DK2694640T3 - Reversion af effekterne af tumormikromiljø ved anvendelse af kimæriske cytokinreceptorer - Google Patents

Reversion af effekterne af tumormikromiljø ved anvendelse af kimæriske cytokinreceptorer

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Publication number
DK2694640T3
DK2694640T3 DK12767723.5T DK12767723T DK2694640T3 DK 2694640 T3 DK2694640 T3 DK 2694640T3 DK 12767723 T DK12767723 T DK 12767723T DK 2694640 T3 DK2694640 T3 DK 2694640T3
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DK
Denmark
Prior art keywords
reversion
chemical
environment
effects
tumor micro
Prior art date
Application number
DK12767723.5T
Other languages
English (en)
Inventor
Ann Marie Leen
Juan F Vera
Original Assignee
Baylor College Medicine
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Publication of DK2694640T3 publication Critical patent/DK2694640T3/da

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
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    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/35—Cytokines
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4238—Regulators of development
    • A61K40/424—Apoptosis related proteins, e.g. survivin or livin
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4256—Tumor associated carbohydrates
    • A61K40/4257—Mucins, e.g. MUC-1
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    • A61K40/41—Vertebrate antigens
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DK12767723.5T 2011-04-08 2012-04-05 Reversion af effekterne af tumormikromiljø ved anvendelse af kimæriske cytokinreceptorer DK2694640T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161473457P 2011-04-08 2011-04-08
PCT/US2012/032322 WO2012138858A1 (en) 2011-04-08 2012-04-05 Reversing the effects of the tumor microenvironment using chimeric cytokine receptors

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DK2694640T3 true DK2694640T3 (da) 2017-11-20

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DK12767723.5T DK2694640T3 (da) 2011-04-08 2012-04-05 Reversion af effekterne af tumormikromiljø ved anvendelse af kimæriske cytokinreceptorer

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Country Link
US (2) US10548921B2 (da)
EP (2) EP2694640B1 (da)
JP (3) JP6066991B2 (da)
CN (2) CN107164330A (da)
AU (3) AU2012240135B2 (da)
CA (1) CA2832569A1 (da)
DK (1) DK2694640T3 (da)
ES (1) ES2649967T3 (da)
MX (2) MX347656B (da)
NO (1) NO2724929T3 (da)
NZ (3) NZ616405A (da)
WO (1) WO2012138858A1 (da)

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