-04-08 Ibis Biosciences, Inc. Compositions for use in identification of antibiotic-resistant bacteria
US20110183343A1 (en) * 2008-10-03 2011-07-28 Rangarajan Sampath Compositions for use in identification of members of the bacterial class alphaproteobacter
US20110183346A1 (en) * 2008-10-03 2011-07-28 Ibis Biosciences, Inc. Compositions for use in identification of neisseria, chlamydia, and/or chlamydophila bacteria
WO2010039848A2 (en) * 2008-10-03 2010-04-08 Ibis Biosciences, Inc. Compositions for use in identification of streptococcus pneumoniae
EP2396803A4 (en) 2009-02-12 2016-10-26 Ibis Biosciences Inc IONIZATION PROBE ASSEMBLIES
WO2010104798A1 (en) 2009-03-08 2010-09-16 Ibis Biosciences, Inc. Bioagent detection methods
WO2010111231A1 (en) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation of microfluidic droplets
US9393564B2 (en) 2009-03-30 2016-07-19 Ibis Biosciences, Inc. Bioagent detection systems, devices, and methods
US8950604B2 (en) 2009-07-17 2015-02-10 Ibis Biosciences, Inc. Lift and mount apparatus
WO2011008972A1 (en) 2009-07-17 2011-01-20 Ibis Biosciences, Inc. Systems for bioagent identification
US9416409B2 (en) * 2009-07-31 2016-08-16 Ibis Biosciences, Inc. Capture primers and capture sequence linked solid supports for molecular diagnostic tests
US9080209B2 (en) 2009-08-06 2015-07-14 Ibis Biosciences, Inc. Non-mass determined base compositions for nucleic acid detection
US20110065111A1 (en) * 2009-08-31 2011-03-17 Ibis Biosciences, Inc. Compositions For Use In Genotyping Of Klebsiella Pneumoniae
US9890408B2 (en) 2009-10-15 2018-02-13 Ibis Biosciences, Inc. Multiple displacement amplification
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
EP4435111A1 (en) 2010-02-12 2024-09-25 Bio-Rad Laboratories, Inc. Digital analyte analysis
WO2011115840A2 (en) * 2010-03-14 2011-09-22 Ibis Biosciences, Inc. Parasite detection via endosymbiont detection
US10221432B2 (en) 2010-06-16 2019-03-05 Conocophillips Company In situ methanogenesis modeling and risk analysis
US20150038348A1 (en) * 2010-07-30 2015-02-05 Taxon Biosciences, Inc. Microbial bioindicators of hydrocarbons in water and in marine sediments and methods for making and using them
CA2810252C (en) 2010-09-10 2019-03-12 Bio-Rad Laboratories, Inc. Detection of rna-interacting regions in dna
WO2012051504A2 (en) 2010-10-14 2012-04-19 Rheonix, Inc. Quantitative multiplexed identification of nucleic acid targets
EP2675913B1 (en) 2011-02-15 2016-12-14 Bio-Rad Laboratories, Inc. Detecting methylation in a subpopulation of genomic dna
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
EP2714970B1 (en) 2011-06-02 2017-04-19 Raindance Technologies, Inc. Enzyme quantification
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
WO2013049613A1 (en) * 2011-09-29 2013-04-04 Luminex Corporation Hydrolysis probes
RU2014123689A (ru) 2011-11-11 2015-12-20 Эксонмобил Апстрим Рисерч Компани Способ определения местоположения, размера и состава флюидов подземной углеводородной залежи
US10309217B2 (en) 2011-11-11 2019-06-04 Exxonmobil Upstream Research Company Method and system for reservoir surveillance utilizing a clumped isotope and/or noble gas data
CN102492022B (zh) * 2011-12-08 2013-05-29 重庆大学 一种新型抗老年痴呆症先导化合物
US20140378319A1 (en) * 2012-02-06 2014-12-25 Exxonmobil Uspstream Reseach Company Method To Determine Location, Size and In Situ Conditions In Hydrocarbon Reservoir With Ecology, Geochemistry, and Biomarkers
US20130210659A1 (en) * 2012-02-10 2013-08-15 Andrew Watson Molecular diagnostic screening assay
EP2843047B1 (en) * 2012-02-27 2019-10-30 Toray Industries, Inc. Nucleic acid detection method
