GT201200066A - Nuevos derivados dihidro-oxazolobenzodiazepinonas, su procedimiento de preparación y las composiciones farmacéuticas que los contienen - Google Patents

Nuevos derivados dihidro-oxazolobenzodiazepinonas, su procedimiento de preparación y las composiciones farmacéuticas que los contienen

Info

Publication number
GT201200066A
GT201200066A GT201200066A GT201200066A GT201200066A GT 201200066 A GT201200066 A GT 201200066A GT 201200066 A GT201200066 A GT 201200066A GT 201200066 A GT201200066 A GT 201200066A GT 201200066 A GT201200066 A GT 201200066A
Authority
GT
Guatemala
Prior art keywords
oxazolobenzodiazepinonas
dihidro
derivatives
new
pharmaceutical compositions
Prior art date
Application number
GT201200066A
Other languages
English (en)
Inventor
István Ling
József Barkóczy
Ferenc Antoni
István Gacsályi
György Lévay
Michael Spedding
László Hársing
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT201200066A publication Critical patent/GT201200066A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A NUEVOS DERIVADOS DIHIDRO-OXAZOLOBENZODIAZEPINONAS, SU PROCEDIMIENTO DE PREPARACIÓN Y LAS COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN.
GT201200066A 2011-03-08 2012-03-08 Nuevos derivados dihidro-oxazolobenzodiazepinonas, su procedimiento de preparación y las composiciones farmacéuticas que los contienen GT201200066A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1100682A FR2972454B1 (fr) 2011-03-08 2011-03-08 Nouveaux derives dihydro-oxazolobenzodiazepinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
GT201200066A true GT201200066A (es) 2013-10-10

Family

ID=44004482

Family Applications (1)

Application Number Title Priority Date Filing Date
GT201200066A GT201200066A (es) 2011-03-08 2012-03-08 Nuevos derivados dihidro-oxazolobenzodiazepinonas, su procedimiento de preparación y las composiciones farmacéuticas que los contienen

Country Status (44)

Country Link
US (1) US8778932B2 (es)
EP (1) EP2497774B1 (es)
JP (1) JP5475816B2 (es)
KR (1) KR101477991B1 (es)
CN (1) CN102675341B (es)
AP (1) AP3344A (es)
AR (1) AR085691A1 (es)
AU (1) AU2012201031B2 (es)
BR (1) BR102012005137A2 (es)
CA (1) CA2771189C (es)
CL (1) CL2012000496A1 (es)
CR (1) CR20120109A (es)
CU (1) CU24134B1 (es)
CY (1) CY1114729T1 (es)
DK (1) DK2497774T3 (es)
EA (1) EA021125B1 (es)
EC (1) ECSP12011711A (es)
ES (1) ES2442293T3 (es)
FR (1) FR2972454B1 (es)
GE (1) GEP20146017B (es)
GT (1) GT201200066A (es)
HN (1) HN2012000485A (es)
HR (1) HRP20140050T1 (es)
IL (1) IL218215A (es)
JO (1) JO2948B1 (es)
MA (1) MA33641B1 (es)
MX (1) MX2012002788A (es)
MY (1) MY162537A (es)
NI (1) NI201200039A (es)
NZ (1) NZ598625A (es)
PE (1) PE20121682A1 (es)
PH (1) PH12012000035A1 (es)
PL (1) PL2497774T3 (es)
PT (1) PT2497774E (es)
RS (1) RS53032B (es)
RU (1) RU2572556C2 (es)
SA (2) SA112330331B1 (es)
SG (1) SG184633A1 (es)
SI (1) SI2497774T1 (es)
TW (1) TWI428342B (es)
UA (1) UA112153C2 (es)
UY (1) UY33927A (es)
WO (1) WO2012120206A1 (es)
ZA (1) ZA201201681B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU230684B1 (hu) * 2014-01-21 2017-08-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Új dihidro-oxazino-benzodiazepin vegyületek és eljárás ezek elõállítására, illetve az ezeket tartalmazó gyógyászati készítmények
DE102016005291B4 (de) 2016-04-29 2024-01-11 Ksg Austria Gmbh Verfahren zur Herstellung eines elektronischen Gerätes in der Form eines Spritzgußteils mit eingelegter Leiterplatte
CN115304620A (zh) * 2021-05-07 2022-11-08 上海赛默罗生物科技有限公司 嘧啶酮衍生物、其制备方法、药物组合物和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0101223B1 (en) 1982-08-06 1987-04-01 Ube Industries, Ltd. process for producing phenylacetones
US5891871A (en) * 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof
UA67749C2 (uk) * 1997-08-12 2004-07-15 Егіш Дьйодьсердьяр Рт. Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування
EP1015457B1 (en) * 1997-08-12 2003-11-26 Egis Gyogyszergyar Rt. 1,3-dioxolo/4,5-h//2,3/benzodiazepine derivatives as ampa/kainate receptor inhibitors
GB9900222D0 (en) * 1999-01-06 1999-02-24 Merck Sharp & Dohme Therapeutic compounds
HU227128B1 (en) * 1999-07-07 2010-07-28 Egyt Gyogyszervegyeszeti Gyar New 2,3-benzodiazepine derivatives
EP1951050A4 (en) * 2005-10-26 2011-04-27 Univ Michigan THERAPEUTIC COMPOSITIONS AND METHOD
HU230760B1 (hu) * 2005-12-30 2018-03-28 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Dihidro-2,3-benzodiazepin-származékok optikai izomerjei, eljárás ezek sztereoszelektív szintézisére, alkalmazásuk, az ezeket tartalmazó gyógyszerkészítmények és az eljárás közbenső termékei
EP2298296A1 (en) * 2009-08-25 2011-03-23 CNRS Centre National De La Recherche Scientifique Composition and method for treating cognitive impairments in down syndrome subjects

