DK2637670T3 - Forebyggelse af uønskede hændelser forårsaget af specifikke cd3-bindingsdomæner - Google Patents
Forebyggelse af uønskede hændelser forårsaget af specifikke cd3-bindingsdomæner Download PDFInfo
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- DK2637670T3 DK2637670T3 DK11788077.3T DK11788077T DK2637670T3 DK 2637670 T3 DK2637670 T3 DK 2637670T3 DK 11788077 T DK11788077 T DK 11788077T DK 2637670 T3 DK2637670 T3 DK 2637670T3
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- Chemical & Material Sciences (AREA)
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- Public Health (AREA)
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Genetics & Genomics (AREA)
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- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Developing Agents For Electrophotography (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Materials For Medical Uses (AREA)
Claims (13)
- FOREBYGGELSE AF UØNSKEDE HÆNDELSER FORÅRSAGET AF SPECIFIKKE CD3-BINDINGSDOMÆNER1. Glucocorticoid (GC) til anvendelse i en fremgangsmåde til bedring, behandling eller profylakse af neurologiske uønskede hændelser, der er forårsaget af administrationen af et CD3-bindingsdomæne, hvor GC’et administreres før administrationen af den første dosis af CD3-bindingsdomænet og før administrationen af den anden dosis og/eller den tredje dosis af CD3-bindingsdomænet.
- 2. Glucocorticoid til anvendelse ifølge krav 1, hvor GC’et er dexamethason.
- 3. Glucocorticoid til anvendelse ifølge et hvilket som helst af de foregående krav, hvor en første dosis af CD3-bindingsdomænet administreres i et første tidsrum og en anden dosis af CD3-bindingsdomænet efterfølgende administreres i et andet tidsrum, hvor den anden dosis overstiger den første dosis.
- 4. Glucocorticoid til anvendelse ifølge krav 3, hvor, efter en første og anden dosis af CD3-bindingsdomænet i et første og et andet tidsrum, en tredje dosis af CD3-bindingsdomænet administreres, hvor den tredje dosis overstiger den første og den anden dosis.
- 5. Glucocorticoid til anvendelse ifølge krav 1 eller 2, hvor CD3-bindingsdomænet administreres kontinuerligt.
- 6. Glucocorticoid til anvendelse ifølge et hvilket som helst af de foregående krav, hvor den neurologiske uønskede hændelse er én eller flere af forstyrrelser af sanser, epileptiske anfald, encefalopati, cerebralt ødem, konfusion, ataksi, apraksi, taleforstyrrelse, hallucinationer, parese, tremor, hovedpine eller desorientering.
- 7. Glucocorticoid til anvendelse ifølge et hvilket som helst af de foregående krav, hvor GC’et administreres efter forekomst af den neurologiske uønskede hændelse.
- 8. Glucocorticoid til anvendelse ifølge et hvilket som helst af de foregående krav, hvor CD3-bindingsdomænet er et bispecifikt enkeltkæde-antistof.
- 9. Glucocorticoid til anvendelse ifølge krav 8, hvor det bispecifikke enkeltkæde-antistof er et CD19 x CD3 bispecifikt enkeltkæde-antistof.
- 10. Glucocorticoid til anvendelse ifølge krav 9, hvor det CD19 x CD3 bispecifikke enkeltkæde-antistof er MT 103.
- 11. Glucocorticoid til anvendelse ifølge et hvilket som helst af de foregående krav, hvor patienten er et menneske.
- 12. Glucocorticoid til anvendelse ifølge et hvilket som helst af de foregående krav, hvor patienten er kendetegnet ved et B/T-celleforhold på mindre end 1:5.
- 13. Glucocorticoid til anvendelse ifølge et hvilket som helst af kravene 1 til 12, hvor CD3-bindingsdomænet binder til humant CD3 epsilon.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41222910P | 2010-11-10 | 2010-11-10 | |
| PCT/EP2011/068862 WO2012062596A1 (en) | 2010-11-10 | 2011-10-27 | Prevention of adverse effects caused by cd3 specific binding domains |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK2637670T3 true DK2637670T3 (da) | 2017-06-19 |
| DK2637670T4 DK2637670T4 (da) | 2024-03-25 |
Family
ID=45044532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11788077.3T DK2637670T4 (da) | 2010-11-10 | 2011-10-27 | Forebyggelse af uønskede hændelser forårsaget af specifikke cd3-bindingsdomæner |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US10130638B2 (da) |
| EP (3) | EP2637670B2 (da) |
| JP (2) | JP6023717B2 (da) |
| KR (1) | KR101891845B1 (da) |
| CN (2) | CN103533943B (da) |
| AU (3) | AU2011328393B2 (da) |
| CA (1) | CA2816668C (da) |
| CL (1) | CL2013001287A1 (da) |
| CR (1) | CR20130278A (da) |
| CY (1) | CY1118894T1 (da) |
| DK (1) | DK2637670T4 (da) |
| EA (1) | EA026075B1 (da) |
| ES (2) | ES2842937T3 (da) |
| FI (1) | FI2637670T4 (da) |
| HR (1) | HRP20170814T4 (da) |
| HU (1) | HUE032782T2 (da) |
| IL (2) | IL226268B (da) |
| LT (1) | LT2637670T (da) |
| MA (1) | MA34726B1 (da) |
| ME (1) | ME02722B (da) |
| MY (1) | MY173177A (da) |
| NZ (1) | NZ610034A (da) |
| PH (1) | PH12013500940A1 (da) |
| PL (1) | PL2637670T5 (da) |
| PT (1) | PT2637670T (da) |
| RS (1) | RS55995B2 (da) |
| SG (2) | SG10201508789TA (da) |
| SI (1) | SI2637670T2 (da) |
| SM (1) | SMT201700250T1 (da) |
| TN (1) | TN2013000250A1 (da) |
| UA (1) | UA113397C2 (da) |
| WO (1) | WO2012062596A1 (da) |
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