SE8003874L - Forfarande for framstellning av bromhexin och medel for anvendning av forfarandet - Google Patents

Forfarande for framstellning av bromhexin och medel for anvendning av forfarandet

Info

Publication number: SE8003874L
Authority: SE; Sweden
Prior art keywords: procedure; agents; benzoxazin; cyclohexylamine; dihydro
Prior art date: 1979-06-01

Application number

SE8003874A

Other languages

English (en)

Other versions

SE433847B (sv

Inventor

B Alhede

N Gelting

H Preikschat

Original Assignee

Gea As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-06-01

Filing date

1980-05-23

Publication date

1980-12-02

1979-06-01 Priority claimed from DK230079A external-priority patent/DK145714C/da

1979-06-01 Priority claimed from DK230179A external-priority patent/DK145718C/da

1980-05-23 Application filed by Gea As filed Critical Gea As

1980-12-02 Publication of SE8003874L publication Critical patent/SE8003874L/sv

1984-06-18 Publication of SE433847B publication Critical patent/SE433847B/sv

Links

OJGDCBLYJGHCIH-UHFFFAOYSA-N bromhexine Chemical compound C1CCCCC1N(C)CC1=CC(Br)=CC(Br)=C1N OJGDCBLYJGHCIH-UHFFFAOYSA-N 0.000 title abstract 2
229960003870 bromhexine Drugs 0.000 title 1
SYZIUAAQNFJPJY-UHFFFAOYSA-N 1,4-dihydro-3,1-benzoxazin-2-one Chemical compound C1=CC=C2COC(=O)NC2=C1 SYZIUAAQNFJPJY-UHFFFAOYSA-N 0.000 abstract 1
RQJFMNQNCRVVFJ-UHFFFAOYSA-N 6,8-dibromo-1,4-dihydro-3,1-benzoxazin-2-one Chemical compound N1C(=O)OCC2=CC(Br)=CC(Br)=C21 RQJFMNQNCRVVFJ-UHFFFAOYSA-N 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
XTUVJUMINZSXGF-UHFFFAOYSA-N N-methylcyclohexylamine Chemical compound CNC1CCCCC1 XTUVJUMINZSXGF-UHFFFAOYSA-N 0.000 abstract 1
PAMIQIKDUOTOBW-UHFFFAOYSA-N N-methylcyclohexylamine Natural products CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 abstract 1
ATHHXGZTWNVVOU-UHFFFAOYSA-N N-methylformamide Chemical compound CNC=O ATHHXGZTWNVVOU-UHFFFAOYSA-N 0.000 abstract 1
238000009835 boiling Methods 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
238000010438 heat treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SE8003874A 1979-06-01 1980-05-23 Forfarande for framstellning av bromhexin SE433847B (sv)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK230079A DK145714C (da)	1979-06-01	1979-06-01	Fremgangsmaade til fremstilling af n-(2-amino-3,5-dibrombenzyl)-n-metylcyklohexylamin
DK230179A DK145718C (da)	1979-06-01	1979-06-01	Dibromforbindelse til anvendelse som mellemprodukt ved fremstilling af n-(2-amino-3,5-dibrombenzyl)-n-metylcyclohexylamin

Publications (2)

Publication Number	Publication Date
SE8003874L true SE8003874L (sv)	1980-12-02
SE433847B SE433847B (sv)	1984-06-18

Family

ID=26066477

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8003874A SE433847B (sv)	1979-06-01	1980-05-23	Forfarande for framstellning av bromhexin

Country Status (11)

Country	Link
AT (1)	AT371800B (sv)
CH (1)	CH642617A5 (sv)
DE (1)	DE3020604A1 (sv)
ES (1)	ES492005A0 (sv)
FI (1)	FI68808C (sv)
GB (1)	GB2053900B (sv)
IE (1)	IE49820B1 (sv)
KE (1)	KE3302A (sv)
NL (1)	NL8003153A (sv)
NO (2)	NO148372C (sv)
SE (1)	SE433847B (sv)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2881955B1 (fr)	2005-02-11	2007-05-11	Oreal	Nanoemulsion cosmetique contenant un compose d'uree hydroxyle
CN102775316B (zh) *	2012-08-17	2013-06-12	夏智红	一种盐酸溴己新化合物及其药物组合物
CN102924295B (zh) *	2012-10-09	2014-10-29	石家庄东方药业有限公司	一种盐酸溴己新晶体及其制备方法和用途
CN103145564B (zh) *	2013-03-15	2014-06-18	湖北美林药业有限公司	盐酸溴己新化合物及其药物组合物

1980
- 1980-05-23 IE IE1081/80A patent/IE49820B1/en unknown
- 1980-05-23 SE SE8003874A patent/SE433847B/sv not_active IP Right Cessation
- 1980-05-27 FI FI801705A patent/FI68808C/fi not_active IP Right Cessation
- 1980-05-29 GB GB8017619A patent/GB2053900B/en not_active Expired
- 1980-05-30 NL NL8003153A patent/NL8003153A/nl not_active Application Discontinuation
- 1980-05-30 CH CH423780A patent/CH642617A5/de not_active IP Right Cessation
- 1980-05-30 DE DE19803020604 patent/DE3020604A1/de not_active Withdrawn
- 1980-05-30 NO NO801617A patent/NO148372C/no unknown
- 1980-05-30 ES ES492005A patent/ES492005A0/es active Granted
- 1980-05-30 AT AT0288580A patent/AT371800B/de not_active IP Right Cessation
1982
- 1982-11-26 NO NO823977A patent/NO148415C/no unknown
1983
- 1983-07-11 KE KE3302A patent/KE3302A/xx unknown

Also Published As

Publication number	Publication date
ES8104185A1 (es)	1981-04-01
CH642617A5 (de)	1984-04-30
NL8003153A (nl)	1980-12-03
NO801617L (no)	1980-12-02
IE49820B1 (en)	1985-12-25
GB2053900B (en)	1983-04-20
NO148372C (no)	1983-09-28
AT371800B (de)	1983-07-25
IE801081L (en)	1980-12-01
FI801705A7 (fi)	1980-12-02
NO148415C (no)	1983-10-12
NO823977L (no)	1980-12-02
ATA288580A (de)	1982-12-15
SE433847B (sv)	1984-06-18
NO148372B (no)	1983-06-20
ES492005A0 (es)	1981-04-01
NO148415B (no)	1983-06-27
KE3302A (en)	1983-08-19
FI68808C (fi)	1985-11-11
DE3020604A1 (de)	1980-12-11
GB2053900A (en)	1981-02-11
FI68808B (fi)	1985-07-31

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Legal Events

Date

Code

Title

Description

1995-01-31

NUG

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