DK230079A - Fremgangsmaade til fremstilling af bromhexin - Google Patents

Fremgangsmaade til fremstilling af bromhexin

Info

Publication number: DK230079A
Authority: DK; Denmark
Prior art keywords: bromhexin; preparing; methylcyclohexylamine; benzoxazin; dihydro
Prior art date: 1979-06-01

Application number

DK230079A

Other languages

English (en)

Other versions

DK145714B (da

DK145714C (da

Inventor

B Alhede

N Gelting

H Preikschat

Original Assignee

Gea Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-06-01

Filing date

1979-06-01

Publication date

1980-12-02

1979-06-01 Application filed by Gea Ag filed Critical Gea Ag

1979-06-01 Priority to DK230079A priority Critical patent/DK145714C/da

1980-05-23 Priority to IE1081/80A priority patent/IE49820B1/en

1980-05-23 Priority to SE8003874A priority patent/SE433847B/sv

1980-05-26 Priority to ZA00803131A priority patent/ZA803131B/xx

1980-05-27 Priority to FI801705A priority patent/FI68808C/fi

1980-05-29 Priority to GB8017619A priority patent/GB2053900B/en

1980-05-30 Priority to DE19803020604 priority patent/DE3020604A1/de

1980-05-30 Priority to CH423780A priority patent/CH642617A5/de

1980-05-30 Priority to NO801617A priority patent/NO148372C/no

1980-05-30 Priority to AT0288580A priority patent/AT371800B/de

1980-05-30 Priority to ES492005A priority patent/ES8104185A1/es

1980-05-30 Priority to BE0/200843A priority patent/BE883577A/fr

1980-05-30 Priority to NL8003153A priority patent/NL8003153A/nl

1980-12-02 Publication of DK230079A publication Critical patent/DK230079A/da

1982-11-26 Priority to NO823977A priority patent/NO148415C/no

1983-02-07 Publication of DK145714B publication Critical patent/DK145714B/da

1983-07-11 Priority to KE3302A priority patent/KE3302A/xx

1983-07-25 Application granted granted Critical

1983-07-25 Publication of DK145714C publication Critical patent/DK145714C/da

Links

SYZIUAAQNFJPJY-UHFFFAOYSA-N 1,4-dihydro-3,1-benzoxazin-2-one Chemical compound C1=CC=C2COC(=O)NC2=C1 SYZIUAAQNFJPJY-UHFFFAOYSA-N 0.000 abstract 1
IOKIELYKONFEPP-UHFFFAOYSA-N 1-bromohex-1-yne Chemical compound CCCCC#CBr IOKIELYKONFEPP-UHFFFAOYSA-N 0.000 abstract 1
RQJFMNQNCRVVFJ-UHFFFAOYSA-N 6,8-dibromo-1,4-dihydro-3,1-benzoxazin-2-one Chemical compound N1C(=O)OCC2=CC(Br)=CC(Br)=C21 RQJFMNQNCRVVFJ-UHFFFAOYSA-N 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
XTUVJUMINZSXGF-UHFFFAOYSA-N N-methylcyclohexylamine Chemical compound CNC1CCCCC1 XTUVJUMINZSXGF-UHFFFAOYSA-N 0.000 abstract 1
PAMIQIKDUOTOBW-UHFFFAOYSA-N N-methylcyclohexylamine Natural products CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 abstract 1
238000009835 boiling Methods 0.000 abstract 1
OJGDCBLYJGHCIH-UHFFFAOYSA-N bromhexine Chemical compound C1CCCCC1N(C)CC1=CC(Br)=CC(Br)=C1N OJGDCBLYJGHCIH-UHFFFAOYSA-N 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
238000010438 heat treatment Methods 0.000 abstract 1
GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK230079A 1979-06-01 1979-06-01 Fremgangsmaade til fremstilling af n-(2-amino-3,5-dibrombenzyl)-n-metylcyklohexylamin DK145714C (da)

