DK241682A - Fremgangsmaade til fremstilling af krystallinske vandoploeselige salte af n-(2-pyridyl)-2-methyl-4-hydroxy-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxid - Google Patents

Fremgangsmaade til fremstilling af krystallinske vandoploeselige salte af n-(2-pyridyl)-2-methyl-4-hydroxy-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxid Download PDF

Info

Publication number: DK241682A
Authority: DK; Denmark
Prior art keywords: crystallinic; benzothiazine; carboxamide; pyridyl; hydroxy
Prior art date: 1981-06-01

Application number

DK241682A

Other languages

English (en)

Other versions

DK149024C (da

DK149024B (da

Inventor

J G Lombardino

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-06-01

Filing date

1982-05-28

Publication date

1982-12-02

1982-05-28 Application filed by Pfizer filed Critical Pfizer

1982-12-02 Publication of DK241682A publication Critical patent/DK241682A/da

1985-12-23 Publication of DK149024B publication Critical patent/DK149024B/da

1986-06-30 Application granted granted Critical

1986-06-30 Publication of DK149024C publication Critical patent/DK149024C/da

Links

QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical class OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 title 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK241682A 1981-06-01 1982-05-28 Analogifremgangsmaade til fremstilling af krystallinske vandoploeselige salte af n-(2-pyridyl)-2-methyl-4-hydroxy-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxid DK149024C (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US26898081A	1981-06-01	1981-06-01
US26898081		1981-06-01
US36706782		1982-04-13
US06/367,067 US4434164A (en)	1981-06-01	1982-04-13	Crystalline benzothiazine dioxide salts

Publications (3)

Publication Number	Publication Date
DK241682A true DK241682A (da)	1982-12-02
DK149024B DK149024B (da)	1985-12-23
DK149024C DK149024C (da)	1986-06-30

Family

ID=26953436

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK241682A DK149024C (da)	1981-06-01	1982-05-28	Analogifremgangsmaade til fremstilling af krystallinske vandoploeselige salte af n-(2-pyridyl)-2-methyl-4-hydroxy-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxid

Country Status (27)

