DK2731947T3 - Substitueret dimerisk quinazolin-derivat, fremstilling og andvendelse deraf i farmaceutiske sammensætninger til behandling af type i- og type ii-diabetes - Google Patents

Substitueret dimerisk quinazolin-derivat, fremstilling og andvendelse deraf i farmaceutiske sammensætninger til behandling af type i- og type ii-diabetes Download PDF

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Publication number
DK2731947T3
DK2731947T3 DK12733784.8T DK12733784T DK2731947T3 DK 2731947 T3 DK2731947 T3 DK 2731947T3 DK 12733784 T DK12733784 T DK 12733784T DK 2731947 T3 DK2731947 T3 DK 2731947T3
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compound
type
disclosure
compounds
treatment
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DK12733784.8T
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Waldemar Pfrengle
Markus Frank
Thomas Klein
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Boehringer Ingelheim Int
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Claims (8)

1. Forbindelse med formlen (IA):
eller en tautomer, enantiomer, diastereomer, blanding eller salt deraf; til anvendelse i forebyggelse eller behandling af lidelser eller sygdomstilstande, der er forbundet med en forøget DPP-IV-aktivitet, eller som kan forebygges eller Undres ved at reducere DPP-IV-aktiviteten, navnlig type I- eller type II-diabetes mellitus.
2. Forbindelse til anvendelse ifølge krav 1 i form af et fysiologisk acceptabelt salt med en uorganisk eller organisk syre eller base.
3. Farmaceutisk sammensætning til anvendelse ved behandling og / eller forebyggelse af type 2-diabetes mellitus og / eller diabetiske komplikationer, der indeholder en forbindelse ifølge krav 1 eller et fysiologisk acceptabelt salt ifølge krav 2 eventuelt sammen med et eller flere farmaceutisk acceptable excipienser.
4. Forbindelse ifølge mindst et af kravene 1 til 2 til anvendelse ved behandling af type II-diabetes mellitus.
5. Forbindelse ifølge mindst et af kravene 1 til 2 til anvendelse i en fremgangsmåde til at behandle eller at forebygge type II-diabetes mellitus, hvilken fremgangsmåde omfatter at indgive forbindelsen ifølge mindst et af kravene 1 til 2, og eventuelt en eller flere andre aktive stoffer, til patienten.
6. Forbindelse til anvendelse ifølge krav 5, hvor det ene eller flere andre aktive stoffer er valgt blandt metformin, sulfonylurinstoffer, nateglinid, repaglinid, thiazolidinedioner (fx pioglitazon), PPAR-gammaagonister, alfa-glucosidaseblokkere, insulin- eller insulinanaloger og GLP-1 og GLP-l-analoger.
7. Farmaceutisk sammensætning til anvendelse ved behandling og / eller forebyggelse af type 2-diabetes mellitus og / eller diabetiske komplikationer omfattende en forbindelse
ifølge krav 1 eller et fysiologisk acceptabelt salt ifølge krav 2 og metformin (fx metformin-hydrochlorid), eventuelt sammen med et eller flere farmaceutisk acceptable excipienser.
8. Farmaceutisk sammensætning til anvendelse ved behandling og / eller forebyggelse af type 2-diabetes mellitus og / eller diabetiske komplikationer omfattende en forbindelse ifølge krav 1 eller et fysiologisk acceptabelt salt ifølge krav 2 og pioglitazon (fx pioglitazon-hydrochlorid), eventuelt sammen med et eller flere farmaceutisk acceptable excipienser.
DK12733784.8T 2011-07-15 2012-07-13 Substitueret dimerisk quinazolin-derivat, fremstilling og andvendelse deraf i farmaceutiske sammensætninger til behandling af type i- og type ii-diabetes DK2731947T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11174266 2011-07-15
EP12170055 2012-05-30
PCT/EP2012/063852 WO2013010964A1 (en) 2011-07-15 2012-07-13 Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions

Publications (1)

Publication Number Publication Date
DK2731947T3 true DK2731947T3 (da) 2019-04-23

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DK12733784.8T DK2731947T3 (da) 2011-07-15 2012-07-13 Substitueret dimerisk quinazolin-derivat, fremstilling og andvendelse deraf i farmaceutiske sammensætninger til behandling af type i- og type ii-diabetes
DK19151416.5T DK3517539T3 (en) 2011-07-15 2012-07-13 Farmaceutiske sammensætninger til behandling af type i og type ii diabetes

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DK19151416.5T DK3517539T3 (en) 2011-07-15 2012-07-13 Farmaceutiske sammensætninger til behandling af type i og type ii diabetes

Country Status (17)

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US (3) US8962636B2 (da)
EP (2) EP2731947B1 (da)
JP (1) JP5876150B2 (da)
KR (2) KR20190062621A (da)
CN (1) CN103781788B (da)
AU (1) AU2012285904C1 (da)
CA (1) CA2841552C (da)
CL (1) CL2014000076A1 (da)
DK (2) DK2731947T3 (da)
EA (1) EA030121B1 (da)
ES (2) ES2934843T3 (da)
HU (2) HUE043540T2 (da)
MX (1) MX366629B (da)
NZ (1) NZ618698A (da)
PH (1) PH12014500137A1 (da)
PL (2) PL2731947T3 (da)
WO (1) WO2013010964A1 (da)

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