Also Published As

Publication number Publication date
TWI428342B (zh) 2014-03-01
CR20120109A (es) 2012-10-05
AR085691A1 (es) 2013-10-23
SI2497774T1 (sl) 2014-02-28
ZA201201681B (en) 2012-11-28
FR2972454A1 (fr) 2012-09-14
EP2497774A1 (fr) 2012-09-12
US8778932B2 (en) 2014-07-15
HRP20140050T1 (hr) 2014-02-14
CL2012000496A1 (es) 2014-07-18
CN102675341B (zh) 2015-02-25
CN102675341A (zh) 2012-09-19
AP3344A (en) 2015-07-31
CU20120041A7 (es) 2013-10-29
DK2497774T3 (da) 2014-01-13
CU24134B1 (es) 2015-11-27
AU2012201031B2 (en) 2015-05-07
CA2771189C (fr) 2014-06-10
SA112330331B1 (ar) 2014-12-01
RU2013144824A (ru) 2015-04-20
BR102012005137A2 (pt) 2015-06-16
PH12012000035A1 (en) 2013-09-09
HN2012000485A (es) 2015-05-11
RU2572556C2 (ru) 2016-01-20
WO2012120206A1 (fr) 2012-09-13
TW201309708A (zh) 2013-03-01
UY33927A (es) 2012-09-28
CY1114729T1 (el) 2016-10-05
PE20121682A1 (es) 2012-12-08
MA33641B1 (fr) 2012-10-01
AP2012006149A0 (en) 2012-04-30
PT2497774E (pt) 2013-11-26
UA112153C2 (uk) 2016-08-10
KR20120102550A (ko) 2012-09-18
NI201200039A (es) 2012-11-09
JP5475816B2 (ja) 2014-04-16
US20120232065A1 (en) 2012-09-13
CA2771189A1 (fr) 2012-09-08
IL218215A (en) 2016-04-21
MY162537A (en) 2017-06-15
JO2948B1 (en) 2016-03-15
NZ598625A (en) 2013-06-28
PL2497774T3 (pl) 2014-03-31
GEP20146017B (en) 2014-01-27
IL218215A0 (en) 2012-07-31
FR2972454B1 (fr) 2013-03-01
JP2012188422A (ja) 2012-10-04
RS53032B (sr) 2014-04-30
EA021125B1 (ru) 2015-04-30
SG184633A1 (en) 2012-10-30
ES2442293T3 (es) 2014-02-11
EA201200267A1 (ru) 2012-10-30
MX2012002788A (es) 2012-09-07
ECSP12011711A (es) 2012-07-31
KR101477991B1 (ko) 2014-12-31
HK1176355A1 (en) 2013-07-26
AU2012201031A1 (en) 2012-09-27
EP2497774B1 (fr) 2013-10-16
SA112330231B1 (ar) 2014-12-01

Similar Documents

Publication Publication Date Title
GT201400142A (es) Nuevos derivados de indolizina, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
GT201400144A (es) Nuevos derivados de pirrol, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
GT201000023A (es) Nuevos derivados de 6-trialzolopiridacina-sulfanil benzotiazol y bencimidazol, su procedimiento de preparacion, su aplicacion como medicamentos, composiciones farmaceuticas y nueva utilizacion principalmente como inhibidores de met.
CU20140095A7 (es) Nuevos derivados fosfatos, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
DOP2013000307A (es) Antagonistas de trpv4
CR20140106A (es) Compuestos y composiciones como inhibidores de la quinasa c-kit
CO7210068A1 (es) Nuevos derivados tienopirimidina, un proceso para su preparación y composiciones farmacéuticas que los contienen
CU20170160A7 (es) Derivadosde fenil-tieno(2,3-d)pirimidina- hidroxi-ésteres, un proceso para su preparación y composiciones farmacéuticas que lo contienen
UY35467A (es) Compuestos orgánicos
PT2773748T (pt) Neurónios dopaminérgicos (da) do mesencéfalo para enxerto
ECSP13013074A (es) Nuevos derivados de piridina
UY34698A (es) Combinaciones farmacéuticas que comprenden un análogo de tionucleótidos
UY34602A (es) ?Derivados de bencimidazolil- e imidazopiridinil-metilamina?
MX338078B (es) Cristales de anticuerpos anti-esclerostina y formulaciones de los mismos.
CR20140275A (es) Triazolopiridinas sustituidas
UY34779A (es) Anticuerpos anti-il-23 y composiciones farmacéuticas que los contienen
CR20150250A (es) Nuevos derivados de piridina
HN2010001537A (es) Nuevos derivados dihidroindolonas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
CR20150204A (es) Nuevos derivados de piridina
MX2017007377A (es) Compuestos organicos.
MX340983B (es) Composiciones farmaceuticas y nutraceuticas de acido abscisico.
EP2815752A4 (en) ORAL PHARMACEUTICAL COMPOSITION
MX347855B (es) Derivados de anilina, su preparación y su aplicación terapéutica.
CO6960548A2 (es) Polimorfos de arry-380, un inhibidor selectivo de herb2 y composiciones farmacéuticas que los contienen
EP2815753A4 (en) ORAL PHARMACEUTICAL COMPOSITION