DK2298362T3 - Reagerende paramagnetiske kontrastmidler til magnetresonansbilledteknik - Google Patents

Reagerende paramagnetiske kontrastmidler til magnetresonansbilledteknik

Info

Publication number
DK2298362T3
DK2298362T3 DK10176761.4T DK10176761T DK2298362T3 DK 2298362 T3 DK2298362 T3 DK 2298362T3 DK 10176761 T DK10176761 T DK 10176761T DK 2298362 T3 DK2298362 T3 DK 2298362T3
Authority
DK
Denmark
Prior art keywords
magnetic resonance
resonance imaging
contrast agents
imaging techniques
paramagnetic contrast
Prior art date
Application number
DK10176761.4T
Other languages
English (en)
Inventor
Silvio Aime
Franco Fedeli
Enzo Terreno
Castelli Daniela Delli
Original Assignee
Bracco Imaging Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa
Application granted granted Critical
Publication of DK2298362T3 publication Critical patent/DK2298362T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK10176761.4T 2002-01-29 2003-01-27 Reagerende paramagnetiske kontrastmidler til magnetresonansbilledteknik DK2298362T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20020001178 EP1331012A1 (en) 2002-01-29 2002-01-29 Responsive paramagnetic MRI contrast agents
EP03702538A EP1469890B1 (en) 2002-01-29 2003-01-27 Responsive paramagnetic mri contrast agents

Publications (1)

Publication Number Publication Date
DK2298362T3 true DK2298362T3 (da) 2013-06-10

Family

ID=8185284

Family Applications (2)

Application Number Title Priority Date Filing Date
DK03702538.4T DK1469890T3 (da) 2002-01-29 2003-01-27 Reaktivt paramagnetisk kontrastmiddel til magnetresonansbilledteknik
DK10176761.4T DK2298362T3 (da) 2002-01-29 2003-01-27 Reagerende paramagnetiske kontrastmidler til magnetresonansbilledteknik

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK03702538.4T DK1469890T3 (da) 2002-01-29 2003-01-27 Reaktivt paramagnetisk kontrastmiddel til magnetresonansbilledteknik

Country Status (6)

Country Link
US (2) US7524483B2 (da)
EP (3) EP1331012A1 (da)
JP (3) JP4850391B2 (da)
AT (1) ATE519505T1 (da)
DK (2) DK1469890T3 (da)
WO (1) WO2003063912A1 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1178837A2 (en) 1999-04-21 2002-02-13 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Method for enhancing contrast produced by mri
EP1331012A1 (en) * 2002-01-29 2003-07-30 BRACCO IMAGING S.p.A. Responsive paramagnetic MRI contrast agents
EP1466629A1 (en) * 2003-04-11 2004-10-13 BRACCO IMAGING S.p.A. Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for "CEST" applications
JP2008513533A (ja) * 2004-09-23 2008-05-01 ゲルベ Ｃｅｓｔイメージング用の造影剤封入システム
WO2006114765A2 (en) * 2005-04-26 2006-11-02 Koninklijke Philips Electronics N.V. Mri involving contrast agent with time modulated contrast enhancement
JP5638752B2 (ja) 2005-04-26 2014-12-10 コーニンクレッカ フィリップス エヌ ヴェ Ｃｅｓｔ活性な常磁性の錯体を含むｍｒｉ造影剤
EP1889086B1 (en) * 2005-04-26 2010-01-13 Koninklijke Philips Electronics N.V. Method for using cest contrast agents in mri
WO2006121889A2 (en) * 2005-05-06 2006-11-16 Epix Pharmaceuticals, Inc. Chemical exchange saturation transfer contrast agents
US7610077B2 (en) * 2005-12-08 2009-10-27 General Electric Compnay Quantitation of sample properties using contrast enhancement from saturation transfer
WO2007115115A2 (en) * 2006-03-29 2007-10-11 Kereos, Inc. Targeted mr imaging agents
US8463358B2 (en) 2006-06-09 2013-06-11 Koninklijke Philips Electronics N.V. Elimination of contrast agent concentration dependency in MRI
US8536866B2 (en) 2007-09-26 2013-09-17 The Johns Hopkins University Frequency referencing for chemical exchange saturation transfer (CEST) MRI
US9701694B2 (en) 2008-12-02 2017-07-11 The University Of Melbourne Nitrogen-containing macrocyclic conjugates as radiopharmaceuticals
WO2011071778A1 (en) 2009-12-07 2011-06-16 Mayo Foundation For Medical Education And Research Device for the delineation of cardiovascular or other anatomical structures
WO2011083730A1 (ja) * 2010-01-06 2011-07-14 株式会社資生堂 Ｎｍｒ用の標準物質、ｎｍｒ用の試料管、ｎｍｒ用のキャピラリー、及び試料のｎｍｒを測定する方法
WO2012006038A2 (en) * 2010-06-28 2012-01-12 The Board Of Regents, The University Of Texas System Agents and compounds for imaging and other applications, and methods of use and synthesis thereof
EP2457594A1 (en) * 2010-11-05 2012-05-30 Bracco Imaging S.p.A Cest systems exhibiting a concentration independent responsiveness
WO2012155076A2 (en) * 2011-05-11 2012-11-15 The Research Foundation Of State University Of New York Imaging contrast agents and uses thereof
JP6047581B2 (ja) 2011-12-06 2016-12-21 ザ ユニバーシティ オブ メルボルン 金属放射性医薬品のためのケージアミン配位子
US10551455B2 (en) 2015-05-04 2020-02-04 Duke University Magnetic resonance imaging (MRI) systems and methods using adiabatic tip-down and matched adiabatic flip-back pulses
JP6964583B2 (ja) * 2015-12-23 2021-11-10 ブラッコ・イメージング・ソシエタ・ペル・アチオニBracco Imaging S.P.A. レシオメトリックパルスｃｅｓｔイメージング

