CR20120185A - Procedimiento para fabricar ácido 2-[(3,5-difluoro-3'-metoxi-1,1'-bifenil-4-il)amino]nicotínico - Google Patents

Procedimiento para fabricar ácido 2-[(3,5-difluoro-3'-metoxi-1,1'-bifenil-4-il)amino]nicotínico

Info

Publication number
CR20120185A
CR20120185A CR20120185A CR20120185A CR20120185A CR 20120185 A CR20120185 A CR 20120185A CR 20120185 A CR20120185 A CR 20120185A CR 20120185 A CR20120185 A CR 20120185A CR 20120185 A CR20120185 A CR 20120185A
Authority
CR
Costa Rica
Prior art keywords
difluoro
metoxi
amino
nicotinic
bifenil
Prior art date
Application number
CR20120185A
Other languages
English (en)
Inventor
Bernardini Maria Carmen Boix
Original Assignee
Almirall Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Sa filed Critical Almirall Sa
Publication of CR20120185A publication Critical patent/CR20120185A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Esta invención se refiere a un procedimiento para fabricar ácido 2-[(3,5-DIFLUORO-3'-METOXI-1,1'-BIFENIL-4-IL)AMINO]NICOTÍNICOque comprende las etapas de:a) proporcionar 3,5-difluoro-3-metoxibifenil-4-aminab) proporcionar y aislar una sal de aminio de la 3,5-difluoro-3 metoxibifenil-4-amina, yc) además hacer reaccionar la sal de aminio de 3,5-difluoro-3- metoxibifenil-4- amina obtenida en b) para obtener ácido 2-[(3,5-DIFLUORO-3'-METOXI-1,1'-BIFENIL-4-IL)AMINO]NICOTÍNICO
CR20120185A 2009-10-16 2012-04-16 Procedimiento para fabricar ácido 2-[(3,5-difluoro-3'-metoxi-1,1'-bifenil-4-il)amino]nicotínico CR20120185A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09382212A EP2314577A1 (en) 2009-10-16 2009-10-16 Process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid

Publications (1)

Publication Number Publication Date
CR20120185A true CR20120185A (es) 2012-06-11

Family

ID=41402565

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20120185A CR20120185A (es) 2009-10-16 2012-04-16 Procedimiento para fabricar ácido 2-[(3,5-difluoro-3'-metoxi-1,1'-bifenil-4-il)amino]nicotínico

Country Status (32)

Country Link
US (1) US8598363B2 (es)
EP (2) EP2314577A1 (es)
JP (1) JP5809630B2 (es)
KR (1) KR101699999B1 (es)
CN (2) CN102574800B (es)
AU (1) AU2010306098B2 (es)
BR (1) BR112012008464B1 (es)
CA (1) CA2776328C (es)
CL (1) CL2012000739A1 (es)
CO (1) CO6430508A2 (es)
CR (1) CR20120185A (es)
CY (1) CY1115161T1 (es)
DK (1) DK2488497T3 (es)
EA (1) EA022805B1 (es)
ES (1) ES2467165T3 (es)
HR (1) HRP20140523T1 (es)
IL (1) IL218446A (es)
IN (1) IN2012DN01938A (es)
ME (1) ME01812B (es)
MX (1) MX2012004033A (es)
MY (1) MY160308A (es)
NZ (1) NZ598429A (es)
PE (1) PE20121173A1 (es)
PH (1) PH12012500548A1 (es)
PL (1) PL2488497T3 (es)
PT (1) PT2488497E (es)
RS (1) RS53319B (es)
SI (1) SI2488497T1 (es)
SM (1) SMT201400064B (es)
UA (1) UA107811C2 (es)
WO (1) WO2011045059A1 (es)
ZA (1) ZA201201563B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2319596B1 (es) 2006-12-22 2010-02-08 Laboratorios Almirall S.A. Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico.
UY31272A1 (es) 2007-08-10 2009-01-30 Almirall Lab Nuevos derivados de ácido azabifenilaminobenzoico
EP2135610A1 (en) * 2008-06-20 2009-12-23 Laboratorios Almirall, S.A. Combination comprising DHODH inhibitors and methotrexate
EP2239256A1 (en) 2009-03-13 2010-10-13 Almirall, S.A. Sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid as DHODH inhibitor
JP7343373B2 (ja) * 2019-12-02 2023-09-12 花王株式会社 香料組成物

