DK2654784T3 - Stabile immunogene sammensætninger af staphylococcus aureus-antigener - Google Patents
Stabile immunogene sammensætninger af staphylococcus aureus-antigener Download PDFInfo
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- DK2654784T3 DK2654784T3 DK11804822.2T DK11804822T DK2654784T3 DK 2654784 T3 DK2654784 T3 DK 2654784T3 DK 11804822 T DK11804822 T DK 11804822T DK 2654784 T3 DK2654784 T3 DK 2654784T3
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/085—Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Immunology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
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Claims (17)
1. Lyofiliseret immunogen sammensætning omfattende: (a) et isoleret Staphylococcus afreus-sammenklumpningsfaktor A (ClfA)-polypeptid, (b) et isoleret Staphylococcus aareus-MntC-polypeptid, (c) et kapselpolysaccharid type 5 (CP5)-CRMi97-konjugat, (d) et kapselpolysaccharid type 8 (CP8)-CRMi97-konjugat, (e) en buffer med en pKa på 6,0 ± 0,6 og (f) et fyldemiddel, hvor ClfA-polypeptidet omfatter et N1-, N2- og N3-domæne.
2. Lyofiliseret immunogen sammensætning ifølge krav 1, hvor sammensætningen yderligere omfatter en isoleret Staphylococcus aureus-sammenklumpningsfaktor B (ClfB).
3. Lyofiliseret immunogen sammensætning ifølge et hvilket som helst af kravene 1-2, hvor det fibrinogen-bindende domæne af ClfA-polypeptidet udviser reduceret binding til fibrinogen, på grund af at det har en aminosyresubstitu-tion ved en eller flere af Tyr 338, Tyr 256, Pro 336, Lys 389, Ala 254 og Ile 387.
4. Lyofiliseret immunogen sammensætning ifølge krav 3, hvor aminosyre-substitutionen ved en eller flere af Tyr 338, Tyr 256, Pro 336, Lys 389, Ala 254 og Ile 387 er til Ala eller Ser.
5. Lyofiliseret immunogen sammensætning ifølge krav 4, hvor Tyr 338 er substitueret til Ala.
6. Lyofiliseret immunogen sammensætning ifølge et hvilket som helst af kravene 1-5, som omfatter vand med mindre end 3 vægtprocent af den samlede vægt af den immunogene sammensætning (% w/w), hvor ClfA-polypeptidet er mellem 0,09% ± 0,027% og 0,85% ± 0,26% w/w, CP5-CRMi97-konjugatet er mellem 0,04% ± 0,013% og 0,42 ± 0,13% w/w, CP8-CRMi97-konjugatet er mellem 0,04% ± 0,013% og 0,42 ± 0,13% w/w, og bufferen er på 2,54% ± 0,76% w/w.
7. Lyofiliseret immunogen sammensætning ifølge et hvilket som helst af kravene 1-6, hvor bufferen omfatter histidin med pH 6,0 ± 0,6.
8. Lyofiliseret immunogen sammensætning ifølge et hvilket som helst af kravene 1-7, hvor fyldemidlet er udvalgt fra gruppen bestående af saccharose, trehalose, mannitol, glycin og sorbitol.
9. Lyofiliseret immunogen sammensætning ifølge krav 8, hvor fyldemidlet er saccharose.
10. Lyofiliseret immunogen sammensætning ifølge krav 9, hvor fyldemidlet er saccharose med 96% ± 0,060% w/w.
11. Lyofiliseret immunogen sammensætning ifølge et hvilket som helst af kravene 1-10, yderligere omfattende et overfladeaktivt stof.
12. Lyofiliseret immunogen sammensætning ifølge krav 11, hvor det overfladeaktive stof er udvalgt fra gruppen bestående af en poloxamer, en polyoxy-ethylenalkylether og en polyoxyethylensorbitanfedtsyreester.
13. Lyofiliseret immunogen sammensætning ifølge krav 12, hvor polyoxy-ethylensorbitanfedtsyreesteren er polysorbat 80.
14. Lyofiliseret immunogen sammensætning ifølge krav 13, hvor polysorbat 80 er på 0,01 % ± 0,005% w/v.
15. Lyofiliseret immunogen sammensætning ifølge et hvilket som helst af kravene 1-14, hvor sammensætningen yderligere omfatter en adjuvans.
