DK2488497T3 - Fremgangsmåde til fremstilling af 2-[(3,5-difluor-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinsyre - Google Patents
Fremgangsmåde til fremstilling af 2-[(3,5-difluor-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinsyreInfo
- Publication number
- DK2488497T3 DK2488497T3 DK10765586.2T DK10765586T DK2488497T3 DK 2488497 T3 DK2488497 T3 DK 2488497T3 DK 10765586 T DK10765586 T DK 10765586T DK 2488497 T3 DK2488497 T3 DK 2488497T3
- Authority
- DK
- Denmark
- Prior art keywords
- difluor
- biphenyl
- methoxy
- amino
- preparing
- Prior art date
Links
- -1 3,5-DIFLUOR-3'-METHOXY-1,1'-BIPHENYL-4-YL Chemical class 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/803—Processes of preparation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09382212A EP2314577A1 (en) | 2009-10-16 | 2009-10-16 | Process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid |
| PCT/EP2010/006283 WO2011045059A1 (en) | 2009-10-16 | 2010-10-14 | Process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2488497T3 true DK2488497T3 (da) | 2014-06-10 |
Family
ID=41402565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10765586.2T DK2488497T3 (da) | 2009-10-16 | 2010-10-14 | Fremgangsmåde til fremstilling af 2-[(3,5-difluor-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinsyre |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US8598363B2 (da) |
| EP (2) | EP2314577A1 (da) |
| JP (1) | JP5809630B2 (da) |
| KR (1) | KR101699999B1 (da) |
| CN (2) | CN102574800B (da) |
| AU (1) | AU2010306098B2 (da) |
| BR (1) | BR112012008464B1 (da) |
| CA (1) | CA2776328C (da) |
| CL (1) | CL2012000739A1 (da) |
| CO (1) | CO6430508A2 (da) |
| CR (1) | CR20120185A (da) |
| CY (1) | CY1115161T1 (da) |
| DK (1) | DK2488497T3 (da) |
| EA (1) | EA022805B1 (da) |
| ES (1) | ES2467165T3 (da) |
| HR (1) | HRP20140523T1 (da) |
| IL (1) | IL218446A (da) |
| IN (1) | IN2012DN01938A (da) |
| ME (1) | ME01812B (da) |
| MX (1) | MX2012004033A (da) |
| MY (1) | MY160308A (da) |
| NZ (1) | NZ598429A (da) |
| PE (1) | PE20121173A1 (da) |
| PH (1) | PH12012500548A1 (da) |
| PL (1) | PL2488497T3 (da) |
| PT (1) | PT2488497E (da) |
| RS (1) | RS53319B (da) |
| SI (1) | SI2488497T1 (da) |
| SM (1) | SMT201400064B (da) |
| UA (1) | UA107811C2 (da) |
| WO (1) | WO2011045059A1 (da) |
| ZA (1) | ZA201201563B (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2319596B1 (es) | 2006-12-22 | 2010-02-08 | Laboratorios Almirall S.A. | Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico. |
| UY31272A1 (es) | 2007-08-10 | 2009-01-30 | Almirall Lab | Nuevos derivados de ácido azabifenilaminobenzoico |
| EP2135610A1 (en) | 2008-06-20 | 2009-12-23 | Laboratorios Almirall, S.A. | Combination comprising DHODH inhibitors and methotrexate |
| EP2239256A1 (en) | 2009-03-13 | 2010-10-13 | Almirall, S.A. | Sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid as DHODH inhibitor |
| JP7343373B2 (ja) * | 2019-12-02 | 2023-09-12 | 花王株式会社 | 香料組成物 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3299971B2 (ja) | 1995-06-21 | 2002-07-08 | アスタ メディカ アクチエンゲゼルシャフト | 一体的に形成された調量装置を備えた薬用粉末カートリッジおよび粉末薬剤吸入器 |
