DK238585A - Peptider og fremstilling deraf - Google Patents

Peptider og fremstilling deraf Download PDF

Info

Publication number: DK238585A
Authority: DK; Denmark
Prior art keywords: chain; terminal end; human insulin; bridging; insulin
Prior art date: 1984-05-30

Application number

DK238585A

Other languages

English (en)

Other versions

DK157938B (da

DK238585D0 (da

DK157938C (da

Inventor

Jan Markussen

Niels Fiil

Gustav Ammerer

Mogens Trier Hansen

Lars Thim

Kjeld Norris

Hans Ole Voigt

Original Assignee

Novo Industri As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-05-30

Filing date

1985-05-29

Publication date

1985-12-01

1984-05-30 Priority claimed from DK266584A external-priority patent/DK266584D0/da

1985-02-08 Priority claimed from DK58285A external-priority patent/DK58285D0/da

1985-05-29 Application filed by Novo Industri As filed Critical Novo Industri As

1985-05-29 Priority to DK238585A priority Critical patent/DK157938C/da

1985-05-29 Publication of DK238585D0 publication Critical patent/DK238585D0/da

1985-12-01 Publication of DK238585A publication Critical patent/DK238585A/da

1990-03-05 Publication of DK157938B publication Critical patent/DK157938B/da

1990-08-27 Application granted granted Critical

1990-08-27 Publication of DK157938C publication Critical patent/DK157938C/da

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
102000004196 processed proteins & peptides Human genes 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 3
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 3
239000002243 precursor Substances 0.000 abstract 3
102000004877 Insulin Human genes 0.000 abstract 2
108090001061 Insulin Proteins 0.000 abstract 2
229940125396 insulin Drugs 0.000 abstract 2
108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
210000004899 c-terminal region Anatomy 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
238000012258 culturing Methods 0.000 abstract 1
238000000338 in vitro Methods 0.000 abstract 1

Landscapes

Preparation Of Compounds By Using Micro-Organisms (AREA)

DK238585A 1984-05-30 1985-05-29 Dna-sekvens for insulinprecursorer, vektorer indeholdende denne sekvens, gaerstammer transformeret med disse vektorer samt en fremgangsmaade til fremstilling af insulinprecursorerne og en fremgangsmaade til fremstilling af humaninsulin DK157938C (da)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DK238585A DK157938C (da)	1984-05-30	1985-05-29	Dna-sekvens for insulinprecursorer, vektorer indeholdende denne sekvens, gaerstammer transformeret med disse vektorer samt en fremgangsmaade til fremstilling af insulinprecursorerne og en fremgangsmaade til fremstilling af humaninsulin

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
DK266584A DK266584D0 (da)	1984-05-30	1984-05-30	Dna-sekvens, der koder for en biosyntetisk insulinprecursor og fremgangsmaade til fremstilling af insulinprecursoren
DK266584		1984-05-30
DK58285A DK58285D0 (da)	1984-05-30	1985-02-08	Peptider samt fremstilling og anvendelse deraf
DK58285		1985-02-08
DK238585		1985-05-29
DK238585A DK157938C (da)	1984-05-30	1985-05-29	Dna-sekvens for insulinprecursorer, vektorer indeholdende denne sekvens, gaerstammer transformeret med disse vektorer samt en fremgangsmaade til fremstilling af insulinprecursorerne og en fremgangsmaade til fremstilling af humaninsulin

Publications (4)

Publication Number	Publication Date
DK238585D0 DK238585D0 (da)	1985-05-29
DK238585A true DK238585A (da)	1985-12-01
DK157938B DK157938B (da)	1990-03-05
DK157938C DK157938C (da)	1990-08-27

Family

ID=27220795

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK238585A DK157938C (da)	1984-05-30	1985-05-29	Dna-sekvens for insulinprecursorer, vektorer indeholdende denne sekvens, gaerstammer transformeret med disse vektorer samt en fremgangsmaade til fremstilling af insulinprecursorerne og en fremgangsmaade til fremstilling af humaninsulin

Country Status (1)

Country	Link
DK (1)	DK157938C (da)

1985
- 1985-05-29 DK DK238585A patent/DK157938C/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK157938B (da)	1990-03-05
DK238585D0 (da)	1985-05-29
DK157938C (da)	1990-08-27

Legal Events

Date	Code	Title	Description
2004-02-02	PBP	Patent lapsed	Country of ref document: DK

Publication	Publication Date	Title
DK323687A (da)	1987-06-25	Insulinprecursorer og fremgangsmaade til fremstilling deraf
IE891976L (en)	1989-12-20	Propeptides
IL95742A (en)	2000-12-06	Recombinant polypeptides and peptides nucleic acids coding for the same and use of these polypeptides and peptides in the diagnosis of tuberculosis
DK238585A (da)	1985-12-01	Peptider og fremstilling deraf
ES2044928T3 (es)	1994-01-16	Enzima alfa-amidante en terminal c y procedimiento para la produccion y el uso del mismo.
AU637589B2 (en)	1993-06-03	Ancrod proteins, their production and use
WO1990000179A3 (fr)	1990-03-08	Nouvelles proteins, adn les codant et leur usage
EP0327360A3 (en)	1990-05-02	Novel polypeptides and dna encoding said polypeptides
DK301090A (da)	1990-12-19	Insulinprecursorer
DE3686036D1 (en)	1992-08-20	New fusion protein contg. small interleukin 2 ballast fragments
GB1210557A (en)	1970-10-28	Synthesis of polypeptides containing cysteine
DK200200302A (da)	2002-02-27	Rekombinante polypeptider omfattende aminosyresekvensen af moden vævsfaktorinhibitor (TFI), polypeptidfragmenter deraf, ekspressionsvektorer der koder for disse, værtsceller transformeret dermed, og fremgangsmåde til fremstilling af et ........