EP3321378B1 (en) 2012-02-27 2021-11-10 Becton, Dickinson and Company Compositions for molecular counting
WO2014005094A1 (en) 2012-06-28 2014-01-03 Taxon Biosciences, Inc. Compositions and methods for identifying and comparing members of microbial communities by computational analysis of amplicon sequences
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10584381B2 (en) 2012-08-14 2020-03-10 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
CN114891871A (zh) 2012-08-14 2022-08-12 10X基因组学有限公司 微胶囊组合物及方法
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP3567116A1 (en) 2012-12-14 2019-11-13 10X Genomics, Inc. Methods and systems for processing polynucleotides
KR20230003659A (ko) 2013-02-08 2023-01-06 10엑스 제노믹스, 인크. 폴리뉴클레오티드 바코드 생성
US20140272959A1 (en) * 2013-03-14 2014-09-18 President And Fellows Of Harvard College Methods of Hybridizing Probes to Genomic DNA
CN105705659B (zh) 2013-08-28 2019-11-29 贝克顿迪金森公司 大规模平行单细胞分析
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
CN105745528A (zh) 2013-10-07 2016-07-06 赛卢拉研究公司 用于以数字方式对阵列上的特征进行计数的方法和系统
CN105765080A (zh) * 2013-11-26 2016-07-13 伯乐实验室公司 用于检测核酸相邻性的方法
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
CA2937226C (en) 2014-03-07 2020-04-21 Exxonmobil Upstream Research Company Exploration method and system for detection of hydrocarbons from the water column
WO2015147370A1 (en) * 2014-03-28 2015-10-01 Seegene, Inc. Detection of target nucleic acid sequences using different detection temperatures
EP3792366A1 (en) * 2014-04-04 2021-03-17 Affymetrix, Inc. Improved compositions and methods for molecular inversion probe assays
US9694361B2 (en) 2014-04-10 2017-07-04 10X Genomics, Inc. Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same
EP4574974A3 (en) 2014-06-26 2025-10-08 10x Genomics, Inc. Methods of analyzing nucleic acids from individual cells or cell populations
KR20170026383A (ko) 2014-06-26 2017-03-08 10엑스 제노믹스, 인크. 핵산 서열의 분석
US12312640B2 (en) 2014-06-26 2025-05-27 10X Genomics, Inc. Analysis of nucleic acid sequences
US20170204452A1 (en) * 2014-07-23 2017-07-20 Steffen Mergemeier Method for the detection of sepsis
GB201413718D0 (en) * 2014-08-01 2014-09-17 Olink Ab Method for selecting a target nucleic acid sequence
US9890617B2 (en) 2014-09-18 2018-02-13 Exxonmobil Upstream Research Company Method to determine the presence of source rocks and the timing and extent of hydrocarbon generation for exploration, production and development of hydrocarbons
WO2016043978A1 (en) 2014-09-18 2016-03-24 Exxonmobil Upstream Research Company Method to enhance exploration, development and production of hydrocarbons using multiply substituted isotopologue geochemistry, basin modeling and molecular kinetics
US10094815B2 (en) 2014-09-18 2018-10-09 Exxonmobil Upstream Research Company Method to enhance exploration, development and production of hydrocarbons using multiply substituted isotopologue geochemistry, basin modeling and molecular kinetics
US10494923B2 (en) 2014-09-18 2019-12-03 Exxonmobil Upstream Research Company Method to perform hydrocarbon system analysis for exploration, production and development of hydrocarbons
CA2961727A1 (en) 2014-09-19 2016-03-24 Taxon Biosciences Inc Plant growth-promoting microbes, compositions, and uses
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
AU2016207023B2 (en) 2015-01-12 2019-12-05 10X Genomics, Inc. Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same
ES2891085T3 (es) * 2015-01-30 2022-01-26 Harvard College Obtención de imágenes sin microscopio
