DK2287858T3 - System og fremgangsmåde til sortering af materialer under anvendelse af holografisk laserstyring - Google Patents
System og fremgangsmåde til sortering af materialer under anvendelse af holografisk laserstyring Download PDFInfo
- Publication number
- DK2287858T3 DK2287858T3 DK10185539.3T DK10185539T DK2287858T3 DK 2287858 T3 DK2287858 T3 DK 2287858T3 DK 10185539 T DK10185539 T DK 10185539T DK 2287858 T3 DK2287858 T3 DK 2287858T3
- Authority
- DK
- Denmark
- Prior art keywords
- particles
- optical
- inflow channel
- liquid inflow
- traps
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 69
- 238000000926 separation method Methods 0.000 title claims description 22
- 239000000463 material Substances 0.000 title description 23
- 230000003287 optical effect Effects 0.000 claims description 194
- 210000004027 cell Anatomy 0.000 claims description 134
- 239000002245 particle Substances 0.000 claims description 110
- 239000007788 liquid Substances 0.000 claims description 29
- 239000012530 fluid Substances 0.000 claims description 19
- 210000002593 Y chromosome Anatomy 0.000 claims description 17
- 210000001766 X chromosome Anatomy 0.000 claims description 12
- 230000003068 static effect Effects 0.000 claims description 11
- 239000007853 buffer solution Substances 0.000 claims description 10
- 238000001514 detection method Methods 0.000 claims description 10
- 238000005259 measurement Methods 0.000 claims description 8
- 230000002147 killing effect Effects 0.000 claims description 6
- 230000008859 change Effects 0.000 claims description 5
- 210000000349 chromosome Anatomy 0.000 claims description 5
- 238000001917 fluorescence detection Methods 0.000 claims description 5
- 238000011144 upstream manufacturing Methods 0.000 claims description 4
- 238000012545 processing Methods 0.000 claims description 3
- 239000000523 sample Substances 0.000 description 35
- 238000000059 patterning Methods 0.000 description 26
- 238000000651 laser trapping Methods 0.000 description 18
- 230000005684 electric field Effects 0.000 description 16
- 238000000920 holographic laser trapping Methods 0.000 description 16
- 230000008901 benefit Effects 0.000 description 15
- 230000033001 locomotion Effects 0.000 description 14
- 230000005855 radiation Effects 0.000 description 12
- 230000008569 process Effects 0.000 description 11
- 238000004590 computer program Methods 0.000 description 10
- 238000003384 imaging method Methods 0.000 description 10
- 239000004973 liquid crystal related substance Substances 0.000 description 10
- 238000010521 absorption reaction Methods 0.000 description 8
- 238000003491 array Methods 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 7
- 210000004153 islets of langerhan Anatomy 0.000 description 7
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 7
- 238000000746 purification Methods 0.000 description 7
- 238000004611 spectroscopical analysis Methods 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 238000012546 transfer Methods 0.000 description 7
- 238000013461 design Methods 0.000 description 6
- 238000010586 diagram Methods 0.000 description 6
- 230000008855 peristalsis Effects 0.000 description 6
- 241000283690 Bos taurus Species 0.000 description 5
- 238000013459 approach Methods 0.000 description 5
- 235000012489 doughnuts Nutrition 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 238000005286 illumination Methods 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 238000012576 optical tweezer Methods 0.000 description 5
- 238000002054 transplantation Methods 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 238000003556 assay Methods 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 230000003595 spectral effect Effects 0.000 description 4
- 238000009987 spinning Methods 0.000 description 4
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 3
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 3
- 239000012620 biological material Substances 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000001878 scanning electron micrograph Methods 0.000 description 3
- 229910052710 silicon Inorganic materials 0.000 description 3
- 239000010703 silicon Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- 230000005641 tunneling Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 239000004988 Nematic liquid crystal Substances 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 235000015278 beef Nutrition 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 230000001066 destructive effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 229910003460 diamond Inorganic materials 0.000 description 2
- 239000010432 diamond Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 210000005260 human cell Anatomy 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 210000004940 nucleus Anatomy 0.000 description 2
- 239000013307 optical fiber Substances 0.000 description 2
- 210000003463 organelle Anatomy 0.000 description 2
- 210000000496 pancreas Anatomy 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 210000001747 pupil Anatomy 0.000 description 2
- 238000007493 shaping process Methods 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 238000000844 transformation Methods 0.000 description 2
- 238000011179 visual inspection Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- PRDFBSVERLRRMY-UHFFFAOYSA-N 2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole Chemical compound C1=CC(OCC)=CC=C1C1=NC2=CC=C(C=3NC4=CC(=CC=C4N=3)N3CCN(C)CC3)C=C2N1 PRDFBSVERLRRMY-UHFFFAOYSA-N 0.000 description 1
- 201000004569 Blindness Diseases 0.000 description 1
- 230000005653 Brownian motion process Effects 0.000 description 1
- 206010017577 Gait disturbance Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 101710186630 Insulin-1 Proteins 0.000 description 1
- 102000029749 Microtubule Human genes 0.000 description 1
- 108091022875 Microtubule Proteins 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 108010067035 Pancrelipase Proteins 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 241000223892 Tetrahymena Species 0.000 description 1
- 241000248384 Tetrahymena thermophila Species 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000002266 amputation Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000001109 blastomere Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 238000005537 brownian motion Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000004163 cytometry Methods 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000009699 differential effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000007877 drug screening Methods 0.000 description 1
- 230000005686 electrostatic field Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 239000003574 free electron Substances 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 210000004602 germ cell Anatomy 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000009027 insemination Effects 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 230000009191 jumping Effects 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000007567 mass-production technique Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000010258 microfractionation Methods 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 238000007431 microscopic evaluation Methods 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 210000004688 microtubule Anatomy 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000010363 phase shift Effects 0.000 description 1
- 229920002120 photoresistant polymer Polymers 0.000 description 1
- 238000009428 plumbing Methods 0.000 description 1
- 229920002939 poly(N,N-dimethylacrylamides) Polymers 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 229910052594 sapphire Inorganic materials 0.000 description 1
- 239000010980 sapphire Substances 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 210000001082 somatic cell Anatomy 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 230000033772 system development Effects 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/32—Micromanipulators structurally combined with microscopes
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H3/00—Production or acceleration of neutral particle beams, e.g. molecular or atomic beams
- H05H3/04—Acceleration by electromagnetic wave pressure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
- G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
- G03H1/04—Processes or apparatus for producing holograms
- G03H1/08—Synthesising holograms, i.e. holograms synthesized from objects or objects from holograms
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
- G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
- G03H1/22—Processes or apparatus for obtaining an optical image from holograms
- G03H1/2294—Addressing the hologram to an active spatial light modulator
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
- G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
- G03H1/0005—Adaptation of holography to specific applications
- G03H2001/0077—Adaptation of holography to specific applications for optical manipulation, e.g. holographic optical tweezers [HOT]
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
- G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
- G03H1/04—Processes or apparatus for producing holograms
- G03H1/08—Synthesising holograms, i.e. holograms synthesized from objects or objects from holograms
- G03H1/0841—Encoding method mapping the synthesized field into a restricted set of values representative of the modulator parameters, e.g. detour phase coding
- G03H2001/085—Kinoform, i.e. phase only encoding wherein the computed field is processed into a distribution of phase differences
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
- G03H2225/00—Active addressable light modulator
- G03H2225/30—Modulation
- G03H2225/32—Phase only
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Optics & Photonics (AREA)
- Dispersion Chemistry (AREA)
- Electromagnetism (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plasma & Fusion (AREA)
- Pathology (AREA)
- Microscoopes, Condenser (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Sorting Of Articles (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Claims (40)
1. Apparat til sortering af partikler omfattende en flowcelle, som har en væskeindstrømningskanal (300) til indføring af en prøve af partikler i en laminær strøm; to udløbskanaler (302, 303), som er anbragt på hver side af væskeindstrømningskanalen (301), idet hver af de to udløbskanaler (302, 303) er egnet til at lade en bufferopløsning strømme derigennem, og hver af de to udløbskanaler (302, 303) er egnet til at indføre bufferopløsningen i de to udløbskanaler (302, 303) ved strømningshastigheder, som opretholder laminær strøm med den laminære strøm i væskeindstrømningskanalen (301); en sorteringsregion, som ikke har nogen mekanisk separering mellem væskeindstrømningskanalen (301) og de to udløbskanaler (302, 303) og de laminære strømme deri; et optisk fældesystem, som er konfigureret til at frembringe en sluseanordning af optiske fælder (305) i væskeindstrømningskanalen tæt ved sorteringsregionen, hvilke optiske fælder (305) er konfigureret til at opfange partiklerne i væskeindstrømningskanalen (301) og separere partiklerne i sorteringsregionen; hvor det optiske fældesystem omfatter en objektivlinse (304) med høj numerisk apertur, som er konfigureret til at implementere sluseanordningen af optiske fælder (305); og et detektionssystem, som er konfigureret til at detektere de opfangede partikler for at bestemme de partikler, der skal separeres i sorteringsregionen.