16. Lyofiliseret immunogen sammensætning ifølge krav 15, hvor adjuvansen er et saponin.
17. Fremgangsmåde til fremstilling af en immunogen sammensætning, omfattende trinnene: (a) at kombinere i en vandig opløsning: (i) et ClfA- polypeptid, hvor ClfA-polypeptidet omfatter et N1-, N2- og N3-domæne, (ii) et CP5-CRM 197-konjugat, (iii) et CP8-CRMi97-konjugat, (iv) et MntC-polypeptid, (v) en buffer med en pKa på 6,0 ± 0,6 og (vi) et fyldemiddel; og (b) at lyofili-sere kombinationen fra trin (a) til dannelse af en kage omfattende mindre end 3 vægtprocent vand.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061426476P | 2010-12-22 | 2010-12-22 | |
| PCT/IB2011/055883 WO2012085872A2 (en) | 2010-12-22 | 2011-12-21 | Stable immunogenic compositions of staphylococcus aureus antigens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2654784T3 true DK2654784T3 (da) | 2017-02-13 |
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| DK16193095.3T DK3150222T3 (da) | 2010-12-22 | 2011-12-21 | Stabile immunogene sammensætninger af staphylococcus aureus-antigener |
| DK11804822.2T DK2654784T3 (da) | 2010-12-22 | 2011-12-21 | Stabile immunogene sammensætninger af staphylococcus aureus-antigener |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16193095.3T DK3150222T3 (da) | 2010-12-22 | 2011-12-21 | Stabile immunogene sammensætninger af staphylococcus aureus-antigener |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20130259896A1 (da) |
| EP (2) | EP2654784B1 (da) |
| JP (1) | JP6097478B2 (da) |
| KR (2) | KR20130114210A (da) |
| CN (1) | CN103826656B (da) |
| AU (1) | AU2011346535B2 (da) |
| BR (1) | BR112013016153A2 (da) |
| CA (1) | CA2819120C (da) |
| DK (2) | DK3150222T3 (da) |
| ES (2) | ES2614815T3 (da) |
| HU (2) | HUE047263T2 (da) |
| IL (1) | IL226793B (da) |
| MX (1) | MX350170B (da) |
| PL (2) | PL3150222T3 (da) |
| PT (2) | PT2654784T (da) |
| RU (1) | RU2570730C2 (da) |
| SI (2) | SI2654784T1 (da) |
| WO (1) | WO2012085872A2 (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
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| NZ553776A (en) | 2004-09-22 | 2010-05-28 | Glaxosmithkline Biolog Sa | Immunogenic composition comprising staphylococcal PNAG and Type 5 and/or 8 Capsular polysaccharide or oligosaccharide. |
| SA110310528B1 (ar) | 2009-06-22 | 2014-07-02 | Wyeth Llc | التركيبات المولدة للمناعة لأنتيجينات ستافيلوكوكس أوريس |
| SG10201406432RA (en) | 2009-06-22 | 2014-11-27 | Wyeth Llc | Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions |
| PL2575870T3 (pl) * | 2010-06-04 | 2017-05-31 | Wyeth Llc | Preparaty szczepionek |
| AU2012266880A1 (en) * | 2011-03-16 | 2013-10-03 | Regents Of The University Of Minnesota | Compositions and methods for inducing immune responses against bacteria in the genus staphylococcus |
| GB201310008D0 (en) * | 2013-06-05 | 2013-07-17 | Glaxosmithkline Biolog Sa | Immunogenic composition for use in therapy |
| US10195262B2 (en) * | 2013-12-04 | 2019-02-05 | Glaxosmithkline Biologicals S.A. | Prevention of Staphylococcus aureus infections by glycoprotein vaccines synthesized in Escherichia coli |
| IL310015B2 (en) * | 2013-12-31 | 2026-02-01 | Access To Advanced Health Inst | Single vial formulation |
| PL3129001T3 (pl) * | 2014-04-10 | 2020-06-29 | Asit Biotech S.A. | Preparat alergenów wolny od hsp |
| CN110996992A (zh) * | 2017-08-16 | 2020-04-10 | 默沙东公司 | 肺炎球菌缀合物疫苗制剂 |
| GB201802339D0 (en) | 2018-02-13 | 2018-03-28 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| KR102646145B1 (ko) | 2018-05-31 | 2024-03-11 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 모공 축소용 조성물 |
| KR102058961B1 (ko) * | 2018-07-28 | 2019-12-24 | 주식회사 엑소코바이오 | 엑소좀의 동결건조 방법 |
| KR102163806B1 (ko) | 2018-07-30 | 2020-10-07 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 피지분비 감소용 조성물 |
| BR112022013730A2 (pt) * | 2020-01-13 | 2022-10-11 | Aptevo Res & Development Llc | Métodos e composições para prevenir a adsorção de proteínas terapêuticas aos componentes do sistema de distribuição de drogas |
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2011
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- 2011-12-21 HU HUE16193095A patent/HUE047263T2/hu unknown
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