DK2382215T3 - Derivater af 2-pyridin-2-yl-pyrazol-3(2h)-on, fremstilling og terapeutisk anvendelse heraf - Google Patents

Derivater af 2-pyridin-2-yl-pyrazol-3(2h)-on, fremstilling og terapeutisk anvendelse heraf

Info

Publication number: DK2382215T3
Authority: DK; Denmark
Prior art keywords: pyrazol; pyridin; derivatives; preparation; therapeutic application
Prior art date: 2008-12-29

Application number

DK09805790.4T

Other languages

English (en)

Inventor

Jean-Michel Altenburger

Valérie FOSSEY

Stéphane Illiano

Géraldine Manette

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-12-29

Filing date

2009-12-24

Publication date

2014-10-27

2008-12-29 Priority claimed from FR0807475A external-priority patent/FR2940652B1/fr

2009-08-28 Priority claimed from FR0904091A external-priority patent/FR2949468B1/fr

2009-12-24 Application filed by Sanofi Sa filed Critical Sanofi Sa

2014-10-27 Application granted granted Critical

2014-10-27 Publication of DK2382215T3 publication Critical patent/DK2382215T3/da

Links

UHZJGBKNLJRCMK-UHFFFAOYSA-N 2-pyridin-2-yl-1h-pyrazol-3-one Chemical class O=C1C=CNN1C1=CC=CC=N1 UHZJGBKNLJRCMK-UHFFFAOYSA-N 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Ophthalmology & Optometry (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Hospice & Palliative Care (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

DK09805790.4T 2008-12-29 2009-12-24 Derivater af 2-pyridin-2-yl-pyrazol-3(2h)-on, fremstilling og terapeutisk anvendelse heraf DK2382215T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR0807475A FR2940652B1 (fr)	2008-12-29	2008-12-29	Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one,leur preparation et leur application en therapeutique
FR0904091A FR2949468B1 (fr)	2009-08-28	2009-08-28	Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur preparation et leur application en therapeutique
PCT/FR2009/052692 WO2010076525A1 (fr)	2008-12-29	2009-12-24	Dérivés de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur préparation et leur application en thérapeutique

Publications (1)

Publication Number	Publication Date
DK2382215T3 true DK2382215T3 (da)	2014-10-27

Family

ID=41728182

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK09805790.4T DK2382215T3 (da)	2008-12-29	2009-12-24	Derivater af 2-pyridin-2-yl-pyrazol-3(2h)-on, fremstilling og terapeutisk anvendelse heraf

Country Status (33)