2. Apparat ifølge krav 1, som omfatter et roterende hjul med et sæt af statiske hologrammer monteret derpå, som er konfigureret til at etablere slusesystemet med et mønster af lavintensitetsfælder (305) og til at ændre dette mønster som en funktion af hjulets rotationsmønster.
3. Apparat ifølge krav 2, som er konfigureret således, at de optiske slusningsfælder (305), der er anbragt ved positionen længst nedstrøms af væskeindstrømningskanalen (301), har en fast intensitet og position og er konfigureret til at opretholde en separation mellem partiklerne i den laminære strøm i væskeindstrømningskanalen.
4. Apparat ifølge krav 2, som er konfigureret således, at de optiske slusningsfælder (305), der er anbragt ved en opstrøms position af væskeindstrømningskanalen, har en omskiftelig intensitet og position for at forstyrre en strøm af partikler, når partiklerne har klumpet sig sammen, og passere gennem partiklerne, når partiklerne er individuelle eller ikke-sammenklumpede partikler.
5. Apparat ifølge krav 1, hvor detektionssystemet er ét af et fluorescensdetektions-system med høj opløsning, et spredningsmålingssystem eller et optisk brydningssystem.
6. Apparat ifølge krav 1, som er konfigureret således, at synsfeltet af objektivlinsen (304) har samme bredde som hver af væskeindstrømningskanalen (301) og de to udløbskanaler (302, 303).
7. Apparat ifølge krav 1, hvor det optiske fældesystem omfatter rumlige lysmodulatorer, som er konfigureret til at frembringe fasemasker til at drive det optiske fældesystem.
8. Apparat ifølge krav 7, som er konfigureret således, at opdateringsraterne af de rumlige lysmodulatorer er 30 Hz eller mere.
9. Apparat ifølge krav 1, hvor partiklerne er celler.
10. Apparat ifølge krav 9, hvor partiklerne er spermceller.
11. Apparat ifølge krav 1, hvor det optiske fældesystem er konfigureret til at opfange og separere partiklerne fra væskeindstrømningskanalen til en hvilken som helst af udløbskanalerne.
12. Apparat ifølge krav 5, hvor detektionssystemet er konfigureret til at analysere partiklerne og identificere partiklerne som ønskede eller uønskede partikler og beskadige eller dræbe de uønskede partikler med en laserstråle.
13. Apparat ifølge krav 10, hvor detektionssystemet er et fluorescensdetektionssystem, som er konfigureret til at detektere spermcellernes fluorescens for at bestemme den underliggende kromosombelastning, og som er konfigureret til at identificere X- fra Y- kromosomer i spermcellerne; og hvor det optiske fældesystem er konfigureret til at sortere X- og Y-kromosombærende spermceller i sorteringsregionen.
14. Apparat ifølge krav 13, som omfatter et farvestof, som specifikt binder til DNA, således at den samlede tilstedeværende fluorescens er et mål for det samlede tilstedeværende DNA.
15. Apparat ifølge krav 13, hvor det optiske fældesystem omfatter en rumlig lysmodula-tor, som er konfigureret til at frembringe fasemasker til at drive det optiske fældesystem.
16. Apparat ifølge krav 13, som er konfigureret til at sortere de X- og Y-kromosombærende spermceller fra væskeindstrømningskanalen under anvendelse af de optiske fælder (305) af det optiske fældesystem til en hvilken som helst af udløbskanalerne.
17. Apparat ifølge krav 13, som er konfigureret således, at én af de X- eller de Y-kromosombærende spermceller beskadiges eller dræbes af en laserstråle.
18. Apparat ifølge krav 1, hvor de to udløbskanaler (301, 302) er parallelle med væskeindstrømningskanalen (301).
19. Fremgangsmåde til sortering af partikler omfattende følgende trin: indføring af en prøve af partikler i en laminær strøm i en væskeindstrømningskanal (301) af en flowcelle; indføring af en bufferopløsning i en laminær strøm i to udløbskanaler (302, 303), hvilke udløbskanaler (302, 303) er anbragt på hver side af væskeindstrømningskanalen (301), hvor bufferopløsningen indføres i udløbskanalerne (302, 303) ved strømningshastigheder, som opretholder laminær strøm med den laminære strøm i væskeindstrømningskanalen; tilvejebringelse af en sorteringsregion, som ikke har nogen mekanisk separering mellem væskeindstrømningskanalen (301) og udløbskanalerne (302, 303) og de laminære strømme deri; frembringelse af en sluseanordning af optiske fælder (305) i væskeindstrømningskanalen (301) under anvendelse af et optisk fældesystem, hvor sluseanordningen af optiske fælder (305) implementeres af en objektivlinse (304) med høj numerisk apertur, som er inkluderet i det optiske fældesystem; opfangning af partiklerne i væskeindstrømningskanalen (301) ved hjælp af sluseanordningen af optiske fælder (305); detektion og identificering af partiklerne under anvendelse af et detektionssystem for at bestemme de partikler, der skal sorteres i sorteringsregionen; separering af partiklerne i sorteringsregionen ved hjælp af sluseanordningen af optiske fælder (305).
20. Fremgangsmåde ifølge krav 19, hvor sluseanordningen af optiske fælder etableres af et sæt af statiske hologrammer, som er monteret i et roterende hjul, således at mønsteret ændres som en funktion af hjulets rotationsmønster.
21. Fremgangsmåde ifølge krav 19, hvor de optiske fælder (305), som er anbragt ved positionen længst nedstrøms af væskeindstrømningskanalen (301), haren fast intensitet og position og er konfigureret til at opretholde en separation mellem partiklerne i den laminære strøm i væskeindstrømningskanalen (301).