US10533414B2 (en) 2015-02-03 2020-01-14 Michael Lawson Applications of advanced isotope geochemistry of hydrocarbons and inert gases to petroleum production engineering
EP3254100B1 (en) 2015-02-03 2020-02-19 Exxonmobil Upstream Research Company Applications of advanced isotope geochemistry of hydrocarbons and inert gases to petroleum production engineering
EP3259371B1 (en) 2015-02-19 2020-09-02 Becton, Dickinson and Company High-throughput single-cell analysis combining proteomic and genomic information
EP4286516A3 (en) 2015-02-24 2024-03-06 10X Genomics, Inc. Partition processing methods and systems
WO2016138496A1 (en) 2015-02-27 2016-09-01 Cellular Research, Inc. Spatially addressable molecular barcoding
WO2016140826A1 (en) 2015-03-02 2016-09-09 Exxonmobil Upstream Research Company Field deployable system to measure clumped isotopes
CN107406888A (zh) 2015-03-30 2017-11-28 赛卢拉研究公司 用于组合条形编码的方法和组合物
US20160299129A1 (en) * 2015-04-07 2016-10-13 Xiaolei Qiu Ultra Sensitive and Specific Multiplex Biosensor System Based on Multiple Cooperative Interactions
EP3286326B1 (en) * 2015-04-23 2025-01-22 Becton, Dickinson and Company Method for whole transcriptome amplification
US11124823B2 (en) 2015-06-01 2021-09-21 Becton, Dickinson And Company Methods for RNA quantification
ES2978111T3 (es) 2015-06-25 2024-09-05 Native Microbials Inc Métodos, aparatos y sistemas para analizar cepas de microorganismos de comunidades heterogéneas complejas, predecir e identificar relaciones funcionales e interacciones de las mismas, y seleccionar y sintetizar conjuntos microbianos basados en las mismas
US10851399B2 (en) 2015-06-25 2020-12-01 Native Microbials, Inc. Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon
WO2018126026A1 (en) 2016-12-28 2018-07-05 Ascus Biosciences, Inc. Methods, apparatuses, and systems for analyzing complete microorganism strains in complex heterogeneous communities, determining functional relationships and interactions thereof, and identifying and synthesizing bioreactive modificators based thereon
US9938558B2 (en) 2015-06-25 2018-04-10 Ascus Biosciences, Inc. Methods, apparatuses, and systems for analyzing microorganism strains from complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon
CN106435744B (zh) 2015-08-13 2022-02-01 生捷科技控股公司 使用y-接头和消失限制位点的文库构建
WO2017044574A1 (en) 2015-09-11 2017-03-16 Cellular Research, Inc. Methods and compositions for nucleic acid library normalization
US11371094B2 (en) 2015-11-19 2022-06-28 10X Genomics, Inc. Systems and methods for nucleic acid processing using degenerate nucleotides
US20170145476A1 (en) * 2015-11-19 2017-05-25 10X Genomics, Inc. Transformable tagging compositions, methods, and processes incorporating same
JP6703824B2 (ja) * 2015-11-30 2020-06-03 シスメックス株式会社 細胞選択方法、細胞検出方法、細胞選択装置、および細胞検出装置
KR102723865B1 (ko) 2015-12-04 2024-10-29 10엑스 제노믹스, 인크. 핵산 분석을 위한 방법 및 조성물
PL3400285T3 (pl) 2016-01-07 2026-05-25 Native Microbials, Inc. Sposoby poprawy wytwarzania mleka poprzez podawanie konsorcjów mikrobiologicznych
EP3452614B1 (en) 2016-05-02 2023-06-28 Becton, Dickinson and Company Accurate molecular barcoding
WO2017197343A2 (en) 2016-05-12 2017-11-16 10X Genomics, Inc. Microfluidic on-chip filters
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
US10301677B2 (en) 2016-05-25 2019-05-28 Cellular Research, Inc. Normalization of nucleic acid libraries
WO2017205691A1 (en) 2016-05-26 2017-11-30 Cellular Research, Inc. Molecular label counting adjustment methods
WO2017209990A1 (en) 2016-05-31 2017-12-07 Exxonmobil Upstream Research Company METHODS FOR lSOLATING NUCLEIC ACIDS FROM SAMPLES
US10640763B2 (en) 2016-05-31 2020-05-05 Cellular Research, Inc. Molecular indexing of internal sequences