Country	Link
US (2)	US8697731B2 (da)
EP (1)	EP2382215B1 (da)
JP (1)	JP5865704B2 (da)
KR (1)	KR101630475B1 (da)
CN (1)	CN102333776B (da)
AR (1)	AR074916A1 (da)
AU (1)	AU2009334570B2 (da)
BR (1)	BRPI0923875A2 (da)
CA (1)	CA2748413A1 (da)
CO (1)	CO6400145A2 (da)
CR (1)	CR20110360A (da)
CY (1)	CY1115635T1 (da)
DK (1)	DK2382215T3 (da)
EA (1)	EA019774B1 (da)
EC (1)	ECSP11011164A (da)
ES (1)	ES2511917T3 (da)
IL (1)	IL213790A (da)
MA (1)	MA32978B1 (da)
MX (1)	MX2011007061A (da)
MY (1)	MY155244A (da)
NI (1)	NI201100132A (da)
NZ (1)	NZ593797A (da)
PA (1)	PA8856101A1 (da)
PE (1)	PE20120338A1 (da)
PL (1)	PL2382215T3 (da)
PT (1)	PT2382215E (da)
SG (1)	SG172422A1 (da)
SI (1)	SI2382215T1 (da)
SM (1)	SMT201400157B (da)
TN (1)	TN2011000308A1 (da)
TW (1)	TWI441828B (da)
WO (1)	WO2010076525A1 (da)
ZA (1)	ZA201104785B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX2011007061A (es)	2008-12-29	2011-12-16	Sanofi Sa	Derivados de 2 piridin- 2-il-pirazol-3 (2h)-ona, su preparacion y aplicacion terapeutica.
EP2361911A1 (en) *	2010-02-18	2011-08-31	GenKyoTex SA	Pyrazolo piperidine derivatives as NADPH oxidase inhibitors
EP2361912A1 (en) *	2010-02-18	2011-08-31	GenKyoTex SA	Pyrazolo piperidine derivatives as NADPH oxidase inhibitors
CA2869130A1 (en) *	2012-03-30	2013-10-03	Daiichi Sankyo Company, Limited	4-alkanoylamino-3-pyrazolone derivatives
CN102731384B (zh) *	2012-07-10	2016-04-06	南开大学	一种6-甲基烟酸叔丁酯的合成方法
EP3336084B1 (en) *	2013-03-29	2021-03-17	Takeda Pharmaceutical Company Limited	6-(5-hydroxy-1h-pyrazol-1-yl)nicotinamide derivatives and their use as phd inhibitors
CN105061316B (zh) *	2015-07-17	2017-12-22	苏州大学	稠环类化合物、制备方法和用途
CN113072562B (zh) *	2021-04-06	2022-01-14	山东大学	一种GSK-3β抑制剂及其制备方法与应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3917469A1 (de) *	1989-05-30	1990-12-06	Bayer Ag	Heterocyclylpyridine
DE4023488A1 (de)	1990-07-24	1992-01-30	Bayer Ag	1-(pyri(mi)dyl-(2)) -5-hydroxy-pyrazol-mikrobizide
US5750088A (en) *	1993-03-30	1998-05-12	The Dupont Merck Pharmaceutical Company	Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals
GB9704762D0 (en)	1997-03-07	1997-04-23	Zeneca Ltd	Chemical process
CN1842332A (zh) *	2003-06-30	2006-10-04	Hif生物公司	化合物、组合物及方法
JP4499721B2 (ja) *	2003-06-30	2010-07-07	ヒフバイオ，インク．	化合物、組成物および方法
DE102005019712A1 (de)	2005-04-28	2006-11-09	Bayer Healthcare Ag	Dipyridyl-dihydropyrazolone und ihre Verwendung
AR059733A1 (es) *	2006-03-07	2008-04-23	Smithkline Beecham Corp	Compuesto derivado de glicina n- sustituida con heteroaromaticos bicicicos, composicion farmaceutica que lo comprende, uso para preparar un medicamento para tratar la anemia y proceso para su preparacion
KR20090066297A (ko) *	2006-10-16	2009-06-23	화이자 프로덕츠 인크.	치료용 피라졸릴 티에노피리딘
DE102006050516A1 (de)	2006-10-26	2008-04-30	Bayer Healthcare Ag	Substituierte Dihydropyrazolone und ihre Verwendung
EP2148877A2 (en) *	2007-05-18	2010-02-03	Bayer Schering Pharma AG	Inhibitors of hypoxia inducible factor (hif) useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
MX2011007061A (es)	2008-12-29	2011-12-16	Sanofi Sa	Derivados de 2 piridin- 2-il-pirazol-3 (2h)-ona, su preparacion y aplicacion terapeutica.
HRP20140680T1 (hr)	2008-12-29	2014-10-10	Sanofi	Derivati 2-piridin-2-ilpirazol-3(2h)-ona, njihovo dobivanje i njihova upotreba u terapiji kao aktivatora hif