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DE19547648A1 (de) 1995-12-20 1997-06-26 Hoechst Ag Zubereitung, enthaltend High Density Lipoproteine und Crotonsäureamidderivate
DE19610955A1 (de) 1996-03-20 1997-09-25 Hoechst Ag Kombinationspräparat, enthaltend 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)- anilid und N-(4-Trifluormethylphenyl)-2-cyan-3- hydroxycrotonsäureamid
GB9804343D0 (en) 1998-02-27 1998-04-22 Univ Cardiff Chemical compounds
SK17632001A3 (sk) 1999-06-10 2003-03-04 Warner-Lambert Company Liečivo na liečbu Alzheimerovej choroby, inhibíciu agregácie amyloidového proteínu a spôsob na zobrazenie depozít amyloidu
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CN1696100B (zh) * 2005-06-01 2010-11-24 黑龙江福和华星制药集团股份有限公司 痤疮治疗药阿达帕林的新型简捷合成方法
ES2319596B1 (es) * 2006-12-22 2010-02-08 Laboratorios Almirall S.A. Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico.
JP5349332B2 (ja) 2007-02-06 2013-11-20 チェルシー・セラピューティクス，インコーポレイテッド 新規化合物、その調製方法、およびその使用
UY31272A1 (es) 2007-08-10 2009-01-30 Almirall Lab Nuevos derivados de ácido azabifenilaminobenzoico
EP2135610A1 (en) 2008-06-20 2009-12-23 Laboratorios Almirall, S.A. Combination comprising DHODH inhibitors and methotrexate
EP2210615A1 (en) 2009-01-21 2010-07-28 Almirall, S.A. Combinations comprising methotrexate and DHODH inhibitors
EP2239256A1 (en) 2009-03-13 2010-10-13 Almirall, S.A. Sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid as DHODH inhibitor
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Also Published As

Publication number Publication date
EA201200594A1 (ru) 2012-11-30
MY160308A (en) 2017-02-28
UA107811C2 (en) 2015-02-25
IL218446A0 (en) 2012-04-30
PL2488497T3 (pl) 2014-07-31
HRP20140523T1 (hr) 2014-07-04
CL2012000739A1 (es) 2012-10-12
EP2488497A1 (en) 2012-08-22
AU2010306098B2 (en) 2015-10-15
CO6430508A2 (es) 2012-04-30
KR101699999B1 (ko) 2017-01-26
US8598363B2 (en) 2013-12-03
PT2488497E (pt) 2014-05-28
KR20120087131A (ko) 2012-08-06
IL218446A (en) 2014-08-31
EP2488497B1 (en) 2014-03-12
ES2467165T3 (es) 2014-06-12
EA022805B1 (ru) 2016-03-31
CN102574800B (zh) 2014-09-17
SI2488497T1 (sl) 2014-08-29
BR112012008464B1 (pt) 2021-08-24
ZA201201563B (en) 2012-11-28
JP5809630B2 (ja) 2015-11-11
RS53319B (sr) 2014-10-31
PH12012500548A1 (en) 2012-11-12
US20120245359A1 (en) 2012-09-27
CY1115161T1 (el) 2016-12-14
HK1168101A1 (en) 2012-12-21
EP2314577A1 (en) 2011-04-27
CA2776328A1 (en) 2011-04-21
JP2013507407A (ja) 2013-03-04
SMT201400064B (it) 2014-07-07
DK2488497T3 (da) 2014-06-10
MX2012004033A (es) 2012-05-08
CA2776328C (en) 2017-08-08
CN102574800A (zh) 2012-07-11
IN2012DN01938A (es) 2015-08-21
WO2011045059A1 (en) 2011-04-21
PE20121173A1 (es) 2012-08-30
CN103936668A (zh) 2014-07-23
NZ598429A (en) 2014-02-28
AU2010306098A1 (en) 2012-03-15
ME01812B (me) 2014-09-20
BR112012008464A2 (pt) 2015-09-22

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