| DE19547648A1 (de) | 1995-12-20 | 1997-06-26 | Hoechst Ag | Zubereitung, enthaltend High Density Lipoproteine und Crotonsäureamidderivate |
| DE19610955A1 (de) | 1996-03-20 | 1997-09-25 | Hoechst Ag | Kombinationspräparat, enthaltend 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)- anilid und N-(4-Trifluormethylphenyl)-2-cyan-3- hydroxycrotonsäureamid |
| GB9804343D0 (en) | 1998-02-27 | 1998-04-22 | Univ Cardiff | Chemical compounds |
| AP2002002387A0 (en) | 1999-06-10 | 2002-03-31 | Warner Lambert Co | Method of inhibiting amyloid aggregation and imaging amyloid deposits. |
| DE60226855D1 (de) | 2001-04-05 | 2008-07-10 | Aventis Pharma Inc | Verwendung von (z)-2-cyano-3-hydroxy-but-2-ensäure-(4'-trifluoromethylphenyl)-amid zur behandlung der multiplen sklerose |
| WO2002102374A1 (en) | 2001-06-19 | 2002-12-27 | Merck & Co., Inc. | Amine salt of an integrin receptor antagonist |
| DE10129703A1 (de) | 2001-06-22 | 2003-01-02 | Sofotec Gmbh & Co Kg | Zerstäubungssystem für eine Pulvermischung und Verfahren für Trockenpulverinhalatoren |
| WO2003006424A1 (en) | 2001-07-10 | 2003-01-23 | 4Sc Ag | Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
| DE10202940A1 (de) | 2002-01-24 | 2003-07-31 | Sofotec Gmbh & Co Kg | Patrone für einen Pulverinhalator |
| US7258118B2 (en) | 2002-01-24 | 2007-08-21 | Sofotec Gmbh & Co, Kg | Pharmaceutical powder cartridge, and inhaler equipped with same |
| AU2003215558A1 (en) * | 2002-02-13 | 2003-09-04 | Glaxo Group Limited | Benzenesulfonamide derivatives as antipsychotic agents |
| AU2003225370A1 (en) * | 2002-04-13 | 2003-11-03 | Hanlim Pharmaceutical Co., Ltd. | Amlodipine nicotinate and process for the preparation thereof |
| AR042206A1 (es) * | 2002-11-26 | 2005-06-15 | Novartis Ag | Acidos fenilaceticos y derivados |
| US7071355B2 (en) | 2002-12-23 | 2006-07-04 | 4 Sc Ag | Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
| WO2004056747A1 (en) | 2002-12-23 | 2004-07-08 | 4Sc Ag | Dhodh-inhibitors and method for their identification |
| SE0400234D0 (sv) | 2004-02-06 | 2004-02-06 | Active Biotech Ab | New compounds, methods for their preparation and use thereof |
| MXPA06013435A (es) | 2004-05-21 | 2007-03-23 | Uab Research Foundation | Composiciones y metodos referentes a inhibidores de sintesis de pirimidina. |
| WO2006022442A1 (ja) | 2004-08-24 | 2006-03-02 | Santen Pharmaceutical Co., Ltd. | ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体 |
| WO2006044741A1 (en) | 2004-10-19 | 2006-04-27 | Aventis Pharmaceuticals Inc. | Use of (z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating inflammatory bowel disease |
| ES2265276B1 (es) | 2005-05-20 | 2008-02-01 | Laboratorios Almirall S.A. | Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico. |
| CN1696100B (zh) * | 2005-06-01 | 2010-11-24 | 黑龙江福和华星制药集团股份有限公司 | 痤疮治疗药阿达帕林的新型简捷合成方法 |
| ES2319596B1 (es) * | 2006-12-22 | 2010-02-08 | Laboratorios Almirall S.A. | Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico. |
| DE602008006679D1 (de) | 2007-02-06 | 2011-06-16 | Chelsea Therapeutics Inc | Neue verbindungen, verfahren zu deren herstellung und deren verwendung |