Country	Link
US (1)	US4434164A (da)
EP (1)	EP0066459B1 (da)
KR (1)	KR850001883B1 (da)
AU (1)	AU529386B2 (da)
BG (1)	BG37377A3 (da)
CA (1)	CA1209571A (da)
DD (1)	DD211560A5 (da)
DE (1)	DE3260718D1 (da)
DK (1)	DK149024C (da)
EG (1)	EG15811A (da)
ES (1)	ES512723A0 (da)
FI (1)	FI74705C (da)
GB (1)	GB2101589A (da)
GR (1)	GR75476B (da)
HK (1)	HK65386A (da)
HU (1)	HU189586B (da)
IE (1)	IE53160B1 (da)
IL (1)	IL65917A (da)
MX (1)	MX6984E (da)
MY (1)	MY8700126A (da)
NO (1)	NO157979C (da)
NZ (1)	NZ200801A (da)
OA (1)	OA07114A (da)
PH (1)	PH17906A (da)
PT (1)	PT74977B (da)
RO (1)	RO84698B (da)
YU (1)	YU42767B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5913714A (ja) *	1982-07-13	1984-01-24	Taito Pfizer Kk	外用消炎鎮痛剤
RO88420A (ro) *	1983-04-25	1986-01-30	Pfizer Inc,Us	Procedeu pentru prepararea unor saruri bazice de piroxican depuse pe suporturi farmaceutice
DE3431588A1 (de) *	1983-09-12	1985-04-04	Pfizer, Inc., New York, N.Y.	Kristalline benzothiazindioxid-salze und diese enthaltende pharmazeutische zusammensetzungen
DE3346526C2 (de) *	1983-12-22	1986-12-11	A. Nattermann & Cie GmbH, 5000 Köln	Pharmazeutisches Präparat zur therapeutischen Behandlung von rheumatischen Erkrankungen
IT1196307B (it) *	1984-10-22	1988-11-16	Chiesi Farma Spa	Formulazioni farmaceutiche acquose di piroxicam monoidrato
US4582831A (en) *	1984-11-16	1986-04-15	Pfizer Inc.	Anti-inflammatory polymorphic monoethanolamine salt of N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide compound, composition, and method of use therefor
US4559326A (en) *	1985-01-31	1985-12-17	Pfizer Inc.	Antiinflammatory compositions and methods
US4623486A (en)	1985-05-29	1986-11-18	Pfizer Inc.	[4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity
US4610982A (en) *	1985-06-03	1986-09-09	Pfizer Inc.	Anti-inflammatory benzo- and thieno-1,2-thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
KR890001236B1 (ko) *	1985-10-02	1989-04-28	화이자 인코포레이티드	소염제 조성물의 제조방법
HU200926B (en) *	1988-10-28	1990-09-28	Egyt Gyogyszervegyeszeti Gyar	Pharmaceutical composition comprising piroxicam and lactose for use in making tablets or capsules
IT1247492B (it) *	1991-04-18	1994-12-17	Francia Farma	Sali ad attivita' antiinfiammatoria, antisettica, detergente e composizioni farmaceutiche
IT1283252B1 (it) *	1996-03-15	1998-04-16	Pulitzer Italiana	Soluzioni di piroxicam iniettabili per via parenterale
GB0031107D0 (en) *	2000-12-20	2001-01-31	Glaxo Group Ltd	Chemical compounds
FR2818641B1 (fr) *	2000-12-21	2004-03-05	Servier Lab	Nouveaux derives de 1,1-dioxo-2h-1,2-benzothiazine 3-carboxamides, leur procede de preparation et les compositions pharmaceutiques que les contiennent
KR100446829B1 (ko) *	2002-02-20	2004-09-04	한국유나이티드제약 주식회사	가용화된 피록시캄을 함유한 확산형 정제의 조성물 및그의 제조방법
ES2622471T5 (es)	2003-05-22	2020-07-23	United Therapeutics Corp	Compuestos y procedimientos para la administración de análogos de prostaciclina
US20050176809A1 (en) *	2004-02-05	2005-08-11	Rodlen Laboratories, Inc.	Method and compositions for treatment of painful disorders
EP1893190A4 (en) *	2005-04-28	2010-07-28	Theraquest Biosciences Llc	METHODS AND COMPOSITIONS FOR TREATING PAIN
US8747897B2 (en)	2006-04-27	2014-06-10	Supernus Pharmaceuticals, Inc.	Osmotic drug delivery system
CN101903324B (zh)	2007-12-17	2013-07-03	联合治疗公司	一种制备Remodulin中的活性成分曲前列素的改良方法
US9593061B2 (en)	2014-10-20	2017-03-14	United Therapeutics Corporation	Synthesis of intermediates for producing prostacyclin derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3591584A (en)	1968-08-27	1971-07-06	Pfizer	Benzothiazine dioxides
US4074048A (en)	1976-05-10	1978-02-14	Warner-Lambert Company	Process for the preparation of 4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides
US4100347A (en)	1976-06-10	1978-07-11	Pfizer Inc.	3,4-Dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-carboxylic acid-1,1-dioxide
DE2756113A1 (de)	1977-12-16	1979-06-21	Thomae Gmbh Dr K	Neue 4-hydroxy-2h-1,2-benzothiazin- 3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4289879A (en)	1980-09-29	1981-09-15	Pfizer Inc.	Synthetic method and intermediate for piroxicam