2009
- 2009-12-24 MX MX2011007061A patent/MX2011007061A/es active IP Right Grant
- 2009-12-24 SI SI200931025T patent/SI2382215T1/sl unknown
- 2009-12-24 MY MYPI2011003011A patent/MY155244A/en unknown
- 2009-12-24 AU AU2009334570A patent/AU2009334570B2/en not_active Ceased
- 2009-12-24 DK DK09805790.4T patent/DK2382215T3/da active
- 2009-12-24 PL PL09805790T patent/PL2382215T3/pl unknown
- 2009-12-24 BR BRPI0923875-1A patent/BRPI0923875A2/pt not_active IP Right Cessation
- 2009-12-24 ES ES09805790.4T patent/ES2511917T3/es active Active
- 2009-12-24 SG SG2011047529A patent/SG172422A1/en unknown
- 2009-12-24 MA MA34029A patent/MA32978B1/fr unknown
- 2009-12-24 PE PE2011001291A patent/PE20120338A1/es not_active Application Discontinuation
- 2009-12-24 EA EA201170900A patent/EA019774B1/ru not_active IP Right Cessation
- 2009-12-24 CA CA2748413A patent/CA2748413A1/fr not_active Abandoned
- 2009-12-24 JP JP2011542887A patent/JP5865704B2/ja not_active Expired - Fee Related
- 2009-12-24 EP EP09805790.4A patent/EP2382215B1/fr active Active
- 2009-12-24 WO PCT/FR2009/052692 patent/WO2010076525A1/fr not_active Ceased
- 2009-12-24 CN CN200980157589.3A patent/CN102333776B/zh not_active Expired - Fee Related
- 2009-12-24 PT PT98057904T patent/PT2382215E/pt unknown
- 2009-12-24 KR KR1020117017677A patent/KR101630475B1/ko not_active Expired - Fee Related
- 2009-12-24 NZ NZ593797A patent/NZ593797A/xx not_active IP Right Cessation
- 2009-12-28 AR ARP090105127A patent/AR074916A1/es unknown
- 2009-12-28 PA PA20098856101A patent/PA8856101A1/es unknown
- 2009-12-28 TW TW098145333A patent/TWI441828B/zh not_active IP Right Cessation
2011
- 2011-06-17 TN TN2011000308A patent/TN2011000308A1/fr unknown
- 2011-06-23 CR CR20110360A patent/CR20110360A/es unknown
- 2011-06-27 IL IL213790A patent/IL213790A/en not_active IP Right Cessation
- 2011-06-27 EC EC2011011164A patent/ECSP11011164A/es unknown
- 2011-06-28 ZA ZA2011/04785A patent/ZA201104785B/en unknown
- 2011-06-28 NI NI201100132A patent/NI201100132A/es unknown
- 2011-06-29 US US13/172,321 patent/US8697731B2/en not_active Expired - Fee Related
- 2011-06-29 CO CO11081313A patent/CO6400145A2/es active IP Right Grant
2014
- 2014-03-07 US US14/200,698 patent/US9359329B2/en not_active Expired - Fee Related
- 2014-10-16 CY CY20141100849T patent/CY1115635T1/el unknown
- 2014-10-29 SM SM201400157T patent/SMT201400157B/xx unknown

Also Published As

Publication number	Publication date
IL213790A (en)	2015-09-24
AR074916A1 (es)	2011-02-23
SG172422A1 (en)	2011-07-28
US20160137627A9 (en)	2016-05-19
MX2011007061A (es)	2011-12-16
WO2010076525A1 (fr)	2010-07-08
EA201170900A1 (ru)	2012-02-28
PT2382215E (pt)	2014-10-16
TN2011000308A1 (fr)	2012-12-17
US20140194470A1 (en)	2014-07-10
US8697731B2 (en)	2014-04-15
EP2382215B1 (fr)	2014-07-16
JP2012513977A (ja)	2012-06-21
CN102333776A (zh)	2012-01-25
TW201028424A (en)	2010-08-01
HK1163679A1 (en)	2012-09-14
AU2009334570A1 (en)	2011-07-21
BRPI0923875A2 (pt)	2015-07-21
US20110301148A1 (en)	2011-12-08
CA2748413A1 (fr)	2010-07-08
MY155244A (en)	2015-09-30
SI2382215T1 (sl)	2020-06-30
KR101630475B1 (ko)	2016-06-14
PE20120338A1 (es)	2012-04-30
PA8856101A1 (es)	2010-07-27
US9359329B2 (en)	2016-06-07
CN102333776B (zh)	2014-05-21
CR20110360A (es)	2011-10-13
KR20110111437A (ko)	2011-10-11
ES2511917T3 (es)	2014-10-23
EA019774B1 (ru)	2014-06-30
TWI441828B (zh)	2014-06-21
JP5865704B2 (ja)	2016-02-17
NZ593797A (en)	2013-01-25
IL213790A0 (en)	2011-07-31
EP2382215A1 (fr)	2011-11-02
SMT201400157B (it)	2015-01-15
ECSP11011164A (es)	2011-07-29
PL2382215T3 (pl)	2015-01-30
ZA201104785B (en)	2012-09-26
CO6400145A2 (es)	2012-03-15
CY1115635T1 (el)	2017-01-04
AU2009334570B2 (en)	2016-06-09
NI201100132A (es)	2011-11-01
MA32978B1 (fr)	2012-01-02

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