Priority Applications (15)

Application Number	Priority Date	Filing Date	Title
DK230079A DK145714C (da)	1979-06-01	1979-06-01	Fremgangsmaade til fremstilling af n-(2-amino-3,5-dibrombenzyl)-n-metylcyklohexylamin
IE1081/80A IE49820B1 (en)	1979-06-01	1980-05-23	3,1-benzoxazine-2-one derivative and process for the production of bromhexin
SE8003874A SE433847B (sv)	1979-06-01	1980-05-23	Forfarande for framstellning av bromhexin
ZA00803131A ZA803131B (en)	1979-06-01	1980-05-26	Process for the production of bromhexin
FI801705A FI68808C (fi)	1979-06-01	1980-05-27	Foerfarande foer framstaellning av bromhexin och en ny dibromfoerening foer anvaendning som mellanprodukt vid foerfarandet
GB8017619A GB2053900B (en)	1979-06-01	1980-05-29	6,8-dibromo-1,4-dihydro-2h-3,1-benzoxazine-2-one and the production of bromhexin
CH423780A CH642617A5 (de)	1979-06-01	1980-05-30	Verfahren zur herstellung von bromhexin.
NO801617A NO148372C (no)	1979-06-01	1980-05-30	Fremgangsmaate til fremstilling av bromheksin
DE19803020604 DE3020604A1 (de)	1979-06-01	1980-05-30	Verfahren zur herstellung von bromhexin
AT0288580A AT371800B (de)	1979-06-01	1980-05-30	Verfahren zur herstellung von bromhexin
ES492005A ES8104185A1 (es)	1979-06-01	1980-05-30	Procedimiento mejorado para la preparacion de n-(2-amino-3,5-dibromobencil)-n-metilciclohexilamina
BE0/200843A BE883577A (fr)	1979-06-01	1980-05-30	Procede de preparation de bromohexine, produit ainsi obtenu et intermediaire de sa preparation
NL8003153A NL8003153A (nl)	1979-06-01	1980-05-30	Werkwijze voor het bereiden van n-(2-amino-3,5-dibroombenzyl)-n-methylcyclohexylamine ("bromhexin").
NO823977A NO148415C (no)	1979-06-01	1982-11-26	Mellomprodukt for anvendelse ved fremstilling av n-(2-amino-3,5-dibrombenzyl)-n-metylcykloheksylamin
KE3302A KE3302A (en)	1979-06-01	1983-07-11	3,1-benzoxazine-2-one derivative and process for the production of bromhexin

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK230079		1979-06-01
DK230079A DK145714C (da)	1979-06-01	1979-06-01	Fremgangsmaade til fremstilling af n-(2-amino-3,5-dibrombenzyl)-n-metylcyklohexylamin

Publications (3)

Publication Number	Publication Date
DK230079A true DK230079A (da)	1980-12-02
DK145714B DK145714B (da)	1983-02-07
DK145714C DK145714C (da)	1983-07-25

Family

ID=8111443

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK230079A DK145714C (da)	1979-06-01	1979-06-01	Fremgangsmaade til fremstilling af n-(2-amino-3,5-dibrombenzyl)-n-metylcyklohexylamin

Country Status (3)

Country	Link
BE (1)	BE883577A (da)
DK (1)	DK145714C (da)
ZA (1)	ZA803131B (da)

1979
- 1979-06-01 DK DK230079A patent/DK145714C/da not_active IP Right Cessation
1980
- 1980-05-26 ZA ZA00803131A patent/ZA803131B/xx unknown
- 1980-05-30 BE BE0/200843A patent/BE883577A/fr not_active IP Right Cessation

Also Published As

Publication number	Publication date
BE883577A (fr)	1980-09-15
DK145714B (da)	1983-02-07
DK145714C (da)	1983-07-25
ZA803131B (en)	1981-05-27

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Legal Events

Date	Code	Title	Description
1991-02-25	PBP	Patent lapsed