US10202641B2 (en) 2016-05-31 2019-02-12 Cellular Research, Inc. Error correction in amplification of samples
CN107507823B (zh) * 2016-06-14 2022-12-20 三星电子株式会社 半导体封装和用于制造半导体封装的方法
WO2018005514A1 (en) 2016-07-01 2018-01-04 Exxonmobil Upstream Research Company Methods to determine conditions of a hydrocarbon reservoir
WO2018044495A1 (en) 2016-09-02 2018-03-08 Exxonmobil Upstream Research Company Geochemical methods for monitoring and evaluating microbial enhanced recovery operations
EP3516079B1 (en) 2016-09-20 2022-06-22 President and Fellows of Harvard College Molecular product authentication systems
IL265478B2 (en) 2016-09-26 2024-10-01 Becton Dickinson Co Measurement of protein expression using reagents with barcoded oligonucleotide sequences
US11015154B2 (en) 2016-11-09 2021-05-25 The Regents Of The University Of California Methods for identifying interactions amongst microorganisms
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
MX2019007760A (es) 2016-12-28 2020-02-10 Ascus Biosciences Inc Metodos, aparatos y sistemas para analisis de cepa de microorganismo de comunidades heterogeneas complejas con analisis rastreador, determinacion de relaciones funcionales e interacciones de estas, y sintesis de agrupaciones microbianas que incluyen agrupaciones microbianas dosificadas y agrupaciones microbianas inoculativas.
WO2018132610A1 (en) 2017-01-13 2018-07-19 Cellular Research, Inc. Hydrophilic coating of fluidic channels
EP4310183B1 (en) 2017-01-30 2025-07-09 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
US11319583B2 (en) 2017-02-01 2022-05-03 Becton, Dickinson And Company Selective amplification using blocking oligonucleotides
MX389322B (es) 2017-04-28 2025-03-20 Native Microbials Inc Metodos para complementar dietas con alto consumo de granos y/o alto valor energetico en rumiantes, mediante la administracion de un bioensamble sintetico de microbios, o cepas purificadas de los mismos
CN116064732A (zh) 2017-05-26 2023-05-05 10X基因组学有限公司 转座酶可接近性染色质的单细胞分析
US10844372B2 (en) 2017-05-26 2020-11-24 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
JP7536450B2 (ja) 2017-06-05 2024-08-20 ベクトン・ディキンソン・アンド・カンパニー 単一細胞用のサンプルインデックス付加
EP3625361A1 (en) 2017-11-15 2020-03-25 10X Genomics, Inc. Functionalized gel beads
WO2019099908A1 (en) 2017-11-17 2019-05-23 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
CN111492068B (zh) 2017-12-19 2025-03-21 贝克顿迪金森公司 与寡核苷酸相关联的颗粒
US12142104B2 (en) 2018-03-22 2024-11-12 President And Fellows Of Harvard College Methods and compositions for molecular authentication
EP3775271B1 (en) 2018-04-06 2025-03-12 10X Genomics, Inc. Systems and methods for quality control in single cell processing
CA3097976A1 (en) 2018-05-03 2019-11-07 Becton, Dickinson And Company High throughput multiomics sample analysis
EP3788170B1 (en) 2018-05-03 2025-01-01 Becton, Dickinson and Company Molecular barcoding on opposite transcript ends
US11649478B2 (en) * 2018-05-21 2023-05-16 ExxonMobil Technology and Engineering Company Identification of hot environments using biomarkers from cold-shock proteins of thermophilic and hyperthermophilic microorganisms
CN108866170A (zh) * 2018-07-13 2018-11-23 北京出入境检验检疫局检验检疫技术中心 一种基于pcr-dgge技术的沙门氏菌分型方法
EP3861134B1 (en) 2018-10-01 2024-09-04 Becton, Dickinson and Company Determining 5' transcript sequences
EP3877520B1 (en) 2018-11-08 2025-03-19 Becton, Dickson And Company Whole transcriptome analysis of single cells using random priming
EP3894552B1 (en) 2018-12-13 2026-01-28 Becton, Dickinson and Company Selective extension in single cell whole transcriptome analysis