22. Fremgangsmåde ifølge krav 19, hvor de optiske fælder (305), som er anbragt ved en opstrøms position af væskeindstrømningskanalen (301), haren omskiftelig intensitet og position for at forstyrre en strøm af partikler, når partiklerne har klumpet sig sammen, og passere gennem partiklerne, når partiklerne er individuelle eller ikke-sammenklumpede partikler.
23. Fremgangsmåde ifølge krav 19, hvor detektionssystemet er ét af et fluorescens-detektionssystem med høj opløsning, et spredningsmålingssystem eller et optisk brydningssystem.
24. Fremgangsmåde ifølge krav 19, hvor synsfeltet af objektivlinsen (304) har samme bredde som hver af væskeindstrømningskanalen (301) og de to udløbskanaler (302, 303).
25. Fremgangsmåde ifølge krav 19, hvor det optiske fældesystem omfatter rumlige lysmodulatorer, som frembringer fasemasker til at drive det optiske fældesystem.
26. Fremgangsmåde ifølge krav 25, hvor opdateringsraterne af de rumlige lysmodula-torer er 30 Hz eller mere.
27. Fremgangsmåde ifølge krav 26, hvor partiklerne er celler.
28. Fremgangsmåde ifølge krav 27, hvor cellerne er spermceller.
29. Fremgangsmåde ifølge krav 19, hvor partiklerne sorteres under anvendelse af de optiske fælder (305) af det optiske fældesystem fra væskeindstrømningskanalen (301) til en hvilken som helst af udløbskanalerne (302, 303).
30. Fremgangsmåde ifølge krav 19, hvor partiklerne identificeres som ønskede eller uønskede partikler, og de uønskede partikler beskadiges eller dræbes med en laserstråle.
31. Fremgangsmåde ifølge krav 19, hvor partiklerne er spermceller med X- og Y-kromosomer, hvor der anvendes et farvestof, som specifikt binder til DNA; hvor detektionssystemet er et fluorescensdetektionssystem, som detekterer spermcellernes fluorescens for at bestemme den underliggende kromosombelastning, og som identificerer X- fra Y-kromosomer i spermcellerne; hvor de X- og Y-kromosombærende spermceller sorteres under anvendelse af optiske fælder (305) af det optiske fældesystem i sorteringsregionen.
32. Fremgangsmåde ifølge krav 31, hvor farvestoffet binder specifikt til DNA, således at den samlede tilstedeværende fluorescens er et mål for det samlede tilstedeværende DNA.
33. Fremgangsmåde ifølge krav 31, hvor spermcellernes strømningshastighed i indstrømningskanalen (301) og strømningshastigheden af bufferopløsning i de to udløbskanaler (302, 303) er den samme.
34. Fremgangsmåde ifølge krav 31, hvor strømningshastigheden i væskeindstrømningskanalen (301) og strømningshastigheden i de to udløbskanaler (302, 303) fastsættes afen forudbestemt separationsafstand mellem spermcellerne, en opdaterings rate af det optiske fældesystem, som udfører separationsfunktionen, og af en forudbestemt bearbejdningshastighed for spermcellerne.
35. Fremgangsmåde ifølge krav 31, hvor bredden af synsfeltet af objektivlinsen med høj numerisk apertur er den samme som bredden af væskeindstrømningskanalen og som bredden af de to udløbskanaler, og længden af synsfeltet af objektivlinsen med høj numerisk apertur afhænger af strømningshastigheden i væskeindstrømningskanalen og de to udløbskanaler, dybden af væskeindstrømningskanalen og de to udløbskanaler og opdateringsraterne af det optiske fældesystem, der anvendes til at styre de optiske fælder.
36. Fremgangsmåde ifølge krav 31, hvor det optiske fældesystem omfatter en rumlig lysmodulator, som frembringer fasemasker til at drive det optiske fældesystem.
37. Fremgangsmåde ifølge krav 31, hvor de X- og Y-kromosombærende spermceller sorteres under anvendelse af de optiske fælder (305) af det optiske fældesystem fra væskeindstrømningskanalen (301) til en hvilken som helst af udløbskanalerne (302, 303).
38. Fremgangsmåde ifølge krav 31, hvor én af de X- eller de Y-kromosombærende spermceller beskadiges eller dræbes af en laserstråle.
39. Fremgangsmåde ifølge krav 30, hvor de partikler, som beskadiges eller dræbes af laserstrålen, er én af X-kromosombærende sperm eller Y-kromosombærende sperm, og drabet frembringer en prøve, som har mere af det andet af det X-kromosom-bærende sperm eller det Y-kromosombærende sperm.
40. Fremgangsmåde ifølge krav 38, hvor beskadigelsen eller drabet ved hjælp af laserstrålen frembringer en prøve, som har mere af det andet af det X-kromosombærende sperm eller det Y-kromosombærende sperm.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39938602P | 2002-07-31 | 2002-07-31 | |
| US43554102P | 2002-12-20 | 2002-12-20 | |
| EP03772098.4A EP1573641B1 (en) | 2002-07-31 | 2003-07-31 | System and method of sorting materials using holographic laser steering |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2287858T3 true DK2287858T3 (da) | 2014-03-17 |
Family
ID=31191266
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14192362.3T DK2889879T3 (da) | 2002-07-31 | 2003-07-31 | System og fremgangsmåde til sortering af materialer under anvendelse af holografisk laserstyring |
| DK10182979.4T DK2270817T3 (da) | 2002-07-31 | 2003-07-31 | System og fremgangsmåde til sortering af materialer under anvendelse af holografisk laserstyring |
| DK03772098.4T DK1573641T3 (da) | 2002-07-31 | 2003-07-31 | System og fremgangsmåde til sortering af materialer under anvendelse af holografisk laserstyring |
| DK10182006.6T DK2270816T3 (da) | 2002-07-31 | 2003-07-31 | System og fremgangsmåde til sortering af materialer under anvendelse af holografisk laserstyring |
| DK10185539.3T DK2287858T3 (da) | 2002-07-31 | 2003-07-31 | System og fremgangsmåde til sortering af materialer under anvendelse af holografisk laserstyring |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14192362.3T DK2889879T3 (da) | 2002-07-31 | 2003-07-31 | System og fremgangsmåde til sortering af materialer under anvendelse af holografisk laserstyring |
| DK10182979.4T DK2270817T3 (da) | 2002-07-31 | 2003-07-31 | System og fremgangsmåde til sortering af materialer under anvendelse af holografisk laserstyring |
