DK2532364T3 - Farmaceutisk sammensætning omfattende anti caprin-1-antistoffer til behandling og/eller forebyggelse af kræft - Google Patents
Farmaceutisk sammensætning omfattende anti caprin-1-antistoffer til behandling og/eller forebyggelse af kræft Download PDFInfo
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- DK2532364T3 DK2532364T3 DK11739865.1T DK11739865T DK2532364T3 DK 2532364 T3 DK2532364 T3 DK 2532364T3 DK 11739865 T DK11739865 T DK 11739865T DK 2532364 T3 DK2532364 T3 DK 2532364T3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3015—Breast
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/23—Immunoglobulins specific features characterized by taxonomic origin from birds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (15)
1. Antistof eller fragment deraf, som binder til et partielt polypeptid af CAPRIN-1, hvor CAPRIN-1 er repræsenteret af en af sekvenserne af SEQ ID NOS: 2 til 30 med lige nummer, og hvor det partielle polypeptid består af aminosyresekvensen repræsenteret af SEQ ID NO: 37 eller en aminosyrese-kvens med 80 % eller mere sekvensidentitet med aminosyresekvensen af SEQ ID NO: 37.
2. Antistof eller fragment deraf ifølge krav 1, som har en cytotoksisk aktivitet mod en kræftcelle, der eksprimerer et CAPRIN-1-protein.
3. Antistof eller fragment deraf ifølge krav 1 eller krav 2, som omfatter en tungkæde-variabel region, som omfatter SEQ ID NO: 40, 41 og 42, og en letkæde-variabel region, som omfatter SEQ ID NO: 44, 45 og 46, og binder til et CAPRIN-1-protein.
4. Antistof eller fragment deraf ifølge krav 1 eller krav 2, som omfatter en tungkæde-variabel region, som omfatter SEQ ID NO: 40, 41 og 42, og en letkæde-variabel region, som omfatter SEQ ID NO: 50, 51 og 52, og binder til et CAPRIN-1-protein.
5. Antistof eller fragment deraf ifølge et af kravene 1 til 4, hvor antistoffet eller fragmentet deraf er monoklonalt.
6. Antistof eller fragment deraf ifølge krav 1 eller krav 2, hvor antistoffet eller fragmentet deraf er polyklonalt.
7. Antistof eller fragment deraf ifølge et af kravene 1 til 5, som er et humaniseret antistof, kimærisk antistof, enkeltkædet antistof eller bispecifikt antistof.
8. Antistof eller fragment deraf ifølge krav 1 eller krav 2 eller krav 5 i afhængighed af krav 1 eller krav 2, som er et humant antistof.
9. Farmaceutisk sammensætning, som omfatter antistoffet eller fragmentet deraf ifølge et af de foregående krav som et aktivstof.
10. Farmaceutisk sammensætning ifølge krav 9, yderligere omfattende et antitumormiddel.
11. Farmaceutisk kombination, som omfatter den farmaceutiske sammensætning ifølge krav 9 og en farmaceutisk sammensætning, som indeholder et antitumormiddel.
12. Antistof eller fragment deraf ifølge et af kravene 1 til 8, farmaceutisk sammensætning ifølge krav 9 eller krav 10 eller farmaceutisk kombination ifølge krav 11 til anvendelse som et medikament.
13. Antistof eller fragment deraf ifølge et af kravene 1 til 8, farmaceutisk sammensætning ifølge krav 9 eller krav 10 eller farmaceutisk kombination ifølge krav 11 til anvendelse i en fremgangsmåde til behandling og/eller forebyggelse af kræft.
14. Antistof, fragment eller farmaceutisk sammensætning til anvendelse ifølge krav 13, hvor fremgangsmåden omfatter indgivelse af antistoffet eller fragmentet deraf ifølge et af kravene 1 til 8 eller den farmaceutiske sammensætning ifølge krav 9 og et antitumormiddel til et individ.
