DK2497774T3 - Dihydrooxazolobenzodiazepinonderivater, fremgangsmåder til fremstilling heraf og farmaceutiske sammensætninger, som indeholder disse forbindelser - Google Patents

Dihydrooxazolobenzodiazepinonderivater, fremgangsmåder til fremstilling heraf og farmaceutiske sammensætninger, som indeholder disse forbindelser

Info

Publication number
DK2497774T3
DK2497774T3 DK12290077.2T DK12290077T DK2497774T3 DK 2497774 T3 DK2497774 T3 DK 2497774T3 DK 12290077 T DK12290077 T DK 12290077T DK 2497774 T3 DK2497774 T3 DK 2497774T3
Authority
DK
Denmark
Prior art keywords
dihydrooxazolobenzodiazepinone
derivatives
compounds
processes
preparation
Prior art date
Application number
DK12290077.2T
Other languages
English (en)
Inventor
Ferenc Antoni
Michael Spedding
Istvan Ling
Jozsef Barkoczy
Istvan Gacsalyi
Gyoergy Levay
Laszlo Harsing
Original Assignee
Servier Lab
Egis Gyogyszergyar Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab, Egis Gyogyszergyar Nyrt filed Critical Servier Lab
Application granted granted Critical
Publication of DK2497774T3 publication Critical patent/DK2497774T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK12290077.2T 2011-03-08 2012-03-07 Dihydrooxazolobenzodiazepinonderivater, fremgangsmåder til fremstilling heraf og farmaceutiske sammensætninger, som indeholder disse forbindelser DK2497774T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1100682A FR2972454B1 (fr) 2011-03-08 2011-03-08 Nouveaux derives dihydro-oxazolobenzodiazepinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
DK2497774T3 true DK2497774T3 (da) 2014-01-13

Family

ID=44004482

Family Applications (1)

Application Number Title Priority Date Filing Date
DK12290077.2T DK2497774T3 (da) 2011-03-08 2012-03-07 Dihydrooxazolobenzodiazepinonderivater, fremgangsmåder til fremstilling heraf og farmaceutiske sammensætninger, som indeholder disse forbindelser

Country Status (44)

Country Link
US (1) US8778932B2 (da)
EP (1) EP2497774B1 (da)
JP (1) JP5475816B2 (da)
KR (1) KR101477991B1 (da)
CN (1) CN102675341B (da)
AP (1) AP3344A (da)
AR (1) AR085691A1 (da)
AU (1) AU2012201031B2 (da)
BR (1) BR102012005137A2 (da)
CA (1) CA2771189C (da)
CL (1) CL2012000496A1 (da)
CR (1) CR20120109A (da)
CU (1) CU24134B1 (da)
CY (1) CY1114729T1 (da)
DK (1) DK2497774T3 (da)
EA (1) EA021125B1 (da)
EC (1) ECSP12011711A (da)
ES (1) ES2442293T3 (da)
FR (1) FR2972454B1 (da)
GE (1) GEP20146017B (da)
GT (1) GT201200066A (da)
HN (1) HN2012000485A (da)
HR (1) HRP20140050T1 (da)
IL (1) IL218215A (da)
JO (1) JO2948B1 (da)
MA (1) MA33641B1 (da)
MX (1) MX2012002788A (da)
MY (1) MY162537A (da)
NI (1) NI201200039A (da)
NZ (1) NZ598625A (da)
PE (1) PE20121682A1 (da)
PH (1) PH12012000035A1 (da)
PL (1) PL2497774T3 (da)
PT (1) PT2497774E (da)
RS (1) RS53032B (da)
RU (1) RU2572556C2 (da)
SA (2) SA112330331B1 (da)
SG (1) SG184633A1 (da)
SI (1) SI2497774T1 (da)
TW (1) TWI428342B (da)
UA (1) UA112153C2 (da)
UY (1) UY33927A (da)
WO (1) WO2012120206A1 (da)
ZA (1) ZA201201681B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU230684B1 (hu) * 2014-01-21 2017-08-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Új dihidro-oxazino-benzodiazepin vegyületek és eljárás ezek elõállítására, illetve az ezeket tartalmazó gyógyászati készítmények
DE102016005291B4 (de) 2016-04-29 2024-01-11 Ksg Austria Gmbh Verfahren zur Herstellung eines elektronischen Gerätes in der Form eines Spritzgußteils mit eingelegter Leiterplatte
CN115304620A (zh) * 2021-05-07 2022-11-08 上海赛默罗生物科技有限公司 嘧啶酮衍生物、其制备方法、药物组合物和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3370616D1 (en) 1982-08-06 1987-05-07 Ube Industries Process for producing phenylacetones
US5891871A (en) * 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof
JP2001512731A (ja) * 1997-08-12 2001-08-28 エギシュ ヂョヂセルヂャール エルテー ＡＭＰＡ／Ｋａｉｎａｔｅ受容体阻害剤としての１，３−ジオキソロ／４，５−Ｈ／２，３／ベンゾジアゼピン誘導体
UA67749C2 (uk) * 1997-08-12 2004-07-15 Егіш Дьйодьсердьяр Рт. Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування
GB9900222D0 (en) * 1999-01-06 1999-02-24 Merck Sharp & Dohme Therapeutic compounds
HU227128B1 (en) * 1999-07-07 2010-07-28 Egyt Gyogyszervegyeszeti Gyar New 2,3-benzodiazepine derivatives
EP1951050A4 (en) * 2005-10-26 2011-04-27 Univ Michigan THERAPEUTIC COMPOSITIONS AND METHOD
HU230760B1 (hu) * 2005-12-30 2018-03-28 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Dihidro-2,3-benzodiazepin-származékok optikai izomerjei, eljárás ezek sztereoszelektív szintézisére, alkalmazásuk, az ezeket tartalmazó gyógyszerkészítmények és az eljárás közbenső termékei
EP2298296A1 (en) * 2009-08-25 2011-03-23 CNRS Centre National De La Recherche Scientifique Composition and method for treating cognitive impairments in down syndrome subjects