| DK03772098.4T DK1573641T3 (da) | 2002-07-31 | 2003-07-31 | System og fremgangsmåde til sortering af materialer under anvendelse af holografisk laserstyring |
| DK10182006.6T DK2270816T3 (da) | 2002-07-31 | 2003-07-31 | System og fremgangsmåde til sortering af materialer under anvendelse af holografisk laserstyring |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7241988B2 (da) |
| EP (8) | EP2270817B1 (da) |
| JP (1) | JP4666348B2 (da) |
| CN (3) | CN102539303B (da) |
| AU (1) | AU2003278700A1 (da) |
| BR (1) | BR0313130A (da) |
| CA (1) | CA2493411A1 (da) |
| DK (5) | DK2889879T3 (da) |
| ES (6) | ES2430963T3 (da) |
| HK (1) | HK1245497A1 (da) |
| WO (1) | WO2004012133A2 (da) |
Families Citing this family (129)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7150834B2 (en) * | 2003-07-31 | 2006-12-19 | Arryx, Inc. | Multiple laminar flow-based rate zonal or isopycnic separation with holographic optical trapping of blood cells and other static components |
| US11243494B2 (en) | 2002-07-31 | 2022-02-08 | Abs Global, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
| CN102539303B (zh) * | 2002-07-31 | 2016-06-15 | 普瑞姆遗传(英国)有限公司 | 利用全息激光控制分类物质的系统和方法 |
| US7118676B2 (en) * | 2003-09-04 | 2006-10-10 | Arryx, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
| US7699767B2 (en) | 2002-07-31 | 2010-04-20 | Arryx, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
| WO2004100175A1 (en) | 2003-05-08 | 2004-11-18 | The University Court Of The University Of St Andrews | Fractionation of particles |
| FR2863181B1 (fr) * | 2003-12-04 | 2006-08-18 | Commissariat Energie Atomique | Procede de tri de particules. |
| US7316982B2 (en) * | 2003-12-24 | 2008-01-08 | Intel Corporation | Controlling carbon nanotubes using optical traps |
| DK2801363T3 (da) | 2004-03-29 | 2018-05-28 | Inguran Llc | Fremgangsmåde til opbevaring af sorterede spermatozoer |
| EP1765228A4 (en) * | 2004-06-28 | 2009-06-10 | Haemonetics Corp | BLOOD COMPONENT SEPARATION SYSTEM HAVING A FIXED SEPARATION COMPARTMENT |
| US20110177547A1 (en) * | 2004-12-10 | 2011-07-21 | Arryx, Inc. | Particle Sorting Using Fluid Streams |
| WO2006063335A2 (en) * | 2004-12-10 | 2006-06-15 | Arryx, Inc. | Automated extraction and purification of samples using optical tweezers |
| EP1851166A2 (en) * | 2005-01-12 | 2007-11-07 | New York University | System and method for processing nanowires with holographic optical tweezers |
| US7586684B2 (en) | 2005-01-21 | 2009-09-08 | New York University | Solute characterization by optoelectronkinetic potentiometry in an inclined array of optical traps |
| US7355696B2 (en) * | 2005-02-01 | 2008-04-08 | Arryx, Inc | Method and apparatus for sorting cells |
| US7574076B2 (en) * | 2005-04-08 | 2009-08-11 | Arryx, Inc. | Apparatus for optically-based sorting within liquid core waveguides |
| US8411915B2 (en) * | 2005-08-04 | 2013-04-02 | Koninklijke Philips Electronics N.V. | Motion compensation in functional imaging |
| WO2007042989A1 (en) * | 2005-10-11 | 2007-04-19 | Ecole Polytechnique Federale De Lausanne (Epfl) | Miniaturized optical tweezer array with an array of reflective elements for reflecting the light back to a focal area |
| US8119976B2 (en) * | 2007-07-03 | 2012-02-21 | Colorado School Of Mines | Optical-based cell deformability |
| US9885644B2 (en) | 2006-01-10 | 2018-02-06 | Colorado School Of Mines | Dynamic viscoelasticity as a rapid single-cell biomarker |
| US9878326B2 (en) * | 2007-09-26 | 2018-01-30 | Colorado School Of Mines | Fiber-focused diode-bar optical trapping for microfluidic manipulation |
| US9487812B2 (en) | 2012-02-17 | 2016-11-08 | Colorado School Of Mines | Optical alignment deformation spectroscopy |
| US7718953B2 (en) * | 2006-04-12 | 2010-05-18 | University Of Delaware | Electromagnetic/optical tweezers using a full 3D negative-refraction flat lens |
| JP2007313378A (ja) * | 2006-05-23 | 2007-12-06 | Keio Gijuku | 光学的物質操作装置 |
| ITMI20061351A1 (it) * | 2006-07-12 | 2008-01-13 | Univ Pavia | Metodo e dispositivo ottico per l'intrappolameto di una particella |
| GB0618605D0 (en) | 2006-09-21 | 2006-11-01 | Univ St Andrews | Optical sorting |
| GB0618606D0 (en) | 2006-09-21 | 2006-11-01 | Univ St Andrews | Optical sorting |
| WO2008127410A2 (en) | 2006-11-07 | 2008-10-23 | New York University | Holographic microfabrication and characterization system for soft matter and biological systems |
| US20120288925A1 (en) * | 2007-01-05 | 2012-11-15 | Cornell University-Cornell Center for Technology Enterprise & Commercialization (CCTEC) | Optical trapping particles, angular optical trap systems, methods of making, and methods of use |
| TWI322280B (en) * | 2007-01-24 | 2010-03-21 | Raydium Semiconductor Corp | Apparatus capable of providing optical tweezers with momentum and method thereof |
| US7746466B2 (en) * | 2007-05-14 | 2010-06-29 | The Regents Of The University Of California | System and method for flow cytometry |
| WO2009002537A1 (en) * | 2007-06-25 | 2008-12-31 | Tufts University | Optical array device and methods of use thereof for screening, analysis and manipulation of particles |
| TWI394984B (zh) | 2007-07-31 | 2013-05-01 | Raydium Semiconductor Corp | 光鑷夾產生裝置與使光鑷夾具有動量之方法以及微粒導引之光鑷夾光場圖形 |
| US10722250B2 (en) | 2007-09-04 | 2020-07-28 | Colorado School Of Mines | Magnetic-field driven colloidal microbots, methods for forming and using the same |
| US20090062828A1 (en) * | 2007-09-04 | 2009-03-05 | Colorado School Of Mines | Magnetic field-based colloidal atherectomy |
| WO2009035623A1 (en) * | 2007-09-11 | 2009-03-19 | Arryx, Inc. | Binding method and apparatus for sorting objects |
| EP2185261A4 (en) * | 2007-09-13 | 2013-08-28 | Arryx Inc | METHODS AND APPARATUSES FOR SORTING OBJECTS IN MEDICO-LEGAL ANALYSIS OF RNA AND IN MEDICAL DIAGNOSES |
| US7772531B2 (en) * | 2007-10-25 | 2010-08-10 | University Of Victoria Innovation And Development Corporation | Adaptive optics based system and method to generate and control multiple optical beams for trapping and manipulating small particles |