15. Antistof, fragment, farmaceutisk sammensætning, farmaceutisk kombination eller antitumormiddel til anvendelse ifølge krav 13 eller krav 14, hvor kræften er brystkræft, hjernetumor, leukæmi, lymfom, lungekræft, mastocytom, nyrekræft, livmoderhalskræft, blærekræft, spiserørskræft, ma-vekræft eller kolorektalkræft.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010023450 | 2010-02-04 | ||
| PCT/JP2011/052382 WO2011096517A1 (ja) | 2010-02-04 | 2011-02-04 | 癌の治療及び／又は予防用医薬組成物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2532364T3 true DK2532364T3 (da) | 2016-08-15 |
Family
ID=44355511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11739865.1T DK2532364T3 (da) | 2010-02-04 | 2011-02-04 | Farmaceutisk sammensætning omfattende anti caprin-1-antistoffer til behandling og/eller forebyggelse af kræft |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8911740B2 (da) |
| EP (1) | EP2532364B1 (da) |
| JP (1) | JP5923985B2 (da) |
| KR (1) | KR101871704B1 (da) |
| CN (1) | CN102834113B (da) |
| AU (1) | AU2011211682B2 (da) |
| BR (1) | BR112012018948B1 (da) |
| CA (1) | CA2788545C (da) |
| DK (1) | DK2532364T3 (da) |
| ES (1) | ES2583777T3 (da) |
| HU (1) | HUE030102T2 (da) |
| MX (1) | MX340016B (da) |
| PL (1) | PL2532364T3 (da) |
| PT (1) | PT2532364T (da) |
| RU (1) | RU2598258C2 (da) |
| WO (1) | WO2011096517A1 (da) |
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| DK2532680T3 (da) | 2010-02-04 | 2015-07-20 | Toray Industries | Medicinsk sammensætning til behandling og/eller forebyggelse af cancer |
| RU2603742C2 (ru) | 2010-02-04 | 2016-11-27 | Торэй Индастриз, Инк. | Фармацевтическая композиция для лечения и/или профилактики рака |
| CA2788545C (en) | 2010-02-04 | 2019-03-26 | Toray Industries, Inc. | Pharmaceutical composition for treating and/or preventing cancer |
| DK2532366T3 (da) | 2010-02-04 | 2017-01-02 | Toray Industries | Farmaceutisk sammensætning til behandling og/eller forebyggelse af cancer |
| HUE040012T2 (hu) * | 2010-02-04 | 2019-02-28 | Toray Industries | Gyógyászati ágens rák kezelésére és/vagy megelõzésére |
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-
2011
- 2011-02-04 CA CA2788545A patent/CA2788545C/en active Active
- 2011-02-04 CN CN201180016880.6A patent/CN102834113B/zh active Active
- 2011-02-04 HU HUE11739865A patent/HUE030102T2/en unknown
- 2011-02-04 KR KR1020127022729A patent/KR101871704B1/ko active Active
- 2011-02-04 BR BR112012018948-4A patent/BR112012018948B1/pt active IP Right Grant
- 2011-02-04 PT PT117398651T patent/PT2532364T/pt unknown
- 2011-02-04 US US13/577,028 patent/US8911740B2/en active Active
- 2011-02-04 PL PL11739865.1T patent/PL2532364T3/pl unknown
- 2011-02-04 MX MX2012008997A patent/MX340016B/es active IP Right Grant
- 2011-02-04 WO PCT/JP2011/052382 patent/WO2011096517A1/ja not_active Ceased
- 2011-02-04 JP JP2011510206A patent/JP5923985B2/ja active Active
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- 2011-02-04 RU RU2012137499/10A patent/RU2598258C2/ru active
- 2011-02-04 DK DK11739865.1T patent/DK2532364T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2598258C2 (ru) | 2016-09-20 |
| KR101871704B1 (ko) | 2018-06-27 |
| CA2788545C (en) | 2019-03-26 |
| JPWO2011096517A1 (ja) | 2013-06-13 |
| AU2011211682A1 (en) | 2012-08-23 |
| US20130071398A1 (en) | 2013-03-21 |
| US8911740B2 (en) | 2014-12-16 |
| BR112012018948A2 (pt) | 2020-10-20 |
| KR20120139719A (ko) | 2012-12-27 |
| RU2012137499A (ru) | 2014-03-10 |
| CN102834113A (zh) | 2012-12-19 |
| WO2011096517A1 (ja) | 2011-08-11 |
| HUE030102T2 (en) | 2017-04-28 |
| EP2532364A4 (en) | 2013-07-31 |
| MX2012008997A (es) | 2012-09-07 |
| EP2532364A1 (en) | 2012-12-12 |
| CA2788545A1 (en) | 2011-08-11 |
| MX340016B (es) | 2016-06-22 |
| EP2532364B1 (en) | 2016-05-04 |
| JP5923985B2 (ja) | 2016-05-25 |
| BR112012018948B1 (pt) | 2021-12-14 |
| ES2583777T3 (es) | 2016-09-22 |
| PL2532364T3 (pl) | 2016-11-30 |
| PT2532364T (pt) | 2016-07-28 |
| AU2011211682B2 (en) | 2015-08-13 |
| CN102834113B (zh) | 2016-03-02 |
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