WO2020150356A1 (en) 2019-01-16 2020-07-23 Becton, Dickinson And Company Polymerase chain reaction normalization through primer titration
EP3914728B1 (en) 2019-01-23 2023-04-05 Becton, Dickinson and Company Oligonucleotides associated with antibodies
CN113454234B (zh) 2019-02-14 2025-03-18 贝克顿迪金森公司 杂合体靶向和全转录物组扩增
CN113924369A (zh) * 2019-03-27 2022-01-11 迪亚金诺德股份公司 一种高通量测序方法和试剂盒
US11965208B2 (en) 2019-04-19 2024-04-23 Becton, Dickinson And Company Methods of associating phenotypical data and single cell sequencing data
WO2021016239A1 (en) 2019-07-22 2021-01-28 Becton, Dickinson And Company Single cell chromatin immunoprecipitation sequencing assay
EP4055160B1 (en) 2019-11-08 2024-04-10 Becton Dickinson and Company Using random priming to obtain full-length v(d)j information for immune repertoire sequencing
CN115279919A (zh) 2020-01-13 2022-11-01 贝克顿迪金森公司 使用含有du的寡核苷酸的细胞捕获
CN115244184A (zh) 2020-01-13 2022-10-25 贝克顿迪金森公司 用于定量蛋白和rna的方法和组合物
WO2021155057A1 (en) 2020-01-29 2021-08-05 Becton, Dickinson And Company Barcoded wells for spatial mapping of single cells through sequencing
US12153043B2 (en) 2020-02-25 2024-11-26 Becton, Dickinson And Company Bi-specific probes to enable the use of single-cell samples as single color compensation control
WO2021231779A1 (en) 2020-05-14 2021-11-18 Becton, Dickinson And Company Primers for immune repertoire profiling
CN115803445A (zh) 2020-06-02 2023-03-14 贝克顿迪金森公司 用于5撇基因表达测定的寡核苷酸和珠
CN111705141B (zh) * 2020-06-29 2023-04-28 福州海关技术中心 一种荧光定量pcr检测鉴定乳状耳形螺的方法
US11932901B2 (en) 2020-07-13 2024-03-19 Becton, Dickinson And Company Target enrichment using nucleic acid probes for scRNAseq
WO2022026909A1 (en) 2020-07-31 2022-02-03 Becton, Dickinson And Company Single cell assay for transposase-accessible chromatin
WO2022047328A1 (en) * 2020-08-31 2022-03-03 Applied Materials, Inc. Slides for calibration of mfish
WO2022109343A1 (en) 2020-11-20 2022-05-27 Becton, Dickinson And Company Profiling of highly expressed and lowly expressed proteins
CN116685850A (zh) 2020-12-15 2023-09-01 贝克顿迪金森公司 单细胞分泌组分析
US11668847B2 (en) 2021-01-04 2023-06-06 Saudi Arabian Oil Company Generating synthetic geological formation images based on rock fragment images
MX2023012736A (es) 2021-04-30 2023-11-09 Root Applied Sciences Inc Dispositivo para recoger material del aire.
WO2023034875A1 (en) 2021-08-31 2023-03-09 Saudi Arabian Oil Company Quantitative hydraulic fracturing surveillance from fiber optic sensing using machine learning
CN114015794B (zh) * 2022-01-06 2022-03-25 山东省中地易采石油技术有限责任公司 一种基于地质微生物群落特征的产液剖面图的构建方法
CA3264896A1 (en) 2022-08-15 2024-02-22 Element Biosciences, Inc. SPATIAL RESOLUTION SURFACE CAPTURE OF NUCLEIC ACIDS
EP4686762A1 (en) * 2024-07-29 2026-02-04 ICHORtec GmbH A method to characterize nucleic acid

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055397A (en) 1987-12-17 1991-10-08 Atlantic Richfield Company Geomicrobiological methods of ore and petroleum exploration
US5093236A (en) * 1988-09-14 1992-03-03 Genecor International, Inc. Microbiological oil prospecting
US5700636A (en) * 1990-10-19 1997-12-23 Becton Dickinson And Company Methods for selectively detecting microorganisms associated with vaginal infections in complex biological samples
US5866330A (en) 1995-09-12 1999-02-02 The Johns Hopkins University School Of Medicine Method for serial analysis of gene expression
US5695937A (en) 1995-09-12 1997-12-09 The Johns Hopkins University School Of Medicine Method for serial analysis of gene expression
US5981190A (en) * 1997-01-08 1999-11-09 Ontogeny, Inc. Analysis of gene expression, methods and reagents therefor