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190744A (en) * 1990-03-09 1993-03-02 Salutar Methods for detecting blood perfusion variations by magnetic resonance imaging
JP3759765B2 (ja) * 1994-03-28 2006-03-29 第一製薬株式会社 リポソーム
WO1995026205A1 (en) 1994-03-28 1995-10-05 Nycomed Imaging A/S Liposomes
EP1178837A2 (en) * 1999-04-21 2002-02-13 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Method for enhancing contrast produced by mri
WO2002043775A2 (en) * 2000-11-20 2002-06-06 GODFREY, Cullen, M. Paramagnetic metal ion-based macrocyclic contrast agents
EP1302465A1 (en) 2001-10-11 2003-04-16 BRACCO IMAGING S.p.A. Enhanced substrate imaging by reversible binding to a paramagnetic complex
EP1331012A1 (en) * 2002-01-29 2003-07-30 BRACCO IMAGING S.p.A. Responsive paramagnetic MRI contrast agents

Also Published As

Publication number Publication date
JP2010088901A (ja) 2010-04-22
EP2298362B1 (en) 2013-03-13
DK1469890T3 (da) 2011-11-14
JP4796643B2 (ja) 2011-10-19
WO2003063912A1 (en) 2003-08-07
US8318134B2 (en) 2012-11-27
JP2011235125A (ja) 2011-11-24
US20050191243A1 (en) 2005-09-01
EP1469890B1 (en) 2011-08-10
EP1469890A1 (en) 2004-10-27
JP2005515842A (ja) 2005-06-02
EP1331012A1 (en) 2003-07-30
US20090234221A1 (en) 2009-09-17
US7524483B2 (en) 2009-04-28
JP4850391B2 (ja) 2012-01-11
EP2298362A1 (en) 2011-03-23
ATE519505T1 (de) 2011-08-15

Similar Documents

Publication Publication Date Title
DK2298362T3 (da) Reagerende paramagnetiske kontrastmidler til magnetresonansbilledteknik
SE9903185D0 (sv) Terapeutisk metod och anordning baserad på magnetism
DE602004027605D1 (de) Medizinische geräte mit kontrastmittel und verfahren zu dessen herstellung
IL180896A0 (en) Method of tumour imaging
DE60336298D1 (de) Medizinische implantierbare vorrichtung zur verminderung der effekten von magnetresonanz
DK1217943T3 (da) Fremgangsmåde og apparat til bestemmelse af autofluorescens af hudvæv
WO2004066805A3 (en) In vivo device for improving diastolic ventricular function
ATE460753T1 (de) Gewölbtes gehäuse für eine implantierbare medizinische vorrichtung
DE602005023608D1 (de) Vorrichtung, system und verfahren zur in-vivo-probenentnahme
EP1530440A4 (en) Non-magnetic medical infusion device
AU7494701A (en) Nrg-2 nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods
ATE298224T1 (de) Blutanalysegerät und stechvorrichtung zur verwendung bei der blutanalyse
DE602004028771D1 (de) Vorrichtung zur Positionsmessung einer in vivo Funkvorrichtung
ATE372096T1 (de) Tibialimplantat mit einem durchgeführten stamm
MXPA02011427A (es) Procedimiento para revestir dispositivos medicos utilizando dioxido de carbono supercritico.
DE60223176D1 (de) Metallkomplexverbindungen
IL159937A0 (en) A method of determining the presence of a target in a vascular system using a targeted mri contrast agent
ATE269524T1 (de) Kühlgerät und verfahren zur verkeimungsindikation
WO2006114738A3 (en) Mri contrast agents comprising cest active paramagnetic complex
ATE452655T1 (de) Verwendung von l-polynukleotiden zur diagnostischen bilderzeugung
DE60207288D1 (de) Gewebespezifische fluoreszierende chelate
WO2003084384A3 (en) Diagnosis of flavivirus infection
WO2003086563A3 (en) Diabetes imaging probes
ATE367840T1 (de) Kanülenhalter
DE60203256D1 (de) System für eine implantierbare medizinische Vorrichtung