DK2477652T3 - Immuniseringsstrategi til forebyggelse af h1ni-infektion - Google Patents
Immuniseringsstrategi til forebyggelse af h1ni-infektion Download PDFInfo
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- DK2477652T3 DK2477652T3 DK10817780.9T DK10817780T DK2477652T3 DK 2477652 T3 DK2477652 T3 DK 2477652T3 DK 10817780 T DK10817780 T DK 10817780T DK 2477652 T3 DK2477652 T3 DK 2477652T3
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- expression vector
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Claims (11)
1. Kimær, adenoviral ekspressionsvektor til beskyttelse mod pandemisk H1N1-influenza, hvilken vektor omfatter en ekspressionskassette omfattende: (a) en første promoter, der er operativt forbundet med en nukleinsyre, der koder for en toll-like receptor-3- (TLR-3) agonist, hvor TLR-3-agonisten er et dobbeltstrenget RNA (dsRNA); og (b) en anden promoter, der er operativt forbundet med en nukleinsyre, der koder for hæmagglutininpolypeptid fra A/CA/04/2009 H1N1-influenza.
2. Kimær, adenoviral ekspressionsvektor ifølge krav 1, hvor nukleinsyren, der koder for TLR-3-agonisten, omfatter et kort hårnåle-RNA.
3. Kimær, adenoviral ekspressionsvektor ifølge krav 1, hvor nukleinsyren, der koder for TLR-3-agonisten, omfatter en sekvens, der er udvalgt fra gruppen bestående af SEQ ID NO: 1-6.
4. Kimær, adenoviral ekspressionsvektor ifølge et hvilket som helst af de foregående krav, hvor den første promoter og den anden promoter er ens.
5. Kimær, adenoviral ekspressionsvektor ifølge krav 4, hvor den første promoter og den anden promoter begge er en CMV-promoter.
6. Farmaceutisk sammensætning omfattende den kimære, adenovirale ekspressionsvektor ifølge et hvilket som helst af de foregående krav og en farmaceutisk acceptabel bærer, hvor den farmaceutiske sammensætning er formuleret til oral, mukosal eller intranasal administration.
7. Farmaceutisk sammensætning til oral indgivelse, hvilken sammensætning omfatter den kimære, adenovirale ekspressionsvektor ifølge et hvilket som helst af kravene 1-5 og en farmaceutisk acceptabel bærer.
8. Immunogent effektiv mængde af en kimær, adenoviral ekspressionsvektor ifølge et hvilket som helst af kravene 1 -5, eller sammensætning ifølge krav 6 eller 7, til anvendelse i en fremgangsmåde til fremkaldelse af et immunrespons på pandemisk H1N1-influenza hos et pattedyr, hvor immunresponset er rettet mod hæmagglutininpolypeptidet, og hvor administrationsvejen er udvalgt fra gruppen bestående af: oral, intranasal og mukosal.
9. Ekspressionsvektor eller sammensætning til anvendelse i fremgangsmåden ifølge krav 8, hvor administrationsvejen er oral.
10. Ekspressionsvektor eller sammensætning til anvendelse i fremgangsmåden ifølge krav 8 eller 9, hvor immunresponset er et mukosalt immunrespons.
11. Ekspressionsvektor eller sammensætning til anvendelse i fremgangsmåden ifølge et hvilket som helst af kravene 8-10, hvor pattedyret er et menneske.
Applications Claiming Priority (2)
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| US24307009P | 2009-09-16 | 2009-09-16 | |
| PCT/US2010/048967 WO2011034950A1 (en) | 2009-09-16 | 2010-09-15 | Immunization strategy to prevent h1n1 infection |
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| DK2477652T3 true DK2477652T3 (da) | 2015-07-20 |
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| DK10817780.9T DK2477652T3 (da) | 2009-09-16 | 2010-09-15 | Immuniseringsstrategi til forebyggelse af h1ni-infektion |
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| EP (1) | EP2477652B1 (da) |
| JP (1) | JP2013505022A (da) |
| DK (1) | DK2477652T3 (da) |
| ES (1) | ES2538007T3 (da) |
| WO (1) | WO2011034950A1 (da) |
| ZA (1) | ZA201201948B (da) |
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| WO2013064584A1 (en) * | 2011-10-31 | 2013-05-10 | Riboxx Gmbh | Double-stranded RNA for immunostimulation |
| DK3107568T3 (da) | 2014-02-20 | 2024-06-03 | Vaxart Inc | Formuleringer til indgivelse til tyndtarmen |
| EA201792512A1 (ru) | 2015-06-12 | 2018-06-29 | Вэксарт, Инк. | Составы для доставки антигенов респираторного синтициального вируса и норовируса в тонкий кишечник |
| GB201603577D0 (en) * | 2016-03-01 | 2016-04-13 | Oxford Genetics Ltd | Promoter |
| CA3048313A1 (en) * | 2017-01-06 | 2018-07-12 | Stabilitech Biopharma Ltd | Virus |
| CN114761558B (zh) | 2019-07-02 | 2025-08-01 | 株式会社Na疫苗研究所 | 新型核糖核酸和基于其的药物组合物 |
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| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
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| FR2723849B1 (fr) | 1994-08-31 | 1997-04-11 | Biovector Therapeutics Sa | Procede pour augmenter l'immunogenicite, produit obtenu et composition pharmaceutique |
| AUPM873294A0 (en) | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| AU2003240978A1 (en) | 2002-05-31 | 2003-12-19 | Genteric, Inc. | Multi-functional polyamines for delivery of biologically-active polynucleotides |
| AU2003262922A1 (en) | 2002-08-30 | 2004-03-19 | Genteric, Inc. | Retroductal salivary gland genetic vaccination |
| WO2004101616A1 (ja) * | 2003-05-14 | 2004-11-25 | Sumitomo Chemical Company, Limited | 肝臓Ｘ受容体αスプライシング変異体タンパク質、その遺伝子及びそれらの利用 |
| CN103122360A (zh) * | 2006-02-28 | 2013-05-29 | 瓦克萨特公司 | 嵌合腺病毒载体 |
-
2010
- 2010-09-15 JP JP2012529880A patent/JP2013505022A/ja active Pending
- 2010-09-15 DK DK10817780.9T patent/DK2477652T3/da active
- 2010-09-15 US US13/496,482 patent/US20120244185A1/en not_active Abandoned
- 2010-09-15 EP EP10817780.9A patent/EP2477652B1/en active Active
- 2010-09-15 ES ES10817780.9T patent/ES2538007T3/es active Active
- 2010-09-15 WO PCT/US2010/048967 patent/WO2011034950A1/en not_active Ceased
-
2012
- 2012-03-15 ZA ZA2012/01948A patent/ZA201201948B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20120244185A1 (en) | 2012-09-27 |
| WO2011034950A1 (en) | 2011-03-24 |
| EP2477652A4 (en) | 2013-01-02 |
| ZA201201948B (en) | 2013-05-29 |
| EP2477652A1 (en) | 2012-07-25 |
| EP2477652B1 (en) | 2015-04-15 |
| JP2013505022A (ja) | 2013-02-14 |
| ES2538007T3 (es) | 2015-06-16 |
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