| US8174742B2 (en) | 2008-03-14 | 2012-05-08 | New York University | System for applying optical forces from phase gradients |
| EP2113300A1 (en) * | 2008-04-25 | 2009-11-04 | Vereniging VU-Windesheim | Method device and system for creating a chemical reaction zone and the use of said device system |
| CA2738652A1 (en) | 2008-09-25 | 2010-04-01 | The Trustees Of Columbia University In The City Of New York | Device, apparatus and method for providing photostimulation and imaging of structures |
| DE102008060332B4 (de) * | 2008-12-03 | 2013-01-10 | Albert-Ludwigs-Universität Freiburg | Verfahren zum Sortieren von mindestens einem Partikel mit einer mikrofluidischen Sortiervorrichtung mit optischer Pinzette |
| EP2387708B1 (en) | 2009-01-16 | 2019-05-01 | New York University | Automated real-time particle characterization and three-dimensional velocimetry with holographic video microscopy |
| US8162149B1 (en) | 2009-01-21 | 2012-04-24 | Sandia Corporation | Particle sorter comprising a fluid displacer in a closed-loop fluid circuit |
| EP2267430A1 (de) | 2009-06-24 | 2010-12-29 | Masterrind GmbH | Vorrichtung und Verfahren zur Selektion von Partikeln |
| EP2507615A2 (en) * | 2009-12-22 | 2012-10-10 | New York University | Sorting colloidal particles into multiple channels with optical forces: prismatic optical fractionation |
| KR20120037134A (ko) * | 2010-10-11 | 2012-04-19 | 삼성전자주식회사 | 이동통신 시스템의 하향링크 수신 장치 및 방법 |
| US10908066B2 (en) | 2010-11-16 | 2021-02-02 | 1087 Systems, Inc. | Use of vibrational spectroscopy for microfluidic liquid measurement |
| EP2453285B1 (en) * | 2010-11-16 | 2013-04-03 | Olympus Corporation | Illumination optical system |
| US9242248B2 (en) * | 2011-09-16 | 2016-01-26 | The University Of North Carolina At Charlotte | Methods and devices for optical sorting of microspheres based on their resonant optical properties |
| US9841367B2 (en) * | 2011-09-16 | 2017-12-12 | The University Of North Carolina At Charlotte | Methods and devices for optical sorting of microspheres based on their resonant optical properties |
| WO2014012031A1 (en) * | 2012-07-13 | 2014-01-16 | The Regents Of The University Of California | High throughput lens-free three-dimensional tracking of sperm |
| US8723104B2 (en) * | 2012-09-13 | 2014-05-13 | City University Of Hong Kong | Methods and means for manipulating particles |
| EP2933327A4 (en) * | 2012-12-12 | 2016-08-03 | Hitachi Chemical Co Ltd | CANCER CELL ISOLATION DEVICE AND METHOD FOR CANCER CELL INSULATION |
| US9757726B2 (en) | 2013-03-14 | 2017-09-12 | Inguran, Llc | System for high throughput sperm sorting |
| US10662408B2 (en) | 2013-03-14 | 2020-05-26 | Inguran, Llc | Methods for high throughput sperm sorting |
| US10371622B2 (en) | 2013-03-14 | 2019-08-06 | Inguran, Llc | Device for high throughput sperm sorting |
| US8961904B2 (en) | 2013-07-16 | 2015-02-24 | Premium Genetics (Uk) Ltd. | Microfluidic chip |
| US11796449B2 (en) | 2013-10-30 | 2023-10-24 | Abs Global, Inc. | Microfluidic system and method with focused energy apparatus |
| JP6733909B2 (ja) | 2013-10-30 | 2020-08-05 | エービーエス グローバル インコーポレイテッド | 複数の物質を識別する装置、複数の物質を識別するコンピュータシステム、複数の物質を識別するための複数の命令をコンピュータに実行させるプログラムおよびサンプル流体混合物中を流れる複数の物質を識別する方法 |
| US9315846B2 (en) | 2014-02-13 | 2016-04-19 | The United States Of America As Represented By Secretary Of The Navy | Fluidic channel based on a filtered, free-space electromagnetic wave source |
| DE102014205535A1 (de) * | 2014-03-25 | 2015-10-01 | Siemens Aktiengesellschaft | Vorrichtung und in-vitro Verfahren zur markierungsfreien Darstellung und Analyse von Zellen und Kristallen in einer biologischen Probe |
| DE102014112270B3 (de) * | 2014-08-27 | 2015-04-23 | Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V. | Verfahren zur Messung der Thrombozytenfunktion |
| WO2016077472A1 (en) | 2014-11-12 | 2016-05-19 | New York University | Colloidal fingerprints for soft materials using total holographic characterization |
| EP3227661A4 (en) | 2014-12-05 | 2019-01-09 | Inguran, LLC | TREATMENT OF CELLS USING MAGNETIC PARTICLES |
| CN107223208B (zh) | 2014-12-09 | 2021-04-09 | 伯克利之光生命科技公司 | 微流体装置中微物体的自动检测和重新定位 |
| US10180388B2 (en) | 2015-02-19 | 2019-01-15 | 1087 Systems, Inc. | Scanning infrared measurement system |
| WO2016156516A2 (en) | 2015-03-31 | 2016-10-06 | Samantree Medical Sa | Systems and methods for in-operating-theatre imaging of fresh tissue resected during surgery for pathology assessment |
| CN107615066B (zh) * | 2015-05-07 | 2020-06-30 | 技术创新动力基金（以色列）有限合伙公司 | 用于包括精子的生物细胞和生物有机体的干涉系统和方法 |
| CN105116538B (zh) * | 2015-07-21 | 2023-02-14 | 大连理工大学 | 斜入射光在石墨烯薄层包裹颗粒表面产生可调谐非梯度光学力的方法 |
| CN105182571A (zh) * | 2015-07-21 | 2015-12-23 | 大连理工大学 | 斜入射光在液晶材料金属多层核-壳体表面产生可调谐非梯度光学力的方法 |
| CN105116535B (zh) * | 2015-07-21 | 2023-02-10 | 大连理工大学 | 线偏振平面光波对衬底上方的石墨烯包裹微粒的可调谐捕获和筛选的方法 |
| FR3044465B1 (fr) | 2015-11-27 | 2018-03-16 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Dispositif de photo-detection a reseau inter-diodes sur-dope par diffusion de metal et procede de fabrication |
| EP3362777B1 (de) | 2015-12-23 | 2023-02-22 | Siemens Healthcare GmbH | Fliesszelle zur analyse von partikeln in einer zu untersuchenden flüssigkeit, verfahren und verwendung |
| WO2017139279A2 (en) | 2016-02-08 | 2017-08-17 | New York University | Holographic characterization of protein aggregates |
| CN105699276B (zh) * | 2016-03-07 | 2018-09-25 | 广东工业大学 | 一种超分辨成像装置及方法 |
| US10162086B2 (en) | 2016-03-07 | 2018-12-25 | Microsoft Technology Licensing, Llc | Imaging through highly diffusive media with wavefront shaping |
| JP6983418B2 (ja) * | 2016-05-19 | 2021-12-17 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 流動内の自動化された単一細胞の細胞学的分類のためのシステムおよび方法 |
| CN106053587B (zh) * | 2016-05-23 | 2019-01-11 | 清华大学深圳研究生院 | 空间分辨图谱采集设备、荧光显影设备及离子迁移谱仪 |
