DK301090A - Insulinprecursorer - Google Patents

Insulinprecursorer Download PDF

Info

Publication number: DK301090A
Authority: DK; Denmark
Prior art keywords: amino acid; insulin; acid residues; human insulin; chain
Prior art date: 1988-06-20

Application number

DK301090A

Other languages

English (en)

Other versions

DK164456C (da

DK164456B (da

DK301090D0 (da

Inventor

Ib Jonassen

Ib Groth Clausen

Einar Bech Jensen

Allan Svendsen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-06-20

Filing date

1990-12-19

Publication date

1990-12-19

1988-06-20 Priority claimed from DK336188A external-priority patent/DK336188D0/da

1990-12-19 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1990-12-19 Priority to DK301090A priority Critical patent/DK164456C/da

1990-12-19 Publication of DK301090A publication Critical patent/DK301090A/da

1990-12-19 Publication of DK301090D0 publication Critical patent/DK301090D0/da

1992-06-29 Publication of DK164456B publication Critical patent/DK164456B/da

1992-11-09 Application granted granted Critical

1992-11-09 Publication of DK164456C publication Critical patent/DK164456C/da

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 11
102000004877 Insulin Human genes 0.000 title abstract 5
108090001061 Insulin Proteins 0.000 title abstract 5
229940125396 insulin Drugs 0.000 title abstract 5
239000002243 precursor Substances 0.000 title abstract 5
125000000539 amino acid group Chemical group 0.000 abstract 5
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 3
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 3
108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
239000005864 Sulphur Substances 0.000 abstract 1
150000001413 amino acids Chemical group 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
238000012258 culturing Methods 0.000 abstract 1
239000001963 growth medium Substances 0.000 abstract 1
239000002609 medium Substances 0.000 abstract 1

Landscapes

Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

DK301090A 1988-06-20 1990-12-19 Insulinprecursor, dna-sekvens, som koder derfor, replicerbart ekspressionsmiddel indeholdende en saadan dna-sekvens samt fremgangsmaade til fremstilling af insulinprecursoren DK164456C (da)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DK301090A DK164456C (da)	1988-06-20	1990-12-19	Insulinprecursor, dna-sekvens, som koder derfor, replicerbart ekspressionsmiddel indeholdende en saadan dna-sekvens samt fremgangsmaade til fremstilling af insulinprecursoren

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
DK336188		1988-06-20
DK336188A DK336188D0 (da)	1988-06-20	1988-06-20	Propeptider
DK8900152		1989-06-19
PCT/DK1989/000152 WO1989012647A1 (en)	1988-06-20	1989-06-19	Insulin precursors
DK301090		1990-12-19
DK301090A DK164456C (da)	1988-06-20	1990-12-19	Insulinprecursor, dna-sekvens, som koder derfor, replicerbart ekspressionsmiddel indeholdende en saadan dna-sekvens samt fremgangsmaade til fremstilling af insulinprecursoren

Publications (4)

Publication Number	Publication Date
DK301090A true DK301090A (da)	1990-12-19
DK301090D0 DK301090D0 (da)	1990-12-19
DK164456B DK164456B (da)	1992-06-29
DK164456C DK164456C (da)	1992-11-09

Family

ID=26066848

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK301090A DK164456C (da)	1988-06-20	1990-12-19	Insulinprecursor, dna-sekvens, som koder derfor, replicerbart ekspressionsmiddel indeholdende en saadan dna-sekvens samt fremgangsmaade til fremstilling af insulinprecursoren

Country Status (1)

Country	Link
DK (1)	DK164456C (da)

1990
- 1990-12-19 DK DK301090A patent/DK164456C/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK164456C (da)	1992-11-09
DK164456B (da)	1992-06-29
DK301090D0 (da)	1990-12-19

Legal Events

Date	Code	Title	Description
2003-05-26	PSP	Patent surrendered

Publication	Publication Date	Title
NO177499C (no)	1995-09-27	Insulin-forstadier, DNA-sekvenser, replikerbare ekspresjonsvektorer og vertsceller
NO174351C (no)	1994-04-20	Fremgangsmåte for fremstilling av human insulinforlöper samt DNA-sekvens og vektor til anvendelse av fremgangsmåten
ES2104635T3 (es)	1997-10-16	Nuevo peptido porcino con una actividad fisiologica (cnp-53).
ATE54410T1 (de)	1990-07-15	Oligopeptid-derivate, deren herstellung und deren verwendung als hautfreundliche tenside.
ATE121754T1 (de)	1995-05-15	Vakzine gegen bordetella.
DK301090A (da)	1990-12-19	Insulinprecursorer
EP0252894A3 (fr)	1989-08-09	Polypeptides hybrides comprenant la somatocrinine et l'alpha1-antitrypsine, méthode pour leur production à partir de clones bactériens et leur utilisation pour la production de somatocrinine
ES2007110A6 (es)	1989-06-01	Un metodo para la preparacion de precursores de insulina.
IL93115A0 (en)	1990-11-05	Process for the preparation of an insulin precursor
DK238585A (da)	1985-12-01	Peptider og fremstilling deraf
IL89896A0 (en)	1989-12-15	Protein antibiotic kedarcidin,its production and pharmaceutical compositions containing it
JPS6480300A (en)	1989-03-27	Production of cholecystokinin pancreozymine