DK2379520T3 - Griseofulvin-analoger til behandling af cancer ved inhibering af centrosomal clusterdannelse - Google Patents

Griseofulvin-analoger til behandling af cancer ved inhibering af centrosomal clusterdannelse

Info

Publication number
DK2379520T3
DK2379520T3 DK09795784.9T DK09795784T DK2379520T3 DK 2379520 T3 DK2379520 T3 DK 2379520T3 DK 09795784 T DK09795784 T DK 09795784T DK 2379520 T3 DK2379520 T3 DK 2379520T3
Authority
DK
Denmark
Prior art keywords
griseofulvine
analogs
inhibiting
cancer treatment
cluster formation
Prior art date
Application number
DK09795784.9T
Other languages
English (en)
Inventor
Blanka Leber
Mads Clausen
Alwin Kraemer
Thomas Larsen
Mads Roennest
Kasper Worm
Original Assignee
Univ Denmark Tech Dtu
Dkfz Krebsforschungszentrum
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Denmark Tech Dtu, Dkfz Krebsforschungszentrum filed Critical Univ Denmark Tech Dtu
Application granted granted Critical
Publication of DK2379520T3 publication Critical patent/DK2379520T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK09795784.9T 2008-12-22 2009-12-22 Griseofulvin-analoger til behandling af cancer ved inhibering af centrosomal clusterdannelse DK2379520T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08172542A EP2204367A1 (en) 2008-12-22 2008-12-22 Griseofulvin analogues for the treatment of cancer by inhibition of centrosomal clustering
PCT/EP2009/067761 WO2010072770A2 (en) 2008-12-22 2009-12-22 Griseofulvin analogues for the treatment of cancer by inhibition of centrosomal clustering

Publications (1)

Publication Number Publication Date
DK2379520T3 true DK2379520T3 (da) 2014-11-03

Family

ID=40668354

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09795784.9T DK2379520T3 (da) 2008-12-22 2009-12-22 Griseofulvin-analoger til behandling af cancer ved inhibering af centrosomal clusterdannelse

Country Status (5)

Country Link
US (1) US9108941B2 (da)
EP (2) EP2204367A1 (da)
DK (1) DK2379520T3 (da)
ES (1) ES2522970T3 (da)
WO (1) WO2010072770A2 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014020101A1 (fr) * 2012-08-01 2014-02-06 Pierre Fabre Medicament Derives de griseofulvine
CN104860909B (zh) * 2015-04-09 2017-03-08 西北农林科技大学 灰黄霉素衍生物、灰黄霉素及其衍生物的抗菌活性应用
CA3018316C (en) 2016-03-30 2021-02-16 Daiichi Sankyo Company, Limited Griseofulvin compound
TWI811243B (zh) 2017-09-29 2023-08-11 日商第一三共股份有限公司 灰黃黴素化合物及醫藥用途
CN108484552B (zh) * 2018-06-15 2020-03-10 河南大学 一种多取代3-苯并呋喃酮螺环己烯衍生物及其制备方法
CN108823110B (zh) * 2018-07-26 2021-07-16 福州工微生物科技有限公司 一株产灰黄霉素的菌株及其应用
CN112972478B (zh) * 2021-02-07 2021-11-16 南通大学 灰黄霉素施密特重排衍生物在制备抗肿瘤药物中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3084102A (en) * 1959-10-14 1963-04-02 Ici Ltd Fungicidal compositions
GB981521A (en) * 1960-05-04 1965-01-27 Glaxo Group Ltd New analogues of griseofulvin and their preparation
JPH03255081A (ja) * 1990-03-01 1991-11-13 Mect Corp dl―グリセオフルビン、dl―グリセオフルビン誘導体およびそれらの中間体の製造方法
KR19990036137A (ko) 1995-08-03 1999-05-25 데이비드 엠 모이어 암 성장을 억제하기 위한 그리세오풀빈의 용도
US20050049207A1 (en) * 2003-09-03 2005-03-03 Kaufmann Doug A. Method of treating and preventing cancer
EP2008652A1 (en) * 2007-06-28 2008-12-31 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Griseofulvin analogues for the treatment of cancer by inhibition of centrosomal clustering

Also Published As

Publication number Publication date
WO2010072770A2 (en) 2010-07-01
EP2204367A1 (en) 2010-07-07
US9108941B2 (en) 2015-08-18
EP2379520B1 (en) 2014-10-08
ES2522970T3 (es) 2014-11-19
US20120035200A1 (en) 2012-02-09
EP2379520A2 (en) 2011-10-26
WO2010072770A3 (en) 2010-12-23

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