DK2278029T3 (da) 2000-04-10 2016-10-03 Taxon Biosciences Inc Fremgangsmåder til undersøgelse og genetisk analyse af populationer

Also Published As

Publication number Publication date
EP2206791A3 (en) 2010-08-04
AU2001253310A1 (en) 2001-10-23
EP2278030B1 (en) 2017-05-24
US20110251983A1 (en) 2011-10-13
US20140011687A1 (en) 2014-01-09
EP2278029A2 (en) 2011-01-26
WO2001077392A3 (en) 2003-03-13
ES2632538T3 (es) 2017-09-14
US20130030712A1 (en) 2013-01-31
EP2206791B1 (en) 2016-07-13
EP2278029B1 (en) 2016-07-13
US8476016B2 (en) 2013-07-02
DK2206791T3 (da) 2016-10-24
US20130030714A1 (en) 2013-01-31
US20040110183A1 (en) 2004-06-10
EP2206791A2 (en) 2010-07-14
US8071295B2 (en) 2011-12-06
WO2001077392B1 (en) 2003-07-03
US20020065609A1 (en) 2002-05-30
US6613520B2 (en) 2003-09-02
EP2278030A2 (en) 2011-01-26
WO2001077392A2 (en) 2001-10-18
DK2278029T3 (da) 2016-10-03
US20140011692A1 (en) 2014-01-09
CA2405629C (en) 2016-11-22
CA2405629A1 (en) 2001-10-18
EP1313879A2 (en) 2003-05-28
EP2278030A3 (en) 2011-02-23
US20150205915A1 (en) 2015-07-23
EP2278029A3 (en) 2011-02-23

Similar Documents

Publication Publication Date Title
DK2278029T3 (da) Fremgangsmåder til undersøgelse og genetisk analyse af populationer
Tiedje et al. Opening the black box of soil microbial diversity
Ranjard et al. Monitoring complex bacterial communities using culture-independent molecular techniques: application to soil environment
Amann Who is out there? Microbial aspects of biodiversity
Ochsenreiter et al. Diversity and abundance of Crenarchaeota in terrestrial habitats studied by 16S RNA surveys and real time PCR
Philippot et al. Spatial patterns of bacterial taxa in nature reflect ecological traits of deep branches of the 16S rRNA bacterial tree
Zhou et al. Bacterial phylogenetic diversity and a novel candidate division of two humid region, sandy surface soils
Ouellette et al. Toxic cyanobacteria: the evolving molecular toolbox
Sliwinski et al. Spatial heterogeneity of crenarchaeal assemblages within mesophilic soil ecosystems as revealed by PCR-single-stranded conformation polymorphism profiling
Kowalska et al. DNA barcoding–A new device in phycologist's toolbox
Scupham et al. Comparison of DNA extraction methods for analysis of turkey cecal microbiota
Lenz et al. Bacterial profiling of soil using genus‐specific markers and multidimensional scaling
Malesevic et al. Metagenomic analysis of bacterial community and isolation of representative strains from Vranjska Banja hot spring, Serbia
Stackebrandt et al. Diversity of uncultured microorganisms in the environment
Rajeev et al. Culture-dependent and-independent strategies in bacterial diversity appraisal
Reineke et al. Microbial Communities: Structural and Functional Analyses with Molecular Biological Approach
Gibb et al. Assessing the relationship between patch type and soil mites: a molecular approach
Sharma et al. Culture independent diversity analysis of soil microbial community and their significance
Anushya et al. Microbial Analysis of Soil and Their Significance in Forensic Science
Waters Investigation of DNA Profiling Methods for Forensic Examination of Soil Evidence
CN118497380A (zh) 一种用于检测施用粪肥或污泥肥农田系统潜在耐药病原菌的方法及其应用
Hamm Bacterial community ecology and fate in integrated livestock production systems
Brillowska‐Dąbrowska et al. ALIS‐FLP: Amplified ligation selected fragment‐length polymorphism method for microbial genotyping
Surridge et al. The Environment and the Tools in Rhizo-and Bioremediation of Contaminated Soil
Khan et al. Recent Methods for Molecular Study of Fungal Community Structure with