1982
- 1982-04-13 US US06/367,067 patent/US4434164A/en not_active Expired - Lifetime
- 1982-05-26 BG BG056786A patent/BG37377A3/xx unknown
- 1982-05-27 NO NO821767A patent/NO157979C/no not_active IP Right Cessation
- 1982-05-27 HU HU821721A patent/HU189586B/hu unknown
- 1982-05-27 DE DE8282302729T patent/DE3260718D1/de not_active Expired
- 1982-05-27 EP EP82302729A patent/EP0066459B1/en not_active Expired
- 1982-05-27 RO RO107688A patent/RO84698B/ro unknown
- 1982-05-28 DK DK241682A patent/DK149024C/da not_active IP Right Cessation
- 1982-05-28 DD DD82240299A patent/DD211560A5/de not_active IP Right Cessation
- 1982-05-28 CA CA000403957A patent/CA1209571A/en not_active Expired
- 1982-05-28 OA OA57703A patent/OA07114A/xx unknown
- 1982-05-28 IE IE1286/82A patent/IE53160B1/en not_active IP Right Cessation
- 1982-05-28 YU YU1137/82A patent/YU42767B/xx unknown
- 1982-05-30 EG EG304/82A patent/EG15811A/xx active
- 1982-05-31 IL IL65917A patent/IL65917A/xx unknown
- 1982-05-31 NZ NZ200801A patent/NZ200801A/en unknown
- 1982-05-31 ES ES512723A patent/ES512723A0/es active Granted
- 1982-05-31 FI FI821918A patent/FI74705C/fi not_active IP Right Cessation
- 1982-05-31 KR KR8202425A patent/KR850001883B1/ko not_active Expired
- 1982-05-31 AU AU84322/82A patent/AU529386B2/en not_active Expired
- 1982-05-31 MX MX8210098U patent/MX6984E/es unknown
- 1982-05-31 GR GR68300A patent/GR75476B/el unknown
- 1982-05-31 PT PT74977A patent/PT74977B/pt unknown
- 1982-06-01 GB GB08215966A patent/GB2101589A/en not_active Withdrawn
- 1982-06-01 PH PH27387A patent/PH17906A/en unknown
1986
- 1986-09-04 HK HK653/86A patent/HK65386A/en not_active IP Right Cessation
1987
- 1987-12-30 MY MY126/87A patent/MY8700126A/xx unknown

Also Published As

Publication number	Publication date
NO821767L (no)	1982-12-02
YU113782A (en)	1984-12-31
KR850001883B1 (ko)	1985-12-28
RO84698B (ro)	1984-09-30
ES8307775A1 (es)	1983-08-01
DK149024C (da)	1986-06-30
GR75476B (da)	1984-07-23
PT74977B (en)	1985-05-17
AU8432282A (en)	1982-12-09
FI821918A0 (fi)	1982-05-31
ES512723A0 (es)	1983-08-01
RO84698A (ro)	1984-07-17
NO157979C (no)	1988-06-22
HK65386A (en)	1986-09-12
IL65917A (en)	1985-08-30
MY8700126A (en)	1987-12-31
PH17906A (en)	1985-01-25
EG15811A (en)	1986-12-30
BG37377A3 (en)	1985-05-15
DD211560A5 (de)	1984-07-18
FI74705C (fi)	1988-03-10
YU42767B (en)	1988-12-31
US4434164A (en)	1984-02-28
AU529386B2 (en)	1983-06-02
CA1209571A (en)	1986-08-12
IE53160B1 (en)	1988-08-03
DE3260718D1 (de)	1984-10-18
OA07114A (fr)	1984-03-31
IL65917A0 (en)	1982-08-31
GB2101589A (en)	1983-01-19
HU189586B (en)	1986-07-28
IE821286L (en)	1982-12-01
DK149024B (da)	1985-12-23
NO157979B (no)	1988-03-14
FI74705B (fi)	1987-11-30
MX6984E (es)	1987-01-19
KR830010108A (ko)	1983-12-26
EP0066459A1 (en)	1982-12-08
NZ200801A (en)	1985-01-31
PT74977A (en)	1982-06-01
EP0066459B1 (en)	1984-09-12

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Legal Events

Date	Code	Title	Description
2002-07-29	PUP	Patent expired