| US11204322B2 (en) * | 2016-06-20 | 2021-12-21 | Plair S.a. | Device and method for detecting and/or characterizing fluid-borne particles |
| AU2017368267B2 (en) | 2016-12-01 | 2022-12-15 | Berkeley Lights, Inc. | Apparatuses, systems and methods for imaging micro-objects |
| CA3045333A1 (en) | 2016-12-01 | 2018-06-07 | Berkeley Lights, Inc. | Automated detection and repositioning of micro-objects in microfluidic devices |
| CN107068230A (zh) * | 2017-05-12 | 2017-08-18 | 深圳大学 | 一种可操纵的光镊模型 |
| EP4435113B1 (en) | 2017-05-18 | 2025-12-10 | 10X Genomics, Inc. | Methods and systems for sorting droplets and beads |
| US10544413B2 (en) | 2017-05-18 | 2020-01-28 | 10X Genomics, Inc. | Methods and systems for sorting droplets and beads |
| CN111316138B (zh) | 2017-05-24 | 2022-05-17 | 纽约市哥伦比亚大学理事会 | 色散工程化介电超表面的宽带消色差平坦光学部件 |
| US10606054B2 (en) | 2017-07-14 | 2020-03-31 | Sony Corporation | Super-resolution far-field scanning optical microscope |
| US10610865B2 (en) | 2017-08-22 | 2020-04-07 | 10X Genomics, Inc. | Droplet forming devices and system with differential surface properties |
| JP7461294B2 (ja) | 2017-08-31 | 2024-04-03 | メタレンズ，インコーポレイテッド | 透過型メタサーフェスレンズ統合 |
| CN107603940B (zh) * | 2017-09-07 | 2020-10-27 | 中国科学技术大学 | 利用楔形光镊光场分选微粒的方法 |
| WO2019083852A1 (en) | 2017-10-26 | 2019-05-02 | 10X Genomics, Inc. | MICROFLUIDIC CHANNEL NETWORKS FOR PARTITIONING |
| US11747603B2 (en) | 2017-10-31 | 2023-09-05 | Samantree Medical Sa | Imaging systems with micro optical element arrays and methods of specimen imaging |
| US10539776B2 (en) | 2017-10-31 | 2020-01-21 | Samantree Medical Sa | Imaging systems with micro optical element arrays and methods of specimen imaging |
| US10928621B2 (en) | 2017-10-31 | 2021-02-23 | Samantree Medical Sa | Sample dishes for use in microscopy and methods of their use |
| TWI662261B (zh) * | 2018-01-17 | 2019-06-11 | 國立交通大學 | 同軸異質整合高光譜系統 |
| CN118295056A (zh) | 2018-01-24 | 2024-07-05 | 哈佛学院院长及董事 | 利用超表面的偏振状态生成 |
| EP3746783B1 (en) | 2018-02-01 | 2024-05-29 | Technology Innovation Momentum Fund (Israel) Limited Partnership | Method and system for evaluating fertility of human spermatozoa |
| US11331670B2 (en) | 2018-05-23 | 2022-05-17 | Abs Global, Inc. | Systems and methods for particle focusing in microchannels |
| JP7526100B2 (ja) | 2018-05-31 | 2024-07-31 | バークレー ライツ，インコーポレイテッド | マイクロ流体デバイスによる微小物体の自動検出及び特徴付け |
| CN108732103B (zh) * | 2018-06-01 | 2020-10-30 | 大连晓辉医药科技有限公司 | 一种基于光流控成像光谱的细胞检测和分类装置 |
| SG11202013228XA (en) | 2018-07-02 | 2021-01-28 | Metalenz Inc | Metasurfaces for laser speckle reduction |
| GB2575658B (en) * | 2018-07-18 | 2020-12-23 | Envisics Ltd | Head-up display |
| US10611995B2 (en) | 2018-08-15 | 2020-04-07 | Deepcell, Inc. | Systems and methods for particle analysis |
| US11815507B2 (en) | 2018-08-15 | 2023-11-14 | Deepcell, Inc. | Systems and methods for particle analysis |
| CN109116041B (zh) * | 2018-08-15 | 2021-11-02 | 深圳大学 | 一种生理环境下细胞密度测算方法 |
| CN109085139A (zh) * | 2018-08-23 | 2018-12-25 | 天津大学 | 红外透射式离轴数字全息显微测量系统 |
| CN109612388B (zh) * | 2018-11-30 | 2020-06-12 | 西安交通大学 | 一种细胞穿孔的光学测量系统和方法 |
| EP3899489B1 (en) | 2018-12-21 | 2025-04-09 | ABS Global, Inc. | System and methods for sub-population identification |
| CN109633916B (zh) * | 2019-01-16 | 2021-03-26 | 长春理工大学 | 一种基于bar条的阵列局域空心光束系统 |
| CN113785187B (zh) | 2019-03-22 | 2025-01-28 | 贝克顿·迪金森公司 | 使用射频多路复用激发数据对荧光成像进行光谱解混 |
| DE102019109787A1 (de) * | 2019-04-12 | 2020-10-15 | Endress+Hauser SE+Co. KG | Hygienegerechter Rohradapter |
| EP3955735B1 (en) | 2019-04-18 | 2024-05-22 | ABS Global, Inc. | System and process for continuous addition of cryoprotectant |
| EP4004608A4 (en) | 2019-07-26 | 2023-08-30 | Metalenz, Inc. | APERTURE METASURFACE AND HYBRID REFRACTIVE METASURFACE IMAGING SYSTEMS |
| US11543338B2 (en) | 2019-10-25 | 2023-01-03 | New York University | Holographic characterization of irregular particles |
| US11578968B1 (en) | 2019-10-31 | 2023-02-14 | President And Fellows Of Harvard College | Compact metalens depth sensors |
| US11628439B2 (en) | 2020-01-13 | 2023-04-18 | Abs Global, Inc. | Single-sheath microfluidic chip |
| US11948302B2 (en) | 2020-03-09 | 2024-04-02 | New York University | Automated holographic video microscopy assay |
| CN111855657B (zh) * | 2020-07-22 | 2022-12-30 | 中国科学技术大学 | 一种基于能量梯度的精子活力评价方法 |
| WO2022087299A1 (en) | 2020-10-21 | 2022-04-28 | Abs Global, Inc. | Methods and systems for processing genetic samples to determine identity or detect contamination |
| US12135270B2 (en) | 2020-11-23 | 2024-11-05 | Abs Global, Inc. | Modular flow cytometry systems and methods of processing samples |
| EP4348780A4 (en) | 2021-05-25 | 2025-04-23 | Metalenz, Inc. | Single element dot pattern projector |
| CN117813548A (zh) * | 2021-05-26 | 2024-04-02 | 光辉科技股份有限公司 | 用于高分辨率三维纳米制造的系统及方法 |
| US11619586B2 (en) * | 2021-07-08 | 2023-04-04 | X Development Llc | System for imaging and selective illumination of targets within a sample |
| CN113533173B (zh) * | 2021-09-17 | 2021-12-21 | 之江实验室 | 通过预加热脱附增强光悬浮微粒真空耐受度的方法与装置 |
| CN113740214B (zh) * | 2021-11-08 | 2022-01-25 | 深圳大学 | 一种基于全息倏逝波光镊的智能分析方法与装置 |
| USD1118965S1 (en) | 2021-11-12 | 2026-03-17 | Abs Global, Inc. | Flow cytometry device |
| CN120188073A (zh) | 2022-03-31 | 2025-06-20 | 梅特兰兹股份有限公司 | 偏振分选超颖表面微透镜阵列设备 |
| CN118567082B (zh) * | 2024-03-22 | 2025-11-11 | 清华大学 | 三维显微成像装置及其成像方法 |
| CN118594637B (zh) * | 2024-05-24 | 2025-10-03 | 哈尔滨工业大学 | 基于全息光阱的微流体智能控制系统及控制方法 |
Family Cites Families (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5966457A (en) * | 1955-06-14 | 1999-10-12 | Lemelson; Jerome H. | Method for inspecting, coding and sorting objects |
| US3649829A (en) | 1970-10-06 | 1972-03-14 | Atomic Energy Commission | Laminar flow cell |
| US3960449A (en) | 1975-06-05 | 1976-06-01 | The Board Of Trustees Of Leland Stanford Junior University | Measurement of angular dependence of scattered light in a flowing stream |