| UY31272A1 (es) | 2007-08-10 | 2009-01-30 | Almirall Lab | Nuevos derivados de ácido azabifenilaminobenzoico |
| EP2135610A1 (en) | 2008-06-20 | 2009-12-23 | Laboratorios Almirall, S.A. | Combination comprising DHODH inhibitors and methotrexate |
| EP2210615A1 (en) | 2009-01-21 | 2010-07-28 | Almirall, S.A. | Combinations comprising methotrexate and DHODH inhibitors |
| EP2228367A1 (en) | 2009-03-13 | 2010-09-15 | Almirall, S.A. | Addition salts of amines containing hydroxyl and/or carboxylic groups with amino nicotinic acid derivatives as DHODH inhibitors |
| EP2239256A1 (en) | 2009-03-13 | 2010-10-13 | Almirall, S.A. | Sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid as DHODH inhibitor |
| EP2230232A1 (en) | 2009-03-13 | 2010-09-22 | Almirall, S.A. | Addition salts of tromethamine with azabiphenylaminobenzoic acid derivatives as DHODH inhibitors |
-
2009
- 2009-10-16 EP EP09382212A patent/EP2314577A1/en not_active Withdrawn
-
2010
- 2010-10-14 KR KR1020127009609A patent/KR101699999B1/ko active Active
- 2010-10-14 HR HRP20140523AT patent/HRP20140523T1/hr unknown
- 2010-10-14 UA UAA201205649A patent/UA107811C2/ru unknown
- 2010-10-14 CA CA2776328A patent/CA2776328C/en active Active
- 2010-10-14 NZ NZ598429A patent/NZ598429A/en unknown
- 2010-10-14 PH PH1/2012/500548A patent/PH12012500548A1/en unknown
- 2010-10-14 CN CN201080046816.8A patent/CN102574800B/zh active Active
- 2010-10-14 PE PE2012000491A patent/PE20121173A1/es active IP Right Grant
- 2010-10-14 PL PL10765586T patent/PL2488497T3/pl unknown
- 2010-10-14 ME MEP-2014-50A patent/ME01812B/me unknown
- 2010-10-14 WO PCT/EP2010/006283 patent/WO2011045059A1/en not_active Ceased
- 2010-10-14 ES ES10765586.2T patent/ES2467165T3/es active Active
- 2010-10-14 MY MYPI2012001685A patent/MY160308A/en unknown
- 2010-10-14 BR BR112012008464-0A patent/BR112012008464B1/pt active IP Right Grant
- 2010-10-14 PT PT107655862T patent/PT2488497E/pt unknown
- 2010-10-14 JP JP2012533527A patent/JP5809630B2/ja active Active
- 2010-10-14 SI SI201030632T patent/SI2488497T1/sl unknown
- 2010-10-14 EP EP10765586.2A patent/EP2488497B1/en active Active
- 2010-10-14 CN CN201410085756.0A patent/CN103936668A/zh active Pending
- 2010-10-14 RS RS20140253A patent/RS53319B/sr unknown
- 2010-10-14 MX MX2012004033A patent/MX2012004033A/es active IP Right Grant
- 2010-10-14 US US13/501,847 patent/US8598363B2/en active Active
- 2010-10-14 DK DK10765586.2T patent/DK2488497T3/da active
- 2010-10-14 AU AU2010306098A patent/AU2010306098B2/en not_active Ceased
- 2010-10-14 EA EA201200594A patent/EA022805B1/ru unknown
-
2012
- 2012-03-01 ZA ZA2012/01563A patent/ZA201201563B/en unknown
- 2012-03-01 IL IL218446A patent/IL218446A/en active IP Right Grant
- 2012-03-05 IN IN1938DEN2012 patent/IN2012DN01938A/en unknown
- 2012-03-23 CL CL2012000739A patent/CL2012000739A1/es unknown
- 2012-04-16 CR CR20120185A patent/CR20120185A/es unknown
- 2012-04-16 CO CO12061780A patent/CO6430508A2/es active IP Right Grant
-
2014
- 2014-06-03 SM SM201400064T patent/SMT201400064B/xx unknown
- 2014-06-06 CY CY20141100405T patent/CY1115161T1/el unknown
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