DK2298362T3 - Reagerende paramagnetiske kontrastmidler til magnetresonansbilledteknik - Google Patents

Reagerende paramagnetiske kontrastmidler til magnetresonansbilledteknik

Info

Publication number
DK2298362T3
DK2298362T3 DK10176761.4T DK10176761T DK2298362T3 DK 2298362 T3 DK2298362 T3 DK 2298362T3 DK 10176761 T DK10176761 T DK 10176761T DK 2298362 T3 DK2298362 T3 DK 2298362T3
Authority
DK
Denmark
Prior art keywords
magnetic resonance
resonance imaging
contrast agents
imaging techniques
paramagnetic contrast
Prior art date
Application number
DK10176761.4T
Other languages
English (en)
Inventor
Silvio Aime
Franco Fedeli
Enzo Terreno
Castelli Daniela Delli
Original Assignee
Bracco Imaging Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa
Application granted granted Critical
Publication of DK2298362T3 publication Critical patent/DK2298362T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK10176761.4T 2002-01-29 2003-01-27 Reagerende paramagnetiske kontrastmidler til magnetresonansbilledteknik DK2298362T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20020001178 EP1331012A1 (en) 2002-01-29 2002-01-29 Responsive paramagnetic MRI contrast agents
EP03702538A EP1469890B1 (en) 2002-01-29 2003-01-27 Responsive paramagnetic mri contrast agents

Publications (1)

Publication Number Publication Date
DK2298362T3 true DK2298362T3 (da) 2013-06-10

Family

ID=8185284

Family Applications (2)

Application Number Title Priority Date Filing Date
DK03702538.4T DK1469890T3 (da) 2002-01-29 2003-01-27 Reaktivt paramagnetisk kontrastmiddel til magnetresonansbilledteknik
DK10176761.4T DK2298362T3 (da) 2002-01-29 2003-01-27 Reagerende paramagnetiske kontrastmidler til magnetresonansbilledteknik

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK03702538.4T DK1469890T3 (da) 2002-01-29 2003-01-27 Reaktivt paramagnetisk kontrastmiddel til magnetresonansbilledteknik

Country Status (6)

Country Link
US (2) US7524483B2 (da)
EP (3) EP1331012A1 (da)
JP (3) JP4850391B2 (da)
AT (1) ATE519505T1 (da)
DK (2) DK1469890T3 (da)
WO (1) WO2003063912A1 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6963769B1 (en) * 1999-04-21 2005-11-08 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method for enhancing contrast produced by MRI
EP1331012A1 (en) * 2002-01-29 2003-07-30 BRACCO IMAGING S.p.A. Responsive paramagnetic MRI contrast agents
EP1466629A1 (en) * 2003-04-11 2004-10-13 BRACCO IMAGING S.p.A. Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for "CEST" applications
US20070292354A1 (en) * 2004-09-23 2007-12-20 Guerbet Contrast Agents Encapsulating Systems for Cest Imaging
EP1881852B1 (en) 2005-04-26 2009-08-19 Koninklijke Philips Electronics N.V. Mri contrast agents comprising cest active paramagnetic complex
US7917188B2 (en) 2005-04-26 2011-03-29 Koninklijke Philips Electronics N.V. Method for using CEST contrast agents in MRI
CN101166988B (zh) * 2005-04-26 2012-06-13 皇家飞利浦电子股份有限公司 改进对mri对比增强的检测的方法和设备
US20060275217A1 (en) * 2005-05-06 2006-12-07 Caravan Peter D Chemical exchange saturation transfer contrast agents
US7610077B2 (en) * 2005-12-08 2009-10-27 General Electric Compnay Quantitation of sample properties using contrast enhancement from saturation transfer
US8003078B2 (en) * 2006-03-29 2011-08-23 Barnes-Jewish Hospital Targeted MR imaging agents
RU2446829C2 (ru) * 2006-06-09 2012-04-10 Конинклейке Филипс Электроникс Н.В. Устранение зависимости от концентрации контрастного агента в мрт
US8536866B2 (en) 2007-09-26 2013-09-17 The Johns Hopkins University Frequency referencing for chemical exchange saturation transfer (CEST) MRI
EP2370447B1 (en) 2008-12-02 2016-07-27 The University of Melbourne Nitrogen-containing macrocyclic conjugates as radiopharmaceuticals
WO2011071778A1 (en) 2009-12-07 2011-06-16 Mayo Foundation For Medical Education And Research Device for the delineation of cardiovascular or other anatomical structures
EP2752677B1 (en) 2010-01-06 2015-07-22 Shiseido Company, Ltd. Sample tube for NMR measurements
WO2012006038A2 (en) * 2010-06-28 2012-01-12 The Board Of Regents, The University Of Texas System Agents and compounds for imaging and other applications, and methods of use and synthesis thereof
EP2457594A1 (en) 2010-11-05 2012-05-30 Bracco Imaging S.p.A Cest systems exhibiting a concentration independent responsiveness
US9302019B2 (en) 2011-05-11 2016-04-05 The Research Foundation For The State University Of New York Fe(II) sequestering agents and uses thereof
WO2013082656A1 (en) 2011-12-06 2013-06-13 The University Of Melbourne Cage amine ligands for metallo-radiopharmaceuticals
US10551455B2 (en) 2015-05-04 2020-02-04 Duke University Magnetic resonance imaging (MRI) systems and methods using adiabatic tip-down and matched adiabatic flip-back pulses
EP3394627B1 (en) * 2015-12-23 2020-06-03 Bracco Imaging S.p.A Ratiometric pulsed cest imaging

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190744A (en) * 1990-03-09 1993-03-02 Salutar Methods for detecting blood perfusion variations by magnetic resonance imaging
DE69527194T2 (de) 1994-03-28 2003-02-06 Daiichi Pharmaceutical Co., Ltd. Liposomen enthaltend ein röntgen- oder ultraschallkontrastmittel
JP3759765B2 (ja) * 1994-03-28 2006-03-29 第一製薬株式会社 リポソーム
US6963769B1 (en) * 1999-04-21 2005-11-08 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method for enhancing contrast produced by MRI
WO2002043775A2 (en) 2000-11-20 2002-06-06 GODFREY, Cullen, M. Paramagnetic metal ion-based macrocyclic contrast agents
EP1302465A1 (en) 2001-10-11 2003-04-16 BRACCO IMAGING S.p.A. Enhanced substrate imaging by reversible binding to a paramagnetic complex
EP1331012A1 (en) * 2002-01-29 2003-07-30 BRACCO IMAGING S.p.A. Responsive paramagnetic MRI contrast agents

Also Published As

Publication number Publication date
JP2010088901A (ja) 2010-04-22
DK1469890T3 (da) 2011-11-14
US20050191243A1 (en) 2005-09-01
JP4850391B2 (ja) 2012-01-11
WO2003063912A1 (en) 2003-08-07
JP2005515842A (ja) 2005-06-02
JP2011235125A (ja) 2011-11-24
EP2298362A1 (en) 2011-03-23
EP1469890A1 (en) 2004-10-27
ATE519505T1 (de) 2011-08-15
US8318134B2 (en) 2012-11-27
JP4796643B2 (ja) 2011-10-19
EP1469890B1 (en) 2011-08-10
US20090234221A1 (en) 2009-09-17
US7524483B2 (en) 2009-04-28
EP1331012A1 (en) 2003-07-30
EP2298362B1 (en) 2013-03-13

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