| US4325706A (en) * | 1980-08-15 | 1982-04-20 | Ortho Diagnostic Systems Inc. | Automated detection of platelets and reticulocytes in whole blood |
| US4424132A (en) | 1981-02-05 | 1984-01-03 | Asahi Kasei Kogyo Kabushiki Kaisha | Apparatus and method for separating blood components |
| US4667830A (en) | 1981-06-15 | 1987-05-26 | The Board Of Trustees Of The Leland Stanford Junior University | Method and means for sorting individual particles into containers for culturing, cloning, analysis, or the like |
| US4409106A (en) | 1981-09-08 | 1983-10-11 | Asahi Kasei Kogyo Kabushiki Kaisha | Apparatus and method for separating blood components |
| US4395397A (en) * | 1981-09-17 | 1983-07-26 | Sidney Farber Cancer Institute, Inc. | Apparatus and method for killing unwanted cells |
| US4660971A (en) | 1984-05-03 | 1987-04-28 | Becton, Dickinson And Company | Optical features of flow cytometry apparatus |
| IN169006B (da) * | 1986-06-26 | 1991-08-10 | Westinghouse Electric Corp | |
| JPS63262565A (ja) | 1987-04-20 | 1988-10-28 | Hitachi Ltd | フロ−セル |
| US4893886A (en) * | 1987-09-17 | 1990-01-16 | American Telephone And Telegraph Company | Non-destructive optical trap for biological particles and method of doing same |
| US4887721A (en) * | 1987-11-30 | 1989-12-19 | The United States Of America As Represented By The United States Department Of Energy | Laser particle sorter |
| US5229297A (en) | 1989-02-03 | 1993-07-20 | Eastman Kodak Company | Containment cuvette for PCR and method of use |
| DE69025256T2 (de) | 1989-10-11 | 1996-06-27 | Canon Kk | Gerät und Verfahren zur Trennung von Teilchen aus flüssigkeitssuspendierten Teilchen in Zusammenhang mit deren Eigenschaften |
| US5100627A (en) | 1989-11-30 | 1992-03-31 | The Regents Of The University Of California | Chamber for the optical manipulation of microscopic particles |
| JPH03297385A (ja) * | 1990-04-16 | 1991-12-27 | Nippon Steel Corp | レーザによる光トラッピングを用いた細胞融合方法 |
| US5194909A (en) | 1990-12-04 | 1993-03-16 | Tycko Daniel H | Apparatus and method for measuring volume and hemoglobin concentration of red blood cells |
| JPH07109384B2 (ja) * | 1991-08-29 | 1995-11-22 | プリマハム株式会社 | 試料面切り出し装置を具備する自動検査装置 |
| DE4300698A1 (de) * | 1993-01-13 | 1994-07-14 | Raimund Schuetze | Vorrichtung und Verfahren zur Handhabung, Bearbeitung und Beobachtung kleiner Teilchen, insbesondere biologischer Teilchen |
| CA2155186A1 (en) | 1993-02-01 | 1994-08-18 | Kevin M. Ulmer | Methods and apparatus for dna sequencing |
| JP2512387B2 (ja) * | 1993-03-23 | 1996-07-03 | 理化学研究所 | 細胞選別方法および細胞補集方法 |
| US5427663A (en) | 1993-06-08 | 1995-06-27 | British Technology Group Usa Inc. | Microlithographic array for macromolecule and cell fractionation |
| US5483469A (en) | 1993-08-02 | 1996-01-09 | The Regents Of The University Of California | Multiple sort flow cytometer |
| USH1960H1 (en) | 1995-04-10 | 2001-06-05 | Alpha Therapeutic Corp. | Automated method and system for testing blood samples |
| US6797942B2 (en) | 2001-09-13 | 2004-09-28 | University Of Chicago | Apparatus and process for the lateral deflection and separation of flowing particles by a static array of optical tweezers |
| US5620857A (en) | 1995-06-07 | 1997-04-15 | United States Of America, As Represented By The Secretary Of Commerce | Optical trap for detection and quantitation of subzeptomolar quantities of analytes |
| JP3819032B2 (ja) * | 1995-08-24 | 2006-09-06 | ザ・テキサス・エイ・アンド・エム・ユニバーシティ・システム | 組織およびその他のランダム媒体における蛍光寿命に基づく撮像および分光分析 |
| US5707808A (en) | 1996-04-15 | 1998-01-13 | The Regents Of The University Of California | Optical selection and collection of DNA fragments |
| US5752606A (en) * | 1996-05-23 | 1998-05-19 | Wilson; Steve D. | Method for trapping, manipulating, and separating cells and cellular components utilizing a particle trap |
| JP3688820B2 (ja) * | 1996-08-26 | 2005-08-31 | 株式会社モリテックス | レーザトラッピング装置及びこれを利用したマイクロマニピュレータ |
| US5800690A (en) | 1996-07-03 | 1998-09-01 | Caliper Technologies Corporation | Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces |
| DK0925494T3 (da) | 1996-09-04 | 2002-07-01 | Scandinavian Micro Biodevices | Mikrostrømningssystem til partikelseparation og analyse |
| CA2277860C (en) | 1997-01-08 | 2005-11-29 | Bristol-Myers Squibb Company | Centrifuge apparatus for separating blood |
| US5939716A (en) | 1997-04-02 | 1999-08-17 | Sandia Corporation | Three-dimensional light trap for reflective particles |
| US6368871B1 (en) | 1997-08-13 | 2002-04-09 | Cepheid | Non-planar microstructures for manipulation of fluid samples |
| US6149867A (en) | 1997-12-31 | 2000-11-21 | Xy, Inc. | Sheath fluids and collection systems for sex-specific cytometer sorting of sperm |
| US6055106A (en) * | 1998-02-03 | 2000-04-25 | Arch Development Corporation | Apparatus for applying optical gradient forces |
| DE19815882A1 (de) | 1998-04-08 | 1999-10-14 | Fuhr Guenther | Verfahren und Vorrichtung zur Manipulierung von Mikropartikeln in Fluidströmungen |
| US6159749A (en) * | 1998-07-21 | 2000-12-12 | Beckman Coulter, Inc. | Highly sensitive bead-based multi-analyte assay system using optical tweezers |
| US6637463B1 (en) | 1998-10-13 | 2003-10-28 | Biomicro Systems, Inc. | Multi-channel microfluidic system design with balanced fluid flow distribution |
| US7116407B2 (en) | 1998-12-15 | 2006-10-03 | Union Biometrica, Inc. | System for axial pattern analysis of multicellular organisms |
| EP1179087B1 (en) | 1999-05-17 | 2019-03-27 | Caliper Life Sciences, Inc. | Focusing of microparticles in microfluidic systems |
| US6287870B1 (en) * | 1999-08-20 | 2001-09-11 | Robert A. Levine | Method and assembly for separating formed constituents from a liquid constituent in a complex biologic fluid sample |
| DE19942265A1 (de) * | 1999-09-04 | 2001-03-08 | Alup Kompressoren Gmbh | Verdichteranlage und Verfahren zur Verdichtung eines Gases |
| FR2798557A1 (fr) * | 1999-09-22 | 2001-03-23 | Christine Nicolino | Eliminateur d'insectes volants |