Also Published As

Publication number Publication date
AP2012006149A0 (en) 2012-04-30
IL218215A (en) 2016-04-21
KR101477991B1 (ko) 2014-12-31
TWI428342B (zh) 2014-03-01
PT2497774E (pt) 2013-11-26
US20120232065A1 (en) 2012-09-13
MA33641B1 (fr) 2012-10-01
TW201309708A (zh) 2013-03-01
JO2948B1 (en) 2016-03-15
GEP20146017B (en) 2014-01-27
MX2012002788A (es) 2012-09-07
ZA201201681B (en) 2012-11-28
AR085691A1 (es) 2013-10-23
RS53032B (sr) 2014-04-30
US8778932B2 (en) 2014-07-15
HN2012000485A (es) 2015-05-11
AP3344A (en) 2015-07-31
GT201200066A (es) 2013-10-10
JP5475816B2 (ja) 2014-04-16
FR2972454A1 (fr) 2012-09-14
ECSP12011711A (es) 2012-07-31
SA112330231B1 (ar) 2014-12-01
EA021125B1 (ru) 2015-04-30
CR20120109A (es) 2012-10-05
MY162537A (en) 2017-06-15
NI201200039A (es) 2012-11-09
WO2012120206A1 (fr) 2012-09-13
IL218215A0 (en) 2012-07-31
HRP20140050T1 (hr) 2014-02-14
UY33927A (es) 2012-09-28
CA2771189A1 (fr) 2012-09-08
SI2497774T1 (sl) 2014-02-28
AU2012201031B2 (en) 2015-05-07
CL2012000496A1 (es) 2014-07-18
PE20121682A1 (es) 2012-12-08
NZ598625A (en) 2013-06-28
SG184633A1 (en) 2012-10-30
EA201200267A1 (ru) 2012-10-30
ES2442293T3 (es) 2014-02-11
HK1176355A1 (en) 2013-07-26
SA112330331B1 (ar) 2014-12-01
CA2771189C (fr) 2014-06-10
CU24134B1 (es) 2015-11-27
CN102675341A (zh) 2012-09-19
CN102675341B (zh) 2015-02-25
AU2012201031A1 (en) 2012-09-27
EP2497774A1 (fr) 2012-09-12
CU20120041A7 (es) 2013-10-29
JP2012188422A (ja) 2012-10-04
KR20120102550A (ko) 2012-09-18
CY1114729T1 (el) 2016-10-05
PL2497774T3 (pl) 2014-03-31
EP2497774B1 (fr) 2013-10-16
FR2972454B1 (fr) 2013-03-01
PH12012000035A1 (en) 2013-09-09
BR102012005137A2 (pt) 2015-06-16
RU2572556C2 (ru) 2016-01-20
UA112153C2 (uk) 2016-08-10
RU2013144824A (ru) 2015-04-20

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