| DE19952322C2 (de) * | 1999-10-29 | 2002-06-13 | Evotec Ag | Verfahren und Vorrichtung zur Partikeltrennung |
| US6944324B2 (en) * | 2000-01-24 | 2005-09-13 | Robotic Vision Systems, Inc. | Machine vision-based singulation verification system and method |
| US6451264B1 (en) | 2000-01-28 | 2002-09-17 | Roche Diagnostics Corporation | Fluid flow control in curved capillary channels |
| US20030186426A1 (en) | 2000-03-15 | 2003-10-02 | The Regents Of The University Of California | Multichannel flow cell for interacting single optically trapped, DNA molecules with different chemical species |
| US7351376B1 (en) * | 2000-06-05 | 2008-04-01 | California Institute Of Technology | Integrated active flux microfluidic devices and methods |
| WO2002023163A1 (en) | 2000-09-15 | 2002-03-21 | California Institute Of Technology | Microfabricated crossflow devices and methods |
| US6744038B2 (en) * | 2000-11-13 | 2004-06-01 | Genoptix, Inc. | Methods of separating particles using an optical gradient |
| US20020115163A1 (en) * | 2000-11-13 | 2002-08-22 | Genoptix | Methods for sorting particles by size and elasticity |
| US20020160470A1 (en) * | 2000-11-13 | 2002-10-31 | Genoptix | Methods and apparatus for generating and utilizing linear moving optical gradients |
| US6833542B2 (en) | 2000-11-13 | 2004-12-21 | Genoptix, Inc. | Method for sorting particles |
| US20030007894A1 (en) | 2001-04-27 | 2003-01-09 | Genoptix | Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles |
| US20020123112A1 (en) * | 2000-11-13 | 2002-09-05 | Genoptix | Methods for increasing detection sensitivity in optical dielectric sorting systems |
| JP4002720B2 (ja) | 2000-11-22 | 2007-11-07 | 独立行政法人科学技術振興機構 | 一細胞長期培養顕微観察装置 |
| US6416190B1 (en) * | 2001-04-27 | 2002-07-09 | University Of Chicago | Apparatus for using optical tweezers to manipulate materials |
| WO2003008943A1 (en) * | 2001-07-19 | 2003-01-30 | Tufts University | Optical array device and methods of use thereof for screening, analysis and manipulation of particles |
| US6838056B2 (en) * | 2002-07-08 | 2005-01-04 | Innovative Micro Technology | Method and apparatus for sorting biological cells with a MEMS device |
| US7118676B2 (en) * | 2003-09-04 | 2006-10-10 | Arryx, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
| US7150834B2 (en) * | 2003-07-31 | 2006-12-19 | Arryx, Inc. | Multiple laminar flow-based rate zonal or isopycnic separation with holographic optical trapping of blood cells and other static components |
| CN102539303B (zh) * | 2002-07-31 | 2016-06-15 | 普瑞姆遗传(英国)有限公司 | 利用全息激光控制分类物质的系统和方法 |
| JP3891925B2 (ja) | 2002-12-03 | 2007-03-14 | ベイバイオサイエンス株式会社 | 生物学的粒子の情報を得る装置 |
| AU2004241455A1 (en) * | 2003-05-16 | 2004-12-02 | University Of Chicago | Optical fractionation methods and apparatus |
-
2003
- 2003-07-31 CN CN201110399487.1A patent/CN102539303B/zh not_active Expired - Fee Related
- 2003-07-31 ES ES03772098T patent/ES2430963T3/es not_active Expired - Lifetime
- 2003-07-31 AU AU2003278700A patent/AU2003278700A1/en not_active Abandoned
- 2003-07-31 DK DK14192362.3T patent/DK2889879T3/da active
- 2003-07-31 BR BRPI0313130-0A patent/BR0313130A/pt not_active IP Right Cessation
- 2003-07-31 EP EP10182979.4A patent/EP2270817B1/en not_active Expired - Lifetime
- 2003-07-31 DK DK10182979.4T patent/DK2270817T3/da active
- 2003-07-31 EP EP14192362.3A patent/EP2889879B1/en not_active Expired - Lifetime
- 2003-07-31 ES ES10182006.6T patent/ES2490618T3/es not_active Expired - Lifetime
- 2003-07-31 US US10/630,904 patent/US7241988B2/en not_active Expired - Fee Related
- 2003-07-31 ES ES15160613.4T patent/ES2659052T3/es not_active Expired - Lifetime
- 2003-07-31 ES ES10182979.4T patent/ES2543211T3/es not_active Expired - Lifetime
- 2003-07-31 EP EP03772098.4A patent/EP1573641B1/en not_active Expired - Lifetime
- 2003-07-31 EP EP10182006.6A patent/EP2270816B1/en not_active Expired - Lifetime
- 2003-07-31 ES ES10185539.3T patent/ES2451765T3/es not_active Expired - Lifetime
- 2003-07-31 CN CN201310236687.4A patent/CN103364326B/zh not_active Expired - Fee Related
- 2003-07-31 ES ES14192362.3T patent/ES2646622T3/es not_active Expired - Lifetime
- 2003-07-31 CA CA002493411A patent/CA2493411A1/en not_active Abandoned
- 2003-07-31 WO PCT/US2003/023822 patent/WO2004012133A2/en not_active Ceased
- 2003-07-31 DK DK03772098.4T patent/DK1573641T3/da active
- 2003-07-31 EP EP20140168200 patent/EP2806427A3/en not_active Withdrawn
- 2003-07-31 EP EP10185539.3A patent/EP2287858B1/en not_active Expired - Lifetime
- 2003-07-31 JP JP2004524205A patent/JP4666348B2/ja not_active Expired - Fee Related
- 2003-07-31 EP EP15160613.4A patent/EP2911158B1/en not_active Expired - Lifetime
- 2003-07-31 CN CN038234432A patent/CN1774623B/zh not_active Expired - Fee Related
- 2003-07-31 EP EP17172322.4A patent/EP3229240A1/en not_active Withdrawn
- 2003-07-31 DK DK10182006.6T patent/DK2270816T3/da active
- 2003-07-31 DK DK10185539.3T patent/DK2287858T3/da active
-
2007
- 2007-06-12 US US11/808,677 patent/US7482577B2/en not_active Expired - Fee Related
-
2018
- 2018-04-11 HK HK18104720.9A patent/HK1245497A1/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2287858T3 (da) | System og fremgangsmåde til sortering af materialer under anvendelse af holografisk laserstyring | |
| US11422504B2 (en) | Multiple laminar flow-based particle and cellular separation with laser steering | |
| US9140690B2 (en) | Method of identifying components in a fluid mixture | |
| HK1212503B (en) | System and method of sorting materials using holographic laser steering | |
| HK1090701B (en) | System and method of sorting materials using holographic laser steering | |
| HK1187406A (en) | System and method of sorting materials using holographic laser steering | |
| HK1187406B (en) | System and method of sorting materials using holographic laser steering | |
| HK1169712B (en) | System and method of sorting materials using holographic laser steering |